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Synergistic strengthening mechanism of Ca^(2+)-sodium silicate to selective separation of feldspar and quartz

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International Journal of Minerals,Metallurgy and Materials 2024年第9期31卷 1985-1995页

作者： Bo Lin Jingzhong Kuang Yiqiang Yang Zheyu Huang Delong Yang mingming yu School of Resources and Environmental Engineering Jiangxi University of Science and TechnologyGanzhou 341000China Jiangxi Key Laboratory of Mining Engineering Ganzhou 341000China

Inhibitors are important for flotation separation of quartz and *** this study,a novel combined inhibitor was used to separate quartz and feldspar in near-neutral *** inhibition of the combined inhibitor was assessed by micro-flotation *** a series of detection methods were used to detect differences in the surface properties of feldspars and quartz after flotation reagents and put forward the synergistic strengthening *** outcomes were pointed out that pre-mixing combined inhibitors were more effective than the addition of Ca^(2+)and SS in sequence under the optimal proportion of 1:5.A concentrate from artificial mixed minerals that was characterized by a high quartz grade and a high recovery was acquired,and was found to be 90.70wt% and 83.70%,*** was demonstrated that the combined inhibitor selectively prevented the action of the collector and feldspar from Fourier-transform infrared(FT-IR)and adsorption capacity *** results of X-ray photoelectron spectroscopy(XPS)indicated that Ca^(2+)directly interacts with the surface of quartz to increase the adsorption of *** contrast,the chemistry property of Al on the feldspar surface was altered by combined inhibitor due to Na^(+)and Ca^(2+)taking the place of K^(+),resulting in the composite inhibitor forms a hydrophilic structure,which prevents the adsorption of the collector on the surface of feldspar by interacting with the Al active *** combination of Ca^(2+)and SS synergically strengthens the difference of collecting property between quartz and feldspar by collector,thus achieving the effect of efficient separation.A new strategy for flotation to separate quartz from feldspar in near-neutral pulp was provided.

关键词： feldspar quartz Ca^(2+)-sodium silicate selective adsorption flotation separation

Effects of Sulfate Chitosan Derivatives on Nonalcoholic Fatty Liver Disease

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Journal of Ocean University of China 2014年第3期13卷 531-537页

作者： yu mingming WANG yuanhong JIANG Tingfu LV Zhihua Key Laboratory of Marine Drugs Ministry of Education Shandong Provincial Key Laboratory of Glycoscience Glycotechnolygy School of Medicine and Pharmacy Ocean University of China

Sulfate chitosan derivatives have good solubility and therapeutic effect on the cell model of NAFLD. The aim of this study was to examine the therapeutic effect of sulfate chitosan derivatives on NAFLD. The male Wistar rats were orally fed high fat emulsion and received sulfate chitosan derivatives for 5 weeks to determine the pre-treatment effect of sulfate chitosan derivatives on NAFLD. To evaluate the therapeutic effect of sulfate chitosan derivatives on NAFLD, the rats were orally fed with high concentration emulsion for 5 weeks, followed by sulfate chitosan derivatives for 3 weeks. Histological analysis and biomedical assays showed that sulfate chitosan derivatives can dramatically prevent the development of hepatic steatosis in hepatocyte cells. In animal studies, pre-treatment and treatment with sulfate chitosan derivatives significantly protected against hepatic steatohepatitis induced by high fat diet according to histological analysis. Furthermore, increased TC, ALT, MDA, and LEP in NAFLD were significantly ameliorated by pre-treatment and treatment with sulfate chitosan derivatives. Furthermore, increased TG, AST, and TNF-α in NAFLD were significantly ameliorated by treatment with sulfate chitosan derivatives. Sulfate chitosan derivatives have good pre-treatment and therapeutic effect on NAFLD.

关键词： NAFLD sulfate chitosan derivatives histological analysis hepatocyte cells rats

^1H NMR Quantification of DHA and EPA in Fish Oil

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Journal of Ocean University of China 2020年第5期19卷 1193-1197页

作者： LV Jinxiao WANG Cong ZHANG Xiuli LV Zhihua yu mingming School of Medicine and Pharmacy Ocean University of ChinaQingdao 266003China Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology Qingdao 266003China Key Laboratory of Glycoscience&Glycotechnology of Shandong Province Qingdao 266003China Key Laboratory of Marine Drugs Ministry of Education of ChinaQingdao 266003China

Fish oil is a popular nutritional product consumed in China. The beneficial effects of fish oil have been attributed to docosahexaenoic acid(DHA) and eicosapentaenoic acid(EPA). Hence, it is crucial to develop a rapid and precise method to determine the contents of EPA and DHA in fish oil. In this study, a rapid and accurate proton nuclear magnetic resonance method for the quantification of DHA and EPA was developed. Dimethyl terephthalate was selected as an internal standard, and the signals at 2.391 ppm for DHA and at 1.697 ppm for EPA were chosen for the quantification. Validation of the method was performed in terms of specificity, precision, and stability. The results indicated that the method was precise and in line with the China Food and Drug Administration guidance. The method has been successfully applied to characterize fish oil capsules obtained from four pharmaceutical companies. This study indicated that the rapid ~1H NMR method is suitable for the quality control of fish oil.

