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Fate of undigested proteins in the pig large intestine:What impact on the colon epithelium?

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Animal Nutrition 2022年第2期9卷 110-118页

作者： François Blachier mireille Andriamihaja Xiang-Feng Kong UMR PNCA Nutrition Physiology and Alimentary BehaviorUniversite Paris-SaclayAgroParisTechINRAEParisFrance Key Laboratory of Agro-Ecological Processes in Subtropical Region Institute of Subtropical AgricultureChinese Academy of SciencesChangshaChina

Apart from its obvious agronomic interest in feeding billions of people worldwide,the porcine species represents an irreplaceable experimental model for intestinal physiologists and *** this review,we give an overview on the fate of proteins that are not fully digested in the pig small intestine,and thus are transferred into the large *** the large intestine,dietary and endogenous proteins are converted to peptides and amino acids(AA)by the action of bacterial proteases and ***,which cannot,except in the neonatal period,be absorbed to any significant level by the colonocytes,are used by the intestinal microbes for protein synthesis and for the production of numerous *** note,the production of the AA-derived metabolites greatly depends on the amount of undigested polysaccharides in the pig's *** effects of these AA-derived bacterial metabolites on the pig colonic epithelium have not yet been largely ***,the available data,performed on colonic mucosa,isolated colonic crypts and colonocytes,indicate that some of them,like ammonia,butyrate,acetate,hydrogen sulfide(H_(2)S),and p-cresol are active either directly or indirectly on energy metabolism in colonic epithelial *** studies in that area will certainly gain from the utilization of the pig colonic organoid model,which allows for disposal of functional epithelial *** studies will contribute to a better understanding of the potential causal links between diet-induced changes in the luminal concentrations of these AA-derived bacterial metabolites and effects on the colon epithelial barrier function and water/electrolyte absorption.

关键词： Gut microbiota Amino acids Bacterial metabolites Pig Large intestine

Machine learning based GNSS signal classifcation and weighting scheme design in the built environment:a comparative experiment

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Satellite Navigation 2023年第1期4卷 54-76,I0003页

作者： Lintong Li mireille Elhajj Yuxiang Feng Washington Yotto Ochieng Department of Civil and Environmental Engineering Imperial College LondonLondonUK Astra-Terra Limited LondonUK

None-Line-of-Sight(NLOS)signals denote Global Navigation Satellite System(GNSS)signals received indirectly from satellites and could result in unacceptable positioning *** meet the high mission-critical transportation and logistics demand,NLOS signals received in the built environment should be detected,corrected,and *** paper proposes a cost-efective NLOS impact mitigation approach using only GNSS *** exploiting more signal Quality Indicators(QIs),such as the standard deviation of pseudorange,Carrier-to-Noise Ratio(C/N0),elevation and azimuth angle,this paper compares machine-learning-based classifcation algorithms to detect and exclude NLOS signals in the pre-processing *** probability of the presence of NLOS is predicted using regression *** a pre-defned threshold,the signals can be classifed as Line-of-Sight(LOS)or *** probability of the occurrence of NLOS is also used for signal subset selection and specifcation of a novel weighting *** novel weighting scheme consists of both C/N0 and elevation angle and NLOS *** results show that the best LOS/NLOS classifcation algorithm is the random *** best QI set for NLOS classifcation is the frst three QIs mentioned above and the diference of azimuth *** classifcation accuracy obtained from this proposed algorithm can reach 93.430%,with 2.810%false *** proposed signal classifer and weighting scheme improved the positioning accuracy by 69.000%and 40.700%in the horizontal direction,79.361%and 75.322%in the vertical direction,and 75.963%and 67.824%in the 3D direction.

关键词： GNSS NLOS FDE Decision tree Weighting scheme

Changes in children’s cardiorespiratory fitness and body mass index over the course of the COVID‑19 pandemic:a 34‑month longitudinal study of 331 primary school children

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World Journal of Pediatrics 2024年第2期20卷 185-188页

作者： Gerald Jarnig Reinhold Kerbl mireille N.M.van Poppel Institute of Human Movement Science Sport and HealthUniversity of GrazMozartgasse 148010 GrazAustria Department of Pediatrics and Adolescent Medicine LKH Hochsteiermark8700 LeobenAustria

In late 2019,heavy restrictions were enforced on public activities worldwide to diminish the spread of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)virus[1].These restrictions,which included school closures and strictly limited sports and leisure opportunities,particularly impacted children and adolescents[2].Lifestyle changes in children and adolescents led to reduced physical activity levels[2,3],increased sedentary behavior[3,4],changes in eating habits,and changes in sleep habits[3].

