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Supramolecular systems for bioapplications:recent research progress in China

Science China Chemistry 2024年第5期67卷 1397-1441页

作者： Yue-Yang Liu Xiao-Yong Yu Yu-Chen Pan Hang Yin Shuang Chao Yujie Li He Ma minzan zuo Kun-Xu Teng Jun-Li Hou Yong Chen Dong-Sheng Guo Ruibing Wang Yuxin Pei Zhichao Pei Jiang-Fei Xu Xiao-Yu Hu Chunju Li Qing-Zheng Yang Leyong Wang Yu Liu Zhan-Ting Li State Key Laboratory of Organometallic Chemistry Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional MoleculesShanghai Institute of Organic ChemistryChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200032China Department of Chemistry Fudan UniversityShanghai 200438China College of Chemistry State Key Laboratory of Elemento-Organic ChemistryCollaborative Innovation Center of Chemical Science and EngineeringNankai UniversityTianjin 300071China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 999078China College of Chemistry&Pharmacy Northwest A&F UniversityYangling 712100China Key Lab of Organic Optoelectronics&Molecular Engineering Department of ChemistryTsinghua UniversityBeijing 100084China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106China Key Laboratory of Radiopharmaceuticals Ministry of EducationCollege of ChemistryBeijing Normal UniversityBeijing 100875China Tianjin Key Laboratory of Structure and Performance for Functional Molecules College of ChemistryTianjin Normal UniversityTianjin 300387China State Key Laboratory of Analytical Chemistry for Life Science Jiangsu Key Laboratory of Advanced Organic MaterialsSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

Supramolecular systems feature dynamic,reversible and stimuli-responsive characteristics,which are not easily achieved by molecular entities.The last decade has witnessed tremendous advances in the investigations of supramolecular systems for various bioapplications,which include drug delivery,anticancer therapy,antibacterial therapy,photodynamic therapy,photothermal therapy,combination therapy,antidotes for residual drugs or toxins,and bioimaging and biosensing.Host-guest chemistry has played a key role in the development of such bioactive supramolecular systems,and natural macrocycles(such as cyclodextrins),synthetic macrocycles(such as calixarenes,cucurbit[n]urils,and pillararenes),and porous framework polymers(such as supramolecular organic frameworks and flexible organic frameworks)have been most successfully used as hosts to build different kinds of host-guest systems for attaining designed biofunctions.The self-assembly of rationally designed amphiphilic molecules,macromolecules and polymers represent another important approach for the construction of supramolecular architectures with advanced biofunctions.In this review,we summarize the important contributions made by Chinese researchers in this field,with emphasis on those reported in the past five years.

关键词： host-guest chemistry drug delivery anticancer and antibacterial photodynamic therapy photothermal therapy antidote transmembrane channel bioimaging and biosensing

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Pillar[5]arene-modified peptide-guanidiniocarbonylpyrrol amphiphiles with gene transfection properties

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Chinese Chemical Letters 2023年第5期34卷 246-249页

作者： Kaiya Wang minzan zuo Tao Zhang Huilan Yue Xiao-Yu Hu College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106China Qinghai Provincial Key Laboratory of Tibetan Medicine Research and Key Laboratory of Tibetan Medicine Research Northwest Institute of Plateau BiologyChinese Academy of SciencesXining 810008China

Pillar[5]arene-modified amphiphilic peptides with varying numbers of guanidiniocarbonylpyrrol(GCP)moieties have been successfully synthesized,which can self-assemble to multivalent cationic superstructures in aqueous solutions.These assembled peptides can condense DNA into various compact multimolecular aggregates to achieve successful intracellular DNA delivery and demonstrate great potential for gene transfection.Transfection efficiencies of the self-assembled superstructures have been evaluated in vitro with He La and HEK 293T cells.We demonstrate that GCP moiety could enhance the cell transfection ability,owing to its excellent binding towards cytomembrane.It was also found that subtle structure difference in peptides 2 and 3 could result in distinct transfection efficacy,which makes it possible to gain an in-depth understanding of their structure-activity relationship.This work presents a good example of rational structural design in achieving effective gene transfection vectors.

关键词： Pillararene Guanidinocarbonylpyrrole Gene transfection Amphiphiles Structure-activity relationship

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The construction of aggregation-induced charge transfer emission systems in aqueous solution directed by supramolecular strategy

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Chinese Chemical Letters 2022年第4期33卷 1975-1978页

作者： Weirui Qian minzan zuo Pengbo Niu Xiao-Yu Hu Leyong Wang Key Laboratory of Mesoscopic Chemistry of MOE Jiangsu Key Laboratory of Advanced Organic MaterialsSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106China Department of Chemistry Xihua UniversityChengdu 610039China

Novel aggregation-induced charge transfer(CT) emission systems with long luminescence lifetime directed by supramolecular strategy have been successfully developed in water. The dimethylacridine-based electron donor(Br Ac) with excellent aggregation ability can co-aggregate with a triazine-based electron acceptor(TRZ) to form nanorods in water, which exhibit CT emission with long lifetime(τ = 0.92 μs).As for a similar electron donor(Qa Ac) with poor aggregation ability, water-soluble pillar[5]arene(WP5)can be introduced to promote the aggregation process, leading to the obvious CT emission with long lifetime(τ = 0.61 μs). In addition, structural modification of the acceptor with substituent groups possessing stronger electron-accepting capabilities will cause red-shift(about 50 nm) of the emission, which allows conveniently constructing long lifetime organic luminescent materials with different emission colors.

