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LncRNAs are involved in regulating ageing and age-related disease through the adenosine monophosphate-activated protein kinase signalling pathway

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Genes & Diseases 2024年第5期11卷 183-197页

作者： Jiamei Li Feng Xiao Siqi Wang Xiaolan Fan Zhi He Taiming Yan Jia Zhang mingyao yang Deying yang College of Animal Science and Technology Sichuan Agricultural UniversityChengduSichuan 611130China Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province Sichuan Agricultural UniversityChengduSichuan 611130China Chengdu Women’s and Children’s Central Hospital School of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan 610017China

A long noncoding RNA(lncRNA)is longer than 200 *** regulates various biological processes mainly by interacting with DNA,RNA,or protein in multiple kinds of biological *** monophosphate-activated protein kinase(AMPK)is activated during nutrient starvation,especially glucose starvation and oxygen deficiency(hypoxia),and exposure to toxins that inhibit mitochondrial respiratory chain complex *** is an energy switch in organisms that controls cell growth and multiple cellular processes,including lipid and glucose metabolism,thereby maintaining intracellular energy homeostasis by activating catabolism and inhibiting *** AMPK signalling pathway consists of AMPK and its upstream and downstream *** upstream targets include proteins such as the transforming growth factor b-activated kinase 1(TAK1),liver kinase B1(LKB1),and calcium/calmodulindependent protein kinase b(CaMKKb),and its downstream targets include proteins such as the mechanistic/mammalian target of rapamycin(mTOR)complex 1(mTORC1),hepatocyte nuclear factor 4a(HNF4a),and silencing information regulatory 1(SIRT1).In general,proteins function relatively independently and *** this article,a review of the currently known lncRNAs involved in the AMPK signalling pathway is presented and insights into the regulatory mechanisms involved in human ageing and age-related diseases are provided.

关键词： Age-related diseases Ageing AMPK signalling pathway Long noncoding RNA microRNA

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富里酸对聚乙烯微塑料污染土壤水分入渗过程的影响

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农业环境科学学报 2024年第5期43卷 1092-1099页

作者：杨明瑶吉恒莹李磐新疆师范大学化学化工学院乌鲁木齐830054 农业农村部西北绿洲农业环境重点实验室乌鲁木齐830091 新疆农业科学院土壤肥料与农业节水研究所乌鲁木齐830091

为研究富里酸对聚乙烯污染土壤水分入渗过程的影响,本研究通过土柱一维垂直入渗试验,分别在含有质量比为0.1%、1%和3%荧光染色聚乙烯污染的土壤中添加0.3%的富里酸进行探究。结果表明:与空白土壤相比,0.1%、1%聚乙烯均减少土壤表面孔状... 详细信息

为研究富里酸对聚乙烯污染土壤水分入渗过程的影响,本研究通过土柱一维垂直入渗试验,分别在含有质量比为0.1%、1%和3%荧光染色聚乙烯污染的土壤中添加0.3%的富里酸进行探究。结果表明:与空白土壤相比,0.1%、1%聚乙烯均减少土壤表面孔状结构和粗糙度,抑制土壤水分入渗速率,减小土壤饱和导水率,3%聚乙烯增加土壤表面孔状结构和粗糙度,降低入渗速率和饱和导水率;施加0.3%富里酸后,0.1%、1%和3%聚乙烯污染土壤表面孔状结构增多,粗糙度增大,水分入渗速率降低,饱和导水率随聚乙烯含量增大而增大,但较不施加富里酸前的饱和导水率分别下降48.75%、32.01%和3.64%;添加0.3%富里酸,可使聚乙烯微塑料在土壤中垂直向下的迁移速度分别提高33.33%、37.50%和38.33%。研究表明,富里酸增加了聚乙烯污染土壤的孔状结构和粗糙度,降低了聚乙烯污染土壤的水分入渗速率和饱和导水率,同时提高了聚乙烯在土壤中垂直向下的迁移速度。

