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TiN海绵颗粒与Ti界面区氮的扩散和相变

稀有金属材料与工程 2001年第4期30卷 257-260页

作者：王达健 G.Naimagon A.mitchell 昆明理工大学云南昆明650093 不列颠哥伦比亚大学

为了理解轻元素 N及 Ti N夹杂在 Ti合金中的溶解行为 ,实验研究了海绵 Ti N颗粒在 Cp Ti和 Ti- 6Al- 4 V合金中界面的扩散和相变行为 ,对比了合金元素对 N的扩散和相变的影响规律。Ti N颗粒在高温下植入液态金属中进行溶解和扩散 ,用电... 详细信息

为了理解轻元素 N及 Ti N夹杂在 Ti合金中的溶解行为 ,实验研究了海绵 Ti N颗粒在 Cp Ti和 Ti- 6Al- 4 V合金中界面的扩散和相变行为 ,对比了合金元素对 N的扩散和相变的影响规律。Ti N颗粒在高温下植入液态金属中进行溶解和扩散 ,用电子探针检测了在铸态和热处理状态下 ,含氮 α相中氮及其合金元素在界面处沿基体金属方向的扩散浓度分布。实验观察到相变区内很陡的 N元素浓度分布 ,结合 Ti- N二元系相平衡特点 ,考察了合金元素对 N扩散和相变的影响。比较 Cp Ti和 Ti- 6Al- 4 V的结果表明 ,Al,V合金元素对界面附近 N的扩散及 Ti N的溶解表现出阻滞作用。

关键词：扩散相变钛合金氮化钛氮

Pre-treatment twice with liposomal clodronate protects against acetaminophen hepatotoxicity through a pre-conditioning effect

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Liver Research 2020年第3期4卷 145-152页

作者： Melissa M.Clemens Joel H.Vazquez stefanie Kennon-McGill sandra s.McCullough Laura P.James mitchell R.McGill Department of Pharmacology and Toxicology College of MedicineUniversity of Arkansas for Medical SciencesLittle RockARUSA Interdisciplinary Graduate Program in Biomedical sciences Graduate SchoolUniversity of Arkansas for Medical SciencesLittle RockARUSA Department of Environmental and Occupational Health Fay W.Boozman College of Public HealthUniversity of Arkansas for Medical SciencesLittle RockARUSA Department of Pediatrics College of MedicineUniversity of Arkansas for Medical SciencesLittle RockARUSA Center for Dietary supplement Research University of Arkansas for Medical SciencesLittle RockARUSA

Background and aim:Acetaminophen(APAP)overdose is a major cause of acute liver injury,but the role of macrophages in the propagation of the hepatotoxicity is *** research revealed that macrophage inhibitors protect against APAP ***,later work demonstrated that macrophage ablation by acute pre-treatment with liposomal clodronate(LC)exacerbates the *** our surprise,during other studies,we observed that pre-treatment twice with LC seemed to protect against APAP hepatotoxicity,in contrast to acute *** aim of this study was to confirm that observation and to explore the ***:We treated mice with empty liposomes(LE)or LC twice per week for 1 week before APAP overdose and collected blood and liver tissue at 0,2,and 6 h *** then measured liver injury(serum alanine aminotransferase activity,histology),APAP bioactivation(total glutathione,APAP-protein adducts),oxidative stress(oxidized glutathione(GssG)),glutamate-cysteine ligase subunit c(Gclc)mRNA,and nuclear factor erythroid 2-related factor(Nrf2)*** also confirmed the ablation of macrophages by F4/80 ***:Pre-treatment twice with LC dramatically reduced F4/80 staining,protected against liver injury,and reduced oxidative stress at 6 h post-APAP,without affecting APAP ***,Gclc mRNA was higher in the LC group at 0 h and total glutathione was higher at 2 h,indicating accelerated glutathione re-synthesis after APAP overdose due to greater basal glutamate-cysteine *** stress was lower in the LC groups at both time ***,total Nrf2 immunofluorescence was higher in the LC ***:We conclude that multiple pre-treatments with LC protect against APAP by accelerating glutathione re-synthesis through glutamate-cysteine *** using twice or possibly more LC pre-treatments to deplete macrophages,including peritoneal macrophages,should be aware of this poss

