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Risk factors for very low-level viremia in patients with chronic hepatitis B virus infection: A single-center retrospective study

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Liver Research 2022年第1期6卷 39-44页

作者： Jiahui Lu Congnan Zhang Pengyuan He Mengdang Ou Jinyu Xia mingxing huang Department of Infectious Disease The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhaiGuangdongChina

Background and aim:Several effective antiviral drugs are now available;however,the risk of liver-related complications is still ***-level viremia(LLV),defined as a hepatitis B virus(HBV)deoxy-ribonucleic acid(DNA)load lower than 2000 IU/mL,is one of the major factors responsible for these *** has been reported that 22.7e43.1%of patients with HBV experience ***,we aimed to explore the risk factors for very LLV(VLLV)during antiviral ***:We collected data of patients with chronic hepatitis B(CHB)who received nucleos(t)ide analog treatment from October 2016 to April *** was defined as an HBV DNA load of 9e20 IU/mL.A total of 139 patients with LLV were matched with 139 patients with a sustained virological response at a 1:1 ratio according to age and ***:Seropositivity rates for hepatitis B e antigen(HBeAg)(45.3%vs.17.3%,P0.050).HBeAg seropositivity(aOR,5.08;95% CI:2.15±12.02;P<0.001 ***,2.78;95% CI:1.16±7.00;P=0.022)and HBsAg levels(aOR,2.75;95% CI:1.41e5.37;P=0.003 ***,2.10;95% CI:1.27±3.46;P=0.004)significantly increased the risk of VLLV,irrespective of the age *** HBsAg(area under the receiver operating characteristic curve(AUC),0.681;95% CI:0.623±0.736;P<0.001)and HBeAg(AUC,0.640;95

关键词： Hepatitis B virus(HBV) Chronic hepatitis B(CHB) Very low-level viremia(VLLV) Risk factors

Prevalence, diagnosis, treatment, and associated factors of hepatitis C in the United States from 1999 to 2018: A population-based cross- sectional study

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Liver Research 2022年第4期6卷 284-288页

作者： Congnan Zhang Jiahui Lu Yajing Zhang Pengyuan He Jinyu Xia mingxing huang Department of Infectious Diseases The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhaiGuangdongChina Intensive Care Unit Jiangmen Central HospitalJiangmenGuangdongChina Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityGuangzhouGuangdongChina Office of the Dean The Third People's Hospital of ZhuhaiZhuhaiGuangdongChina

Background and aim:Hepatitis C virus(HCV)infection is one of the major global health challenges,leading to a significant increase in rates of hepatic fibrosis,cirrhosis and hepatocellular carcinoma.A comprehensive nationwide survey of trends in prevalence and associated factors could facilitate pre-ventive behavioral ***,we sought to determine prevalence,diagnosis,treatment,and risk factors for HCV infection in the general United States(US)***:This was a secondary analysis of the publicly available data from the US National Health and Nutrition Examination Survey(NHANES).The prevalence of HCV-RNA-positive(HCV-RNAþ)was weighted using patient serum sample data collected from 1999 to 2018.A propensity score matching model was used due to the imbalance in the number of HCV-RNAþand HCV-RNA-negative(HCV-RNA?)*** variables included gender,age,educational level,marital status,language,household size,alcohol consumption,smoking,number of family members and family income to poverty ***:The weighted prevalence of HCV-RNAþwas 1.11%(95%confidence interval(CI):1.02e1.20),1.58%(95%CI:1.42e1.74)for men and 0.67%(95%CI:0.57e0.77)for women aged 20 years or older in the US from 1999 to *** weighted prevalence of HCV-RNAþincreased from 0.87%(95%CI:0.62e1.12)in 2013e2014,0.95%(95%CI:0.68e1.22)in 2015e2016 to 1.00%(95%CI:0.72e1.28)in 2017e2018,*** propensity-matched analysis,patients with HCV-RNAþwere more likely to be non-Hispanic black,and have had drug use and blood ***,the weighted diagnostic and treatment rates were 56.27%(95%CI:50.90e61.64)and 35.40%(95%CI:27.64e43.16)from 1999 to 2018,***:Active HCV infection rate increased between 2013 and 2018,varied by demographic and risk *** the direct-acting antiviral era,affordable treatment and universal screening have the potential to improve overall national health.