关键词：富里酸微塑料聚乙烯土柱迁移

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Continuous-Time Channel Prediction Based on Tensor Neural Ordinary Differential Equation

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China Communications 2024年第1期21卷 163-174页

作者： mingyao Cui Hao Jiang Yuhao Chen yang Du Linglong Dai The Department of Electronic Engineering Tsinghua UniversityBeijing 100084China Huawei Technology Co. Ltd.Chengdu Research InstituteChengdu 611730China

Channel prediction is critical to address the channel aging issue in mobile *** channel prediction techniques are mainly designed for discrete channel prediction,which can only predict the future channel in a fixed time slot per frame,while the other intra-frame channels are usually recovered by ***,these approaches suffer from a serious interpolation loss,especially for mobile millimeter-wave *** solve this challenging problem,we propose a tensor neural ordinary differential equation(TN-ODE)based continuous-time channel prediction scheme to realize the direct prediction of intra-frame ***,inspired by the recently developed continuous mapping model named neural ODE in the field of machine learning,we first utilize the neural ODE model to predict future continuous-time *** improve the channel prediction accuracy and reduce computational complexity,we then propose the TN-ODE scheme to learn the structural characteristics of the high-dimensional channel by low-dimensional learnable *** results show that the proposed scheme is able to achieve higher intra-frame channel prediction accuracy than existing schemes.

关键词： channel prediction massive multipleinput-multiple-output millimeter-wave communications ordinary differential equation

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一种卧床患者靠枕的设计与应用

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中国中西医结合急救杂志 2024年第3期31卷 364-366页

作者：金惠林沈倍任杨铭窈潘薇贺达海翟振威桐乡市中医医院老年医学科浙江桐乡314500 嘉兴市王店人民医院老年医学科浙江嘉兴314011

卧床患者多采用后背垫物体、抬高床头位置等方法来获取半卧位姿势。但现有方法存在执行力不足、角度估计错误、意识不强、遗忘、舒适度下降、易引起压疮和吸入性肺炎等缺点。为了解决现有卧床患者进食体位摆放方法的不足之处,桐乡市中... 详细信息

卧床患者多采用后背垫物体、抬高床头位置等方法来获取半卧位姿势。但现有方法存在执行力不足、角度估计错误、意识不强、遗忘、舒适度下降、易引起压疮和吸入性肺炎等缺点。为了解决现有卧床患者进食体位摆放方法的不足之处,桐乡市中医医院老年医学科团队特设计了一种卧床患者靠枕,用于卧床患者进食时或其他要求半卧位时使用,并获得了国家实用新型专利(专利号:ZL 202122859891.4)。使用时将该装置靠枕放在平坦的床上,靠枕背面紧靠床头用于支撑,防止滑动。患者放于靠置槽内,头部置于第1靠置槽内,肩背部置于第2靠置槽内,腰腹部置于第3靠置槽内,双手放置在靠枕两侧的扶手位置。卧床患者靠枕使用方法简单易学、方便、经济实用、省时省力,而且方便监督检查,能减少误吸、压疮等并发症的发生,进而减轻患方经济负担,改善生活质量,提高患者和家属的满意度,值得在临床推广使用。

关键词：卧床患者靠枕误吸

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Structural insight into the dual-antagonistic mechanism of AB928 on adenosine A_(2)receptors

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Science China(Life Sciences) 2024年第5期67卷 986-995页

作者： Yuan Weng Xinyu yang Qiansen Zhang Ying Chen Yueming Xu Chenyu Zhu Qiong Xie Yonghui Wang Huaiyu yang mingyao Liu Weiqiang Lu Gaojie Song Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghai 200241China Department of Medicinal Chemistry School of PharmacyFudan UniversityShanghai 201203China

