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Irisin-loaded electrospun core-shell nanofibers as calvarial periosteum accelerate vascularized bone regeneration by activating the mitochondrial SIRT3 pathway

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Regenerative Biomaterials 2024年第1期3卷 44-57页

作者： Xi Hua mingzhuang hou Lei Deng Nanning Lv Yong Xu Xuesong Zhu Huilin Yang Qin Shi Hao Liu Fan He Department of Orthopaedics The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Orthopaedic Institute Suzhou Medical CollegeSoochow UniversitySuzhou 215000China Department of Orthopedics Suzhou Wuzhong People’s HospitalSuzhouJiangsu Province 215128China Department of Orthopedic Surgery Lianyungang Clinical College of Xuzhou Medical UniversityLianyungang 222003China

The scarcity of native periosteum poses a significant clinical barrier in the repair of critical-sized bone *** challenge of enhancing regenerative potential in bone healing is further compounded by oxidative stress at the fracture ***,the introduction of artificial periosteum has demonstrated its ability to promote bone regeneration through the provision of appropriate mechanical support and controlled release of proosteogenic *** this study,a poly(L-lactic acid)(PLLA)/hyaluronic acid(HA)-based nanofibrous membrane was fabricated using the coaxial electrospinning *** incorporation of irisin into the core-shell structure of PLLA/HA nanofibers(PLLA/HA@Irisin)achieved its sustained *** vitro experiments demonstrated that the PLLA/HA@Irisin membranes exhibited favorable *** osteogenic differentiation of bone marrow mesenchymal stem cells(BMMSCs)was improved by PLLA/HA@Irisin,as evidenced by a significant increase in alkaline phosphatase activity and matrix ***,PLLA/HA@Irisin significantly enhanced the mitochondrial function of BMMSCs via the activation of the sirtuin 3 antioxidant *** assess the therapeutic effectiveness,PLLA/HA@Irisin membranes were implanted in situ into critical-sized calvarial defects in *** results at 4 and 8 weeks post-surgery indicated that the implantation of PLLA/HA@Irisin exhibited superior efficacy in promoting vascularized bone formation,as demonstrated by the enhancement of bone matrix synthesis and the development of new blood *** results of our study indicate that the electrospun PLLA/HA@Irisin nanofibers possess characteristics of a biomimetic periosteum,showing potential for effectively treating critical-sized bone defects by improving the mitochondrial function and maintaining redox homeostasis of BMMSCs.

关键词： periosteum irisin mitochondrial function critical-sized bone defect redox homeostasis

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Activation of NRF2 by celastrol increases antioxidant functions and prevents the progression of osteoarthritis in mice

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Chinese Journal of Natural Medicines 2024年第2期22卷 137-145页

作者： LIU Mingming GUO Jiatian ZHAO Jing LI Hongye FENG Xiaoxiao LIU Haojun ZHANG Hao JIA Xuejun WEI Rushuai LI Fang CHEN Chong hou mingzhuang LV Nanning XU Haiyan Department of human anatomy Xuzhou Medical UniversityXuzhou 221004China Department of Orthopedic Surgery The Affiliated Lianyungang Clinical College of Xuzhou Medical University(The Second People’s Hospital of Lianyungang)Lianyungang 222003China Department of Orthopaedics The First Afliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Institute of Hematology Xuzhou Medical UniversityXuzhou 221004China

Excessive oxidative stress impairs cartilage matrix metabolism balance,significantly contributing to osteoarthritis(OA)***(CSL),a drug derived from Tripterygium wilfordii,has recognized applications in the treatment of cancer and immune system disorders,yet its antioxidative stress mechanisms in OA remain *** study aimed to substantiate CSL’s chondroprotective effects and unravel its underlying *** investigated CSL’s impact on chondrocytes under both normal and inflammatory *** vitro,CSL mitigated interleukin(IL)-1β-induced activation of proteinases and promoted cartilage extracellular matrix(ECM)*** vivo,intra-articular injection of CSL ameliorated cartilage degeneration and mitigated subchondral bone lesions in OA ***,it was found that inhibiting nuclear factor erythroid 2-related factor 2(NRF2)abrogated CSL-mediated antioxidative functions and exacerbated the progression of *** study is the first to elucidate the role of CSL in the treatment of OA through the activation of NRF2,offering a novel therapeutic avenue for arthritis therapy.

