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A review: Challenges and opportunities for artificial intelligence and robotics in the offshore wind sector

Energy and AI 2022年第2期8卷 177-212页

作者： Daniel mitchell jamie Blanche Sam Harper Theodore Lim Ranjeetkumar Gupta Osama Zaki Wenshuo Tang Valentin Robu Simon Watson David Flynn Smart Systems Group Institute of SensorsSignals and SystemsSchool of Engineering and Physical SciencesHeriot-Watt UniversityEdinburghEH144ASUnited Kingdom Centre for Mathematics and Computer Science Intelligent and Autonomous Systems GroupCWIAmsterdam1098 XG Netherlands Algorithms Group Faculty of Electrical EngineeringMathematics and Computer Science(EEMCS)Delft University of Technology(TU Delft)Delft2628 XE Netherlands The University of Manchester Department of Electrical and Electronic EngineeringOxford RoadManchesterM139PL United Kingdom james Watt School of Engineering University of GlasgowG128QQUnited Kingdom

The UK has set plans to increase offshore wind capacity from 22GW to 154GW by 2030. With such tremendous growth, the sector is now looking to Robotics and Artificial Intelligence (RAI) in order to tackle lifecycle service barriers as to support sustainable and profitable offshore wind energy production. Today, RAI applications are predominately being used to support short term objectives in operation and maintenance. However, moving forward, RAI has the potential to play a critical role throughout the full lifecycle of offshore wind infrastructure, from surveying, planning, design, logistics, operational support, training and decommissioning. This paper presents one of the first systematic reviews of RAI for the offshore renewable energy sector. The state-of-the-art in RAI is analyzed with respect to offshore energy requirements, from both industry and academia, in terms of current and future requirements. Our review also includes a detailed evaluation of investment, regulation and skills development required to support the adoption of RAI. The key trends identified through a detailed analysis of patent and academic publication databases provide insights to barriers such as certification of autonomous platforms for safety compliance and reliability, the need for digital architectures for scalability in autonomous fleets, adaptive mission planning for resilient resident operations and optimization of human machine interaction for trusted partnerships between people and autonomous assistants. Our study concludes with identification of technological priorities and outlines their integration into a new ‘symbiotic digital architecture’ to deliver the future of offshore wind farm lifecycle management.

关键词： Artificial intelligence Autonomous systems Digitalization Offshore renewable energy Offshore wind farms Robotics

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对角斜撑转向架

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中国铁道科学 1982年第1期 50-62页

作者： j.R.mitchell 英国运输部机械工程研究所所长

铁道车辆在直线线路上的稳定性和曲线通过性能是互相关联的,但设计人员往往不得不牺牲后者以图取得所需的运行速度。对角斜撑转向架,又称交叉支撑转向架或径向转向架,在其轮对之间加以几何联系,从而大大提高了其设计柔性,显著地增进了... 详细信息

铁道车辆在直线线路上的稳定性和曲线通过性能是互相关联的,但设计人员往往不得不牺牲后者以图取得所需的运行速度。对角斜撑转向架,又称交叉支撑转向架或径向转向架,在其轮对之间加以几何联系,从而大大提高了其设计柔性,显著地增进了曲线通过性能而不象通常那样伴随着临界速度的降低。本文叙述了所进行的理论研究工作和对角斜撑转向架在线路试验中所得到的实践经验。

关键词：转向架车辆三大件兆牛顿转向装置曲线通过临界速度斜撑

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畅通英语基础教程 1

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丛书名：畅通英语系列教材

2005年

作者：（英）H.Q.mitchell （英）j.Scott 《畅通英语》改编组改编

教育部职业教育与成人教育司推荐教材高等职业教育英语教学用书(五年制适用)畅通英语系列教材:本书共包括16个单元(每四个单元后各有一个复习单元)，每单元包括3课内容，前两课注重词汇、会话、语法的学习和练习，第三课注重阅读、听... 详细信息