The adenosine subfamily G protein-coupled receptors A_(2A)R and A_(2B)R have been identified as promising cancer immunotherapy *** of the A_(2A)R/A_(2B)R dual antagonists,AB928,has progressed to a phaseⅡclinical trial to treat rectal ***,the precise mechanism underlying its dual-antagonistic properties remains ***,we report crystal structures of the A_(2A)R complexed with AB928 and a selective A_(2A)R antagonist *** structures revealed a common binding mode on A_(2A)R,wherein the ligands established extensive interactions with residues from the orthosteric and secondary *** contrast,the cAMP assay and A_(2A)R and A_(2B)R molecular dynamics simulations indicated that the ligands adopted distinct binding modes on A_(2B)*** analysis of their chemical structures suggested that AB928 readily adapted to the A_(2B)R pocket,while 2-118 did not due to intrinsic *** disparity potentially accounted for the difference in inhibitory efficacy between A_(2B)R and A_(2A)*** study serves as a valuable structural template for the future development of selective or dual inhibitors targeting A_(2A)R/A_(2B)R for cancer therapy.

关键词： adenosine receptor A2AR A2BR inhibitor dual-antagonism drug discovery

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Overexpression of human Achaete-Scute homologs in Drosophila

Overexpression of human Achaete-Scute homologs in Drosophila

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第二届全国发育生物学大会

作者： Boyuan Sun Qing Liang mingyao yang Institute of Animal Genetics and Breeding Sichuan Agricultural University

Even when humans lose most of their hair,some bristles such as axillary hair,pubic hair and beard areas *** is unclear which selector genes target the sites for hair *** the genetic changes in human are unknown,we do know that Drosophila uses a single genetic locus-the Achaete-Scute Complex to demarcate the territories where bristles can form throughout the *** is presumed that a comparable center exists in the human *** using bioinformatics searches,we find that there are five isoforms of Drosophila Achaete-Scute homologs in *** the phylogenetic tree,we recognize that hASH1 and hASH2 come from the same ancestor,while hASH3-5 originate from another *** test which isoform is possibly responsible for hair growth,we cloned the human Achaete-Scute homologs(hASH1)and hASH4 into *** vector and made transgenic flies containing hASH1 and hASH4 *** crossing the pnr-Gal4 driver-which gives an expression pattern in notum-to transgenic flies,we find that GFP staining in both lines show the expected expression pattern in the lower part of the wing disc identical to expression of gene *** adults,we find that overexpression of hASHl induce additional macrochaetes on the fly notum,which is similar to the patterns when overexpression Drosophila scute ***,overexpression of hASH4 did not produce extra macrochaetes on the notum of *** comparing protein structures,we identify both human Achaete-Scute homologs have the basic helix-loop-helix(bHLH)domains but hASH4 has a shorter sequence in c-terminal motif,implying hASH4 loses of proneural function due to lack of c-terminal *** results suggest that,due to duplication of this proneural gene,the isoform of hASHl keeps the function in hair(bristle)*** isoform of hASH4 has evolved to divergent function,which is no long essential for hair(bristle)growth and mainly contributes to regulation of skin development.

关键词： Achaete-Scute homologs Drosophila bristle pattern overexpression

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Global supply chain resilience:Facts,rationales and responses

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Economic and Political Studies 2024年第3期12卷 345-361页

作者： Zhiyuan Li mingyao Xu School of Economics Fudan UniversityShanghaiChina

Increasing uncertainties in international trade policies have raised concerns about the possible break of global supply *** paper reviews relevant studies shedding light on global supply chain *** first summarise some key facts and current developments of *** then review mechanisms through which shocks are transmitted along the global supply ***,we discuss the production relocation or sale adjustment of firms in response to shocks for maintaining supply chain resilience,from which we obtain some hints on how the resilience can be *** also highlight some implications and directions for future research.