关键词： Hepatitis C virus(HCV) Epidemiology Risk factors United States HCV-RNA

Effects of intestine-specific deletion of fibroblast growth factor 15 on alcoholic liver disease development in mice

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Liver Research 2022年第2期6卷 84-92页

作者： Bo Kong mingxing huang Rulaiha E.Taylor Daniel Rizzolo Katherine D.Otersen Grace L.Guo Department of Pharmacology and Toxicology Ernest Mario School of PharmacyRutgersThe State University of New JerseyPiscatawayNJUSA Department of Infectious Diseases The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhaiGuangdongChina Environmental and Occupational Health Sciences Institute RutgersThe State University of New JerseyPiscatawayNJUSA Rutgers Center for Lipid Research RutgersThe State University of New JerseyPiscatawayNJUSA VA New Jersey Health Care System Veterans Administration Medical CenterEast OrangeNJUSA

Background and aims:Alcoholic liver disease(ALD)is an important and growing cause for the development of chronic liver diseases in the *** acid(BA)levels are increased in patients with ALD anddysregulation of BA homeostasis worsens *** synthesis is critically regulated by fibroblast growthfactor(FGF)15 in mice and FGF19 in ***15/19 are mainly produced in the ileum and their mainfunction is to suppress BA synthesis in the liver through the activation of fibroblast growth factor receptor 4(FGFR4)on *** effects of intestine-specific Fgf15 deficiency on the development ofALD were determined in the current ***:Enterocyte-specific Fgf15 knockout mice(Fgf15intint^(-/-))and the established mouse model bychronic and binge ethanol feeding(NIAAA model)were adapted in this ***:The Fgf15intint^(-/-)mice had increased BA pool size,consistent with negative effects of FGF15-FGFR4signaling on BA *** were not obviously physical and hepatic histological abnormalitiespresented in Fgf15intint^(-/-)mice compared to wild-type *** alcohol treatment,the Fgf15intint^(-/-)mice exhibited a higher degree of liver injury,increased hepatic expression of Cd14,a receptor forlipopolysaccharide expressed in the liver,and increased hepatic lipid *** did not observe alterations in the levels of fibrosis in the liver or expression of genes involved in hepatic fibrosis,regardless ofgenotypes or following the alcohol ***:FGF15 may prevent hepatic steatosis in the development of ALD in mice,and maintainingFGF19/FGFR4 signaling may be critical in the prevention and/or treatment of ALD in humans in thefuture.

关键词： Fibroblast growth factor 15(FGF15) Farnesoid X receptor(FXR) Bile acid(BA) Alcoholic fatty liver disease Alcoholic steatohepatitis

Thermal Stability and Decomposition Kinetics of Polysuccinimide

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American Journal of Analytical Chemistry 2013年第12期4卷 749-755页

作者： Li Zhang mingxing huang Cairong Zhou School of Chemical Engineering and Energy Zhengzhou University Zhengzhou China

The thermal stability and decomposition kinetics of polysuccinimide (PSI) were investigated using analyzer DTG-60 under high purity nitrogen atmosphere at different heating rates (3, 6, 9, 12 K/min). The thermal decomposition mechanism of PSI was determined by Coats-Redfern method. The kinetic parameters such as activation energy (E), pre-exponential factor (A) and reaction order (n) were calculated by Flynn-Wall-Ozawa and Kissinger methods. The results show that the thermal decomposition of PSI under nitrogen atmosphere mainly occurs in the temperature range of 619.15-693.15 K, the reaction order (n) was , the activation energy (E) and pre-exponential factor (A) were obtained to be 106.585 kJ/mol and 4.644 × 109 min-1, the integral and differential forms of the thermal decomposition mechanism of PSI were found to be and , respectively. The results play an important role in understanding the thermodynamic properties of polysuccinimide.

