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Journal of Materials Science & Technology 2019年第9期35卷 1894-1905页

作者： Mingli Lin Huanhuan Liu Jingjing Deng Ran An minjuan shen Yanqiu Li Xu Zhang School of Stomatology Hospital of Stomatology Tianjin Medical University

The significant role of the polyelectrolytic nature of non-collagenous proteins (NCPs) in regulating the in vivo mineralization of collagen provides important insights for scientists searching for analogues of NCPs to achieve in vitro collagen mineralization. Polyampholyte carboxymethyl chitosan (CMC) has both carboxyl and amino groups, which allows it to act as a cationic or anionic polyelectrolyte below or above its isoelectric point (IP), respectively. In this study, CMC was employed as the analogue of NCPs to stabilize amorphous calcium phosphate (ACP) under acidic conditions (pH < 3.5) via the formation of CMC/ACP nanocomplexes. In the presence of both ACP nanoparticles and acid collagen molecules, ACP nanoparticles could be integrated into collagen fibrils during the process of collagen self-assembly and achieve intrafibrillar mineralization of collagen in vitro (i.e., synchronous self-assembly/mineralization (SSM) of collagen). This mode of mineralization is different from established mechanisms in which mineralization follows the self-assembly (MFS) of collagen. Thus, SSM provides a new strategy for developing materials from mineralized collagen scaffolds.

关键词： Synchronous self-assembly/mineralization Intrafibrillar mineralization Polyampholyte Carboxymethyl chitosan Amorphous calcium phosphate

基于密集台阵的青藏高原东北缘地壳精细结构及九寨沟地震震源区结构特征分析

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地球物理学报 2018年第5期61卷 2075-2087页

作者：李敏娟沈旭章张元生刘旭宙梅秀苹中国地震局兰州地震研究所兰州730000 中山大学地球科学与工程学院广州510275

基于青藏高原东北缘密集宽频带野外流动观测台阵以及固定台站资料,利用双差层析成像方法对地震位置和研究区的地壳速度结构进行了反演.最终用于联合反演的地震事件合计9644个.结果显示青藏高原东北缘速度结构具有明显的横向不均匀性.从... 详细信息

基于青藏高原东北缘密集宽频带野外流动观测台阵以及固定台站资料,利用双差层析成像方法对地震位置和研究区的地壳速度结构进行了反演.最终用于联合反演的地震事件合计9644个.结果显示青藏高原东北缘速度结构具有明显的横向不均匀性.从整体上看,青藏高原地区表现为低速异常,鄂尔多斯表现为高速异常,而扬子地块亦表现为高速异常.不同深度处速度结构表现不一致,同一深度处P波速度结构和S波速度结构也有明显差异.由西秦岭北缘断裂带、临潭—宕昌断裂以及礼县—罗家堡断裂围限的地震活动强烈的区域中,P波速度结构由深度0km时呈现的低速异常,逐渐过渡到5km时高低速相间分布的特征;而S波速度结构在此区域中,由近地表0km时高低速相间分布的特征,逐渐过渡到30km时几乎表现为低速异常.2017年8月8日九寨沟7级地震所在的塔藏断裂、岷江断裂和雪山断裂围限区域,在深度20km处的P波速度结构和周围存在明显差异,九寨沟地震处于高速异常与低速异常的过渡带内.此外,2013年7月22日发生在青藏高原东北缘的岷漳县6.6级地震,震源区所在的临潭—宕昌断裂附近的P波速度结构在15km深度处也有明显特征,震源位置所在区域也处于高低速过渡带.该区域这种地壳内部高低速过渡带可能是应力比较容易积累而发生中强地震的一个重要场所.

关键词：青藏高原东北缘九寨沟地震双差层析成像高低速过渡带

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生肌玉红纱条治疗乳头皲裂40例

中医外治杂志 2009年第3期18卷 8-9页

作者：沈敏娟钱华江苏省吴江市第一人民医院皮肤科江苏吴江215200 兰州大学第一附属医院甘肃兰州730000

目的:探讨生肌玉红纱条治疗乳头皲裂的临床疗效。方法:将78例患者随机分为治疗组与对照组,治疗组予生肌玉红纱条治疗,对照组予湿润烧伤膏治疗。结果:总有效率治疗组为97.50%,对照组为84.21%。经统计学处理,两组临床疗效相当。两组止痛... 详细信息

目的:探讨生肌玉红纱条治疗乳头皲裂的临床疗效。方法:将78例患者随机分为治疗组与对照组,治疗组予生肌玉红纱条治疗,对照组予湿润烧伤膏治疗。结果:总有效率治疗组为97.50%,对照组为84.21%。经统计学处理,两组临床疗效相当。两组止痛时间、疗程比较,经统计学处理,治疗组优于对照组。结论:生肌玉红纱条可促进乳头皲裂愈合,治疗期间无需断奶,对哺乳婴儿无副作用。

