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Food Science and Human Wellness 2024年第4期13卷 2068-2078页

作者： Hongxuan Li Shasha Cheng Yuhong Wang Yilin sun Jiaxin Zhang mingshuang sun Chaoxin Man Yu Zhang Yujun Jiang Key Laboratory of Dairy Science Ministry of EducationCollege of Food Science and EngineeringNortheast Agricultural UniversityHarbin 150030China

Oxidative stress is one of the main ways to cause alcohol-induced liver injury,and alcoholic liver disease(ALD)has been a common health problem *** acid bacteria(LAB)is also considered as a potential treatment to alleviate alcohol-induced liver *** plantarum J26 is a LAB isolated from Chinese traditional fermented dairy products with excellent probiotic *** study aimed to establish a mice model of alcoholic liver injury through acute-on-chronic alcohol feeding and to study the alleviating effect of pre-intake of *** J26 on alcohol-induced oxidative liver injury and focus on its potential mechanism of alleviating *** results showed that pre-intake of *** J26 could improve liver pathological changes,reduce lipid accumulation,increase mitochondrial ATP and mitochondrial(mtDNA)levels,and alleviate liver *** addition,pre-intake *** J26 can improve the level of short-chain fatty acids(SCFAs)in the intestines in mice,short chain fatty acids can be used as a signaling molecule activation of nuclear factor E2-related factor 2(Nrf2)signaling pathway to alleviate liver oxidative stress,and maintain mitochondrial homeostasis by regulating the expression of genes related to mitochondrial dynamics and autophagy,thereby reducing cell apoptosis to alleviate alcohol-induced oxidative liver injury.

关键词： Alcoholic liver disease Probiotics Nuclear factor E2-related factor 2(Nrf2) Oxidative stress Short-chain fatty acids

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稀土Ce对2A12铝合金耐蚀性的影响

热加工工艺 2024年第10期53卷 112-115,118页

作者：赵慧颖李涛曹阁范静孙明双内蒙古科技大学材料与冶金学院内蒙古包头014010

通过室内周期浸润腐蚀实验方法,研究了稀土Ce对2A12铝合金在含Cl-海洋大气模拟环境中的腐蚀行为。采用蔡司显微镜观察了铸态金相组织,用能量色散谱仪(EDS)分析了腐蚀产物元素组成。采用失重法分析了2A12铝合金腐蚀动力学规律,采用电化... 详细信息

通过室内周期浸润腐蚀实验方法,研究了稀土Ce对2A12铝合金在含Cl-海洋大气模拟环境中的腐蚀行为。采用蔡司显微镜观察了铸态金相组织,用能量色散谱仪(EDS)分析了腐蚀产物元素组成。采用失重法分析了2A12铝合金腐蚀动力学规律,采用电化学极化曲线分析了2A12铝合金腐蚀后的电化学行为。结果表明,稀土的加入使得2A12铝合金的均匀性得到改善,腐蚀速率明显减小,腐蚀电流密度降低,腐蚀电压增加。稀土Ce的加入使得2A12铝合金锈层更致密而导致铝合金基体表面的电化学反应缓慢。

关键词：稀土Ce 2A12铝合金腐蚀

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A systematic in vitro investigation on poly-arginine modified nanostructured lipid carrier: Pharmaceutical characteristics, cellular uptake, mechanisms and cytotoxicity

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Asian Journal of Pharmaceutical Sciences 2017年第1期12卷 51-58页

作者： mingshuang sun Yunyun Gao Zhihong Zhu Huixin Wang Cuiyan Han Xinggang Yang Weisan Pan Shenyang Pharmaceutical University No.103Wenhua RoadShenyang 110016China Qiqihar Medical University No.333Bukuibei RoadQiqihar 161000China

The aim of the present study was to develop a poly-arginine modified nanostructured lipid carrier(R-NLC) by fusion-emulsification method and to test its pharmaceutical characteristics. The influence of R-NLC on A549 cells like cellular uptake and cytotoxicity was also appraised using unmodified NLC as the controlled group. As the results revealed, R-NLC had an average diameter of about 40 nm and a positive zeta potential of about +17 mv, the entrapment efficiency decreased apparently, and no significant difference on the in vitro drug release was found after R8-modification. The cellular uptake and cytotoxicity increased obviously compared with unmodified NLC. The cellular uptake mechanisms of R-NLC involved energy, macropinocytosis, clathrin-mediated endocytosis, and caveolin-mediated endocytosis. The outcomes of the present study strongly support the theory that cell penetrating peptides have the ability of enhancing the cellular uptake of nanocarriers.