关键词： Acetaminophen(APAP) Acute liver failure(ALF) Damage-associated molecular patterns(DAMPs) Drug-induced liver injury Liposomal clodronate(LC) Kupffer cells Nuclear factor erythroid 2-related factor(Nrf2) sterile inflammation stress response

Review of current reconstructive approaches for pan-brachial plexus injuries

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Plastic and Aesthetic Research 2023年第1期10卷 258-269页

作者： sean M.mitchell Justin W.Zumsteg Karan A.Desai Department of Hand&Upper Extremity surgery Orlando Health Jewett Orthopedic InstituteOrlandoFL 32806USA

Pan-brachial plexus injuries present a challenging clinical problem,resulting in severe impairment of motor and sensory function in the upper *** current literature has outlined several promising methodologies for treatment,a consensus has yet to be *** this review,we present three general approaches for reconstructing the upper extremity in these complex cases.

关键词： Pan-brachial plexus injuries brachial plexus reconstructive techniques

An Evaluation of the Introduction of Modified Cropping Practices in Yunnan Province,China,Using surveys of Farmers’ Households

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Agricultural sciences in China 2009年第2期8卷 188-202页

作者： M subedi T J Hocking M A Fullen A R McCrea E Milne D J mitchell WU Bo-zhi school of Applied sciences University of Wolverhampton Wulfruna Street Wolverhampton WV1 1LY UK The Macaulay Institute Craigiebuckler Aberdeen AB15 8QH UK Yunnan Agricultural University Kunming 650201 P.R.China

Problems associated with land degradation are serious in China. sloping land in south China has experienced a decline in crop productivity by 30-60% due to soil erosion and it has been predicted that most topsoil will be lost within the next 100 years if current erosion rates continue. Considering these situations, an agro-environmental research and development project （sustainable Highland Agriculture in south-East Asia- sHAsEA） was conducted in a catchment in Yunnan Province, China, to address the objectives of increasing crop productivity in sustainable and environmentally-friendly ways. A range of cropping practices was developed and implemented in a rural upland catchment （Wang Jia）. At the end of the project, farmers were surveyed to evaluate project effectiveness. All farmers from Wang Jia Catchment, who were involved in project implementation, were surveyed. A sample of farmers working in an adjacent catchment （not associated with the project） was surveyed for comparative purposes. Farmers had different perceptions of the cropping practices employed. Contour cultivation was preferred and likely to be adopted. Others practices such as straw mulching and intercropping were seen as less appropriate and unlikely to be adopted. Polythene mulch was recognized as effective, but likely to be adopted only if financial returns were favourable. The availability of relevant information had an important impact on the extent of technology testing by farmers and their willingness to adopt the practices in the future.

关键词： cropping practices farmers' perceptions household survey Yunnan China

Pancreas preserving distal duodenectomy: A versatile operation for a range of infra-papillary pathologies

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World Journal of Gastroenterology 2017年第23期23卷 4252-4261页

作者： W Kyle mitchell Pradeep F Thomas Abed M Zaitoun Adam J Brooks Dileep N Lobo Gastrointestinal surgery Nottingham Digestive Diseases CentreNational Institute for Health Research Nottingham Biomedical Research CentreNottingham University Hospitals and University of NottinghamQueen's Medical Centre Cellular Pathology Nottingham Digestive Diseases CentreNational Institute for Health Research Nottingham Biomedical Research CentreNottingham University Hospitals and University of NottinghamQueen's Medical Centre

To investigate the range of pathologies treated by pancreas preserving distal duodenectomy (PPDD) and present the outcome of *** lesions of the duodenum are treated conventionally by pancreaticoduodenectomy. Lesions distal to the major papilla may be suitable for a pancreas-preserving distal duodenectomy, potentially reducing morbidity and mortality. We present our experience with this procedure. selective intraoperative duodenoscopy assessed the relationship of the papilla to the lesion. After duodenal mobilisation and confirmation of the site of the lesion, the duodenum was transected distal to the papilla and beyond the duodenojejunal flexure and a side-to-side duodeno-jejunal anastomosis was formed. Patients were identified from a prospectively maintained database and outcomes determined from digital health records with a dataset including demographics, co-morbidities, mode of presentation, preoperative imaging and assessment, nutritional support needs, technical operative details, blood transfusion requirements, length of stay, pathology including lymph node yield and lymph node involvement, length of follow-up, complications and outcomes. Related published literature was also ***-four patients had surgery with the intent of performing PPDD from 2003 to 2016. Nineteen underwent PPDD successfully. Two patients planned for PPDD proceeded to formal pancreaticoduodenectomy (PD) while three had unresectable disease. Median post-operative follow-up was 32 mo. Pathologies resected included duodenal adenocarcinoma (n = 6), adenomas (n = 5), gastrointestinal stromal tumours (n = 4) and lipoma, bleeding duodenal diverticulum, locally advanced colonic adenocarcinoma and extrinsic compression (n = 1 each). Median postoperative length of stay (LOs) was 8 d and morbidity was low [pain and nausea/vomiting (n = 2), anastomotic stricture (n = 1), pneumonia (n = 1), and overwhelming post-splenectomy sepsis (n = 1, asplenic patient)]. PP

