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Mining intrinsic information of convalescent patients after suffering coronavirus disease 2019 in Wuhan

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Journal of Traditional Chinese Medicine 2022年第2期42卷 279-288页

作者： YAN Shixing LüYi LIU Ziqing REN Meng HE Haiyang xiao Li GUO Feng PENG Miao LI xiaoxia WANG Yong XU Xi YANG Tao SHAO Zuoyu HUANG Jingjing xiao mingzhong Department of TCM Data Intelligence Shanghai Daosh Medical Technology Co.Ltd.Shanghai 201200China Hepatic Disease Institute Hubei Key Laboratory of Theoretical and Applied Research of Liver and Kidney in Traditional Chinese MedicineHubei Provincial Hospital of Traditional Chinese MedicineWuhan 430061China Affiliated Hospital of Hubei University of Chinese Medicine Wuhan 430061China Hubei Academy of Traditional Chinese Medicine Wuhan 430074China Electronical Medical Records and Information Management Center Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai 200437China Chinese Medicine Development research Center Shanghai Literature Institute of TCMShanghai 200025China College of Acupuncture and Massage Shanghai University of Traditional Chinese MedicineShanghai 201203China College of Artificial Intelligence and Information Technology Institute of Information and Technology Nanjing University of Chinese MedicineNanjing 210023China

OBJECTIVE:To summarize the potential characteristics of convalescent patients with coronavirus disease 2019(COVID-19)in China based on emerging clinical tongue data and guide the treatment and recovery of COVID-19 patients from the perspective of Traditional Chinese Medicine tongue ***:In this study,we developed and validated radiomics-based and lab-based methods as a novel approach to provide individualized pretreatment evaluation by analyzing different features to mine the orderliness behind tongue data of convalescent *** addition,this study analyzed the tongue features of convalescent patients from clinical tongue qualitative values,including thick and thin,fur,peeling,fat and lean,tooth marks and cracked,and greasy and putrid ***:We included 2164 tongue images in total(34%from day 0,35.4%from day 14 and 30.6%from day 28)from convalescent *** significance results are shown as ***,as the recovery time prolongs,the L average values of tongue and coat decrease from 60.21 to 57.18 and from 60.06 to 57.03 ***,the decrease of abnormality rate of tongue coat,included greasy tongue fur,putrid fur,teeth-mark,thick-thin fur,are of significant statistical difference(P<0.05).Thirdly,the average value of gray-level cooccurrence matrices increases from 0.173 to 0.194,the average value of entropy increases from 0.606 to 0.665,the average value of inverse difference normalized decrease from 0.981 to 0.979,and the average value of dissimilarity decrease from 0.1576 to *** details of other radiomics features are describe in results ***:Our experiment shows that patients in different recovery periods have a relationship with quantitative values of tongue images,including L color space of the tongue and coat radiomics features *** relationship can help clinical doctors master the recovery and health of patients as soon as possible and improve their understanding of the potential me

关键词： COVID-19 tongue inspection quantitative values dynamic change mechanisms radiomics features analysis

Regional Evaluations of the Meteorological Drought Characteristics across the Pearl River Basin, China

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American Journal of Climate Change 2012年第1期1卷 48-55页

作者： Qiang Zhang mingzhong xiao xiaohong Chen Department of Water Resources and Environment Sun Yat-sen University Guangzhou China Key Laboratory of Water Cycle and Water Security in Southern China of Guangdong High Education Institute Sun Yat-sen University Guangzhou China School of Geography and Planning and Guangdong Key Laboratory for Urbanization and Geo-Simulation Sun Yat-sen University Guangzhou China

Regional evaluation of drought characteristics provides critical information for water resource management. In this case, this study attempts to analyze the probability behaviors of drought events of a given severity in the Pearl River Basin and to construct severity-area-frequency curves of drought events. Due to possible impacts of complicated topographical properties and diverse climate types within the Pearl River Basin, the entire Pearl River Basin is subdivided into different homogeneous regions. In general, the Pearl River Basin can be categorized into four homogeneous regions, and the severity-area-frequency analysis results for the short-, medium- and long-term drought episodes within each homogeneous regions indicate stressful challenge for the water resource management in the Pearl River Basin due to the fact that severe droughts usually occur over the entire Pearl River Basin. Meanwhile, the Pearl River Delta will face a higher risk of drought when compared to other regions of the Pearl River Basin in terms of the medium-term drought. The Pearl River Basin is highly economically development and is heavily populated, thus impacts of droughts and related resilience resolutions or policies should be taken into account in the formulation of regional sustainable development of water resources and socio-economy within the Pearl River Basin, China.

