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Sprayed PAA-CaO_(2)nanoparticles combined with calcium ions and reactive oxygen species for antibacterial and wound healing

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Regenerative Biomaterials 2023年第1期10卷 1356-1371页

作者： Hong Yu Jiale Sun Kepeng She mingqi lv Yiqiao Zhang Yawen Xiao Yangkun Liu Changhao Han Xinyue Xu Shuqing Yang Guixue Wang Guangchao Zang Tissue and Cell Biology Lab Teaching&Management CenterChongqing Medical UniversityChongqing 400016China Chongqing University Central Hospital Chongqing Emergency Medical CenterChongqing 400030China Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular ImplantsBioengineering College of Chongqing UniversityChongqing 400030China Jinfeng Laboratory Chongqing 401329China

The most common socioeconomic healthcare issues in clinical are burns,surgical incisions and other skin *** lesion healing can be achieved with nanomedicines and other drug application *** study developed a nano-spray based on cross-linked amorphous calcium peroxide(CaO_(2))nanoparticles of polyacrylic acid(PAA)for treating skin wounds(PAA-CaO_(2)nanoparticles).CaO_(2)serves as a‘drug’precursor,steadily and continuously releasing calcium ions(Ca^(2+))and hydrogen peroxide(H_(2)O_(2))under mildly acidic conditions,while PAA-CaO_(2)nanoparticles exhibited good spray behavior in aqueous *** demonstrated that PAA-CaO_(2)nanoparticles exhibited low cytotoxicity and allowed L929 cells proliferation and migration in *** effectiveness of PAA-CaO_(2)nanoparticles in promoting wound healing and inhibiting bacterial growth in vivo was assessed in SD rats using full-thickness skin defect and Staphylococcus aureus(***)-infected wound models based *** results revealed that PAA-CaO_(2)nanoparticles demonstrated significant advantages in both ***,the infected rats’skin defects healed in 12 *** benefits are linked to the functional role of Ca^(2+)coalesces with H_(2)O_(2)as known antibacterial and healing-promoted ***,we developed nanoscale PAA-CaO_(2)sprays to prevent bacterial development and heal skin lesions.

关键词： polyacrylic acid calcium peroxide nanomedicines antibacterial wound healing

Photocrosslinking silver nanoparticles–aloe vera–silk fibroin composite hydrogel for treatment of full-thickness cutaneous wounds

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Regenerative Biomaterials 2021年第6期8卷 46-58页

作者： Yangkun Liu JinChuan Fan mingqi lv Kepeng She Jiale Sun Qingqing Lu Changhao Han SongTao Ding Shuang Zhao GuiXue Wang YuChan Zhang GuangChao Zang Institute of Life Science And Laboratory of Tissue and Cell BiologyLab Teaching&Management CenterChongqing Medical UniversityChongqing 400016China Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular ImplantsBioengineering College of Chongqing UniversityChongqing 400030China

Damage to the skin causes physiological and functional *** most effective treatment approach is the use of wound *** fibroin(SF)is a promising candidate biomaterial for regulating wound healing;however,its antibacterial properties and biological activity must be further *** this study,a photocrosslinking hydrogel was developed to treat full-thickness cutaneous *** composite hydrogel(Ag-AV-SF hydrogel)was prepared by introducing the silver nanoparticles(AgNPs)and aloe vera(AV)as the *** vitro study exhibited great antibacterial ability,biocompatibility and cell-proliferation and-migration-promoting *** also showed the pH-response releasing properties which release more AgNPs in a simulated chronic infection *** healing effect evaluation in vivo showed the healing-promoting ability of the Ag-AV-SF hydrogel was stronger than the single-modifiers groups,and the healing rate of it reached 97.02%on Day 21,higher than the commercial wound dressing,silver sulfadiazine(SS)cream on ***,the histological and protein expression results showed that the Ag-AV-SF hydrogel has a greater effect on the pro-healing regenerative phenotype with M2 macrophages at the early stage,reconstructing the blood vessels networks and inhibiting the formation of *** summary,the Ag-AV-SF hydrogel developed in this study had good physical properties,overwhelming antibacterial properties,satisfactory biocompatibility and significantly promoting effect on cell proliferation,migration and wound ***,our results suggest that the Ag-AV-SF hydrogel we developed has great potential for improving the wound healing in clinical treatment.