关键词： respiratory acute children

Hepatocellular carcinoma: Epidemiology, risk factors and pathogenesis

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World Journal of Gastroenterology 2008年第27期14卷 4300-4308页

作者： Asmaa Ibrahim Gomaa Shahid A Khan mireille B Toledano Imam Waked Simon D Taylor- Robinson Department of Hepatology and Gastroenterology Imperial College London St Mary’s Hospital Campus Department of Epidemiology and Public Health Imperial College London St Mary’s Hospital Campus National Liver Institute Menoufiya University

Hepatocellular carcinoma (HCC) is the commonest primary malignant cancer of the liver in the world. Given that the burden of chronic liver disease is expected to rise owing to increasing rates of alcoholism, hepatitis B and C prevalence and obesity-related fatty liver disease, it is expected that the incidence of HCC will also increase in the foreseeable future. This article summarizes the international epidemiology, the risk factors and the pathogenesis of HCC, including the roles of viral hepatitis, toxins, such as alcohol and aflatoxin, and insulin resistance.

关键词： Hepatocellular carcinoma Epidemiology Risk factors Aetiology Pathogenesis

The association of cardiovascular mortality with a first-degree family member history of different cardiovascular diseases

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Journal of Geriatric Cardiology 2021年第10期18卷 816-824页

作者： Charbel Gharios mireille Leblebjian Samia Mora Roger S.Blumenthal Miran A.Jaffa Marwan M.Refaat Department of Internal Medicine Division of CardiologyAmerican University of Beirut Medical CenterBeirutLebanon Cardiovascular Imaging Research Center Massachusetts General Hospital and Harvard Medical SchoolBostonMAUSA Epidemiology and Population Health Department Faculty of Health SciencesAmerican University of BeirutBeirutLebanon Center for Lipid Metabolomics Divisions of Preventive and Cardiovascular MedicineBrigham and Women’s Hospital and Harvard Medical SchoolBostonMAUSA The Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease BaltimoreMDUSA Department of Biochemistry and Molecular Genetics American University of Beirut Faculty of MedicineBeirutLebanon

OBJECTIVE To investigate which history of cardiovascular disease[coronary heart disease(CHD),stroke,or peripheral arterial disease]in a first-degree family member predicts cardiovascular *** We studied a prospective cohort(the Lipid Research Clinics Prevalence Study)from ten primary care centers across North *** primary outcome was cardiovascular mortality,assessed using Cox survival *** There were 8,646 participants(mean age:47.4±12.1 years,46%women,52%of participants with hyperlipidemia)who were followed up for a mean duration of 19.4±4.9 *** were 1,851 deaths(21%),including 852 cardiovascular deaths.A paternal,maternal or sibling history of premature CHD(before 60 years)was present in 26%of participants,of stroke in 27%of participants,and of peripheral arterial disease in 24%of *** adjusting for risk factors(age,sex,systolic blood pressure,diastolic blood pressure,body mass index,smoking,fasting glucose,low-density lipoprotein cholesterol and triglycerides),only a paternal history of premature or any CHD,a maternal history of diabetes mellitus or premature or any CHD,and a sibling history of premature CHD,hypertension,or hyperlipidemia were individually predictive of cardiovascular *** adjusting for risk factors and the mentioned familial factors,only paternal and maternal histories of CHD,espe-cially before 60 years,remained predictive of cardiovascular mortality,with a somewhat higher association for a maternal history[adjusted hazard ratio(aHR)=1.99,95%CI:1.36−2.92,P<0.001 for maternal history of premature CHD;aHR=1.52,95%CI:1.10−2.10,P=0.011 for paternal history of premature CHD].Family history of stroke or peripheral arterial disease did not predict cardiovascular *** history of premature CHD predicted cardiovascular mortality independently of baseline age(<60 years and≥60 years),hypertension,or hyperlipidemia and carried more important prognostic value in men rather than wo-m

关键词： cardiovascular Lipid mentioned

Expression, Purification, Crystallization and Molecular Replacement Studies of TorI, an Inhibition Protein of Tor System

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Chinese Journal of Structural Chemistry 2007年第5期26卷 594-598页

作者： HUANG Wei YUAN Cai Ansaldi mireille Morelli Xavier Edward J. Meehan CHEN Li-Qing HUANG Ming-Dong State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter The Chinese Academy of Sciences Fuzhou Fujian 350002 China Graduate School of the Chinese Academy of Sciences Beo＇ing 100039 China Laboratoire de Chimie Bacte＇rienne Institut de Biologie Structurale et Microbiologie CentreNational de la Recherche Scientifique 31 Chemin Joseph Aiguier 13402 Marseille Cedex 20 France Laboratoire de Chimie Bactoéienne CNRS/IBSM BIP Laboratory 31 Chemin Joseph Aiguier 13402 Marseille Cedex 20 France Laboratory for Structural Biology Department of Chemistry Graduate Programs of Biotechnology Chemistry and Materials Science University of Alabama in Huntsville Huntsville AL 35899 USA

TorI, a Tor system inhibitor acting through protein-protein interaction with the TorR response regulator, is an excisionase that interacts with the integrase and DNA during prophage excision. It has been crystallized by the vapor-diffusion method using polyethylene glycol 3350 as a precipitant at pH 8.5. The X-ray diffraction data sets from the TorI crystal was collected at a resolution of 2.1 , using a synchrotron source. The crystal belongs to primitive monoclinic lattice with cell parameters of 46.210 × 53.992 × 73.561A

