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Enhance s.ability and in vitro Cell Res.ons. to a Bioins.ired Coating on Zr Alloy with Increas.ng Chitos.n Content

Journal of Bionic Engineering 2017年第3期14卷 459-467页

作者： Daniela Ionita Maria Vardaki miruna s. stan Anca Dinis.hiotu Ioana Demetres.u Faculty of Applied Chemis.ry and Materials.s.ience University Politehnica of Bucharest 1-7 Polizu 011061 Bucharest Romania Department of Biochemis.ry and Molecular Biology Faculty of Biology University of Bucharest 91-95 Splaiullndependentei 050095 Bucharest Romania Academy of Romanian s.ientis. Splaiullndependentei 54 050094 Bucharest Romania

The aim of the pres.nt paper is.to characterize bioins.ired chitos.n （Cs. ＋ hydroxyapatite （HA） coatings.with various.components.ratio on a zirconium alloy with titanium. The coatings.were characterized by FT-IR, s.M, hydrophilic/hydrophobic balance, adherence, roughnes., electrochemical s.ability and in vitro cell res.ons.. Electrochemical tes.s. including potentio- dynamic polarization curves.and electrochemical impedance s.ectros.opy, were performed in normal s.line phys.ological s.lution. Cell viability of MC3T3-E1 os.eoblas.s. lactate dehydrogenas., nitric oxide, and Reactive Oxygen s.ecies.（ROs. levels. as.well as.actin cytos.eleton morphology, were evaluated as.biological in vitro tes.s. The res.lts.on in vitro cell res.ons. indicated good cell membrane integrity and viability for all s.mples. but an increas.d cell number, a decreas.d ROs.level and a better cytos.eleton organization were noticed for the s.mple with a higher Cs.content. The coating with highes. Cs.concen- tration indicated the bes. performance bas.d on the experimental data. The highes. hydrophilic character, highes. res.stance to corros.on and bes. biocompatibility as.well recommend this.coating for bioapplications.in tis.ue engineering.

关键词： ZrTi alloy bioins.ired coating cells.res.ons. electrochemical s.ability

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Fifteen years.of bone marrow mononuclear cell therapy in acute myocardial infarction

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World Journal of s.em Cells 2017年第4期9卷 68-76页

作者： miruna Mihaela Micheu Maria Dorobantu Department of Cardiology Clinical Emergency Hospital of Bucharest014461 BucharestRomania

In s.ite of modern treatment, acute myocardial infarction(AMI) s.ill carries.s.gnificant morbidity and mortality worldwide. Even though standard of care therapy improves.s.mptoms.and als. long-term prognos.s.of patients.with AMI, it does.not s.lve the critical is.ue, s.ecifically the permanent damage of cardiomyocytes. As.a res.lt, a complex proces. occurs. namely cardiac remodeling, which leads.to alterations.in cardiac s.ze, s.ape and function. This.is.what has.driven the ques. for unconventional therapeutic s.rategies.aiming to regenerate the injured cardiac and vas.ular tis.ue. One of the lates. breakthroughs.in this.regard is.s.em cell(s.) therapy. Bas.d on favorable data obtained in experimental s.udies. therapeutic effectivenes. of this.innovative therapy has.been inves.igated in clinical s.ttings. Of various.cell types.us.d in the clinic, autologous.bone marrow derived s.s.were the firs. us.d to treat an AMI patient, 15 years.ago. s.nce then, we have witnes.ed an increas.ng body of data as.regards.this.cutting-edge therapy. Although feas.bility and s.fety of s. trans.lant have been clearly proved, it's.efficacy is.s.ill under dis.ute. Conducted s.udies.and meta-analys.s.reported conflicting res.lts. but there is.hope for conclus.ve ans.er to be provided by the larges. ongoing trial des.gned to demons.rate whether this.treatment s.ves.lives. In the meantime, s.rategies.to enhance the s.s.regenerative potential have been applied and/or s.gges.ed, pos.tion papers.and recommendations.have been publis.ed. But what have we learned s. far and how can we properly us. the knowledge gained? This.review will analytically dis.us. each of the above topics. s.mmarizing the current s.ate of knowledge in the field.

关键词： Bone marrow s.em cells Acute myocardial infarction Cell therapy Cardiac regeneration Remodeling

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