关键词：乳头皲裂生肌玉红纱条外治法

几种因素对高代水稻花药愈伤组织同工酶及分化的影响

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辽宁农业科学 1988年第6期 10-13页

作者：沈敏娟邵元忠钱德杞沈阳农业大学遗传所

随着抗性细胞突变体筛选的研究的深入,继而产生的突出问题是随着继代培养时间的延长,离体培养组织和细胞的分化及再生植株的能力逐渐下降以至完全消失。关于如何提高高代愈伤组织分化频率,国内外已有许多报道,主要涉及后代染色体的变化... 详细信息

随着抗性细胞突变体筛选的研究的深入,继而产生的突出问题是随着继代培养时间的延长,离体培养组织和细胞的分化及再生植株的能力逐渐下降以至完全消失。关于如何提高高代愈伤组织分化频率,国内外已有许多报道,主要涉及后代染色体的变化,至于激素对酶的影响在高代中尚未见到,为此,我们以高代水稻花药愈伤组织(继代15次培养600天直至继代19次培养天数720天)为试材,研究了不同激素、琼脂、甘露醇对高代愈伤组织分化的影响,以及在分化过程中呼吸强度和同工酶的变化。

关键词：愈伤组织 BA 呼吸强度创伤组织呼吸速率水稻花药继代培养愈伤组织分化同工酶

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口腔种植成骨材料的研究现状及进展

口腔医学 2023年第1期43卷 11-17页

作者：牛丽娜沈敏娟方明军事口腔医学国家重点实验室国家口腔疾病临床医学研究中心陕西省口腔医学重点实验室空军军医大学口腔医院修复科浙江大学医学院附属口腔医院浙江大学口腔医学院浙江省口腔疾病临床医学研究中心浙江省口腔生物医学研究重点实验室浙江大学癌症研究院

随着口腔种植技术的快速发展，种植修复已逐渐成为牙列缺损和牙列缺失患者的首选治疗方案。种植区牙槽骨骨量充足是种植修复成功的前提条件及关键因素。然而，临床上种植区牙槽骨骨量不足十分常见，影响种植修复体的功能发挥、美学效果... 详细信息

随着口腔种植技术的快速发展，种植修复已逐渐成为牙列缺损和牙列缺失患者的首选治疗方案。种植区牙槽骨骨量充足是种植修复成功的前提条件及关键因素。然而，临床上种植区牙槽骨骨量不足十分常见，影响种植修复体的功能发挥、美学效果及远期疗效。口腔植骨材料配合骨增量手术是目前临床常用重建缺失骨组织，使其骨量满足种植要求的方法之一。口腔植骨材料的自身特性如生物相容性、骨传导、骨诱导及骨生成等性能对植骨成功率具有至关重要的影响。该文从植骨材料的性能、分类及临床运用三个方面重点介绍口腔种植成骨材料的研究现状及最新进展，以期为成骨材料的临床选择及种植修复成功率的提高提供理论指导。

关键词：口腔种植植骨材料骨增量引导骨组织再生技术

Low-frequency Stimulation at the Subiculum Prevents Extensive Secondary Epileptogenesis in Temporal Lobe Epilepsy

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Neuroscience Bulletin 2024年第5期40卷 564-576页

作者： Yujia shen Yiwei Gong Xiaoli Da Shajing Gao Shuo Zhang minjuan Sun Yuanzhi Yang Xiaoyun Qiu Menghan Li Yang Zheng Fan Fei Yi Wang Zhong Chen Cenglin Xu Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical ScienceZhejiang Chinese Medical UniversityHangzhou310053China Institute of Pharmacology and Toxicology NHC and CAMS Key Laboratory of Medical NeurobiologyCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou310058China Department of Neurology First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou310003China Department of Pharmacy The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou310003China

Secondary epileptogenesis is characterized by increased epileptic susceptibility and a tendency to generate epileptiform activities outside the primary *** is one of the major resultants of pharmacoresistance and failure of surgical outcomes in epilepsy,but still lacks effective ***,we aimed to test the effects of low-frequency stimulation(LFS)at the subiculum for secondary epileptogenesis in a mouse ***,secondary epileptogenesis was simulated at regions both contralateral and ipsilateral to the primary focus by applying successive kindling *** kindled at the right CA3 showed higher seizure susceptibilities at both the contralateral CA3 and the ipsilateral entorhinal cortex and had accelerated kindling processes compared with naive *** at the ipsilateral subiculum during the primary kindling progress at the right CA3 effectively prevented secondary epileptogenesis at both the contralateral CA3 and the ipsilateral entorhinal cortex,characterized by decreased seizure susceptibilities and a retarded kindling process at those secondary *** application along with the primary epileptogenesis was ***,the effects of LFS on secondary epileptogenesis were associated with its inhibitory effect at the secondary focus through interfering with the enhancement of synaptic connections between the primary and secondary *** results imply that LFS at the subiculum is an effective preventive strategy for extensive secondary epileptogenesis in temporal lobe epilepsy and present the subiculum as a target with potential translational importance.