关键词： ^1H NMR EPA DHA fish oil quality control

Multi-organelle-targeting pH-dependent NIR fluorescent probe for lysosomal viscosity

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Chinese Chemical Letters 2023年第3期34卷 378-382页

作者： Huili Wang Yishuo Sun Xuemei Lin Wei Feng Zhanxian Li mingming yu Green Catalysis Center and College of Chemistry Zhengzhou UniversityZhengzhou 450001China Department of Chemistry State Key Laboratory of Molecular Engineering of PolymersInstitutes of Biomedical Sciences&Collaborative Innovation Center of Chemistry for Energy MaterialsFudan UniversityShanghai 200433China

The normal operation of lysosome, mitochondria, Golgi apparatus and endoplasmic reticulum plays a significant role in maintaining cell homeostasis. Reflecting the state and function of lysosomes, viscosity is a pivotal parameter to assess the stability of microenvironment. Herein, based on TICT mechanism,a new NIR pH-dependent fluorescent probe DCIC with push-pull electronic moiety was synthesized to identify the lysosomes viscosity. In viscous media, DCIC was highly sensitive to viscosity, fluorescence intensity increased by 180 times as viscosity increased from 1.0 cp to 438.4 cp. In addition, DCIC have high localization ability for lysosome, mitochondria, Golgi apparatus, and endoplasmic reticulum and can monitor lysosomal viscosity fluctuations with laser confocal microscopy.

关键词： NIR Lysosomal viscosity PH-dependent Multi-organelle localization

Recovering rare earths,lithium and fluorine from rare earth molten salt electrolytic slag using sub-molten salt method

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Journal of Rare Earths 2024年第9期42卷 1774-1781,I0005页

作者： Delong Yang mingming yu yusufujiang Mubula Weiquan yuan Zheyu Huang Bo Lin Guangjun Mei Tingsheng Qiu School of Resources and Environmental Engineering Jiangxi University of Science and TechnologyGanzhou341000China Jiangxi Key Laboratory of Mining Engineering Jiangxi University of Science and TechnologyGanzhou341000China School of Resources and Environmental Engineering Wuhan University of TechnologyWuhan430070China Gannan Institute of Science and Technology Ganzhou341000China

Viewing the problem of high ene rgy consumption in the process of recovering rare earths from rare earth molten salt electrolysis slag,an environmentally friendly and low carbon process by sub-molten salt decomposition was *** thermodynamic analysis of sub-molten salt reaction indicates that the recovery of rare earths from the slag using sub-molten salt medium is thermodynamically *** this process,the rare earth fluoride and lithium in the slag are almost transformed into rare earth hydroxide,sodium fluoride and lithium hydroxide,fluorine and lithium are transferred into the washing solution,and the rare earths in the residues can be leached into solution by acid *** the optimum reaction conditions of reaction temperature 200℃,reaction time 3 h,NaOH initial concentration 80%,NaOH-Slag mass ratio 3:1,the leaching efficiency of rare earths,fluorine and lithium can reach to 99.05%,98.23% and 99.22%.After evaporation,the fluorine and lithium in the washing solution can be obtained in the forms of sodium fluoride and lithium fluoride,the recovery efficiency reach 95.5%and 92.8%,*** RE oxides(99.53%) can be obtained from the leaching solution after precipitation and roasting.

关键词： Rare earth electrolysis slag Sub-molten salt Green extraction Fluorine Lithium Recovery

Development and Validation of UHPLC-MS/MS Method for Quantifying of Agarotriose:An Application for Pharmacokinetic,Tissue Distribution,and Excretion Studies in Rats

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Journal of Ocean University of China 2023年第6期22卷 1683-1691页

作者： yuE Jiali CHENG Wei WEI Shutong LIU Guilin ZHOU Meichen LV Zhihua yu mingming School of Medicine and Pharmacy Ocean University of ChinaQingdao 266003China Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology Qingdao 266003China Key Laboratory of Glycoscience&Glycotechnology of Shandong Province Qingdao 266003China Key Laboratory of Marine Drugs Ministry of Education of ChinaQingdao 266003China

