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Chinese Journal of Polymer Science 2009年第1期27卷 121-130页

作者： Hetal J.patel mitesh g.patel Kirit H.patel Arabinda K.Ray Rajni M.patel Department of Chemistry Sardar Patel UniversityVallabh Vidyanagar-388120GujaratIndia

Some copolymers of 2,4-dichlorophenyl acrylate (2,4-DCPA) with styrene (St) of different teed compositions were prepared by tree radical polymerization technique using 2,2′-azobisisobutyronitrile (AIBN) as an initiator,and the copolymers were characterized by IR *** copolymer composition obtained by UV-spectra led to determination of reactivity ratio by employing Fineman-Ross (F-R) and Kelen-Tudos (K-T) *** molecular weight,as well as intrinsic viscosity,was obtained by vapor pressu...

关键词： Copolymers Reactivity ratios Vapor pressure osmometry Thermal analysis Antimicrobial screening

An efficient synthesis of 3'-quinolinyl substituted imidazole-5-one derivatives catalyzed by zeolite and their antimicrobial activity

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Chinese Chemical Letters 2012年第3期23卷 273-276页

作者： Harshad g.Kathrotiya Nilav A.patel Ranjan g.patel Manish P.patel Department of Chemistry Sardar Patel UniversityVallabh Vidyanagar388120 GujaratIndia

A series of some new quinoline based imidazole-5-one derivatives have been synthesized by the fusion of oxazol-5-ones,various p-substituted anilines and zeolite in *** the derivatives were subjected to an in vitro ant... 详细信息

关键词： Imidazolinone Quinoline Zeolite Antimicrobial activity

Synthesis and in vitro antimicrobial activity of N-arylquinoline derivatives bearing 2-morpholinoquinoline moiety

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Chinese Chemical Letters 2012年第4期23卷 427-430页

作者： Jigar A.Makawana Manish P.patel Ranjan g.patel Department of Chemistry Sardar Patel UniversityVallabh Vidyanagar 388120GujaratIndia

A new series of N-arylquinoline derivatives 5a-x bearing 2-morpholinoquinoline moiety has been synthesized by one pot base catalyzed cyclocondensation reaction of 2-morpholinoquinoline-3-carbaldehydes 2a-c,malononitrile 3 andβ-enaminones 4a-h. All the synthesized compounds were screened for their in vitro antimicrobial activity against six bacterial pathogens,namely Streptococcus pneumoniae,Clostridium tetani,Bacillus subtilis,Salmonella typhi,Vibrio cholerae,Escherichia coli and against two fungal pathogens,Aspergillus fumigatus and Candida albicans using broth microdilution MIC *** the compounds studied,majority of the compounds were found to active against ***,*** and *** as compared to first-line standard drugs.

关键词： N-arylquinoline 2-Morpholinoquinoline-3-carbaldehyde In vitro antimicrobial activity MCR

Intratympanic corticosteroids in Ménière's disease:A mini-review

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Journal of Otology 2017年第3期12卷 117-124页

作者： mitesh patel Division of Brain Sciences Imperial College London Charing Cross Hospital London W6 8RF UK

This article reviews the effectiveness of intratympanic corticosteroids for vertigo control in Meniere's disease at 2-years follow-up according to the guidelines expressed by the American Academy of Otolaryngology-Head & Neck Surgery. Despite the increased use of intratympanic corticosteroids for vertigo control in Meniere's disease there is debate as to their effectiveness, particularly compared to gentamicin. Even so,after just a single course of injections, corticosteroids can reliably provide complete vertigo control(Class A) at 2-years in about 50% of cases as indicated in a recent double-blind randomized controlled clinical trial(patel et al., 2016). But the effectiveness of intratympanic corticosteroids truly increases when treatment is provided 'as-needed', whereby complete vertigo control is established in up to 91% of cases. On the basis of available literature, there is good evidence to recommend the use of intratympanic steroid treatment for vertigo control in Meniere's disease, but patients must be monitored for non-response. The rationale for treating patients as-needed and the possible reasons for corticosteroid nonresponse are discussed.

关键词： Meniere's disease Intratympanic Corticosteroid Dexamethasone Methylprednisolone

One step synthesis of pyrido[1,2-a]benzimidazole derivatives of aryloxypyrazole and their antimicrobial evaluation

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Chinese Chemical Letters 2013年第2期24卷 123-126页

作者： Hardik H.Jardosh Chetan B.Sangani Manish P.patel Ranjan g.patel Department of Chemistry Sardar Patel UniversityVallabh Vidyanagar-388120GujaratIndia

Received 3 September 2012 Received in revised form 16 October 2012 Accepted 31 December 2012 Available online 6 February 2013

关键词： AryloxypyrazolePyrido[ 1 2-a]benzimidazoleMulticomponent reactionAntimicrobial activity

Microwave assisted synthesis of novel Hantzsch 1,4-dihydropyridines,acridine-1,8-diones and polyhydroquinolines bearing the tetrazolo[1,5-α]quinoline moiety and their antimicrobial activity assess

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Chinese Chemical Letters 2011年第12期22卷 1407-1410页

作者： Niraj K.Ladani Divyesh C.Mungra Manish P.patel Ranjan g.patel Department of Chemistry Sardar Patel UniversityVallabh Vidyanagar 388120GujaratIndia

Microwave assisted efficient Hantzsch reaction via four-component coupling reactions of tetrazolo[1,5-α]quinoline-4-carbal-dehyde, dimedone/cyclohexane-1,3-dione,ethyl/methyl acetoacetate and ammonium acetate was described as the preparation of tetrazolo[1,5-α]quinoline based 1,4-dihydropyridines,acridine-1,8-diones and *** process presented here is simple,rapid,environmentally welcoming and high *** the derivatives were subjected to an in vitro antimicrobial screening against a representative panel of bacteria and fungi and results worth further investigations.