关键词： Regional Drought Severity-Area-Frequency Curves Cluster Algorithm The Pearl River Basin

Classification of metabolic-associated fatty liver disease subtypes based on TCM clinical phenotype

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Gastroenterology & Hepatology Research 2023年第1期5卷 6-12页

作者： Chenxia Lu Hui Zhu mingzhong xiao xiaodong Li Department of Hepatology Hubei Key Laboratory of the theory and application research of liver and kidney in traditional Chinese medicineHubei Provincial Hospital of Traditional Chinese MedicineWuhan 430061China Affiliated Hospital of Hubei University of Chinese Medicine Wuhan 430061China Hubei Province Academy of Traditional Chinese Medicine Wuhan 430074China The Clinical Medical College of Traditional Chinese Medicine Hubei University of Chinese MedicineWuhan 430065China

Objective:To classify the subtypes of metabolic-associated fatty liver disease(MAFLD)and provide new insights into the heterogeneity of ***:Electronic medical records(EMR)of MAFLD diagnosed in accordance with the diagnostic criteria of Hubei Provincial Hospital of Traditional Chinese Medicine from 2016-2020 were included in the *** physical annotation,and the data on each clinical phenotype was normalized according to corresponding aspirational *** MAFLD heterogeneous medical record network(HEMnet)was constructed using sex,age,disease diagnosis,symptoms,and Western medicine prescriptions as nodes and the co-occurrence times between phenotypes as edges.K-means clustering was used for disease *** risk(RR)was used to assess the specificity of each *** methods were used to compare differences in laboratory indicators among ***:A total of patients(12,626)with a mean age of 55.02(±14.21)years were included in the *** can be divided into five subtypes:digestive diseases(C0),mental disorders and gynecological diseases(C1),chronic liver diseases and decompensated complications(C2),diabetes mellitus and its complications(C3),and immune joint system diseases(C4).Conclusions:Patients with MAFLD experience various symptoms and *** classification of MAFLD based on the HEMnet method is highly reliable.

关键词： metabolic-associated fatty liver disease electronic medical records disease classification heterogeneous medical record network disease heterogeneity

Distinct gut microbiota and health outcomes in asymptomatic infection,viral nucleic acid test re-positive,and convalescent COVID-19 cases

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mLife 2022年第2期1卷 183-197页

作者： Ruqin Lin mingzhong xiao Shanshan Cao Yu Sun Linhua Zhao xiaoxiao Mao Peng Chen xiaolin Tong Zheyuan Ou Hui Zhu Dong Men xiaodong Li Yiqun Deng Xian-En Zhang Jikai Wen Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms College of Life SciencesSouth China Agricultural UniversityGuangzhouChina Hepatic Disease Institute Hubei Key Laboratory of Theoretical and Applied Research of Liver and Kidney in Traditional Chinese MedicineHubei Provincial Hospital of Traditional Chinese MedicineWuhanChina State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhanChina National Laboratory of Biomacromolecules Institute of BiophysicsChinese Academy of SciencesBeijingChina Department of Endocrinology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijingChina Guangdong Laboratory for Lingnan Modern Agriculture South China Agricultural UniversityGuangzhouChina Hubei Province Academy of Traditional Chinese Medicine WuhanChina Faculty of Synthetic Biology Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenChina University of Chinese Academy of Sciences BeijingChina