A sensitive,rapid,and robust ultra-high performance liquid chromatography-tandem mass spectrometry(UHPLC-MS/MS)method was established for the first time to quantify agarotriose(A3)in rat plasma,tissues,urine,and feces.A3 and stachyose(internal standard)were separated by a BEH amide column at 65℃under the mobile phase of 10 mmol L^(-1)ammonium ace-tate-acetonitrile(42:58,v/v)with 350µ*** acquisition of transitions was carried out in multiple reaction monitoring(MRM)pattern operating with positive ionization at m/z 509.16>329.15 for A3 and m/z 689.15>527.11 for *** linearity ranges of A3 were 10 to 5000nmolL^(-1)for plasma,20 to 10000nmolL^(-1)for tissues,and 40 to 20000nmolL^(-1)for urine and *** accuracy and precision ranged from 90.9%to 111.6%and 0.7%to 10.1%,*** stability was between 86.1%and 102.5%.The extraction recovery was consistent and *** matrix effect ranged from 1.5%to 11.4%.The pharmacokinetic,tissue dis-tribution,and excretion studies were successfully conducted with the validated *** showed that A3 could be absorbed by rats,and the absolute bioavailability was 6.7%.Furthermore,it was rapidly distributed in rat tissues and mainly eliminated via feces excretion(67.0%)after oral *** intravenous bolus,85.5%was recovered,and renal excretion was the primary path-way(77.6%)for cumulative recovery.

关键词： agarotriose UHPLC-MS/MS pharmacokinetic tissue distribution excretion

Ratiometric fluorescent detection of acidic pH in lysosome with carbon nanodots

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Chinese Chemical Letters 2017年第10期28卷 1969-1974页

作者： Yangyang He Zhanxian Li Qingyan Jia Bingjie Shi Hongyan Zhang Liuhe Wei mingming yu College of Chemistry and Molecular Engineering Zhengzhou University Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences

It is significant for cell physiology to keep the homeostasis of p H, and it is highly demanded to develop ratiometric fluorescent sensors toward p H. In this work, under mild condition, through the electrostatic interaction between carbon nanodots（CDs） and organic molecules, two novel ratiometric fluorescence hybrid nanosensors were fabricated for sensing acidic p H. These nanohybrid systems possess dual emission peaks at 455 and 527 nm under a single excitation wavelength of 380 nm in acidic p H *** the increasing of p H, the fluorescence of the 1,8-naphthalimide derivative completely quenches,while the blue fluorescence of CDs keeps constant. Furthermore, the CDsàorganic molecular nanohybrids exhibit excellent anti-disturbance ability, reversible p H sensing ability, and a linear response range in wide p H range respectively. Besides the ability to target lysosome, with one of the nanosensor, stimulated p H change has been successfully tracked in a ratiometric manner via fluorescence imaging.

关键词： Acidic pH Fluorescence Carbon dot Hybrid nanosensor Lysosome-targeted

FRET-based ratiometric fluorescent detection of arginine in mitochondrion with a hybrid nanoprobe

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Chinese Chemical Letters 2020年第2期31卷 443-446页

作者： yueyue Li Yanan Ban Ruihui Wang Zheng Wang Zhanxian Li Chenjie Fang mingming yu College of Chemistry and Molecular Engineering Zhengzhou UniversityZhengzhou 450001China School of Pharmaceutical Sciences Capital Medical UniversityBeijing 100069China

A ratiometric fluorescent hybrid nanoprobe CDs-1 for arginine(Arg),exhibiting high sensitivity(the limit of detection,LOD,being 6.5×10^-8 mol/L) and excellent selectivity and anti-interference ability,was fabricated through fluorescence resonance energy transfer(FRET) and the electrostatic attraction between positively-charged hemicyanine molecules and negatively-charged carbon dots(CDs).Arg can be quantitatively detected in the concentration range from 6.0×10^-5 mol/L to 2.7×10^-4 mol/***,due to its ability to target mitochondrion and low cytotoxicity,intracellular Arg was succes s fully tracked through ratiometric fluorescence imaging.

关键词： FRET Ratiometric Arg Mitochondrion Nanoprobe Cell imaging

A lipid droplets-targetable fluorescent probe for polarity detection in cells of iron death,inflammation and fatty liver tissue

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Chinese Chemical Letters 2024年第6期35卷 365-369页

作者： Xing Tian Di Wu Wanheng Wei Guifu Dai Zhanxian Li Benhua Wang mingming yu Green Catalysis Center and College of Chemistry Zhengzhou UniversityZhengzhou 450001China School of Life Sciences Zhengzhou UniversityZhengzhou 450001China Shenzhen Research Institute of Central South University Shenzhen 518057China

Abnormal accumulation and metabolism of lipid droplets can lead to a variety of ***,a key parameter of the microenvironment,is closely associated with many diseases and dysfunctions in the *** is important to elucidate the relationship between the physiological activity of lipid droplets(LDs)and the polarity of the *** this work,based on push-pull mechanism,a fluorescent probe(E)-3-(5-(4-(diphenylamino)phenyl)thiophen-2-yl)-1-(2-hydroxyphenyl)prop-2-en-1-one(PPTH)with aggregation-induced emission(AIE)properties for the detection of polarity changes in cells was *** not only visualize intracellular polarity fluctuation of iron death and inflammation but also distinguish between normal and fatty liver tissue.

关键词： Lipid droplets AIE Polarity Ferroptosis Fatty liver