ISBN: (纸本)7040161486

教育部职业教育与成人教育司推荐教材高等职业教育英语教学用书(五年制适用)畅通英语系列教材:本书共包括16个单元(每四个单元后各有一个复习单元)，每单元包括3课内容，前两课注重词汇、会话、语法的学习和练习，第三课注重阅读、听力、口语和写作的综合训练。

关键词：英语高等教育

来源：畅想之星图书光盘版（南... 畅想之星图书光盘版（南... 评论

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Effect of plasma surface treatment of poly(dimethylsiloxane) on the permeation of pharmaceutical compounds

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journal of Pharmaceutical Analysis 2017年第5期7卷 338-342页

作者： Laura j.Waters Catherine V.Finch A.K.M.Mehedi H.Bhuiyan Karl Hemming john C.mitchell Department of Pharmacy School of Applied Science University of Huddersfield Medway Centre for Pharmaceutical Sciences University of Greenwich

This paper addresses the modification of poly(dimethylsiloxane), i.e. PDMS, using plasma surface treatment and a novel application of the membrane created. A set of model compounds were analysed to determine their permeation through PDMS, both with and without plasma treatment. It was found that plasma treatment reduced permeation for the majority of compounds but had little effect on some compounds, such as caffeine,with results indicating that polarity plays an important role in permeation, as is seen in human skin. Most importantly, a direct correlation was observed between plasma-modified permeation data and literature data through calculation of membrane permeability(K_p) values suggesting plasma-modified silicone membrane(PMSM) could be considered as a suitable in vivo replacement to predict clinical skin permeation.

关键词： Permeation PDMS Silicone Plasma Flux Hydrophobicity

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Factors associated with refractory pain in emergency patients admitted to emergency general surgery

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World journal of Emergency Medicine 2021年第1期12卷 12-17页

作者： William Gilliam jackson FBarr Brandon Bruns Brandon Cave jordan mitchell Tina Nguyen jamie Palmer Mark Rose Safura Tanveer Chris Yum Quincy K.Tran johns Hopkins University Baltimore 21218USA Research Associate Program in Emergency Medicine and Critical Care Department of Emergency MedicineUniversity of Maryland School of MedicineBaltimore 21201USA R Adams Cowley Shock Trauma Center University of Maryland School of MedicineBaltimore 21201USA Department of Surgery University of Maryland School of MedicineBaltimore 21201USA Louisiana State University Louisiana 70803USA University of Maryland School of Medicine Baltimore 21201USA Department of Emergency Medicine University of Maryland School of MedicineBaltimore 21201USA

BACKGROUND: Oligoanalgesia in emergency departments (EDs) is multifactorial. A previousstudy reported that emergency providers did not adequately manage patients with severe paindespite objective findings for surgical pathologies. Our study aims to investigate clinical andlaboratory factors, in addition to providers’ interventions, that might have been associated witholigoanalgesia in a group of ED patients with moderate and severe pains due to surgical ***: We conducted a retrospective study of adult patients who were transferred directlyfrom referring EDs to the emergency general surgery (EGS) service at a quaternary academic centerbetween january 2014 and December 2016. Patients who were intubated, did not have adequaterecords, or had mild pain were excluded. The primary outcome was refractory pain, which wasdefi ned as pain reduction <2 units on the 0–10 pain scale between triage and ED ***: We analyzed 200 patients, and 58 (29%) had refractory pain. Patients with refractory painhad signifi cantly higher disease severity, serum lactate (3.4±2.0 mg/dL vs. 1.4±0.9 mg/dL, P=0.001), and lessfrequent pain medication administration (median [interquartile range], 3 [3–5] vs. 4 [3–7], P=0.001), whencompared to patients with no refractory pain. Multivariable logistic regression showed that the number of painmedication administration (odds ratio [OR] 0.80, 95% confi dence interval [95% CI] 0.68–0.98) and ED serumlactate levels (OR 3.80, 95% CI 2.10–6.80) were signifi cantly associated with the likelihood of refractory ***: In ED patients transferring to EGS service, elevated serum lactate levelswere associated with a higher likelihood of refractory pain.