关键词： Microwave assisted Tetrazolo[1 5-α]quinoline 1 4-Dihydropyridine Acridine-1 8-dione Polyhydroquinoline Antimicrobial activity

Synthesis and in vitro antimicrobial screening of new pyrano[4,3-b]pyrane derivatives of 1H-pyrazole

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Chinese Chemical Letters 2012年第1期23卷 57-60页

作者： Chetan B.Sangani Divyesh C.Mungra Manish P.patel Ranjan g.patel Department of Chemistry Sardar Patel UniversityVallabh Vidyanagar 388120GujaratIndia

A new series of pyrano[4,3-b]pyrane 4a-l bearing 1H-pyrazole has been synthesized by one pot base catalyzed cyclocondensation reaction of 1H-pyrazole-4-carbaldehyde la-1,malononitrile 2 and 4-hydroxy-6-methylpyrone *** the synthesized compounds were screened against six bacterial pathogens,namely ***,***,***,***,***, *** and antifungal activity against,two fungal pathogens,*** and *** using broth microdilution MIC method. Some of the compounds are found to be equipotent or more potent than that of commercial drugs,against most of employed strains.

关键词： Pyranopyrane MCR Pyrazole-4-carbaldehyde Antimicrobial activity

Development and validation of a RP-HPLC method for the simultaneous determination of Embelin,Rottlerin and Ellagic acid in Vidangadi churna

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Journal of Pharmaceutical Analysis 2012年第5期2卷 366-371页

作者： Rakesh K.patel Vishal R.patel Madhavi g.patel S.K.patel College of Pharmaceutical Education and Research KhervaMehsanaIndia Department of Pharmacognosy Baroda College of PharmacyParul Group of InstitutesLimdaVadodaraGujarat 391760India Parul Institute of Pharmacy Parul Group of InstitutesLimdaVadodaraIndia

Vidangadi churna is a popular Ayurvedic formulation described in the chapter Krimicikitsa of the Ayurvedic literature Cakradatta for the treatment of Krimiroga. The preparation is a composite mixture of the fine powder of fruits of Vidang （Embelia ribs）, glandular trichomes of the fruits of Kamala （Mallotus philippensis）, mature fruits of Harde （Terminalia chehula）, Saindhava and Yavakshara. The use of reversed phase C18 column eluted with gradient mobile phase of acetonitrile and water enabled the efficient separation of the chemical markers in 22 rain. Validation of the method was performed in order to demonstrate its selectivity, accuracy, precision, repeatability and recovery. All calibration curves showed good linear correlation coefficients （r2〉0.995） within the tested ranges. Three markers in Vidangadi churna were quantitied with respect to Embelin （0.647%, w/w）, Rottlerin （4.419%, w/w）, and Ellagic acid （0.459%, w/w）. lntraand inter-day RSDs of retention times and peak areas were less than 3.12%. The recoveries were between 99.66% and 102.33%. In conclusion, a method has been developed for the simultaneous quantification of three markers in Vidangadi churna. The RP-HPLC method was simple, precise and accurate and can be used for the quality control of the raw materials as well as formulations.

关键词： Vidangadi churnaEmbelin Rottlerin Ellagic acid RP-HPLC

Molecular iodine catalyzed synthesis of tetrazolo[1,5-a]-quinoline based imidazoles as a new class of antimicrobial and antituberculosis agents

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Chinese Chemical Letters 2012年第12期23卷 1367-1370页

作者： Divyesh C.Mungra Harshad g.Kathrotiya Niraj K.Ladani Manish P.patel Ranjan g.patel Department of Chemistry Sardar Patel University

A series of some new tetrazolo[1,5-a]quinoline based tetrasubstituted imidazole derivatives 6a-i have been synthesized by a reaction of tetrazolo[ 1,5-a]quinoline-4-carbaldehyde 3a-d, benzil 4, aromatic amine 5a--c and ammonium acetate in the presence of iodine through one-pot multi-component reaction （MCR） approach. All the derivatives were screened for antimicrobial and antituberculosis activities and results worth further investigations.

关键词： Tetrazolo[1,5-a]quinoline Imidazole MCR Iodine Antimicrobial activity Antituberculosis activity

Synthesis,characterization and antimicrobial activity of some new biquinoline derivatives containing a thiazole moiety

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Chinese Chemical Letters 2012年第4期23卷 454-457页

作者： Nirav K.Shah Nimesh M.Shah Manish P.patel Ranjan g.patel Department of Chemistry Sardar Patel UniversityVallabh Vidyanagar 388120GujaratIndia

A series of new biquinoline derivatives containing a thiazole moiety were synthesized by a one-pot,base-catalyzed cyclocondensation reaction of 2-chloro-3-formyl quinoline,malononitrile and *** the synthesized compounds were characterized by elemental analysis,FT-IR,~1H NMR and ^（13）C NMR *** the synthesized compounds were screened against three bacterial pathogens,namely Bacillus cereus,*** and Escherichia coli and for antifungal activity against three fungal pathogens,Aspergillus niger,Fusarium oxisporum and Rhizopus using the disc diffusion method.

关键词： Quinoline Multicomponent reaction Thiazole Antimicrobial activity