Gut microbiota composition is suggested to associate with coronavirus disease 2019(COVID-19)severity,but the impact of gut microbiota on health outcomes is largely *** recruited 81 individuals from Wuhan,China,including 13 asymptomatic infection cases(Group A),24 COVID-19 convalescents with adverse outcomes(Group C),31 severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)re-positive cases(Group D),and 13 non-COVID-19 healthy controls(Group H).The microbial features of Groups A and D were similar and exhibited higher gut microbial diversity and more abundant short-chain fatty acid(SCFA)-producing species than Group *** C was enriched with opportunistic pathogens and virulence factors related to adhesion and toxin *** abundance of SCFA-producing species was negatively correlated,while Escherichia coli was positively correlated with adverse *** three groups(A,C,and D)were enriched with the mucusdegrading species Akkermansia muciniphila,but decreased with Bacteroides-encoded carbohydrate-active *** pathways of vitamin B6 metabolic and folate biosynthesis were decreased,while selenocompound metabolism was increased in the three ***,the secondary bile acid(BA)metabolic pathway was enriched in Group *** resistance genes were common among the three ***,the gut microbiota was related to the health outcomes of *** supplementations(SCFAs,BA,selenium,folate,vitamin B6)may be beneficial to COVID-19 patients.

关键词： COVID-19 gut microbiota health outcomes re-positive SARS-CoV-2

有氧运动联合丹皮酚PLGA纳米粒对肥胖伴高脂血症大鼠的保护作用

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中国比较医学杂志 2019年第12期29卷 88-93页

作者：刘静肖明中武汉民政职业学院康复医疗学院武汉430079 湖北省中医院肥胖体重管理中心武汉430074

目的探讨有氧运动联合丹皮酚PLGA纳米粒对肥胖伴高脂血症大鼠的血生化及脂代谢作用影响。方法清洁级雄性SD大鼠40只,采用高脂饮食诱导8周构建肥胖伴高脂血症模型,将模型大鼠随机分为模型对照组(Model),有氧运动组(MS),丹皮酚PLGA纳米粒... 详细信息

目的探讨有氧运动联合丹皮酚PLGA纳米粒对肥胖伴高脂血症大鼠的血生化及脂代谢作用影响。方法清洁级雄性SD大鼠40只,采用高脂饮食诱导8周构建肥胖伴高脂血症模型,将模型大鼠随机分为模型对照组(Model),有氧运动组(MS),丹皮酚PLGA纳米粒组(MP)和有氧运动联合丹皮酚PLGA纳米粒组(SP),每组8只,连续干预6周并测量体重;干预结束后采用全自动血生化分析仪对大鼠血清中的总胆固醇(TC)、甘油三酯(TG)和高密度脂蛋白(HDL-C)的含量进行分析并计算肝脏系数;同时对血清中的脂蛋白酶(LPL)肝脂酶(HL)含量进行检测,并对腹部脂肪进行取样做HE染色分析。结果MS组、MP组和SP组的体重、血生化参数、肝脏系数、脂蛋白酶和肝脂酶含量等指标与模型对照组相比均得到改善,且SP干预组的效果最优,与模型对照组相比均具统计学差异(P<0.01),而MS与MP相比,没有统计学差异。腹部脂肪病理学切片统计结果表明相同视野下SP干预组大鼠腹部脂肪细胞较小,数目最多。结论有氧运动联合丹皮酚PLGA纳米粒干预能够明显改善由高脂饮食诱导的肥胖伴脂质代谢紊乱,能够降低肝脏指数,有效调节脂质代谢缓解脂肪蓄积。

关键词：有氧运动丹皮酚PLGA纳米粒高脂血症肥胖脂代谢

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基于多变量概率分析的珠江流域干旱特征研究

地理学报 2012年第1期67卷 83-92页

作者：肖名忠张强陈晓宏中山大学水资源与环境系广州510275 中山大学华南地区水循环与水安全广东省普通高校重点实验室广州510275 中山大学广东省城市化与地理环境空间模拟重点实验室广州510275