关键词： Torl inhibitor crystallization X-ray diffraction

Natural hydroxyanthraquinoid pigments as potent food grade colorants:an overview

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Natural Products and Bioprospecting 2012年第5期2卷 174-193页

作者： Yanis CARO Linda ANAMALE mireille FOUILLAUD Philippe LAURENT Thomas PETIT Laurent DUFOSSE Département Agroalimentaire ESIROIUniversitéde La RéunionSainte-ClotildeIle de la RéunionFrance LCSNSA Facultédes Sciences et des TechnologiesUniversitéde La RéunionSainte-ClotildeIle de la RéunionFrance Département Génie Biologique IUTUniversitéde La RéunionSaint-PierreIle de la RéunionFrance

Natural pigments and colorants are widely used in the world in many industries such as textile dying,food processing or cosmetic *** the natural products of interest are various compounds belonging to carotenoids,anthocyanins,chlorophylls,melanins,betalains...The review emphasizes pigments with anthraquinoid skeleton and gives an overview on hydroxyanthraquinoids described in Nature,the first one ever *** in consumption,production and regulation of natural food grade colorants are given,in the current global *** second part focuses on the description of the chemical structures of the main anthraquinoid colouring compounds,their properties and their biosynthetic *** natural sources of such pigments are summarized,followed by discussion about toxicity and carcinogenicity observed in some *** a conclusion,current industrial applications of natural hydroxyanthraquinoids are described with two examples,carminic acid from an insect and Arpink red^(™)from a filamentous fungus.

关键词： anthraquinone hydroxyanthraquinone natural colorant food colorant microbial pigment biotechnology mycotoxin contamination

Incidence and mortality of primary liver cancer in England and Wales: Changing patterns and ethnic variations

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World Journal of Gastroenterology 2014年第6期20卷 1544-1553页

作者： Nimzing G Ladep Shahid A Khan Mary ME Crossey Andrew V Thillainayagam Simon D Taylor-Robinson mireille B Toledano Gastroenterology and Hepatology Section Division of Diabetes Endocrinology and Metabolism Department of Medicine Imperial College London MRC-HPA Centre for Environment and Health Department of Epidemiology and Biostatistics School of Public Health Imperial College London

AIM: To explore recent trends, modes of diagnosis, ethnic distribution and the mortality to incidence ratio of primary liver cancer by subtypes in England and Wales.

关键词： Primary liver cancer Hepatocellular carcinoma Intrahepatic bile duct England and Wales Ethnicity

Regional variation in routes to diagnosis of cholangiocarcinoma in England from 2006 to 2017

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World Journal of Gastroenterology 2023年第24期29卷 3825-3842页

作者： Amy Zalin-Miller Sophie Jose Craig Knott Lizz Paley Daniela Tataru Helen Morement mireille B Toledano Shahid A Khan Department of Analytics Health Data Insight CICCambridge CB215XEUnited Kingdom Disease Registration Service NHS EnglandLondon E144PUUnited Kingdom CEO AMMFLondon CM241QWUnited Kingdom MRC Centre for Environment and Health School of Public HealthImperial College LondonLondon SW72BXUnited Kingdom Liver Unit Division of Digestive DiseasesImperial College LondonLondon W21NYUnited Kingdom

BACKGROUND Incidence of cholangiocarcinoma(CCA)is rising,with overall prognosis remaining very *** for the high mortality of CCA include its late presentation in most patients,when curative options are no longer feasible,and poor response to systemic therapies for advanced *** presentation presents a large barrier to improving outcomes and is often associated with diagnosis via mergency presentation(EP).Earlier diagnoses may be made by Two Week Wait(TWW)referrals through General practitioner(GP).We hypothesise that TWW referrals and EP routes to diagnosis differ across regions in *** To investigate routes to diagnosis of CCA over time,regional variation and influencing *** We linked patient records from the National Cancer Registration Dataset to Hospital Episode Statistics,Cancer Waiting Times and Cancer Screening Programme datasets to define routes to diagnosis and certain patient characteristics for patients diagnosed 2006-2017 in *** used linear probability models to investigate geographic variation by assessing the proportions of patients diagnosed via TWW referral or EP across Cancer Alliances in England,adjusting for potential *** between the proportion of people diagnosed by TWW referral and EP was investigated with Spearman’s correlation *** Of 23632 patients diagnosed between 2006-2017 in England,the most common route to diagnosis was EP(49.6%).Non-TWW GP referrals accounted for 20.5%of diagnosis routes,13.8%were diagnosed by TWW referral,and the remainder 16.2%were diagnosed via an‘other’or Unknown *** proportion diagnosed via a TWW referral doubled between 2006-2017 rising from 9.9%to 19.8%,conversely EP diagnosis route declined,falling from 51.3%to 46.0%.Statistically significant variation in both the TWW referral and EP proportions was found across Cancer ***,presence of comorbidity and underlying liver disease were independently associated with both a lowe

关键词： Cholangiocarcinoma Route to diagnosis Two Week Wait Emergency presentation Regional variation