Sarcopenic obesity in liver disease: Handling both sides of the penny
Sarcopenic obesity in liver disease: Handling both sides of the penny作者机构：Department of Gastroenterology and HepatologyTianjin Medical University General HospitalTianjinChina Department of GastroenterologyTianjin Medical University General Hospital Airport HospitalTianjinChina
出 版 物：《Portal Hypertension & Cirrhosis》 (门静脉高压与肝硬化（英文）)
年 卷 期：2022年第1卷第1期
页 面：42-56页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：hepatocellular carcinoma liver cirrhosis NAFLD pathogenesis sarcopenic obesity
摘 要：Skeletal muscle and fat tissue show distinct pathophysiological roles and pivotal *** culmination of muscle wasting and fat accumulation represents an opposite terminal of each ***,this situation has been designated as sarcopenic ***,sarcopenic obesity still lacks a unanimous definition,diagnostic criteria,and generalized modalities for assessment in the context of versatile liver ***,the underpinning mechanisms by which a combination of abnormal skeletal muscle and fat tissue leads to the progression of liver disease and impairs health‐related consequences are still ***,the interplay between skeletal muscle and fat,and the driving factors that shift different body compositions are not well ***,in this review,we discuss skeletal muscle and fat components,with the purpose of conceptualization,as well as interpret their roles in liver *** focus on the definitions,diagnostic criteria,and currently available measurements for sarcopenic obesity in the *** comprehensively discuss recent data and evidence regarding the potential role of sarcopenic obesity in the development and progression of numerous liver diseases and associated conditions,including nonalcoholic fatty liver disease,chronic viral hepatitis,cirrhosis,and liver ***,explicit information related to the pathogenesis of sarcopenic obesity from basic research is also provided in this narrative ***,we discuss,from the clinical perspective of view,how to manage sarcopenic obesity using nutritional,physical,and pharmacological methods.
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