关键词： Serum lactate Refractory pain Emergency general surgery Emergency department

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Chemotherapy predictors and a time-dependent chemotherapy effect in metastatic esophageal cancer

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World journal of Gastrointestinal Oncology 2022年第2期14卷 511-524页

作者： Lauren Midthun Sungjin Kim Andrew Hendifar Arsen Osipov Samuel j Klempner joseph Chao May Cho Michelle Guan Veronica R Placencio-Hickok Alexandra Gangi Miguel Burch De-Chen Lin Kevin Waters Katelyn Atkins mitchell Kamrava jun Gong Department of Medicine Division of Hematology and OncologyCedars-Sinai Medical CenterLos AngelesCA 90048United States Biostatistics and Bioinformatics Research Center Cedars Sinai Medical CenterLos AngelesCA 90048United States Samuel Oschin Cancer Center Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Medicine Beth Israel Deaconess Medical Center/Harvard Medical SchoolBrigham and Women's Hospital/Harvard Medical SchoolBostonMA 02114United States Department of Medical Oncology and Therapeutics Research City of Hope Comprehensive Cancer CenterDuarteCA 91010United States Division of Hematology and Oncology Department of MedicineUniversity of CaliforniaIrvineCA 92697United States Department of Medicine Cedars Sinai Medical CenterLos AngelesCA 90048United States Department of Surgery Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Pathology and Laboratory Medicine Cedars Sinai Medical CenterLos AngelesCA 90048United States Department of Radiation Oncology Cedars Sinai Medical CenterLos AngelesCA 90048United States Department of Radiation Oncology Cedars-Sinai Medical CenterLos AngelesCA 90048United States

BACKGROUND Chemotherapy has long been shown to confer a survival benefit in patients with metastatic esophageal ***,not all patients with metastatic disease receive *** To evaluate a large cancer database of metastatic esophageal cancer cases to identify predictors of receipt to chemotherapy and *** We interrogated the National Cancer Database(NCDB)between 2004-2015 and included patients with M1 disease who had received or did not receive chemotherapy.A logistic regression model was used to examine the associations between chemotherapy and potential confounders and a Cox proportional hazards model was employed to examine the effect of chemotherapy on overall survival(OS).Propensity score analyses were further performed to balance measurable confounders between patients treated with and without *** A total of 29182 patients met criteria for inclusion in this analysis,with 21911(75%)receiving chemotherapy and 7271(25%)not receiving *** median follow-up was 69.45 *** median OS for patients receiving chemotherapy was 9.53 mo(9.33-9.72)vs 2.43 mo(2.27-2.60)with no *** of diagnosis 2010-2014[odds ratio(OR):1.29,95%confidence interval(CI):1.17-1.43,P value$46000(OR:1.49,95%CI:1.27-1.75,P value<0.001),and node-positivity(OR:1.35,95%CI:1.20-1.52,P<0.001)were independent predictors of receiving chemotherapy,while female gender(OR:0.86,95%CI:0.76-0.98,P=0.019),black race(OR:0.76,95%CI:0.67-0.93,P=0.005),uninsured status(OR:0.41,95%CI:0.33-0.52,P<0.001),and high Charlson Comorbidity Index(CCI)(OR for CCI≥2:0.61,95%CI:0.50-0.74,P<0.001)predicted for lower odds of receiving *** the effect of chemotherapy on OS using a time-dependent coefficient showed that chemotherapy was associated with improved OS up to 10 mo,after which there is no significant effect on ***,uninsured status[hazard ratio(HR):1.20,95%CI:1.09-1.31,P<0.001],being from the geographic

关键词： Esophageal cancer Metastatic Chemotherapy Predictors Survival

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Does Selection for Seedling Tiller Number in Perennial Biomass Feedstocks Translate to Yield and Quality Improvements in Mature Swards?