关键词： Polysuccinimide Thermal Gravimetric Analysis Thermal Stability Decomposition Kinetics

The provincial pattern of the relationship between urbanization and economic development in China

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Journal of Geographical Sciences 2014年第1期24卷 33-45页

作者： CHEN mingxing huang Yongbin TANG Zhipeng LU Dadao LIU Hui MA Li Key Laboratory of Regional Sustainable Development Modeling CAS Institute of Geographic Sciences andNatural Resources Research CAS Beijing 100101 China

Understanding the relationship between China＇s urbanization and economic de- velopment on a provincial scale is of profound theoretical and practical significance. Based on data from 124 countries or regions throughout the world and 31 provinces or autonomous regions in China, applying improved methods using the quadrant map approach, this paper analyzed the spatial pattern of the relationship between China＇s urbanization and economic development level. The study identified the following results. （1） The 31 province-level re- gions fall into six categories： only one region is in the category of sharp over-urbanization, 3 regions are in medium over-urbanization, 11 slight over-urbanization, 8 basic coordination, one medium under-urbanization, and seven slight under-urbanization. （2） There are signifi- cant regional differences on a provincial scale in the relationships between urbanization and the level of economic development. （3） The provincial pattern of urbanization and economic development is significantly different between east and west. The eastern coastal areas are mainly over-urbanized, while the central and western regions are mainly under-urbanized. （4） The relationship between urbanization and the level of economic development is similar to the Matthew effect. Hence, two important insights are proposed. First, the phenomenon of over-urbanization in some developed regions should be viewed with some concern and vigi- lance. Second, urbanization needs to be speeded up moderately in the central and western regions.

关键词： urbanization economic development relationship provincial pattern China

A novel fibroblast growth factor 15-dependent and bile acid-independent promotion of liver regeneration in mice

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Cancer Biology & Medicine 2018年第S1期15卷 6-7页

作者： Bo Kong Ruibing Sun mingxing huang Monica Chow Xiaobo Zhong Wen Xie Yi-Horng Lee Grace L.Guo School of Life Sciences Guangzhou UniversityGuangzhouChina Department of Pharmacology and Toxicology Ernest Mario School of PharmacyRutgers UniversityPiscatawayNJUSA Key Laboratory of Drug Metabolism and Pharmacokinetics China Pharmaceutical UniversityNanjingChina Department of Infectious Diseases The Fifth Affiliated Hospital of Sun Yat-Sen University(SYSU)ZhuhaiChina Department of General Surgery Rutgers-Robert Wood Johnson Medical SchoolNew BrunswickNJUSA Department of Pharmaceutical Sciences School of PharmacyUniversity of ConnecticutStorrsCTUSA Center for Pharmacogenetics and Department of Pharmaceutical Sciences University of PittsburghPittsburghPennsylvaniaUSA Division of Pediatric Surgery Department of SurgeryRutgers-Robert Wood Johnson Medical SchoolNew BrunswickNJUSA Environmental and Occupational Health Sciences Institute(EOHSI) RutgersThe State University of New JerseyPiscatawayNJUSA

Objective:The role of intestine-derived factors in promoting liver regeneration after partial hepatectomy(PHx)are not entirely known,but bile acids(BAs)and fibroblast growth factor 15(Fgf15)that are highly expressed in the mouse ileum could promote hepatocyte ***15 strongly suppresses the synthesis of BAs,and emerging evidence indicates that Fgf15 is important for liver regeneration.

关键词： novel fibroblast mice

Treating COVID-19 with Chloroquine

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Journal of Molecular Cell Biology 2020年第4期12卷 322-325页

作者： mingxing huang Tiantian Tang Pengfei Pang Man Li Ruolan Ma Jiahui Lu Jingxian Shu Yingying You Binghui Chen Jiabi Liang Zhongsi Hong Huili Chen Ling Kong Dajiang Qin Duanqing Pei Jinyu Xia Shanping jiang Hong Shan Department of Infectious Diseases The Fifth Affiliated HospitalSun Yat-sen University(SYSU)Zhuhai 519000China Guangdong Provincial Key Laboratory of Biomedical Imaging The Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China Department of Respiratory and Critical Care Medicine Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Institute of Pulmonary Diseases Sun Yat-sen UniversityGuangzhou 510120China Interventional Medical Center The Fifth Affiliated HospitalSun Yat-Sen UniversityZhuhai 519000China Research Center of Molecular Imaging The Fifth Affiliated HospitalSun Yat-Sen UniversityZhuhai 519000China Guangzhou Regenerative Medicine and Health Guangdong Laboratory Guangzhou 510700China Guangzhou Institutes of Biom edicine and Health Chinese Academy of SciencesGuangzhou 510530China Department of Pharmacy The Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China Department of Stomatology The Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China Department of Radiology The Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China University of Chinese Academy of Sciences Beijing 100049China

