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Regulation of surface carbides on palladium nanocubes with zeolitic imidazolate frameworks for propyne selective hydrogenation

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Nano Research 2021年第5期14卷 1559-1564页

作者： Linzhong Wu mingyu Chu Jin Gong Muhan Cao yu Liu Yong Xu Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials and DevicesSoochow UniversityNo.199 Ren’ai RoadSuzhou215123China Guangzhou Key Laboratory of Low-Dimensional Materials and Energy Storage Devices Collaborative Innovation Center of Advanced Energy MaterialsSchool of Materials and EnergyGuangdong University of TechnologyGuangzhou510006China

The selective hydrogenation of propyne to propylene has attracted great attention in chemical industry for removing trace amount of propyne for producing polymer-grade propylene. As the state-of-the-art catalyst, Pd suffers from the disadvantage of poor propylene selectivity due to the over-hydrogenation of propylene to propane. We here demonstrate that Pd nanocubes (NCs) coated by zeolitic imidazolate frameworks (i.e., Pd NCs@ZIF-8) can serve as highly active and selective catalysts for propyne selective hydrogenation (PSH). Benefitting from the unique properties and abundant groups of ZIF-8, Pd carbide (Pd-C) is formed on the surface of Pd NCs after thermal treatment, which acts the active sites for PSH to propylene. More importantly, the content of Pd-C can be precisely controlled by altering the calcination temperature without aggregation of Pd NCs and obvious changes in the framework of ZIF-8. The formation of Pd-C on Pd NCs@ZIF-8 can strongly suppress the H2 adsorption, and thus selectively catalyze propyne to propylene. Consequently, the optimized catalyst (i.e., Pd NCs@ZIF-8-100) exhibits a propylene selectivity of 96.4% at a propyne conversion of 93.3% at 35 °C and atmospheric pressure. This work may not only provide an efficient catalyst for PSH, but also shed a new light on the catalytic application of ZIFs.

关键词： propyne selective hydrogenation Pd nanocubes zeolitic imidazolate frameworks core-shell nanostructures Pd carbide

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High-member low-dimensional Sn-based perovskite solar cells

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Science China Chemistry 2023年第2期66卷 459-465页

作者： Hansheng Li Zihao Zang Qi Wei Xianyuan Jiang mingyu Ma Zengshan Xing Jingtian Wang Danni yu Fei Wang Wenjia Zhou Kam Sing Wong Philip C.Y.Chow yuanyuan Zhou Zhijun Ning School of Physical Science and Technology ShanghaiTech UniversityShanghai201210China Department of Physics Hong Kong University of Science and TechnologyHong Kong999077China Department of Mechanical Engineering The University of Hong KongHong Kong999077China Department of Physics Hong Kong Baptist UniversityHong Kong999077China

Sn-based perovskites are promising thin-film photovoltaic materials for their ideal bandgap and the eco-friendliness of Sn,but the performance of Sn-based perovskite solar cells is hindered by the short carrier diffusion length and large defect density in nominally-synthesized Sn-based perovskite *** we demonstrate that a long carrier diffusion length is achievable in quasi-2D Sn-based perovskite films consisting of high-member low-dimensional Ruddlesden-Popper(RP)phases with a preferred crystal orientation *** key to the film synthesis is the use of a molecular additive formed by phenylethylammonium cations and optimally mixed halide-pseudohalide anions,which favorably tailors the quasi-2D Sn-based perovskite crystallization *** high-member RP film structure effectively enhances device short-circuit current density,giving rise to an increased power conversion efficiency(PCE)of 14.6%.The resulting device demonstrates a near-unity shelf stability upon1,000 h in nitrogen.A high reproductivity is also achieved with a count of 50 devices showing PCEs within a narrow range from minimum 13.0%to maximum 14.6%.

关键词： Sn-based perovskite lead-free perovskite solar cells low-dimensional structure optoelectronics device

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Sarcopenic obesity in liver disease: Handling both sides of the penny

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Portal Hypertension & Cirrhosis 2022年第1期1卷 42-56页

作者： Yangyang Hui Binxin Cui Xiaoyu Wang mingyu Sun Yifan Li Wanting Yang Gaoyue Guo Lihong Mao Zihan yu Xiaofei Fan Chao Sun Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalTianjinChina Department of Gastroenterology Tianjin Medical University General Hospital Airport HospitalTianjinChina