关键词： Pancreas preserving distal duodenectomy Duodenojejunostomy Duodenal disease surgical technique Adults Indications Treatment Outcome

Regulation of Parkin-dependent mitophagy by Bcl-2-associated athanogene(BAG)family members

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Neural Regeneration Research 2021年第4期16卷 684-685页

作者： Minesh Kapadia mitchell L.De snoo Lorraine V.Kalia suneil K.Kalia Krembil Research Institute Toronto Western HospitalUniversity Health NetworkTorontoONCanada Faculty of Medicine University of TorontoTorontoONCanada Department of Laboratory Medicine and Pathobiology University of TorontoTorontoONCanada Tanz Centre for Research in Neurodegenerative Diseases Division of NeurologyDepartment of MedicineUniversity of TorontoToronto Western HospitalUniversity Health NetworkTorontoONCanada Division of Neurosurgery Department of SurgeryUniversity of TorontoToronto Western HospitalUniversity Health NetworkTorontoONCanada

Mitochondria are essential organelles that play a central role in cellular metabolism and *** broad range of functions include supplying energy,regulating signaling pathways,and maintaining control of cell proliferation and *** defective mitochondria can perturb cellular homeostasis,quality control mechanisms have evolved to preserve mitochondrial fidelity in response to stress and aging(Palikaras et al.,2018).Persistent defects,however,trigger elimination of the entire organelle by an evolutionarily conserved set of cellular processes that specifically remove dysfunctional or surplus *** selective degradation of the mitochondria through autophagy,termed mitophagy,is important in fine-tuning mitochondrial number.

关键词： remove elimination metabolism

Equity and seeking treatment for young children with fever in Nigeria: a cross-sectional study in Cross River and Bauchi states

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Infectious Diseases of Poverty 2015年第1期4卷 1-8页

作者： Bikom Patrick Odu steven mitchell Hajara Isa Iyam Ugot Robbinson Yusuf Anne Cockcroft Neil Andersson CIET Trust 71 Oxford RoadSaxonwoldJohannesburg 2196South Africa CIET/PRAM Department of Family MedicineMcGill University5858 Côte-des-NeigesSuite 300MontrealQC H3Z 1Z1Canada Community Health Department and Roll Back Malaria Program CalabarCross River StateNigeria state Ministry of Health BauchiBauchi StateNigeria CIET Trust Botswana PO Box 1240GaboroneBotswana

Background:Poor children have a higher risk of contracting malaria and may be less likely to receive effective *** is an important cause of morbidity and mortality in Nigerian children and many cases of childhood fever are due to *** study examined socioeconomic factors related to taking children with fever for treatment in formal health ***:A household survey conducted in Bauchi and Cross River states of Nigeria asked parents where they sought treatment for their children aged 0–47 months with severe fever in the last month and collected information about household socio-economic *** also recorded whether there was a health facility in the *** used treatment of severe fever in a health facility to indicate likely effective treatment for *** analysis in each state examined associations with treatment of childhood fever in a health ***:43%weighted(%wt)of 10,862 children had severe fever in the last month in Cross River,and 45%wt of 11,053 children in *** these,less than half(31%wt Cross River,44%wt Bauchi)were taken to a formal health facility for *** were more likely to be taken to a health facility if there was one in the community(OR 2.31[95%CI 1.57–3.39]in Cross River,OR 1.33[95%CI 1.0–1.7]in Bauchi).Children with fever lasting less than five days were less likely to be taken for treatment than those with more prolonged fever,regardless of whether there was such a facility in their *** mothers were more likely to take children with fever to a formal health *** communities with a health facility in Cross River,children from less-poor households were more likely to go to the facility(OR 1.30;95%CI 1.07-1.58).Conclusion:There is inequity of access to effective malaria treatment for children with fever in the two states,even when there is a formal health facility in the *** the details of inequity of access in th