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American journal of Plant Sciences 2023年第11期14卷 1223-1234页

作者： Robert B. mitchell Kenneth P. Vogel Susan j. Tunnell james L. Stubbendieck Wheat Sorghum and Forage Research Unit USDA-ARS Lincoln NE USA Department of Agronomy and Horticulture University of Nebraska Lincoln NE USA

Breeding for seedling traits in herbaceous perennial biomass feedstocks that translate into increased biomass yield or quality in established swards could accelerate the development of perennial grass cultivars for bioenergy or forage. In previously reported research, breeding for single large tillers (ST) or multiple tillers (MT, ≥3) six weeks after planting for two generations in big bluestem (Andropogon gerardii Vitman) and switchgrass (Panicum virgatum L.) base populations produced ST and MT populations that differed significantly for seedling and mature plant traits including biomass yield in spaced planted nurseries. Our objective was to evaluate these ST and MT populations in sward trials to determine the effect of these genetic changes on biomass yield and quality when the plants were grown in competitive sward conditions. Big bluestem monocultures of the base, ST, and MT populations were evaluated at three locations in Nebraska in 2001 and 2002 as randomized complete block experiments with four replicates. Switchgrass monocultures of the base, ST, and MT populations were evaluated in 2003, 2004, and 2005 near Mead, NE as a randomized complete block with six replicates. In both big bluestem and switchgrass, the ST and MT populations did not consistently differ from the base population or each other for biomass yield or forage quality. These results demonstrate the importance of evaluating perennial grasses in sward trials and not relying solely on greenhouse-grown plants or space-planted nurseries to develop selection criteria and make selection decisions.

关键词： Seedling Tiller Number Perennial Biomass

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A Highly Efficient Agrobacterium-Mediated Method for Transient Gene Expression and Functional Studies in Multiple Plant Species

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Plant Communications 2020年第5期1卷 129-140页

作者： Youjun Zhang Moxian Chen Beata Siemiatkowska mitchell Rey Toleco Yue jing Vivien Strotmann jianghua Zhang Yvonne Stahl Alisdair R.Fernie Center of Plant Systems Biology and Biotechnology 4000 PlovdivBulgaria Max-Planck-Institut fur Molekulare Pflanzenphysiologie Am Muhlenberg 114476 Potsdam-GolmGermany Department of Biology Hong Kong Baptist Universityand State Key Laboratory of AgrobiotechnologyThe Chinese University of Hong KongShatinHong Kong Institute for Developmental Genetics Heinrich Heine UniversityDusseldorfGermany

Although the use of stable transformation technology has led to great insight into gene function,its application in high-throughput studies remains ***-infiltration have been widely used in species such as Nicotiana benthamiana for the rapid detection of gene expression and protein interaction analysis,but this technique does not work efficiently in other plant species,including Arabidopsis *** an efficient high-throughput transient expression system is currently lacking in the model plant species ***,we developed a method that is characterized by high efficiency,reproducibility,and suitability for transient expression of a variety of functional proteins in *** and 7 other plant species,including Brassica oleracea,Capsella rubella,Thellungiella salsuginea,Thellungiella halophila,Solanum tuberosum,Capsicum annuum,and *** of this method was independently verified in three independent research facilities,pointing to the robustness of this ***,in addition to demonstrating the utility of this technique in a range of species,we also present a case study employing this method to assess protein–protein interactions in the sucrose biosynthesis pathway in Arabidopsis.

关键词： transient expression agro-infiltration subcellular localization protein-protein interaction

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Chronic exposure to excess iron promotes EMT and cancer via p53 loss in pancreatic cancer

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Asian journal of Pharmaceutical Sciences 2020年第2期15卷 237-251页

作者： Yangzom D.Bhutia jiro Ogura Paul j.Grippo Carolina Torres Toshihiro Sato mitchell Wachtel Sabarish Ramachandran Ellappan Babu Sathish Sivaprakasam Devaraja Rajasekaran Bradley Schniers Nhu On Logan Smoot Muthusamy Thangaraju jaya P.Gnana-Prakasam Vadivel Ganapathy Department of Cell Biology and Biochemistry Texas Tech University Health Sciences CenterLubbockTX 79430USA Department of Pharmaceutical Sciences Tohoku University Hospital1-1 Seiryo-machiAoba-kuSendaiMiyagi 980-8574Japan Department of Medicine University of Illinois at ChicagoChicagoIL 60607USA Department of Surgical Pathology Texas Tech University Health Sciences CenterLubbockTX 79430USA Department of Biological Sciences Texas Tech UniversityLubbockTX 79410USA Department of Chemistry and Biochemistry Texas Tech UniversityLubbockTX 79410USA Department of Biochemistry and Molecular Biology Augusta UniversityAugustaGA 30912USA Department of Ophthalmology St.Louis UniversitySt.LouisMO 63104USA