关键词： Poly-arginine NLC Cellular uptake Mechanisms Cytotoxicity

中强脉冲电场叉指式平板处理室的多物理场仿真与试验

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中国农业大学学报 2022年第10期27卷 186-195页

作者：王思敏甘芝霖孙爱东孙铭爽北京林业大学生物科学与技术学院北京100083 林业食品加工与安全北京市重点实验室北京100083 东北农业大学食品学院哈尔滨150030

处理室是脉冲电场系统的关键部件,为改善处理室的结构和性能,设计并优化一种在中强脉冲电场下的处理室。运用COMSOL Multiphysics软件对优化前后处理室的电场、流场和温度场进行分析,测定物料出口温度和杀菌效果对优化效果进行实际评价... 详细信息

处理室是脉冲电场系统的关键部件,为改善处理室的结构和性能,设计并优化一种在中强脉冲电场下的处理室。运用COMSOL Multiphysics软件对优化前后处理室的电场、流场和温度场进行分析,测定物料出口温度和杀菌效果对优化效果进行实际评价,基于优化后的处理室对比中强脉冲电场处理和巴氏杀菌处理对蓝莓果汁的品质影响。结果表明:1)研究得到的直角型叉指式平板处理室,除电极拐角处存在电场尖峰外,其他区域的电场强度分布均匀,均为2kV/cm,与理论值相同,优化后的圆角型叉指式平板处理室在拐角处消除了电场尖峰,电场强度峰值由22.7kV/cm降低至2.64kV/cm,电场强度分布更加均匀,物料出口温度降低了4.3℃,温度和流速分布均得到改善;2)基于叉指式平板处理室搭建的中强脉冲电场处理系统具有显著的杀菌效果,电场强度大于2kV/cm时,直角型和圆角型叉指式平板处理室均使大肠杆菌菌落数下降了3lg(CFU/mL)以上,但圆角型叉指式平板处理室的物料温度升高幅度显著降低,效果更好,与仿真结果一致;3)与热处理相比,中强脉冲电场处理更好地保持了蓝莓果汁的pH、颜色、花色苷和抗氧化能力。本研究研发的叉指式平板处理室具有良好的杀菌效果,优化后物料温升更小,能够较好地保持蓝莓果汁的品质。

关键词：平板式处理室杀菌叉指结构中强脉冲电场 COMSOL Multiphysics

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山羊乳及其制品营养与功能特性的研究进展

食品科学 2023年第5期44卷 212-221页

作者：李艾黎刘串马艺鸣王雪莹李春孙铭爽东北农业大学食品学院乳品科学教育部重点实验室黑龙江哈尔滨150030 黑龙江省绿色食品科学研究院黑龙江哈尔滨150023 黑龙江欧能达乳业有限公司黑龙江哈尔滨150028

山羊乳及相关制品由于丰富的营养价值和良好的健康功效受到越来越多消费者的关注。山羊乳属于一种资源稀缺型特种乳,与牛乳相比,其干物质含量较高、易消化,且致敏性较低,还是多种生物活性成分的良好来源。因此,山羊乳可用于加工制作适... 详细信息

山羊乳及相关制品由于丰富的营养价值和良好的健康功效受到越来越多消费者的关注。山羊乳属于一种资源稀缺型特种乳,与牛乳相比,其干物质含量较高、易消化,且致敏性较低,还是多种生物活性成分的良好来源。因此,山羊乳可用于加工制作适合各种人群的保健性能产品,也可作为益生元和益生菌等功能成分的载体。本文就山羊乳营养成分、功能特性以及加工处理等研究领域的前沿成果进行综述,着重介绍山羊乳相关制品预防与缓解多种疾病的作用与机制,为山羊乳高值化产品的开发提供参考。

关键词：山羊乳营养功能特性加工处理

Fossil Equidae in the Linxia Basin with Biostratigraphic and Paleozoogeographic Significance

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Acta Geologica Sinica(English Edition) 2024年第1期98卷 1-9页

作者： sun Boyang Key Laboratory of Vertebrate Evolution and Human Origins of the Chinese Academy of Sciences Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijing 100044China

The Linxia Basin is characterized by an abundance of Cenozoic sediments,that contain exceptionally rich fossil *** are abundant in the Linxia Basin,the fossil record of equids in this region including 16 species that represent 10 *** comparison to other classic late Cenozoic areas in China,the Linxia Basin stands out,because the fauna and chronological data accompanying Linxia equids render them remarkably useful for *** anchitheriines in the region,such as Anchitherium and Sinohippus,represent early equids that appeared in the late stages of the middle and late Miocene,*** the equines,most species of Chinese hipparions have been identified in the Linxia Basin and some species of the genera Hipparion and Hippotherium have FAD records for ***,Equus eisenmannae is one of the earliest known species of Equus in the Old World and is well-represented at the Longdan *** species with precise geohistorical distributions can serve as standards for high-resolution chronological units within this *** at the eastern margin of the Tibetan Plateau and subject to considerable uplift,the Linxia Basin has served as a biogeographic transition area for equids throughout the late Cenozoic.

