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Assessment of liver fibrosis by a noninvasive method of transient elastography and biochemical markers

World Journal of Gastroenterology 2006年第27期12卷 4325-4330页

作者： Masaki Kawamoto Toru Mizuguchi Tadashi Katsuramaki minoru nagayama Hideki Oshima Hiroyuki Kawasaki Takayuki Nobuoka Yasutoshi Kimura Koichi Hirata Department of Surgery Ⅰ Sapporo Medical University HospitalSapporo Medical University School of MedicineS-1W-16Chuo-KuSapporoHokkaido 060-8543Japan

AIM： To assess the correlation between the fibrotic area （FA） as calculated by a digital image analysis （DIA）, and to compare the diagnostic accuracy of FibroScan to the other existing Liver fibrosis （LF） markers using the receiver operating curve analysis.METHODS： We recruited 30 patients who underwent a liver resection for three different etiologies including normal liver, hepatitis B, and hepatitis C. Liver stiffness was measured by using a FibroScan. The FA was then calculated by DIA to evaluate LF in order to avoid any sampling bias. RESULTS： The FA negatively correlated with Prothrombin time （PT）, platelet count, lecithin-cholesterol acyltransferase （LCAT）, and pre-albumin （ALB）. On the other hand, the findings of FibroScan correlated with similar markers. The FA positively correlated with FibroScan, serum hyaluronate level, and type Ⅳ collagen level, and aspartate transaminase to platelet ratio index （APRI）. The area under the receiver operating curve for FibroScan was higher than that for the other markers, even though the statistical significance was minimal. CONCLUSION： Our findings suggest that FibroScan can initially be used to assess LF as an alternative to a liver biopsy （LB） and serum diagnosis, because it is a safe method with comparable diagnostic accuracy regarding the existing LF markers.

关键词： Cirrhosis Digital image analysis Fibro-Scan Fibrotic area Hyaluronate Lecithin-cholesterol acyltransferase Liver fibrosis Pre-albumin

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Scoring criteria for determining the safety of liver resection for malignant liver tumors

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World Journal of Meta-Analysis 2019年第5期7卷 234-248页

作者： Kohei Harada minoru nagayama Yoshiya Ohashi Ayaka Chiba Kanako Numasawa Makoto Meguro Yasutoshi Kimura Hiroshi Yamaguchi Masahiro Kobayashi Koji Miyanishi Junji Kato Toru Mizuguchi Departments of Surgery Surgical Scienceand OncologySapporo Medical UniversitySapporoHokkaido 060-8556Japan Division of Radiology Sapporo Medical University HospitalSapporoHokkaido 060-8556Japan Sapporo Medical University Postgraduate School of Health Science and Medicine Sapporo Medical UniversitySapporoHokkaido 060-8556Japan Research and Education Center for Clinical Pharmacy Kitasato University School of PharmacyTokyo 108-8641Japan Department of Internal Medicine IV Sapporo Medical UniversitySapporoHokkaido 060-8556Japan Department of Nursing and Surgical Science Sapporo Medical UniversitySapporo 0608543Japan

BACKGROUND Liver resection has become safer as it has become less ***,the minimum residual liver volume(RLV)required to maintain homeostasis is ***,the formulae used to calculate standard liver volume(SLV)are *** To review previously reported SLV formulae and the methods used to evaluate the minimum RLV,and explore the association between liver volume and *** A systematic review of Medline,PubMed,and grey literature was *** in the retrieved articles were cross-checked manually to obtain further *** last search was conducted on January 20,*** developed an SLV formula using data for 86 consecutive patients who underwent hepatectomy at our institution between July 2009 and August *** Linear regression analysis revealed the following formula:SLV(mL)=822.7×body surface area(BSA)?183.2(R2=0.419 and R=0.644,P<0.001).We retrieved 25 studies relating to SLV formulae and 12 studies about the RLV required for safe liver *** the previously reported formulae included various coefficient and constant values,a simplified version of the SLV,the common SLV(cSLV),can be calculated as follows:cSLV(mL)=710 or 770×*** minimum RLV for normal and damaged livers ranged from 20%-40%and 30%-50%,*** Sapporo score indicated that the minimum RLV ranges from 35%-95%depending on liver *** We reviewed SLV formulae and the minimum RLV required for safe liver *** Sapporo score is the only liver function-based method for determining the minimum RLV.

关键词： Standard liver volume Residual liver volume Hepatectomy Mortality Liver failure Liver function

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