根据珠江流域42个站点1960-2005年的46年日降水资料,以6个月尺度的SPI值表征珠江流域干旱情况。通过Mann-Kendall趋势分析研究了珠江流域干旱时间演变特征,同时基于多变量Copula函数,在定义的两种不同干旱情景下,根据两变量联合重现期... 详细信息

根据珠江流域42个站点1960-2005年的46年日降水资料,以6个月尺度的SPI值表征珠江流域干旱情况。通过Mann-Kendall趋势分析研究了珠江流域干旱时间演变特征,同时基于多变量Copula函数,在定义的两种不同干旱情景下,根据两变量联合重现期及其对应的第二重现期,比较性地研究了珠江流域的干旱风险。研究结果表明:(1)珠江流域西部有变旱的趋势而东部有变湿润的趋势,其中显著的变旱趋势集中在11、12、1月,显著的变湿趋势集中在6、7月。同时除个别站点外,干旱历时和干旱严重程度趋势不显著;(2)珠江流域整体上干旱风险较大,东部要比西部干旱风险高。珠江流域内发生长历时干旱时,干旱严重程度也往往很大,对干旱风险管理很不利。在发生严重程度的干旱时,珠江流域东部的干旱高风险区域增加,威胁珠江三角洲地区水资源安全;(3)由于第二重现期综合考虑了各种情况,可能第二重现期对干旱风险分析的结果更稳健一些。

关键词：干旱干旱风险 Copula函数第二重现期珠江

Neutralization against SARS-CoV-2 Delta/Omicron variants and B cell response after inactivated vaccination among COVID-19 convalescents

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Frontiers of Medicine 2023年第4期17卷 747-757页

作者： Hao Wang Yu Yuan Bihao Wu mingzhong xiao Zhen Wang Tingyue Diao Rui Zeng Li Chen Yanshou Lei Pinpin Long Yi Guo Xuefeng Lai Yuying Wen Wenhui Li Hao Cai Lulu Song Wei Ni Youyun Zhao Kani Ouyang Jingzhi Wang Qi Wang Li Liu Chaolong Wang An Pan xiaodong Li Rui Gong Tangchun Wu Ministry of Education and State Key Laboratory of Environmental Health(Incubating) School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China CAS Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China Affiliated Hospital of Hubei University of Chinese Medicine Wuhan 430061China Hubei Provincial Hospital of Traditional Chinese Medicine Wuhan 430061China

Emerging SARS-CoV-2 variants have made COVID-19 convalescents susceptible to re-infection and have raised concern about the efficacy of inactivated vaccination in neutralization against emerging variants and antigen-specific B cell *** this end,a study on a long-term cohort of 208 participants who have recovered from COVID-19 was conducted,and the participants were followed up at 3.3(Visit 1),9.2(Visit 2),and 18.5(Visit 3)months after SARS-CoV-2 *** were classified into three groups(no-vaccination(n=54),one-dose(n=62),and two-dose(n=92)groups)on the basis of the administration of inactivated *** neutralizing antibody(NAb)titers against the wild-type virus continued to decrease in the no-vaccination group,but they rose significantly in the one-dose and two-dose groups,with the highest NAb titers being observed in the two-dose group at Visit *** NAb titers against the Delta variant for the no-vaccination,one-dose,and two-dose groups decreased by 3.3,1.9,and 2.3 folds relative to the wild-type virus,respectively,and those against the Omicron variant decreased by 7.0,4.0,and 3.8 folds,***,the responses of SARS-CoV-2 RBD-specific B cells and memory B cells were boosted by the second vaccine *** showed that the convalescents benefited from the administration of the inactivated vaccine(one or two doses),which enhanced neutralization against highly mutated SARS-CoV-2 variants and memory B cell *** doses of inactivated vaccine among COVID-19 convalescents are therefore recommended for the prevention of the COVID-19 pandemic,and vaccination guidelines and policies need to be updated.