关键词： Secondary epileptogenesis Low-frequency stimulation Subiculum Temporal lobe epilepsy

Investigation on step overcharge to self-heating behavior and mechanism analysis of lithium ion batteries

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Journal of Energy Chemistry 2023年第4期79卷 301-311页

作者： Fengling Yun Shiyang Liu Min Gao Xuanxuan Bi Weijia Zhao Zenghua Chang minjuan Yuan Jingjing Li Xueling shen Xiaopeng Qi Ling Tang Yi Cui Yanyan Fang Lihao Guo Shangqian Zhao Xiangjun Zhang Shigang Lu China Automotive Battery Research Institute Co. Ltd.Beijing 101407China China Electric Power Research Institute Beijing 100192China China GRINM Group Corporation Limited(GRINM Group) Beijing 100088China GRINM(GuangDong)Advanced Materials Technology Research Institute Foshan 528000GuangdongChina General Research Institute for Nonferrous Metals Beijing 100088China Institute of Materials Genome Engineering Shanghai UniversityShanghai 200444China

To obtain intrinsic overcharge boundary and investigate overcharge mechanism,here we propose an innovative method,the step overcharge test,to reduce the thermal crossover and distinguish the overcharge thermal behavior,including 5%state of charge(SOC)with small current overcharge and resting until the temperature equilibrium under adiabatic *** intrinsic thermal response and the self-excitation behaviour are analysed through temperature and voltage changes during the step overcharge *** results show that the deintercalated state of the cathode is highly correlated to self-heating parasitic *** reaching the upper limit of Negative/Positive(N/P)ratio,the temperature changes little,the heat generation is significantly induced by the reversible heat(endothermic)and ohmic heat,which could balance each *** that the lithium metal is gradually deposited on the surface of the anode and reacts with electrolyte upon overcharge,inducing selfheating side ***,this spontaneous thermal reaction could be“self-extinguished”.When the lithium in cathode is completely deintercalated,the boundary point of overcharge is about 4.7 V(~148%SOC,>40℃),and from this point,the self-heating behaviour could be continuously triggered until thermal runaway(TR)without additional *** whole static and spontaneous process lasts for 115 h and the side reaction heat is beyond 320,000 *** continuous self-excitation behavior inside the battery is attributed to the interaction between the highly oxidized cathode and the solvent,which leads to the dissolution of metal *** dissolved metal ions destroy the SEI(solid electrolyte interphase)film on the surface of the deposited Li of anode,which induces the thermal reaction between lithium metal and the *** interaction between cathode,the deposited Li of anode,and solvent promotes the temperature of the battery to rise *** the temperature of the battery reaches more

关键词： Lithium ion battery Step overcharge Self-heating Boundary Heat generation Amount of lithium

Effects of pioglitazone on proliferation and differentiation of human preadipocytes

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Journal of Nanjing Medical University 2007年第2期21卷 99-103页

作者： Jianying Zhou minjuan Ge Yamei Wang Haiwei Wu Jie shen Xianghua Ma Department of Endocrine the First Affiliated Hospital of Nanjing Medical University Nanjing 210029 China Department of Endocrine the First People＇s Hospital of Changzhou Changzhou 213003 China Staff Room of Etiological Agentmicrobiology Nanjing Medical University Nanjing 210029 China Gene Therapy Center the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029 China

Objective： To explore the effects of thiazolidinediones （TZDs） pioglitazone on proliferation and differentiation of human preadipocytes. Methods：Omental adipose tissue biopsies were obtained from 15 patients who were undergoing elective open-abdominal surgery. The primary culture and differentiated induction of human preadipocytes were performed, and the human preadipo-cytes were treated with pioglitazone at different concentrations at proper moments. Dynamic morphological changes of the human preadipocytes were observed, and their proliferation and differentiation were assessed with Colorimetric MTT Assay and Oil Red O Staining. Results：After 24 hours and 72 hours with pioglitazone, 0.1 μmol/L （μmol/ml） pioglitazone increased the MTT values of the human preadipocytes by 25.3% and 34.8%,respectively（P 〈 0.05）, while 1 μmol/L pioglitazone by 27.4% and 26.6%（P 〈 0.05）, compared with the control group without pioglitazone. The human preadipocytes with pioglitazone cumulated more adipose in the endochylema than those without pioglitazone obviously. 0.1 μmol/L pioglitazone increased the differentiation degree of the human preadipocytes differentiated for 8-10 days by 44.81% and 1 μmol/L pioglitazone by 53.76%（P 〈 0.05）. Conclusion：Thi- azolidinediones pioglitazone may significantly promote the proliferation and differentiation of the human omental preadipocytes.