Skeletal muscle and fat tissue show distinct pathophysiological roles and pivotal *** culmination of muscle wasting and fat accumulation represents an opposite terminal of each ***,this situation has been designated as sarcopenic ***,sarcopenic obesity still lacks a unanimous definition,diagnostic criteria,and generalized modalities for assessment in the context of versatile liver ***,the underpinning mechanisms by which a combination of abnormal skeletal muscle and fat tissue leads to the progression of liver disease and impairs health‐related consequences are still ***,the interplay between skeletal muscle and fat,and the driving factors that shift different body compositions are not well ***,in this review,we discuss skeletal muscle and fat components,with the purpose of conceptualization,as well as interpret their roles in liver *** focus on the definitions,diagnostic criteria,and currently available measurements for sarcopenic obesity in the *** comprehensively discuss recent data and evidence regarding the potential role of sarcopenic obesity in the development and progression of numerous liver diseases and associated conditions,including nonalcoholic fatty liver disease,chronic viral hepatitis,cirrhosis,and liver ***,explicit information related to the pathogenesis of sarcopenic obesity from basic research is also provided in this narrative ***,we discuss,from the clinical perspective of view,how to manage sarcopenic obesity using nutritional,physical,and pharmacological methods.

关键词： hepatocellular carcinoma liver cirrhosis NAFLD pathogenesis sarcopenic obesity

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骨科住院医师在运动医学专科轮转期间微创临床思维及内镜手术能力培训实践

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中国毕业后医学教育 2024年第1期8卷 41-44页

作者：杨明宇马林陈禹袁成松陶旭唐康来白智宏周兵华中国人民解放军陆军军医大学第一附属医院运动医学中心重庆400038 中国人民解放军陆军军医大学第一附属医院骨科重庆400038 西南大学教师教育学院重庆400715

随着全民健身运动的兴起,运动人群和运动类型快速增加导致运动损伤发病率增高及病种类型增多,运动医学这门新兴临床学科近年来也得到了快速发展,作为骨科住院医师规范化培训(简称住培)包含的一门亚专业,微创临床思维和内镜手术能力是运... 详细信息

随着全民健身运动的兴起,运动人群和运动类型快速增加导致运动损伤发病率增高及病种类型增多,运动医学这门新兴临床学科近年来也得到了快速发展,作为骨科住院医师规范化培训(简称住培)包含的一门亚专业,微创临床思维和内镜手术能力是运动医学临床诊疗的两大核心。骨科住院医师在运动医学专科轮转阶段,如何在指导医师指导下提高微创临床思维及内镜手术能力是本阶段培训的目的和难点。该文总结了骨科住院医师在运动医学专科轮转期间微创临床思维及内镜手术能力的培训实践。

关键词：骨科运动医学住院医师规范化培训培养模式

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Dissecting the Contributing Role of Divergent Adipose Tissue to Multidimensional Frailty in Cirrhosis

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Journal of Clinical and Translational Hepatology 2023年第1期11卷 58-66页

作者： Lihong Mao Chaoqun Li Xiaoyu Wang mingyu Sun Yifan Li Zihan yu Binxin Cui Gaoyue Guo Wanting Yang Yangyang Hui Xiaofei Fan Jie Zhang Kui Jiang Chao Sun Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalTianjinChina Tianjin Institute of Digestive Disease Tianjin Medical University General HospitalTianjinChina Department of Internal Medicine Tianjin Hexi HospitalTianjinChina Department of Gastroenterology Tianjin Medical University General Hospital Airport HospitalTianjinChina

Background and Aims:Emerging evidence has demonstrated that abnormal body composition may potentiate the development of frailty,whereas little work focuses on the role of divergent adipose ***,we aimed to determine the potential contribution of adipose tissue distribution to multidimensional frailty in decompensated ***:We conducted a retrospective cohort *** adipose tissues were assessed by computed tomography-derived subcutaneous adipose tissue index(SATI),visceral adipose tissue index(VATI)and total adipose tissue index(TATI),*** was identified by our validated self-reported Frailty *** binary logistic models incorporating different covariates were established to assess the relationship between adipose tissue distribution and ***:The study cohort comprised 245 cirrhotic patients with 45.3%being *** median Frailty Index,body mass index(BMI)and model for end-stage liver disease(MELD)score were 0.11,24.3 kg/m2 and 8.9 points,*** both men and women,patients who were frail exhibited lower levels of SATI in comparison with nonfrail *** inversely correlated with Frailty Index in the entire cohort(rs=−0.1361,p=0.0332).Furthermore,SATI or TATI was independently associated with frail phenotype in several multiple logistic regression models adjusting for age,BMI,presence of ascites,sodium,Child-Pugh class or MELD score in ***:In the context of decompensated cirrhosis,low SATI and concomitant TATI were associated with higher risk of being *** findings highlight the importance to further apply tissue-specific tools of body composition in place of crude metric like BMI.