关键词： Aggregation-induced charge transfer emission Supramolecular strategy Long luminescence lifetime Self-assemble Co-aggregate

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Supramolecular Nanohelix Fabricated by Pillararene-Based Host–Guest System for Chirality Amplification, Transfer, and Circularly Polarized Luminescence in Water

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CCS Chemistry 2022年第10期4卷 3426-3439页

作者： Krishnasamy Velmurugan Adil Murtaza Azhar Saeed Jianing Li Kaiya Wang minzan zuo Qian Liu Xiao-Yu Hu College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106 School of Physics MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed MatterXi’an Jiaotong UniversityXi’an 710049 State Key Laboratory for Mechanical Behaviour of Materials Shaanxi International Research Center for Soft MatterXi’an Jiaotong UniversityXi’an 710049

Amplified chirality and Förster resonance energy transfer(FRET)-assisted chirality transfer frommolecular to nanoscale level have been shown to play a vital role in co-assembled nanohelix for potential energy transfer in biological systems.Herein,we have constructed a chiral host–guest complex donor system for chiral amplification via induced chirality of pillar[5]arene host and loaded it with an achiral dye acceptor to demonstrate how chirality-assisted excitation energy transfer occurred in the supramolecular nanohelix system in an aqueous medium.

关键词： host–guest interaction supramolecular chirality chirality transfer circularly polarized luminescence supramolecular self-assembly

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A Novel Prescribed-Performance Path-Following Problem for Non-Holonomic Vehicles

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IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1476-1484页

作者： Zirui Chen Jingchuan Tang Zongyu zuo Seventh Research Division Beihang University(BUAA)Beijing 100191China IEEE

The issue of achieving prescribed-performance path following in robotics is addressed in this paper,where the aim is to ensure that a desired path within a specified region is accu-rately converged to by the controlled vehicle.In this context,a novel form of the prescribed performance guiding vector field is introduced,accompanied by a prescribed-time sliding mode con-trol approach.Furthermore,the interdependence among the pre-scribed parameters is discussed.To validate the effectiveness of the proposed method,numerical simulations are presented to demonstrate the efficacy of the approach.

关键词： Guiding vector field non-holonomic vehicle path following prescribed performance sliding mode control

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Mitigating gut immune adverse effects in CTLA-4 blockade for antitumor efficacy

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Science China(Life Sciences) 2024年第7期67卷 1539-1541页

作者： Shijun He Jianping zuo Zemin Lin Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese MedicineShanghai 201203China School of Pharmacy University of Chinese Academy of SciencesBeijing 100049China

By creating an immune checkpoint blockade-induced colitis model,Lo et al.(2024)have suggested a strategy for alleviating gastrointestinal immune-related adverse events while preserving the antitumor stimulatory effect... 详细信息

关键词： al. immune gastrointestinal

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A combined evaluation of the characteristics and antibiotic resistance induction potential of antibiotic wastewater during the treatment process

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Journal of Environmental Sciences 2024年第4期138卷 626-636页

作者： Sun Miao Yanyan Zhang Cong Men Yiou Mao Jiane zuo State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China School of Energy and Environmental Engineering Beijing Key Laboratory of Resource-Oriented Treatment of Industrial PollutantsUniversity of Science and Technology BeijingBeijing 100083China High School Affiliated to Renmin University of China Beijing 100080China Tsinghua Shenzhen International Graduate School Shenzhen 518055China

Antibiotic wastewater contains a variety of pollutant stressors that can induce and promote antibiotic resistance(AR)when released into the environment.Although these substances are mostly in concentrations lower than those known to induce AR individually,it is possible that antibiotic wastewater discharge might still promote the AR transmission risk via additive or synergistic effects.However,the comprehensive effect of antibiotic wastewater on AR development has rarely been evaluated,and its treatment efficiency remains unknown.Here,samples were collected from different stages of a cephalosporin production wastewater treatment plant,and the potential AR induction effect of their chemical mixtures was explored through the exposure of the antibiotic-sensitive Escherichia coli K12 strain.Incubation with raw cephalosporin production wastewater significantly promoted mutation rates(3.6×10^(3)-9.3×10^(3)-fold)and minimum inhibition concentrations(6.0-6.7-fold)of E.coli against ampicillin and chloramphenicol.This may be attributed to the inhibition effect and oxidative stress of cephalosporin wastewater on E.coli.The AR induction effect of cephalosporin wastewater decreased after the coagulation sedimentation treatment and was completely removed after the full treatment process.A Pearson correlation analysis revealed that the reduction in the AR induction effect had a strong positive correlation with the removal of organics and biological toxicity.This indicates that the antibiotic wastewater treatment had a collaborative processing effect of conventional pollutants,toxicity,and the AR induction effect.This study illustrates the potential AR transmission risk of antibiotic wastewater and highlights the need for its adequate treatment.