关键词： COVID-19 convalescent SARS-CoV-2 inactivated vaccination neutralizing antibody B cell response

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非酒精性脂肪性肝病预测模型的特征分析

中国全科医学 2021年第30期24卷 3888-3892,3899页

作者：高小莲肖明中陶军秀艾亚婷湖北中医药大学湖北省武汉市430065 湖北省中医院湖北省武汉市430061 湖北省中医药研究所湖北省武汉市430074

作为疾病风险评估的量化工具,疾病预测模型有助于识别高危人群,为健康管理提供参考依据,而非酒精性脂肪性肝病(NAFLD)预测模型研究尚未引起中国肝病健康管理领域研究者的充分关注。本文针对性地在PubMed、Web of Science、中国知网等数... 详细信息

作为疾病风险评估的量化工具,疾病预测模型有助于识别高危人群,为健康管理提供参考依据,而非酒精性脂肪性肝病(NAFLD)预测模型研究尚未引起中国肝病健康管理领域研究者的充分关注。本文针对性地在PubMed、Web of Science、中国知网等数据库进行了文献查阅,得到8种NAFLD预测模型,分别是脂肪肝指数(FLI)、肝脂肪变性指数(HSI)、肝脂肪百分比、Framingham脂肪变性指数(FSI)、ZJU指数、NAFLD筛查评分(NSS)、Young Jin Park模型、Mika Aizawa模型。通过归纳上述8种NAFLD预测模型的建模方法、模型的质量表现、模型的表达及应用现状发现,Logistic回归分析是主要的建模方法,模型区分度较好,模型多采取内部验证,NAFLD预测模型的研究还存在较大的开发空间。

关键词：非酒精性脂肪性肝病预测模型 Logistic模型

Dynamics of the SARS-CoV-2 antibody response up to 10 months after infection

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Cellular & Molecular Immunology 2021年第7期18卷 1832-1834页

作者： Hao Wang Yu Yuan mingzhong xiao Li Chen Youyun Zhao Haiwei Zhang Pinpin Long Yana Zhou Xi Xu Yanshou Lei Bihao Wu Tingyue Diao Hao Cai Li Liu Zuoyu Shao Jingzhi Wang Yansen Bai Kai Wang Miao Peng Linlin Liu Shi Han Fanghua Mei Kun Cai Yake Lei An Pan Chaolong Wang Rui Gong xiaodong Li Tangchun Wu Ministry of Education and State Key Laboratory of Environmental Health(Incubating) School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Hepatic Disease Institute Hubei Key Laboratory of Theoretical and Applied Research of Liver and Kidney in Traditional Chinese MedicineHubei Provincial Hospital of Traditional Chinese MedicineWuhanChina Affiliated Hospital of Hubei University of Chinese Medicine WuhanChina Hubei Province Academy of Traditional Chinese Medicine WuhanChina CAS Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhanChina University of Chinese Academy of Sciences BeijingChina Hubei Provincial Center for Disease Control and Prevention WuhanChina

COVID-19 caused by SARS-CoV-2 infection has caused substantial morbidity and mortality worldwide and paralyzed the international *** the magnitude and duration of the antibody response to SARS-CoV-2 is important to achieve a balance between curbing the pandemic and minimizing adverse effects on society.1 Although the antibody response to SARS-CoV-2 within 9 months has been extensively studied,2,3,4,5,6 little is known about the magnitude and kinetics of antibody responses for over 9 ***,with limited observations over 9 months(n<100),2,7,8 several studies have produced inconsistent conclusions about antibody dynamics,suggesting different rates of antiviral antibody positivity at the last follow-up.2,7,8 These studies have been limited by a lack of measurement of neutralizing antibodies(NAbs),7 of inclusion of mild or asymptomatic cases,2,8 and of further exploration of potential predisposing factors for antibody dynamics.2,7 Considering the individual heterogeneity(such as disease severity)8 and time-dependent nature1 of the immune response,in-depth characterization of SARS-CoV-2 antibody kinetics across disease severity groups over a long period is urgently ***,we repeatedly tested IgM,IgG,viral spike protein receptor-binding dom(anti-RBD)IgG,and NAb titers in COVID-19 patients during a follow-up period of up to 10 months and explored potential predisposing factors of antibody titers during follow-up.

关键词： infection severity mortality