关键词： Frailty Adipose tissue Liver cirrhosis Subcutaneous adipose tissue index

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Efficient scarless skin regeneration enabled by loading micronized amnion in a bioinspired adhesive wound dressing

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Aggregate 2023年第5期4卷 96-111页

作者： Huicong Zhang mingyu Song Changhong Hu Zhiyi Zhang Shuqi Zhang Yan Zhang Yingming Yang Puxu Zhou Liwen Zheng Lan Li Mengjie Mao yu Shrike Zhang Ping Ji Ximu Zhang Chongqing Key Laboratory of Oral Disease and Biomedical Sciences and Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education and Stomatological Hospital of Chongqing Medical University ChongqingChina Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolCambridgeMassachusettsUSA Department of Preventive Dentistry State Key Laboratory of Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengduChina School of Stomatology Zunyi Medical UniversityZunyiChina

Complete skin reconstruction is a hierarchical,physiological assembly process involving healing of the epidermis,dermis,vasculature,nerves,and cutaneous *** date,few works have reported complete skin regeneration,particularly lacking vascular structures and hair follicles after full skin *** this study,a hydrogel derived from the skin secretion of Andrias davidianus(SSAD)that features adhesiveness was used as a bioactive scaffold to load micronized amnion(MA).The SSAD hydrogel was found to promote the migration and proliferation of amnion stem cells and human keratinocytes,as well as inhibit their apoptosis in *** a rat full-skin defect model,the regeneration of skin appendages was observed at the wound area,achieving scarless *** analyses further validated that SSAD could positively regulate cell migration,proliferation,and *** functions might be attributed to the abundant growth factors present in the *** by the delivery of MA,SSAD loaded with the MA could achieve a significantly better skin regeneration effect than SSAD or MA used alone,providing a simple yet highly effective means to obtain complete,scarless skin regeneration,suggesting favorable potential for clinical translation.

关键词： amnion Andrias davidianus cell delivery cutaneous appendages scarless wound dressing

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电针夹脊穴后不同时间点对坐骨神经慢性压迫性损伤大鼠P2X4、P2X7蛋白表达的影响

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康复学报 2018年第1期28卷 37-40页

作者：陈慧娥黄明愉余文英林栋林丽莉福建中医药大学针灸学院福建福州350122

目的:观察电针(EA)夹脊穴后不同时间点对坐骨神经慢性压迫性损伤(CCI)模型大鼠P2X4、P2X7蛋白表达的影响,探讨电针镇痛在神经病理性疼痛中的后效应特点。方法:将成年雄性SD大鼠进行热痛阈筛选并选取24只,采用随机数字表法分为空白组、... 详细信息

目的:观察电针(EA)夹脊穴后不同时间点对坐骨神经慢性压迫性损伤(CCI)模型大鼠P2X4、P2X7蛋白表达的影响,探讨电针镇痛在神经病理性疼痛中的后效应特点。方法:将成年雄性SD大鼠进行热痛阈筛选并选取24只,采用随机数字表法分为空白组、模型组、电针后1 h组、电针后12 h组,每组各6只。模型组及电针后1 h、12 h组建立CCI模型,电针后1 h、12 h组于造模后第7天电针双侧L3~5夹脊穴20 min各1次。各组于造模后第7天、取材前进行热痛阈测定,采用Western Blot检测大鼠脊髓腰膨大P2X4、P2X7蛋白相对表达水平。结果:造模后,电针后1 h、12 h组和模型组比空白组的热痛阈明显下降(P0.05);Western Blot结果显示,模型组较空白组P2X4、P2X7蛋白相对表达升高(P0.05)。结论:电针可能通过下调P2X4、P2X7表达来提高CCI大鼠的热痛阈,具有一定的后效应特点,其后效应可延续至1 h或1 h以上。

关键词：慢性压迫性损伤神经病理性疼痛电针 P2X 后效应

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Autotrophic potential in mesophilic heterotrophic bacterial isolates from Sino-Pacific marine sediments

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Acta Oceanologica Sinica 2017年第2期36卷 69-77页

作者： CAO Wenrui DAS Anindita SAREN Gaowa JIANG mingyu ZHANG Hongjie yu Xinke Key laboratory of Marine Geology and Environment (MAGE) Institute of Oceanology Chinese Academy of Sciences (IO-CAS) Qingdao 266071 China Institute of Biophysics Chinese Academy of Sciences (IBP-CAS) Beijing 100101 China Council of Scientific and Industrial Research (CSIR) National Institute of Oceanography Dona Paula Panaji 403004 India Maharashtra Association for the Cultivation of Science (MACS) Agharkar Research Institute Pune 411004 India