关键词： Antibiotic wastewater treatment plant Antibiotic resistance Antibiotic resistance induction effect Correlation analysis Biological toxicity

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Single and combined effects of secondary polyethylene microplastic on the growth of Pak choi and the soil microbiome composition

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Frontiers of Environmental Science & Engineering 2024年第5期18卷 1-12页

作者： Jiamin Hu Zhenwen Xie Jiane zuo State Key Joint Laboratory of Environmental Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing100084China Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhen518055China

It has been confirmed that microplastics(MPs)are present in the environment.This study simulated secondary PE-MPs via aging and mechanical processes to evaluate their effects on Pak choi(Brassica rapa L.)over 21 d.Two common pollutants,dichlorodiphenyltrichloroethane(DDT)and naphthalene,were used in the combined toxicity tests.The results indicated that the growth of Pak choi was significantly inhibited after exposure to secondary PE-MPs,and the combined effects were antagonistic,owing to the adsorption capacity of secondary PE-MPs to DDT and naphthalene.Oxidative stress in Pak choi can be markedly affected,leading to oxidative damage to plant cells.The moisture content,soil bulk density,soil density,cation exchange capacity(CEC),and FDA hydrolase in the planted soils increased in the treated groups,and the TOC content changed significantly.We also found that the microbial composition of the soil in the DDT and naphthalene groups showed more significant alterations than that in the other groups.Alpha diversity analysis showed that species diversity increased in the combined groups but indicated a clear downward trend in the single MPs groups.This study suggests that secondary PE-MPs harm the growth of Pak choi and can change soil properties,revealing the harm to the ecosystem of MPs in the soil.

关键词： Secondary PE-MPs Combined effects Oxidative stress Soil properties Bacterial community

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Three-dimensional limit variation analysis on the ultimate pullout capacity of the anchor cables based on the Hoek-Brown failure criterion

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Journal of Mountain Science 2024年第3期21卷 1036-1047页

作者： zuo Shi ZHAO Lianheng HU Shihong College of Civil Engineering Changsha UniversityChangsha 410022China Hunan Provincial Key Laboratory for Disaster Prevention and Mitigation of Rail Transit Engineering Structure Key Laboratory of Heavy-Haul Railway Engineering StructureMinistry of EducationCentral South UniversityChangsha 410075China College of Civil Engineering Central South UniversityChangsha 410075China

Only simplified two-dimensional model and a single failure mode are adopted to calculate the ultimate pullout capacity(UPC)of anchor cables in most previous research.This study focuses on a more comprehensive combination failure mode that consists of bond failure of an anchorage body and failure of an anchored rock mass.The three-dimensional ultimate pullout capacity of the anchor cables is calculated based on the Hoek-Brown failure criterion and variation analysis method.The numerical solution for the curvilinear function in fracture plane is obtained based on the finite difference theory,which more accurately reflects the failure state of the anchor cable,as opposed to that being assumed in advance.The results reveal that relying solely on a single failure mode for UPC calculations has limitations,as changes in parameter values not only directly impact the UPC value but also can alter the failure model and thus the calculation method.

关键词： Anchor cable Ultimate pullout capacity(UPC) Failure model Variation analysis Hoek-Brown failure criterion

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Multi-circular formation control with reinforced transient profiles for nonholonomic vehicles:A path-following framework

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Defence Technology（防务技术） 2024年第1期31卷 278-287页

作者： Jintao Zhang Xingling Shao Wendong Zhang Zongyu zuo School of Instrument and Electronics North University of ChinaTaiyuan 030051China State Key Laboratory of Dynamic Measurement Technology North University of ChinaTaiyuan 030051China Seventh Research Division School of Automation Science and Electrical EngineeringBeihang UniversityBeijing 100191China

This article investigates a multi-circular path-following formation control with reinforced transient profiles for nonholonomic vehicles connected by a digraph.A multi-circular formation controller endowed with the feature of spatial-temporal decoupling is devised for a group of vehicles guided by a virtual leader evolving along an implicit path,which allows for a circumnavigation on multiple circles with an anticipant angular spacing.In addition,notice that it typically imposes a stringent time constraint on time-sensitive enclosing scenarios,hence an improved prescribed performance control(IPPC)using novel tighter behavior boundaries is presented to enhance transient capabilities with an ensured appointed-time convergence free from any overshoots.The significant merits are that coordinated circumnavigation along different circles can be realized via executing geometric and dynamic assignments independently with modified transient profiles.Furthermore,all variables existing in the entire system are analyzed to be convergent.Simulation and experimental results are provided to validate the utility of suggested solution.

关键词： Multi-circular formation Reinforced transient profiles Nonholonomic vehicles Path following

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