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浅谈“暴力伤医”的原因与规避

中医药临床杂志 2015年第9期27卷 1230-1233页

作者：王亚玲尤吾兵王莉解明月方明安徽中医药大学安徽合肥230012

据报道，近年“暴力伤医”事件频发，平均每所医院每年高达27起，致医生死亡的情况时有发生，医院竟成了社会暴力的宣泄口。“暴力伤医”危害着医护人员的根本利益，破坏着正常的医疗秩序，也直接影响着社会的稳定发展。

关键词：暴力伤医原因与规避医患医院

C_(2)H_(2)气体流量对WC-DLC涂层结构与性能的影响

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真空科学与技术学报 2024年第3期44卷 212-219页

作者：谢焕钧徐长云唐令韩明月罗阳李刘合中国航发中传机械有限公司长沙410200 北京航空航天大学机械工程及自动化学院北京100191

文章采用直流磁控溅射技术制备WC-DLC耐磨涂层,为了探究C_(2)H_(2)流量对WC-DLC涂层表截面形貌、微观结构、力学和摩擦学性能的影响,在10−50 mL/min C_(2)H_(2)流量下制备了WC-DLC涂层并进行表征分析。结果表明,随着C_(2)H_(2)流量的增... 详细信息

文章采用直流磁控溅射技术制备WC-DLC耐磨涂层,为了探究C_(2)H_(2)流量对WC-DLC涂层表截面形貌、微观结构、力学和摩擦学性能的影响,在10−50 mL/min C_(2)H_(2)流量下制备了WC-DLC涂层并进行表征分析。结果表明,随着C_(2)H_(2)流量的增加,涂层中碳含量增加,晶粒逐渐细化,由柱状晶逐渐转变为细晶粒,涂层变得更加致密;涂层纳米硬度与sp3杂化的C原子含量密切相关,随着涂层中sp3-C含量的增加,硬度先升高然后降低,磨损率也先升高降低;随着碳原子含量升高,涂层中出现大量的非晶碳,表面晶粒非晶化,涂层的摩擦系数逐渐减小且更加稳定。

关键词： WC-DLC 涂层 C_(2)H_(2) 流量纳米硬度结合力摩擦磨损

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井槽高效利用技术在渤海油田海上平台的应用

重庆科技学院学报（自然科学版） 2017年第3期19卷 12-18页

作者：韩耀图庞明越林家昱谢涛陈毅中海石油(中国)有限公司天津分公司天津300452 西南石油大学石油与天然气工程学院成都610500

随着海上油田开发的推进,如何高效利用海上平台井槽,对于解决预留井槽不足、产能下降问题意义重大。采用单筒双井技术能够高效利用海上平台井槽资源,但钻井大尺寸隔水导管的下入,给钻完井工程带来一定挑战。针对渤中34-1油田F平台前期... 详细信息

随着海上油田开发的推进,如何高效利用海上平台井槽,对于解决预留井槽不足、产能下降问题意义重大。采用单筒双井技术能够高效利用海上平台井槽资源,但钻井大尺寸隔水导管的下入,给钻完井工程带来一定挑战。针对渤中34-1油田F平台前期研究中井槽利用问题,通过对隔水导管下入尺寸与方式的研究,结合配套的钻井技术进行了方案优化。提出了特殊尺寸Φ838.2 mm+914.4 mm复合隔水导管钻井下入方案,经论证分析可知,该方案能够满足技术要求,并取得了较好的经济效益。

关键词：海上油田单筒双井大尺寸复合隔水导管

Leading manufacture of the large-scale weldless stainless steel forging ring:Innovative approach by the multilayer hot-compression bonding technology

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Journal of Materials Science & Technology 2021年第12期71卷 84-86页

作者： mingyue Sun Bin Xu Bijun xie Dianzhong Li Yiyi Li Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang110016China

Here,we report the leading manu facture of the large-scale integral weldless stainless steel forging ring(φ=15.6 m)by the multilayer additive hot-compression bonding ***,the detailed interface healing mecha nism involving interfacial oxide evolution is elucidated,which validates the feasibility and reliability of the technique we proposed.