Microbial carbon fixation is a paramount process in the ocean especially below the photic zone both in water and sedimentary ecosystems. Autotrophic microbes that fix carbon dioxide are renowned. However, the question whether heterotrophs can also fix carbon is intriguing. Ten heterotrophically grown, identified bacterial isolates from the Sino-Pacific marine sediments were tested for autotrophic uptake potential with and without addition of electron donors. Nine of the ten isolates showed carbon uptake capacity without addition of any substrate at very low rates in the order of 10^（-8） to 10^（-4） fmol/（cell·h）. The addition of manganese and ammonium at 1 mmol/L final concentration enhanced the uptake potential. Addition of 1 mmol/L final concentrations of reduced iron（10^（-6） to10^（-5） fmol/（cell·h） and sulfide（10^（-5） fmol/（cell·h） decreased the uptake potential significantly at p〈0.1. Bacterial tolerance to formaldehyde suggested propensities of anaplerotic chemical reactions that form metabolic intermediates of C-1 metabolism pathways. The isolates displayed high metabolic flexibility. With the changes in electron donors, the isolates metabolically toggled between relatively anoxic reductive iron/sulfur cycles and the oxidative cycles of manganese/ammonium and vice-versa. This property makes these microbes successful survivors in the highly dynamic Sino-Pacific sediments.

关键词： autotrophy bacteria mesophiles heterotrophs Sino-Pacific

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Synthesis of selective PAK4 inhibitors for lung metastasis of lung cancer and melanoma cells

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Acta Pharmaceutica Sinica B 2022年第6期12卷 2905-2922页

作者： Peilu Song Fan Zhao Dahong Li Jiqiang Qu Miao Yao yuan Su Hanxun Wang Miaomiao Zhou yujie Wang Yinli Gao Feng Li Dongmei Zhao Fengjiao Zhang yu Rao mingyu Xia Haitao Li Jian Wang Maosheng Cheng Key Laboratory of Structure-Based Drug Design&Discovery of Ministry of Education Shenyang Pharmaceutical UniversityShenyang 110016China MOE Key Laboratory of Protein Sciences School of Pharmaceutical SciencesMOE Key Laboratory of Bioorganic Phosphorus Chemistry Chemical BiologyTsinghua UniversityBeijing 100084China MOE Key Laboratory of Protein Sciences Beijing Advanced Innovation Center for Structural BiologyTsinghua-Peking Joint Center for Life SciencesSchool of Life Sciences and School of MedicineTsinghua UniversityBeijing 100084China School of Traditional Chinese Materia Medica Shenyang Pharmaceutical UniversityShenyang 110016China School of Life Science and Biopharmaceutics Shenyang Pharmaceutical UniversityShengyang 110016China Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China Department of Cell Biology Key Laboratory of Cell BiologyMinistry of Public Healthand Key Laboratory of Medical Cell BiologyMinistry of EducationChina Medical UniversityShenyang 110001China

The p21 activated kinase 4(PAK4) is serine/threonine protein kinase that is critical for cancer *** by X-ray crystallography and structure-based optimization,we report a novel subseries of C-3-substituted 6-ethynyl-1 H-indole derivatives that display high potential and specificity towards group Ⅱ *** these inhibitors,compound 55 exhibited excellent inhibitory activity and kinase selectivity,displayed superior anti-migratory and anti-invasive properties against the lung cancer cell line A549 and the melanoma cell line *** 55 exhibited potent in vivo antitumor metastatic efficacy,with over 80% and 90% inhibition of lung metastasis in A549 or B16-BL6 lung metastasis models,*** mechanistic studies demonstrated that compound 55 mitigated TGF-β1-induced epithelial-mesenchymal transition(EMT).

关键词： Anti-cancer PAK4 inhibitor Kinase selectivity Cocrystallization Lung metastasis EMT

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响应面法优化无麸质面条复合改良剂

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河北工业科技 2014年第4期31卷 306-310页

作者：陈辉刘心洁胡朝辉于明玉李雪梅河北科技大学生物科学与工程学院河北石家庄050018 邯郸市疾病预防控制中心河北邯郸056000

选取水溶性胶体结冷胶、可得然胶及黄原胶为自变量,无麸质面条的咀嚼性为响应值,采用Box-Behnken设计的方法,研究各自变量及其交互作用对无麸质面条的咀嚼性的影响,以增加无麸质食品的种类并对无麸质面条的加工起到一定的指导作用。确... 详细信息

选取水溶性胶体结冷胶、可得然胶及黄原胶为自变量,无麸质面条的咀嚼性为响应值,采用Box-Behnken设计的方法,研究各自变量及其交互作用对无麸质面条的咀嚼性的影响,以增加无麸质食品的种类并对无麸质面条的加工起到一定的指导作用。确定无麸质面条复合改良剂的最佳添加量(每100g原料面粉干基总质量中的所含质量):结冷胶0.1g,可得然胶0.1g,黄原胶0.21g,在此条件下,面条咀嚼性为134.21mJ。

关键词：结冷胶可得然胶黄原胶无麸质面条响应面

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