关键词： Global supply chain globalisation resilience

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Foreign Ownership and International Trade Performance in China

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China & World Economy 2024年第2期32卷 42-72页

作者： Zhiyuan Li Yichun Lin mingyao Xu School of Economics Fudan University Shanghai Institute of International Finance and Economics China School of Economics Fudan UniversityChina

We investigate the causal relationship between foreign ownership and international trade performance by comparing foreign-acquired firms with similar domestic-acquired firms in China with regard to changes in their post-acquisition international trade *** findings indicate that foreign ownership significantly enhanced the probability of both exporting and importing,and strongly increased trade *** ownership took effect from the year of the acquisition and persisted for at least 2 *** stimulated both processing trade and ordinary trade,and expanded products and trading ***-acquisition trade performance also exhibited heterogeneity based on the different pre-acquisition and post-acquisition *** for the underlying mechanisms,we show that firms experienced significant output expansion,increased export dependence,and eased financial constraints after foreign acquisition.

关键词： domestic acquisition foreign acquisition foreign ownership international trade performance

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Targeting complement hyperactivation:a novel therapeutic approach for severe pneumonia induced by influenza virus/staphylococcus aureus coinfection

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Signal Transduction and Targeted Therapy 2024年第1期9卷 51-54页

作者： Leili Jia Haihua Luo Lizhong Li mingyao Wang Jiangfeng Liu Yuan Liang Shan Li Yong Jiang Juntao yang Hongbin Song Institute for Disease Control and Prevention of PLA BeijingChina Guangdong Provincial Key Laboratory of Proteomics State Key Laboratory of Organ Failure ResearchSchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China State Key Laboratory of Common Mechanism Research for Major Diseases Institute of Basic Medical SciencesChinese Academy of Medical Science and Peking Union Medical College100005 BeijingChina

Dear Editor,Infections by the influenza virus are a significant and widespread global health threat,as these infections have an annual death toll ranging from 290,000 to 650,000.1 A significant proportion of these fatalities are attributed to secondary bacterial pneumonia,a severe complication commonly caused by ubiquitous respiratory pathogens such as Staphylococcus aureus(***).2 Of particular concern is the increased morbidity and mortality rates in individuals infected simultaneously with influenza virus and methicillin-resistant ***(MRSA).3 The concurrent presence of bacteria and influenza virus usually causes acute respiratory distress syndrome(ARDS),which is associated with acute lung injury(ALI),severe lung tissue edema,and widespread ***,determining the complex mechanisms underlying the synergistic interplay will require further investigation with a suitable coinfection mouse *** our previous study,we utilized different sequential coinfections at various time points to model influenza A virus and MRSA coinfection.

关键词： influenza pneumonia lung

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Investigating the reactivation of historical landslides during the 2022 Luding M_(S)6.8 earthquake

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Earthquake Science 2024年第3期37卷 200-209页

作者： Tao Wei mingyao Xia Xinxin Zhang Shaojian Qi State Key Laboratory of Geohazard Prevention and Geo-environment Protection Chengdu University of TechnologyChengdu610059China

On September 5,2022,a strong earthquake with a magnitude of MS6.8 struck Luding County in Sichuan Province,China,triggering thousands of landslides along the Dadu River in the northwest-southeast(NW-SE)*** investigated the reactivation characteristics of historical landslides within the epicentral area of the Luding earthquake to identify the initiation mechanism of earthquake-induced *** of the two newly triggered and historical landslides were analyzed using manual and threshold methods;the spatial distribution of landslides was assessed in relation to topographical and geological factors using remote sensing *** study sheds light on the spatial distribution patterns of landslides,especially those that occur above historical landslide *** results revealed a similarity in the spatial distribution trends between historical landslides and new ones induced by *** landslides tend to be concentrated within a range of 0.2 km from the river and 2 km from the ***,both rivers and faults predominantly influenced the reactivation of historical ***,the reactivated landslides are characterized by their small to medium size and are predominantly situated in historical landslide *** number of reactivated landslides surpassed that of previously documented historical landslides within the study *** provide insights into the critical factors responsible for historical landslides during the 2022 Luding earthquake,thereby enhancing our understanding of the potential implications for future co-seismic hazard assessments and mitigation strategies.

关键词： Luding earthquake co-seismic landslides historical landslides spatial distribution landslide reactivation

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