Classification of metabolic-associated fatty liver disease subtypes based on TCM clinical phenotype

作     者：Chenxia Lu Hui Zhu Mingzhong Xiao Xiaodong Li 

作者机构：Department of HepatologyHubei Key Laboratory of the theory and application research of liver and kidney in traditional Chinese medicineHubei Provincial Hospital of Traditional Chinese MedicineWuhan 430061China Affiliated Hospital of Hubei University of Chinese MedicineWuhan 430061China Hubei Province Academy of Traditional Chinese MedicineWuhan 430074China The Clinical Medical College of Traditional Chinese MedicineHubei University of Chinese MedicineWuhan 430065China 

出 版 物：《Gastroenterology & Hepatology Research》 (胃肠与肝病学杂志（英文）)

年 卷 期：2023年第5卷第1期

页      面：6-12页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by grants from the Key project Natural Science Foundation of Hubei Province(No.2020CFA023) Project of the State Administration of Traditional Chinese Medicine(No Z155080000004):Key Laboratory of Liver and Kidney Treatment of Chronic Liver Diseases 

主　　题：metabolic-associated fatty liver disease electronic medical records disease classification heterogeneous medical record network disease heterogeneity 

摘      要：Objective:To classify the subtypes of metabolic-associated fatty liver disease(MAFLD)and provide new insights into the heterogeneity of ***:Electronic medical records(EMR)of MAFLD diagnosed in accordance with the diagnostic criteria of Hubei Provincial Hospital of Traditional Chinese Medicine from 2016-2020 were included in the *** physical annotation,and the data on each clinical phenotype was normalized according to corresponding aspirational *** MAFLD heterogeneous medical record network(HEMnet)was constructed using sex,age,disease diagnosis,symptoms,and Western medicine prescriptions as nodes and the co-occurrence times between phenotypes as edges.K-means clustering was used for disease *** risk(RR)was used to assess the specificity of each *** methods were used to compare differences in laboratory indicators among ***:A total of patients(12,626)with a mean age of 55.02(±14.21)years were included in the *** can be divided into five subtypes:digestive diseases(C0),mental disorders and gynecological diseases(C1),chronic liver diseases and decompensated complications(C2),diabetes mellitus and its complications(C3),and immune joint system diseases(C4).Conclusions:Patients with MAFLD experience various symptoms and *** classification of MAFLD based on the HEMnet method is highly reliable.