关键词： The largest stainless steel forging ring Interface bonding Interfacial oxides Multilayer additive hot-compression bonding

UPLC-Q-TOF/MS-based metabolomics reveals modulatory effects of Mesona chinensis Benth polysaccharide in liver injury mice induced by cyclophosphamide

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Food Science and Human Wellness 2023年第2期12卷 584-595页

作者： Yuzhen Hong mingyue Shen Qiang Yu Yi Chen Jianhua xie State Key Laboratory of Food Science and Technology Nanchang UniversityNanchang 330047China

The main purpose of this study was to investigate the improvement effect of Mesona chinensis Benth polysaccharide(MP)on cyclophosphamide(CTX)induced liver injury in *** explore metabolic profile of liver tissue and feces among normal group,CTX-induced group and MP management group based on metabolomics method by using UPLC-Q-TOF/*** results showed that MP could alleviate liver injury and promote the production of short chain fatty acids(SCFAs),with the best dose of 200 mg/kg·body weight(bw).The principal component analysis(PCA)and orthogonal partial least squares discriminant analysis(OPLSDA)scores plots of the liver and feces samples showed a clear separation among normal,model and highdose of MP(MPH).There were 18 endogenous metabolites in liver and 29 endogenous metabolites in feces,which were mainly involved in 8 metabolic pathways:taurine and hypotaurine metabolism,phenylalanine metabolism,α-linolenic acid metabolism,tricarboxylic acid(TCA)cycle,phenylalanine,tyrosine and tryptophan biosynthesis,arachidonic acid metabolism,sphingolipid metabolism as well as tryptophan ***,a common metabolite arachidonic acid was observed in liver and feces *** endogenous metabolites may be considered to be MP’s response to liver *** will help to further understand the mechanism of MP and provide a basis for further research.

关键词： Metabolomics Polysaccharide Liver injury Cyclophosphamide

Apoptosis of colon cancer CT-26 cells induced polysaccharide from Cyclocarya paliurus and its phosphorylated derivative via intrinsic mitochondrial passway

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Food Science and Human Wellness 2023年第5期12卷 1545-1556页

作者： Liuming xie mingyue Shen Rong Huang Xuan Liu Yue Yu Hanyu Lu Jianhua xie State Key Laboratory of Food Science and Technology Nanchang UniversityNanchang 330047China

In this study,the antitumor properties and the possible molecular mechanisms of Cyclocarya paliurus polysaccharide(CP)and its phosphorylated derivative(P-CP)on CT-26 mouse colon carcinoma cells were *** found that CP had high inhibition ratio against CT-26 *** flow cytometry results found that CP treatment could cause the intracellular acidification,arrest the cell cycle in the S phase and increase reactive oxygen species ***,CP treatment triggered mitochondrial membrane potential depolarization and Ca^(2+)overloading,and broke down the balance of antioxidant system,Na^(+)/K^(+)-ATPase and Ca^(2+)-*** analysis found CP induced cell apoptosis through improving the activities of caspase-3 and caspase-9,and increasing the level of cytochrome ***,the comparative study of antitumor effect on CT-26 cells displayed that the phosphorylation enhanced antitumor activities of *** results suggest CP is a potential natural therapeutic agent for colon cancer and phosphorylation represents an effective method of enhancing the antitumor activity of CP.

关键词： Cyclocarya paliurus polysaccharide Phosphorylated Colorectal cancer Mitochondrial apoptosis pathway

Physicochemical, structural characterization, and antioxidant activities of chondroitin sulfate from Oreochromis niloticus bones

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Food Science and Human Wellness 2023年第4期12卷 1102-1108页

作者： Jun Yang mingyue Shen Ting Wu Xianxiang Chen Huiliang Wen Jianhua xie State Key Laboratory of Food Science and Technology Nanchang UniversityNanchang 330047China

In this study,chondroitin sulfate was extracted from Oreochromis niloticus bones(OCS)and isolated to three fractions(OCS-1,OCS-2,and OCS-3).The physicochemical properties and structure characterization including monosaccharide,disaccharide compositions,molecular weight(Mw)of OCS were determined by HPAEC,HPLC-SAX,HPGPC,FT-IR spectra,and 1D/2D ***,their thermal properties,crystalline structure,and microstructure were also *** showed that their Mw were between 10 kDa and 50 ***-6 was the predominant disaccharide unit in four OCS,and the CS-4/CS-6 ratios were close to CS from shark ***,the results of antioxidant activity showed that different fractions of OCS had a distinct DPPH radical,hydroxyl radical,and ABTS+radical scavenging ***-1 has the highest scavenging activities in DPPH and hydroxyl radical compared with other fractions,which showed a higher medicinal *** findings may lay some theoretical basis for the potential application development of OCS.