关键词： Osteoarthritis Celastrol Articular cartilage Extracellular matrix NRF2

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Biomimetic melatonin-loaded silk fibroin/GelMA scaffold strengthens cartilage repair through retrieval of mitochondrial functions

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Journal of Materials Science & Technology 2023年第15期146卷 102-112页

作者： mingzhuang hou Yijian Zhang Yang Liu Xiaoyang Ge Xiayu Hu Zhijian Zhao Xin Tian Tao Liu Huilin Yang Xi Chen Fan He Xuesong Zhu Department of Orthopaedics The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Orthopaedic Institute Medical CollegeSoochow UniversitySuzhou 215007China Department of Pathology The Third Affiliated Hospital of Soochow UniversityChangzhou 213003China

Articular cartilage injury induced by collision or trauma is a common sports-related condition that may progress to pain,dysfunction,and secondary osteoarthritis(OA).Limited by self-renewal potential,cartilage regeneration faces a quandary while bio-inspired novel strategies are urgently *** this study,by a soft freezing method and surface modification technique,a multi-functional silk fibroin(SF)plus gelatin methacrylate(GelMA)scaffold laden with melatonin(MT)was ***-GelMA@MT scaffold demonstrated enhanced biomechanical characteristics and long-acting melatonin *** vitro treatment with SF-GelMA@MT induced the synthesis of cartilage extracellular matrix(ECM)***,sustained release of melatonin yielded robust chondroprotective effects via improving mitochondrial polarization and antioxidant ***-GelMA@MT implantation boosted cartilage renascence in a full-thickness cartilage defect model via mitochondria-associated sirtuins 1(SIRT1)-superoxide dismutase 2(SOD2)signaling pathway in *** summary,this research proposed a welldesigned bionic composite scaffold that promotes cartilage regeneration via mitochondrial function enhancement,which is of tremendous potential for cartilage tissue engineering.

关键词： Cartilage injury Silk fibroin Gelatin methacrylate Melatonin Mitochondri

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Preparation of Laser Cladding Coating Undercooling Cu-based Alloy and Co on Non-equilibrium Solidification Structure

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Journal of Wuhan University of Technology(Materials Science) 2024年第2期39卷 463-472页

作者：田徐铭 CAO Shichao hou Kai hou Xiaopeng WANG Hongfu 张煜 Department of Outpatient Xinzhou People’s HospitalXinzhou 034099China School of Mechanical Engineering North University of ChinaTaiyuan 030051China Department of Neurosurgery Xinzhou People’s HospitalXinzhou 034099China Department of Orthopedics Xinzhou People’s HospitalXinzhou 034099China

The effect of the gradient content of Co element on the solidification process of Cu-based alloy under deep under cooling conditions was *** non-equilibrium solidification structure of the under cooled alloy samples were *** is found that the rapidly solidified alloy has undergone twice grain refinement during the undercooling *** and significance of the maximum undercooling refinement structure of Cu60Ni35Co5 at T=253 K were ***-density defects were observed,such as dislocations,stacking faults networks,and twinning *** standard FCC diffraction pattern represents that it is still a single-phase *** on the metallographic diagram,EBSD and TEM data analysis,it is illustrated that the occurrence of grain refinement under high undercooling is due to stress induced *** addition,the laser cladding technology is used to coat Co-based alloy(Stellite12) coating on 304 stainless steel substrate;the microstructure of the coating cross-section was *** was found that the microstructure of the cross-section is presented as columnar crystals,planar crystals,and disordered growth direction,so that the coating has better hardness and wear *** electrochemical corrosion of the substrate and coating,it can be seen that the Co and Cr elements present in the coating are more likely to form a dense passivation film,which improved the corrosion resistance of the coating.