关键词： pioglitazone human preadipocytes proliferation and differentiation insulin sensitivity

互联网使用对农业碳排放效率的影响——来自豫湘黑三省粮食种植户的实证检验

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资源科学 2024年第7期46卷 1314-1329页

作者：沈玉洁裴小涵赵敏娟西北农林科技大学经济管理学院杨陵712100 西安财经大学西安710100

【目的】在信息化快速发展的背景下,厘清互联网使用对农业碳排放效率的影响机制,对促进农业可持续发展具有重要意义。【方法】本文基于2021年对河南、湖南和黑龙江3省1192份粮食种植户的实地调研数据,将农业碳排放纳入非期望产出的核算... 详细信息

【目的】在信息化快速发展的背景下,厘清互联网使用对农业碳排放效率的影响机制,对促进农业可持续发展具有重要意义。【方法】本文基于2021年对河南、湖南和黑龙江3省1192份粮食种植户的实地调研数据,将农业碳排放纳入非期望产出的核算框架,运用超效率SBM模型测算农业碳排放效率,并采用处理效应模型剖析互联网使用对农业碳排放效率的影响。【结果】①互联网使用显著提高农业碳排放效率,并且使用互联网获取的农业信息类型越多,越有利于农业碳排放效率的提高。②互联网使用分别通过农业绿色生产技术采纳和市场参与影响农业碳排放效率。③异质性分析发现,与使用互联网关注气象信息与政府规制信息相比,使用互联网关注农业绿色生产技术信息更能显著提高农业碳排放效率。④分样本研究发现,互联网使用对高受教育程度组、风险厌恶组以及高社会关系组农户的农业碳排放效率具有显著的正向效应。【结论】应通过加大农村互联网基础设施建设投入,建立农业科技服务平台和农产品信息平台,拓宽农户市场参与渠道以及提高农户互联网技术应用素养等措施提升农业碳排放效率,加速农业绿色发展转型。

关键词：互联网使用绿色生产技术采纳市场参与农业碳排放效率超效率SBM

BGB-A445,a novel non-ligand-blocking agonistic anti-OX40 antibody,exhibits superior immune activation and antitumor effects in preclinical models

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Frontiers of Medicine 2023年第6期17卷 1170-1185页

作者： Beibei Jiang Tong Zhang minjuan Deng Wei Jin Yuan Hong Xiaotong Chen Xin Chen Jing Wang Hongjia Hou Yajuan Gao Wenfeng Gong Xing Wang Haiying Li Xiaosui Zhou Yingcai Feng Bo Zhang Bin Jiang Xueping Lu Lijie Zhang Yang Li Weiwei Song Hanzi Sun Zuobai Wang Xiaomin Song Zhirong shen Xuesong Liu Kang Li Lai Wang Ye Liu Department of Biology BeiGene(Beijing)Co.Ltd.Beijing 102206China Department of Discovery Biomarkers BeiGene(Beijing)Co.Ltd.Beijing 102206China Department of Clinic Development BeiGene(Beijing)Co.Ltd.Beijing 102206China Department of Biologics BeiGene(Beijing)Co.Ltd.Beijing 102206China

t OX40 is a costimulatory receptor that is expressed primarily on activated CD4+,CD8+,and regulatory T *** ligation of OX40 to its sole ligand OX40L potentiates T cell expansion,differentiation,and activation and also promotes dendritic cells to mature to enhance their cytokine ***,the use of agonistic anti-Ox40 antibodies for cancer immunotherapy has gained great ***,most of the agonistic anti-OX40 antibodies in the clinic are OX40L-competitive and show limited ***,we discovered that BGB-A445,a non-ligand-competitive agonistic anti-OX40 antibody currently under clinical investigation,induced optimal T cell activation without impairing dendritic cell *** addition,BGB-A445 dose-dependently and significantly depleted regulatory T cells in vitro and in vivo via antibody-dependent cellular *** the MC38 syngeneic model established in humanized OX40 knock-in mice,BGB-A445 demonstrated robust and dose-dependent antitumor efficacy,whereas the ligand-competitive anti-Ox40 antibody showed antitumor efficacy characterized by a hook ***,BGB-A445 demonstrated a strong combination antitumor effect with an anti-PD-1 *** together,our findings show that BGB-A445,which does not block OX40-OX40L interaction in contrast to clinical-stage anti-OX40 antibodies,shows superior immune-stimulating effects and antitumor efficacy and thus warrants further clinical investigation.

关键词： BGB-A445 OX40 agonistic antibody OX40L noncompetitive