关键词： severe fever Malaria Equity Access to care Nigeria

Linking the Gawler Craton and Mount Isa Province through hydrothermal systems in the Peake and Denison Domain,northeastern Gawler Craton

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Geoscience Frontiers 2023年第5期14卷 108-125页

作者： mitchell J.Bockmann Justin L.Payne Martin Hand Laura J.Morrissey Antonio P.Belperio Department of Earth sciences University of AdelaideAdelaideSAAustralia Mineral Exploration Cooperative Research Centre University of AdelaideAdelaideSAAustralia UnisA sTEM University of South AustraliaAdelaideSAAustralia Mineral Exploration Cooperative Research Centre Future Industries InstituteUniversity of South AustraliaAdelaideSAAustralia Demetallica Ltd NorwoodSAAustralia

Tectonic reconstructions of Proterozoic Australia commonly place the Peake and Denison Domain of the northeastern Gawler Craton at the interface between the North and south Australian cratons prior to the reconfiguration of Australia’s main tectonic components in the ***,this reconstruction is largely based on palaeomagnetic data as the geological correlations between these regions are currently limited,particularly during the *** early Mesoproterozoic period is significant as it corresponds to major IOCG mineralization in the eastern Gawler Craton between 1600 Ma and 1575 Ma,and IOCG mineralization in the Mount Isa Province largely between 1550 Ma and 1490 ***,determining the relationship of the Peake and Denison Domain to the Gawler Craton and Mount Isa Province during this period is essential to evaluating mineral prospectivity in the northeastern Gawler *** U–Pb LA-ICP-Ms geochronology on zircon and titanite improves our understanding of the tectonothermal and hydrothermal history the Peake and Denison Domain during the latePalaeoproterozoic,early-Mesoproterozoic and the Cambrian–Ordovician *** formed within largely calc-silicate alteration assemblages indicates the Peake and Denison Domain has a protracted history of hydrothermal activity,recording events at c.1565 Ma,1530–1515 Ma,c.1500 Ma,c.1465 Ma and c.490 *** highly calcic nature of the c.1565–1500 Ma alteration in the Peake and Denison Domain shares strong similarities in age and character to the regional calcic-sodic alteration recorded in the Mount Isa *** suggest the two regions were influenced by similar hydrothermal systems during the early Mesoproterozoic,supporting reconstruction models that place the Peake and Denison Domain near the Mount Isa Province during the *** highlights the prospectivity of the Peake and Denison Domain for Isan-style IOCG mineralization,but requires consideration of the post-

关键词： Peake and Denison Gawler Craton Mount Isa IOCG Tectonic reconstruction Titanite

Training data selection for accuracy and transferability of interatomic potentials

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npj Computational Materials 2022年第1期8卷 1795-1803页

作者： David Montes de Oca Zapiain mitchell A.Wood Nicholas Lubbers Carlos ZP.ereyra Aidan P.Thompson Danny Perez sandia National Laboratories AlbuquerqueNM87185USA Computer Computationaland Statistical Sciences DivisionLos Alamos National LaboratoryLos AlamosNM87545USA Mechanical and Aerospace Engineering University of California DavisDavisCA95616USA Theoretical Division Los Alamos National LaboratoryLos AlamosNM87545USA

Advances in machine learning(ML)have enabled the development of interatomic potentials that promise the accuracy of first principles methods and the low-cost,parallel efficiency of empirical ***,ML-based potentials struggle to achieve transferability,i.e.,provide consistent accuracy across configurations that differ from those used during *** order to realize the promise of ML-based potentials,systematic and scalable approaches to generate diverse training sets need to be *** work creates a diverse training set for tungsten in an automated manner using an entropy optimization ***,multiple polynomial and neural network potentials are trained on the entropy-optimized dataset.A corresponding set of potentials are trained on an expert-curated dataset for tungsten for *** models trained to the entropy-optimized data exhibited superior transferability compared to the expert-curated ***,the models trained to the expert-curated set exhibited a significant decrease in performance when evaluated on out-of-sample configurations.

关键词： entropy transfer configuration