关键词： silk fibroin silver nanoparticles aloe vera hydrogel wound healing

基于3D运动轨迹解析与隐马尔可夫模型的动作识别算法

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光学技术 2018年第6期44卷 747-756页

作者：曾珍珍蔡盛腾吕明琪广东科学技术职业学院计算机工程技术学院广东珠海519090 东莞理工学院机械工程学院广东东莞523808 杭州师范大学信息科学与工程学院浙江杭州311121

针对当前动作识别技术中通常忽略上下文信息,且其局部形状描述对噪声敏感,难以有效处理运动模式的类内变化等不足,提出一种3D运动轨迹解析耦合隐马尔可夫模型的动作识别算法。定义四种轨迹基元（直线、平面圆弧、左螺旋线与右螺旋线）,... 详细信息

针对当前动作识别技术中通常忽略上下文信息,且其局部形状描述对噪声敏感,难以有效处理运动模式的类内变化等不足,提出一种3D运动轨迹解析耦合隐马尔可夫模型的动作识别算法。定义四种轨迹基元（直线、平面圆弧、左螺旋线与右螺旋线）,采用基于Kalman的线性平滑器来降低干扰信息与异常值,将3D轨迹分解和解析成不同的轨迹基元,充分减少干扰信息对轨迹数据的影响,同时保持形状和运动特性。为了避免丢失详细的局部形状信息,设计一种形状描述符,将轨迹基元进一步分割成子基元,将每个运动轨迹表示为子基元的时间序列。引入隐马尔可夫模型,根据运动数据的先验知识来模拟运动分类,基于最大后验概率准则来进行运动识别。实验结果表明：与当前流行的动作识别算法比较,所提算法能有效识别各种动作类别,对尺度变化,以及局部噪声和局部遮挡具有更高的识别精度。

关键词：动作识别轨迹基元形状描述符隐马尔可夫模型最大后验概率

基于演化模式挖掘和代价敏感学习的交通拥堵指数预测

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高技术通讯 2020年第9期30卷 918-927页

作者：张翔宇张强吕明琪中国科学院计算技术研究所北京100190 中国科学院大学北京100049 北京赛迪时代信息产业股份有限公司北京100048 浙江工业大学计算机学院杭州310014

交通拥堵指数预测是智能交通系统的核心能力之一。然而,现有方法大多采用回归模型,在长期交通拥堵指数预测任务上表现不佳。针对此问题,本文提出了一种融合演化模式挖掘和代价敏感学习的交通拥堵指数预测方法。首先,采用序列模式挖掘算... 详细信息

交通拥堵指数预测是智能交通系统的核心能力之一。然而,现有方法大多采用回归模型,在长期交通拥堵指数预测任务上表现不佳。针对此问题,本文提出了一种融合演化模式挖掘和代价敏感学习的交通拥堵指数预测方法。首先,采用序列模式挖掘算法从交通拥堵指数历史数据中发现长期演化模式。同时,采用代价敏感学习技术对交通拥堵指数数据与多种时空特征之间的关联进行学习。最后,通过Stacking框架对演化模式挖掘和代价敏感学习的能力进行融合。基于杭州市真实交通拥堵指数数据集进行的实验表明,本文提出的方法对未来5天交通拥堵指数的预测误差比现有方法降低了10%以上。

关键词：交通拥堵指数预测序列模式挖掘代价敏感学习数据融合城市计算

基于GPS轨迹挖掘的兴趣地点个性化推荐方法

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高技术通讯 2021年第1期31卷 75-83页

作者：张翔宇张强吕明琪中国科学院计算技术研究所北京100190 中国科学院大学北京100049 浙江工业大学计算机学院杭州310014 北京赛迪时代信息产业股份有限公司北京100048

随着全球定位系统(GPS)等定位设备的普及,用户可方便地记录其GPS轨迹,这使得自动从用户的GPS轨迹中发现兴趣地点(POI)(如餐厅、商场、景点)并在用户之间进行推荐成为可能。因此,本文提出了一种基于GPS轨迹挖掘的兴趣地点个性化推荐方法... 详细信息

