Risk factors for very low-level viremia in patients with chronic hepatitis B virus infection: A single-center retrospective study
作者机构：Department of Infectious DiseaseThe Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhaiGuangdongChina
出 版 物：《Liver Research》 (肝脏研究（英文）)
年 卷 期：2022年第6卷第1期
页 面：39-44页
核心收录：
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学]
基 金：This work was supported by the grant from Zhuhai Medical and Health Technology Project(20181117E030074) the Department of Science and Technology of Guangdong Province of China(2021A1515010458)
主 题：Hepatitis B virus(HBV) Chronic hepatitis B(CHB) Very low-level viremia(VLLV) Risk factors
摘 要：Background and aim:Several effective antiviral drugs are now available;however,the risk of liver-related complications is still ***-level viremia(LLV),defined as a hepatitis B virus(HBV)deoxy-ribonucleic acid(DNA)load lower than 2000 IU/mL,is one of the major factors responsible for these *** has been reported that 22.7e43.1%of patients with HBV experience ***,we aimed to explore the risk factors for very LLV(VLLV)during antiviral ***:We collected data of patients with chronic hepatitis B(CHB)who received nucleos(t)ide analog treatment from October 2016 to April *** was defined as an HBV DNA load of 9e20 IU/mL.A total of 139 patients with LLV were matched with 139 patients with a sustained virological response at a 1:1 ratio according to age and ***:Seropositivity rates for hepatitis B e antigen(HBeAg)(45.3%vs.17.3%,P0.050).HBeAg seropositivity(aOR,5.08;95% CI:2.15±12.02;P0.001 ***,2.78;95% CI:1.16±7.00;P=0.022)and HBsAg levels(aOR,2.75;95% CI:1.41e5.37;P=0.003 ***,2.10;95% CI:1.27±3.46;P=0.004)significantly increased the risk of VLLV,irrespective of the age *** HBsAg(area under the receiver operating characteristic curve(AUC),0.681;95% CI:0.623±0.736;P0.001)and HBeAg(AUC,0.640;95
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