A novel coronavirus disease 2019(COVID-19)emerged around December 2019 in Wuhan,China and has spread rapidly worldwide(Lu et al.,2020).Until March 27,2020,the Chinese health authorities had reported 82082 confirmed COVID-19 cases in China with 3298 deaths and 381443 confirmed cases with 20787 deaths outside *** World Health Organization(WHO)named the virus SARS-CoV-2,which belongs to a distinct clade from the human severe acute respiratory syndrome CoV(SARS-CoV)and Middle East respiratory syndrome CoV(MERSCoV)(Zhu et al.,2020).

关键词： al. respiratory acute

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伞衣优化设计对群伞系统气动特性的影响分析

国防科技大学学报 2022年第3期44卷 121-130页

作者：董海波隋蓉黄明星北京空间机电研究所北京100094

发展群伞减速着陆系统是实现大载重航天器高效减速和无损着陆要求的关键。借助空气动力学理论对群伞系统中单具降落伞的气动性能进行仿真分析,以仿真结果做参考开展大型环帆伞构型优化设计。在仿真方法正确性和收敛性的基础上,以多种单... 详细信息

发展群伞减速着陆系统是实现大载重航天器高效减速和无损着陆要求的关键。借助空气动力学理论对群伞系统中单具降落伞的气动性能进行仿真分析,以仿真结果做参考开展大型环帆伞构型优化设计。在仿真方法正确性和收敛性的基础上,以多种单伞构型条件下的群伞系统作为研究对象,重点研究群伞系统在伞衣充满状态时的气动阻力性能和姿态稳定性。通过对仿真结果进行流场分析和数据对比发现,开窗开缝设计既能够确保群伞系统具有良好的阻力特性,又能够维持群伞系统的工作稳定性,避免单伞之间由于受力而发生碰撞现象。

关键词：群伞系统大载重回收优化设计数值模拟气动特性

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垃圾焚烧电厂烟气降温模拟分析

环境污染与防治 2011年第7期33卷 27-31,35页

作者：黄明星刘丹西南交通大学环境科学与工程学院四川成都610031

采用fluent软件对江苏某垃圾焚烧厂的烟气2级喷水减温流程分别进行了模拟,并根据模拟结果分析了反应塔和冷却塔内烟气的温度、流速、湿度等在塔内的径向分布情况。结果表明,冷却塔和反应塔在不同进口烟气温度下将烟气温度降低到各自相... 详细信息

采用fluent软件对江苏某垃圾焚烧厂的烟气2级喷水减温流程分别进行了模拟,并根据模拟结果分析了反应塔和冷却塔内烟气的温度、流速、湿度等在塔内的径向分布情况。结果表明,冷却塔和反应塔在不同进口烟气温度下将烟气温度降低到各自相应同一值时所需喷水量的模拟值和实际值均具有较好的一致性,模拟结果具有一定的可靠性;冷却塔内烟气温度分别从200、210、220、230℃降低至170℃时,随着进口烟气温度的升高,喷水量的增加,烟气降温的速度越来越快,塔内烟气温度趋于稳定的高度越来越低,反应塔内烟气温度分别从160、170℃降低至150℃时,随着进口烟气温度的升高,喷水量的增加,塔内烟气温度趋于稳定的高度也越来越低;通过对冷却塔进口烟气温度为200℃和反应塔进口烟气温度为170℃时的喷水降温过程模拟,发现冷却塔内的降温效果明显好于反应塔,2塔的烟气流速分布基本相似,而烟气湿度分布稍有不同。

关键词：垃圾焚烧计算流体力学烟气降温