随着全球定位系统(GPS)等定位设备的普及,用户可方便地记录其GPS轨迹,这使得自动从用户的GPS轨迹中发现兴趣地点(POI)(如餐厅、商场、景点)并在用户之间进行推荐成为可能。因此,本文提出了一种基于GPS轨迹挖掘的兴趣地点个性化推荐方法。该方法与现有主流的兴趣地点推荐平台具有以下不同:首先,现有平台假设兴趣地点是事先已知的,而该方法通过一个层次化聚类算法从用户GPS轨迹中自动挖掘兴趣地点。其次,现有平台的推荐模式为平台向用户推荐,因此仅考虑了用户的偏好,忽略了用户之间的社交关联对推荐效果的影响。针对此问题,该方法基于用户交叠访问行为计算用户之间的社交信任度,基于用户访问行为的相似性计算其对兴趣地点偏好的相似度,在此基础上提出了一种能够融合用户信任度和相似度的评分算法。文本基于真实GPS轨迹数据对提出的方法进行了评测,实验结果表明,本文所提方法的综合推荐性能明显优于简单的基于访问数量的推荐方法、仅基于用户信任度的推荐方法及仅基于偏好相似度的推荐方法。

关键词：个性化兴趣地点(POI)推荐基于位置社会网络全球定位系统(GPS)轨迹时空数据挖掘

Blood diagnostic and prognostic biomarkers in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第9期20卷 2556-2570页

作者： Yongting lv Hongfu Li Department of Neurology Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina Department of Medical Genetics and Center for Rare disease Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina Nanhu Brain-Computer Interface Institute HangzhouZhejiang Province

Amyotrophic lateral sclerosis is a devastating neurodegenerative disease for which the current treatment approaches remain severely *** principal pathological alterations of the disease include the selective degeneration of motor neurons in the brain,brainstem,and spinal cord,as well as abnormal protein deposition in the cytoplasm of neurons and glial *** biological markers under extensive scrutiny are predominantly located in the cerebrospinal fluid,blood,and even *** these biomarke rs,neurofilament proteins and glial fibrillary acidic protein most accurately reflect the pathologic changes in the central nervous system,while creatinine and creatine kinase mainly indicate pathological alterations in the peripheral nerves and *** light chain levels serve as an indicator of neuronal axonal injury that remain stable throughout disease progression and are a promising diagnostic and prognostic biomarker with high specificity and ***,there are challenges in using neurofilament light chain to diffe rentiate amyotrophic lateral sclerosis from other central nervous system diseases with axonal *** fibrillary acidic protein predominantly reflects the degree of neuronal demyelination and is linked to non-motor symptoms of amyotrophic lateral sclerosis such as cognitive impairment,oxygen saturation,and the glomerular filtration *** DNA-binding protein 43,a pathological protein associated with amyotrophic lateral sclerosis,is emerging as a promising biomarker,particularly with advancements in exosome-related *** is currently lacking for the value of creatinine and creatine kinase as diagnostic markers;however,they show potential in predicting disease *** the vigorous progress made in the identification of amyotrophic lateral sclerosis biomarkers in recent years,the quest for definitive diagnostic and prognostic biomarke rs remains a formidable *** review summarizes the lat

关键词： amyotrophic lateral sclerosis biomarker blood biomarkers diagnosis glial fibrillary acidic protein neurofilament light chain prognosis TAR DNA-binding protein 43

In situ polymerization of poly(3,4-ethylenedioxythiophene)protective layer towards stable zinc anode

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Nano Research 2025年第1期18卷 382-394页

作者： Debin Luo Peng Zhou Xiaowei lv Panpan Sun Xiaohua Sun Hewei Zhao College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion MaterialsChina Three Gorges UniversityYichang 443002China Hubei Three Gorges Laboratory Yichang 443007China School of Chemistry Beihang UniversityBeijing 100191China

