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Collagen membrane functionalized with magnesium oxide via room-temperature atomic layer deposition promotes osteopromotive and antimicrobial properties

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Bioactive Materials 2023年第12期30卷 46-61页

作者： Soumya Saha Raphael Cavalcante Costa mirela caroline silva Joao Matheus Fonseca-Santos Lin Chen Abhijit H.Phakatkar Harshdeep Bhatia Leonardo P.Faverani Valentim A.R.Barao Tolou Shokuhfar Cortino Sukotjo Christos Takoudis Department of Biomedical Engineering University of Illinois ChicagoChicagoUSA Department of Prosthodontics and Periodontology Piracicaba Dental SchoolUniversity of Campinas(UNICAMP)PiracicabaSao PauloBrazil Department of Diagnosis and Surgery Division of Oral and Maxillofacial Surgery and ImplantologySao Paulo State University(UNESP)School of DentistryAraçatubaSao PauloBrazil Department of Periodontics Center for Wound Healing and Tissue RegenerationCollege of DentistryUniversity of Illinois ChicagoChicagoUSA Department of Chemical Engineering University of Illinois ChicagoChicagoUSA Department of Restorative Dentistry University of Illinois Chicago College of DentistryChicagoUSA

Artificial bone grafting materials such as collagen are gaining interest due to the ease of production and ***,collagen must be supplemented with additional coating materials for improved ***,we report room-temperature atomic layer deposition(ALD)of MgO,a novel method to coat collagen membranes with *** techniques such as X-ray photoelectron spectroscopy,Raman spectroscopy,and electron beam dispersion mapping confirm the chemical nature of the *** electron and atomic force microscopies show the surface topography and morphology of the collagen fibers were not altered during the ALD of *** release of magnesium ions promotes bone growth,and we show the deposited MgO film leaches trace amounts of Mg when incubated in phosphate-buffered saline at 37◦*** coated collagen membrane had a superhydrophilic surface immediately after the deposition of *** film was not toxic to human cells and demonstrated antibacterial properties against bacterial ***,in vivo studies performed on calvaria rats showed MgO-coated membranes(200 and 500 ALD)elicit a higher inflammatory response,leading to an increase in angiogenesis and a greater bone formation,mainly for Col-MgO500,compared to uncoated *** on the characterization of the MgO film and in vitro and in vivo data,the MgO-coated collagen membranes are excellent candidates for guided bone regeneration.

关键词： coating magnesium atomic

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Impact of Hepatits B Vaccination as an Important Indicator for Immunization Program in Albania

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Journal of Life Sciences 2014年第2期8卷 115-119页

作者： Erida Nelaj mirela Lika silva Bino Department of Epidemiology and Control of Infectious Disease Institute of Public Health Tirana 1007 Albania Department of Biology Faculty of Natural Sciences Tirana University Tirana 1016 Albania

Albania has been a country with a high prevalence of hepatitis B virus. Hepatitis B vaccine has been introduced nationwide in Albanian Immunization Program in 1994. Hepatitis B is given at birth, as a separate antigen, followed by three doses at 2, 4 and 6 months, where Hepatitis B, starting from 2009, is part of pentavalent vaccine of DTP-HepB-Hib. The aim of this study was to evaluate Immunization Program with Hepatitis B vaccination in order to prove program efficacy, increase public confidence in immunizations and advocate for sustainable immunization programs. Methodology was based on three components such as Immunization coverage surveys, serologic surveys and surveillance for acute cases of Hepatitis B. Results of this study showed that vaccination coverage is really high, more than 95% all over the country and with drop-out rates less than 10%. Anti-HBs levels in immunized children were very high in comparison with unimmunized ones. Incidence of HBV in children 0-14 years old is almost zero. Such results tell us that Hepatitis B vaccination is one of the most fruitful strategies for long term control of Hepatitis B disease.

关键词： Hepatitis B immunization vaccination coverage Anti-HBs HBV incidence.

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Use of the Scar Acceleration Method - Mac<sup>®</sup>in the Treatment of Vulvovaginal Candidiasis: A Proposal for Treatment in Public Health in Sus, Brazil

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Open Journal of Applied Sciences 2020年第11期10卷 758-765页

作者： Marcus Vinícius de Mello Pinto Miriam Viviane Baron Mikaela da silva Corrêa Juliana Berton Carla Ohana Castanho de Mattos Mariane Pieczaki Aline Ronis Esteban Fortuny mirela Rodrigues Padilha Instituto Celulare Petrópolis Brazil Diagnostra Clinic Santiago Chile The Postgraduate Program in Medicine and Health Sciences at the Pontifical Catholic University of Rio Grande do Sul Porto Alegre Brazil The Physiotherapy Course at the Higher Education Center of Campos Gerais—CESCAGE Ponta Grossa Brazil The Pharmacy Course at the Higher Education Center of Campos Gerais—CESCAGE Ponta Grossa Brazil

Vulvovaginal candidiasis is an infection of the genital mucosa, which involves the vulva and vagina caused by yeast. It is considered a recurrent pathology and a public health problem that causes discomfort by the triggers and that, when left untreated, can lead to health problems. The present study is a report of two cases treated with the MAC® - Scar Acceleration Method - (MAC®) methodology at the Physiotherapy School Clinic of Teaching Center of Campos Gerais (CESCAGE) as a pilot for the proposal to implement the protocol at the Municipal Center for Women’s Health—CMM in the municipality of Ponta Grossa—PR, Brazil. The patients were referred by Basic Health Units in the city with complaints of pruritus, vaginal discharge and local burning with the diagnosis of candidiasis evidenced by culture and antibiogram. Patients were treated with photodynamic therapy using the MAC® method for 14 consecutive days with 660 nm red laser phototherapy, 100 mW of power, 9 joules of energy, photosensitizing the drug Turmeric Long in one of the participants and propolis in the other, using 1% methylene blue dye. Both patients and researchers did not

关键词： Candidiasis Vaginal Infections Women’s Health Methylene Blue Photodynamic Therapy

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