关键词： non-equilibrium solidification structure undercooling recrystallization laser cladding coating

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Integral Operators Between Fock Spaces

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Chinese Annals of Mathematics,Series B 2024年第2期45卷 265-278页

作者： Yongqing LIU Shengzhao hou School of Mathematics and Statistics Changshu Institute of TechnologySuzhou 215006JiangsuChina School of Mathematical Sciences Soochow UniversitySuzhou 215006JiangsuChina

In this paper,the authors study the integral operator■induced by a kernel functionφ(z,·)∈F_α~∞between Fock *** 1≤p≤∞,they prove that S_φ:F_α^(1)→F_α^(p)is bounded if and only if■where k_(a)is the normali... 详细信息

关键词： Fock spaces Integral operators Normalized reproducing kernel

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In-Plane Dynamic Crushing Behaviors of a Vertex-Based Hierarchical Auxetic Honeycomb

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Acta Mechanica Solida Sinica 2024年第1期37卷 53-62页

作者： Yichen Zan Xiuhui hou Zichen Deng School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi'an 710072China MIIT Key Laboratory of Dynamics and Control of Complex Systems Northwestern Polytechnical UniversityXi'an 710072China School of Aeronautics Northwestern Polytechnical UniversityXi'an 710072China State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial EquipmentDalian University of TechnologyDalian 116024China

Auxetic metamaterials,which exhibit the negative Poisson’s ratio(NPR)effect,have found wide applications in many engineering ***,their high porosity inevitably weakens their bearing capacity and impact *** improve the energy absorption efficiency of auxetic honeycombs,a novel vertex-based hierarchical star-shaped honeycomb(VSH)is designed by replacing each vertex in the classical star-shaped honeycomb(SSH)with a newly added self-similar *** analytical model is built to investigate the Young’s modulus of VSH,which shows good agreement with experimental results and numerical *** in-plane dynamic crushing behaviors of VSH at three different crushing velocities are investigated,and empirical formulas for the densification strain and plateau stress are *** results reveal more stable deformation modes for VSH,attributed to the addition of self-similar star-shaped ***,compared with SSH under the same relative densities,VSH exhibits better specific energy absorption and higher plateau ***,VSH is verified to be a better candidate for energy absorption while maintaining the auxetic *** study is expected to provide a new design strategy for auxetic honeycombs.

关键词： Vertex-based hierarchical star-shaped honeycomb Auxetic honeycomb Energy absorption Plateau stress Negative Poisson's ratio

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An Improved Method for Approximating the Infinite-Horizon Value Function of the Discrete-Time Switched LQR Problem

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Journal of Systems Science & Complexity 2024年第1期37卷 22-39页

作者： hou Tan LI Yuanlong LIN Zongli Department of Automation Shanghai Jiao Tong UniversityShanghai 200240China Key Laboratory of System Control and Information Processing Ministry of Education of ChinaShanghai 200240China Shanghai Engineering Research Center of Intelligent Control and Management Shanghai 200240China Charles L.Brown Department of Electrical and Computer Engineering University of VirginiaCharlottesvilleVA 22904-4743USA

This paper considers the problem of approximating the infinite-horizon value function of the discrete-time switched LQR *** particular,the authors propose a new value iteration method to generate a sequence of monotonically decreasing functions that converges exponentially to the value *** method facilitates us to use coarse approximations resulting from faster but less accurate algorithms for further value iteration,and thus,the proposed approach is capable of achieving a better approximation for a given computation time compared with the existing *** numerical examples are presented in this paper to illustrate the effectiveness of the proposed method.

关键词： Optimal control switched linear systems switched LQR problem.

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Theoretical study on the stability of nanobubbles and its verification in molecular dynamics simulation

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Particuology 2024年第4期87卷 99-105页

作者： Sheng Mi Chaofeng hou Wei Ge School of Chemical Engineering and Technology Tianjin UniversityTianjin300072China State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy of SciencesBeijing.100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

The stability of vapor nanobubbles in bulk liquid was investigated theoretically and the critical bubble size was derived from macroscale thermodynamic equations,below which the system destabilizes with sharp drop in *** critical size was quantitatively verified in molecular dynamic simulation using the Lennard-Jones model of argon,where stronger attraction between the molecules at lower density is found to contribute most to the drop of system pressure and,as the Laplace pressure on the curved bubble interface fails to balance the pressure difference across the interface,the bubbles become *** theoretical model could be extended to other systems where reliable equations of state and interfacial tension are available.