Aqueous zinc-ion devices are considered promising candidates for energy storage due to their high safety,low cost and relatively high energy ***,the dendrite growth,hydrogen evolution reaction(HER)and corrosion of the zinc anode significantly limit the development of Zn-ion ***,an inexpensive poly(3,4-ethylenedioxythiophene)(PEDOT)protective layer was constructed in situ on the Zn surface using electropolymerization to suppress dendrite growth and side reactions,thereby enhancing the reversibility of *** and theoretical calculations revealed that this hydrophilic protective layer promotes the desolvation process of hydrated Zn^(2+)and facilitates the transport of zinc ions,thus improving the thermodynamic and kinetic properties of Zn^(2+)deposition and inhibiting interfacial side ***,the optimized PEDOT@Zn symmetric battery exhibited a cycling stability exceeding 1250 h at 0.5 mA·cm^(-2)and 0.25 mAh·cm^(-2),with a significantly reduced overpotential(from 91.8 to 35 mV).With the assistance of the PEDOT protective layer,the PEDOT@Zn//Cu battery maintained approximately 99.5%Coulombic efficiency after 450 ***-situ scanning electron microscopy(SEM)and in situ optical microscopy characterizations further confirmed that the PEDOT protective layer can effectively suppress the growth of zinc ***,the Zn-ion capacitors assembled by the PEDOT@Zn and activated carbon also demonstrated outstanding cycling stability.

关键词： zinc-ion devices zinc anode poly(3 4-ethylenedioxythiophene)(PEDOT) dendrite desolvation process

The pivotal role of microglia in injury and the prognosis of subarachnoid hemorrhage

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Neural Regeneration Research 2025年第7期20卷 1829-1848页

作者： Wenjing Ning Shi lv Qian Wang Yuzhen Xu Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina Department of Central Laboratory The Affiliated Taian City Central Hospital of Qingdao UniversityTaianShandong ProvinceChina

Subarachnoid hemorrhage leads to a series of pathological changes,including vascular spasm,cellular apoptosis,blood–brain barrier damage,cerebral edema,and white matter ***,which are the key immune cells in the central nervous system,maintain homeostasis in the neural environment,support neurons,mediate apoptosis,participate in immune regulation,and have neuroprotective *** evidence has shown that microglia play a pivotal role in the pathogenesis of subarachnoid hemorrhage and affect the process of injury and the prognosis of subarachnoid ***,microglia play certain neuroprotective roles in the recovery phase of subarachnoid *** approaches aimed at modulating microglia function are believed to attenuate subarachnoid hemorrhage *** provides new targets and ideas for the treatment of subarachnoid ***,an in-depth and comprehensive summary of the role of microglia after subarachnoid hemorrhage is still *** review describes the activation of microglia after subarachnoid hemorrhage and their roles in the pathological processes of vasospasm,neuroinflammation,neuronal apoptosis,blood–brain barrier disruption,cerebral edema,and cerebral white matter *** also discusses the neuroprotective roles of microglia during recovery from subarachnoid hemorrhage and therapeutic advances aimed at modulating microglial function after subarachnoid ***,microglia in subarachnoid hemorrhage are targeted with TLR inhibitors,nuclear factor-κB and STAT3 pathway inhibitors,glycine/tyrosine kinases,NLRP3 signaling pathway inhibitors,Gasdermin D inhibitors,vincristine receptorαreceptor agonists,ferroptosis inhibitors,genetic modification techniques,stem cell therapies,and traditional Chinese ***,most of these are still being evaluated at the laboratory *** clinical studies and data on subarachnoid hemorrhage are required to improve the treatment of subarachnoid hemor

关键词： apoptosis blood–brain barrier brain edema microglia neuroinflammation neuron neuroprotection subarachnoid hemorrhage vasoconstriction white matter injury

基于ZigBee技术的多节点设备无线物联自组网设计

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微型机与应用 2014年第8期33卷 51-54页

作者：安康张慧熙王李冬吕明琪杭州师范大学钱江学院浙江杭州310012

设计了一种基于ZigBee的多节点设备无线物联自组网络,采用ZigBee芯片CC2530构建终端采集节点、路由节点和协调器节点。终端采集节点周期性采集数据并通过多跳路由和协调器将数据上报到PC监控端。系统节点之间能够自组织构建网络,节点发... 详细信息

设计了一种基于ZigBee的多节点设备无线物联自组网络,采用ZigBee芯片CC2530构建终端采集节点、路由节点和协调器节点。终端采集节点周期性采集数据并通过多跳路由和协调器将数据上报到PC监控端。系统节点之间能够自组织构建网络,节点发生故障时,网络能够自我修复,使系统正常工作。

关键词： ZigBee 自组网无线传感器网络