Based on the evidence that hemochromatosis, an iron-overload disease, drives hepatocellular carcinoma, we hypothesized that chronic exposure to excess iron, either due to genetic or environmental causes, predisposes an individual to cancer. Using pancreatic cancer as our primary focus, we employed cell culture studies to interrogate the connection between excess iron and cancer, and combined in vitro and in vivo studies to explore the connection further. Ferric ammonium citrate was used as an exogenous iron source. Chronic exposure to excess iron induced epithelial-mesenchymal transition(EMT) in normal and cancer cell lines, loss of p53, and suppression of p53 transcriptional activity evidenced from decreased expression of p53 target genes(p21, cyclin D1, Bax, SLC7A11). To further extrapolate our cell culture data, we generated EL-KrasG12D( EL-Kras) mouse(pancreatic neoplastic mouse model) expressing Hfe+/+ and Hfe-/- genetic background. p53 target gene expression decreased in EL-Kras/Hfe-/- mouse pancreas compared to EL-Kras/Hfe+/+ mouse pancreas. Interestingly, the incidence of acinar-to-ductal metaplasia and cystic pancreatic neoplasms(CPN) decreased in EL-Kras/Hfe-/- mice, but the CPNs that did develop were larger in these mice than in EL-Kras/Hfe+/+ mice. In conclusion, these in vitro and in vivo studies support a potential role for chronic exposure to excess iron as a promoter of more aggressive disease via p53 loss and SLC7A11 upregulation within pancreatic epithelial cells.

关键词： SLC7A11 p53 Iron Heme Epithelial-mesenchymal transition

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Restoration of Motor Function through Delayed Intraspinal Delivery of Human IL-10-Encoding Nucleoside-Modified mRNA after Spinal Cord Injury

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Research 2023年第4期2023卷 131-144页

作者： LászlóGál Tamás Bellák Annamária Marton Zoltán Fekécs Drew Weissman Dénes Török Rachana Biju Csaba Vizler Rebeka Kristóf mitchell B.Beattie Paulo j.C.Lin Norbert Pardi Antal Nógrádi Krisztián Pajer Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary National Biotechnology Laboratory Institute of GeneticsBiological Research CentreSzegedHungary Institute of Biochemistry Biological Research CentreSzegedHungary Department of Medicine University of PennsylvaniaPhiladelphiaPA19104USA Acuitas Therapeutics VancouverBCV6T 1Z3Canada

Efficient in vivo delivery of anti-inflammatory proteins to modulate the microenvironment of an injured spinal cord and promote neuroprotection and functional recovery is a great ***-modified messenger RNA(mRNA)has become a promising new modality that can be utilized for the safe and efficient delivery of therapeutic ***,we used lipid nanoparticle(LNP)-encapsulated human interleukin-10(hIL-10)-encoding nucleoside-modified mRNA to induce neuroprotection and functional recovery following rat spinal cord contusion *** administration of hIL-10 mRNA-LNP to rats led to a remarkable reduction of the microglia/macrophage reaction in the injured spinal segment and induced significant functional recovery compared to ***,hIL-10 mRNA treatment induced increased expression in tissue inhibitor of matrix metalloproteinase 1 and ciliary neurotrophic factor levels in the affected spinal segment indicating a time-delayed secondary effect of IL-105 d after *** results suggest that treatment with nucleoside-modified mRNAs encoding neuroprotective factors is an effective strategy for spinal cord injury repair.

关键词： protective Restoration utilized

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