关键词： Nanobubble Stability Phase diagram Critical size

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Tailored energy absorption for a novel auxetic honeycomb structure under large deformation

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 63-80页

作者： Xiuhui hou Bin Wang Zichen Deng School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi'an 710129China MIIT Key Laboratory of Dynamics and Control of Complex Systems Northwestern Polytechnical UniversityXi'an 710072China School of Aeronautics Northwestern Polytechnical UniversityXi'an 710072China State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial EquipmentDalian University of TechnologyDalian 116024China

In comparison to conventional hexagonal honeycomb structures,auxetic metamaterials with re-entrant configurations have exhibited superior mechanical properties in terms of energy *** further enhance the energy absorption capacity of these materials,a novel re-entrant honeycomb configuration,named novel auxetic re-entrant honeycomb(NARH),is developed by incorporating“”-shaped cell walls into the conventional auxetic re-entrant honeycomb(ARH).Two analytical models for the plateau stress are formulated to consider the plastic deformation of NARH during quasi-static compression and the dynamic impact using the linear momentum ***-static compression tests on 3D printed NARH honeycomb specimens and finite element simulations are performed to verify the effectiveness of the theoretical *** exhibits higher plateau stresses compared with ARH during compression,which can be attributed to the presence of more plastic hinges formed in *** hinges,the embedded parts with inclined cell walls,not only improve stability by forming stable triangles during compression but also enhance the energy absorption capacity.A parametric study is conducted to analyze the effect of impact velocity,thickness,and incline angle of cell walls on *** simulations demonstrate higher sensitivity of the mechanical properties to impact velocity and cell wall *** ribs to the“”-shaped cell walls in NARH further reduces the initial peak force during dynamic crushing while maintaining high energy *** research provides valuable guidelines for the design of energy absorption metamaterials.

关键词： absorption walls shaped

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Bioinspired nanofluidic iontronics for brain-like computing

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Nano Research 2024年第2期17卷 503-514页

作者： Lejian Yu Xipeng Li Chunyi Luo Zhenkang Lei Yilan Wang Yaqi hou Miao Wang Xu hou State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Institute of Artificial Intelligence Xiamen UniversityXiamen 361005China Department of Physics Research Institute for Biomimetics and Soft MatterFujian Provincial Key Laboratory for Soft Functional Materials ResearchJiujiang Research InstituteCollege of Physical Science and TechnologyXiamen UniversityXiamen 361005China The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province Department of BiomaterialsResearch Center of Biomedical Engineering of XiamenCollege of MaterialsXiamen UniversityXiamen 361005China The Institute of Flexible Electronics(IFE Future Technologies)Xiamen UniversityXiamen 361005China Binzhou Institute of Technology Binzhou 256600China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361102China Engineering Research Center of Electrochemical Technologies of Ministry of Education Xiamen UniversityXiamen 361005China

The human brain performs computations via a highly interconnected network of *** inspiration from the information delivery and processing mechanism of the human brain in central nervous systems,bioinspired nanofluidic iontronics has been proposed and gradually engineered to overcome the limitations of the conventional electron-based von Neumann architecture,which shows the promising potential to enable efficient brain-like *** and tunable nanofluidic ion transport behaviors and spatial confinement show promising controllability of charge carriers,and a wide range of structural and chemical modification paves new ways for realizing brain-like ***,a comprehensive framework of mechanisms and design strategy is summarized to enable the rational design of nanofluidic systems and facilitate the further development of bioinspired nanofluidic *** review provides recent advances and prospects of the bioinspired nanofluidic iontronics,including ion-based brain computing,comprehension of intrinsic mechanisms,design of artificial nanochannels,and the latest artificial neuromorphic functions ***,the challenges and opportunities of bioinspired nanofluidic iontronics in the pioneering and interdisciplinary research fields are proposed,including brain–computer interfaces and artificial neurons.

关键词： human brain ion transport nanofluidics brain-like computing memristive effect

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