关键词： Equidae Cenozoic biostratigraphy paleozoogeography Linxia Basin

Achieving simultaneously high conversion and high selectivity for light olefins directly producing from syngas

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Science China Chemistry 2024年第3期67卷 753-754页

作者： Yuhan sun Shanxi Research Institute Huairou Research LaboratoryTaiyuan 030032China Institute of Carbon Neutrality ShanghaiTech UniversityShanghai 201210China

The activity and selectivity are two primary indexes of a successful catalyst for chemical reactions. However,achieving a high activity and a high selectivity simultaneously is a long-standing challenge in catalysis, the socalled activity-selectivity trade-off. In the article recently published in Science, a research team led by Prof.

关键词： selectivity simultaneous catalysis

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论儿童小说中狂欢化叙事的精神实质及意义

中国海洋大学学报（社会科学版） 2022年第2期 121-128页

作者：徐德荣孙明双中国海洋大学外国语学院山东青岛266100

儿童小说中的狂欢化叙事具有独特的表现机制和精神实质。以大卫·威廉姆斯的作品为例,从情节、人物和语言风格三个方面探究其儿童小说的狂欢化叙事机制。狂欢化叙事的精神实质是解放儿童、以儿童为本位的儿童文学创作思想,具体表现在对... 详细信息

儿童小说中的狂欢化叙事具有独特的表现机制和精神实质。以大卫·威廉姆斯的作品为例,从情节、人物和语言风格三个方面探究其儿童小说的狂欢化叙事机制。狂欢化叙事的精神实质是解放儿童、以儿童为本位的儿童文学创作思想,具体表现在对社会等级秩序的颠覆、对成人权威的反叛和对发声权利的追求三个方面。儿童小说中的狂欢化叙事实现了表现手法与精神实质的辩证统一,对于儿童文学中价值观念的传达有着深刻的启发意义,体现出狂欢化儿童文学尊重儿童独有生命形态,实现儿童本位创作的本质诉求。

关键词：儿童文学儿童小说狂欢化大卫·威廉姆斯儿童本位

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ONE-PARAMETER FINITE DIFFERENCE METHODS AND THEIR ACCELERATED SCHEMES FOR SPACE-FRACTIONAL SINE-GORDON EQUATIONS WITH DISTRIBUTED DELAY

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Journal of Computational Mathematics 2024年第3期42卷 705-734页

作者： Tao sun Chengjian Zhang Haiwei sun School of Mathematics and Statistics Huazhong University of Science and TechnologyWuhan 430074China Hubei Key Laboratory of Engineering Modeling and Scientific Computing Huazhong University of Science and TechnologyWuhan 430074China Department of Mathematics University of MacaoMacaoChina

This paper deals with numerical methods for solving one-dimensional(1D)and twodimensional(2D)initial-boundary value problems(IBVPs)of space-fractional sine-Gordon equations(SGEs)with distributed *** 1D problems,we construct a kind of oneparameter finite difference(OPFD)*** is shown that,under a suitable condition,the proposed method is convergent with second order accuracy both in time and *** implementation,the preconditioned conjugate gradient(PCG)method with the Strang circulant preconditioner is carried out to improve the computational efficiency of the OPFD *** 2D problems,we develop another kind of OPFD *** such a method,two classes of accelerated schemes are suggested,one is alternative direction implicit(ADI)scheme and the other is ADI-PCG *** particular,we prove that ADI scheme can arrive at second-order accuracy in time and *** some numerical experiments,the computational effectiveness and accuracy of the methods are further ***,for the suggested methods,a numerical comparison in computational efficiency is presented.

关键词： Fractional sine-Gordon equation with distributed delay One-parameter finite difference methods Convergence analysis ADI scheme PCG method

Organic thin-film transistors and related devices in life and health monitoring

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Nano Research 2024年第2期17卷 426-444页

作者： Chenfang sun Tie Wang Tianjin Key Laboratory of Drug Targeting and Bioimaging Life and Health Intelligent Research InstituteTianjin University of TechnologyTianjin 300384China

The early determination of disease-related biomarkers can significantly improve the survival rate of ***,a series of explorations for new diagnosis technologies,such as optical and electrochemical methods,have been devoted to life and health *** thin-film transistor(OTFT),as a state-of-the-art nano-sensing technology,has attracted significant attention from construction to application owing to the merits of being label-free,low-cost,facial,and rapid detection with multi-parameter ***,interference from non-specific adsorption is inevitable in complex biological samples such as body liquid and exhaled gas,so the reliability and accuracy of the biosensor need to be further improved while ensuring sensitivity,selectivity,and ***,we overviewed the composition,mechanism,and construction strategies of OTFTs for the practical determination of disease-related biomarkers in both body fluids and exhaled *** results show that the realization of bio-inspired applications will come true with the rapid development of high-effective OTFTs and related devices.

关键词： organic thin-film transistors biosensors biomarkers organic bioelectronics organic semiconductors healthcare