关键词： Oreochromis niloticus by-products Chondroitin sulfate Structural characterization Antioxidant

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数智时代科技成果供需对接机制

科技管理研究 2024年第7期44卷 87-95页

作者：谢科范尹明月刘然梁本部武汉理工大学管理学院湖北武汉430070 湖北技术交易所湖北武汉430072 武汉理工大学法学与人文社会学院湖北武汉430070

为探究我国数智时代科技成果供需对接影响因素和机制作用,梳理我国科技成果供需对接模式及演变历程,构建科技成果供需对接影响因素概念模型,运用扎根理论和文献分析方法归纳出供方、需方、平台、政策、资金和技术因素等影响因素,运用DEM... 详细信息

为探究我国数智时代科技成果供需对接影响因素和机制作用,梳理我国科技成果供需对接模式及演变历程,构建科技成果供需对接影响因素概念模型,运用扎根理论和文献分析方法归纳出供方、需方、平台、政策、资金和技术因素等影响因素,运用DEMATEL方法分析影响因素之间的影响度。基于分析结果,提出我国科技成果供需对接机制为从应需引供模式转变为掘需育供模式,从上下游关系转变为共同体关系,从局域平台转变为广域平台,从信息化转变为智慧化,从单点服务转变为全链条服务,从技术发展转变为多要素融合发展。

关键词：科技成果转化技术交易平台供需对接机制设计

基于因子分析和聚类分析的800例斑秃患儿中医证候研究

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中医杂志 2024年第4期65卷 388-394页

作者：谢颖王燕平庄明月杜美皎许泳龙杨玉媚杨顶权北京中医药大学北京市100029 中日友好医院

目的总结儿童斑秃的中医证候规律,为临床辨证论治提供依据。方法回顾性分析2012年1月1日至2021年12月31日中日友好医院毛发医学中心收治的800例斑秃患儿的临床资料。采用四诊信息调查表收集患儿的临床资料,包括:临床特征(就诊年龄、发... 详细信息

目的总结儿童斑秃的中医证候规律,为临床辨证论治提供依据。方法回顾性分析2012年1月1日至2021年12月31日中日友好医院毛发医学中心收治的800例斑秃患儿的临床资料。采用四诊信息调查表收集患儿的临床资料,包括:临床特征(就诊年龄、发病年龄、病程、家族史、严重程度分级),斑秃发病相关因素(诱因),四诊信息(包括睡眠、饮食、情绪、二便等)。对其进行描述性频数分析、秩和检验、因子分析和聚类分析,并结合临床资料归纳出主要的中医证候分布情况。结果800例斑秃患儿男449例,女351例;就诊时处于婴儿期8例(1.00%),幼儿期36例(4.50%),学龄前期180例(22.50%),学龄期380例(47.50%),青春期196例(24.50%);平均就诊年龄(8.31±3.86)岁,平均发病年龄(5.40±3.82)岁,平均病程(2.94±2.77)年;重度斑秃患儿527例(65.87%);85例(13.56%)患儿有脱发家族史;772例患儿(96.50%)首次脱发诱因不详,28例(3.50%)患儿表示存在明显诱因,包括惊吓(9例)、高热(5例)、过敏反应(4例)、微量元素(锌、铁等)缺乏(4例)、饮食不当(2例)、环境因素(1例,新房装修)、特应性皮炎(1例)、变异性哮喘(1例)和肺炎(1例)。四诊信息共40个,出现频率前10位的依次为踢被子(380例,47.50%)、挑食(369例,46.13%)、睡卧不宁(334例,41.75%)、易怒(334例,41.75%)、偏食(306例,38.25%)、脾气暴躁(297例,37.13%)、大便干(233例,29.13%)、小便黄(215例,26.88%)、咬指甲(213例,26.63%)、口臭(211例,26.38%)。根据因子分析和聚类分析得出5种中医证型,依次为气血亏虚证(110例,13.75%)、脾虚失荣证(114例,14.25%)、肾精不足证(140例,17.50%)、饮食积滞证(150例,18.75%)、肝郁脾虚证(286例,35.75%)。各年龄段和各SALT分级的患儿均以肝郁脾虚证为主。结论儿童斑秃中医证候以气血亏虚、脾虚失荣、肾精不足、饮食积滞、肝郁脾虚证为主,其中不同年龄及病情分级均以肝郁脾虚证为多见。

关键词：斑秃儿童中医证候肝郁脾虚因子分析聚类分析