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Effects of Sulfate Chitosan Derivatives on Nonalcoholic Fatty Liver Disease

Effects of Sulfate Chitosan Derivatives on Nonalcoholic Fatty Liver Disease

作     者:YU Mingming WANG Yuanhong JIANG Tingfu LV Zhihua 

作者机构:Key Laboratory of Marine Drugs Ministry of Education Shandong Provincial Key Laboratory of Glycoscience Glycotechnolygy School of Medicine and Pharmacy Ocean University of China 

出 版 物:《Journal of Ocean University of China》 (中国海洋大学学报(英文版))

年 卷 期:2014年第13卷第3期

页      面:531-537页

核心收录:

学科分类:1002[医学-临床医学] 100201[医学-内科学(含:心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基  金:supported by the National High Technology Research and Development Program of China (863 Program 2006AA090401) 

主  题:NAFLD sulfate chitosan derivatives histological analysis hepatocyte cells rats 

摘      要:Sulfate chitosan derivatives have good solubility and therapeutic effect on the cell model of NAFLD. The aim of this study was to examine the therapeutic effect of sulfate chitosan derivatives on NAFLD. The male Wistar rats were orally fed high fat emulsion and received sulfate chitosan derivatives for 5 weeks to determine the pre-treatment effect of sulfate chitosan derivatives on NAFLD. To evaluate the therapeutic effect of sulfate chitosan derivatives on NAFLD, the rats were orally fed with high concentration emulsion for 5 weeks, followed by sulfate chitosan derivatives for 3 weeks. Histological analysis and biomedical assays showed that sulfate chitosan derivatives can dramatically prevent the development of hepatic steatosis in hepatocyte cells. In animal studies, pre-treatment and treatment with sulfate chitosan derivatives significantly protected against hepatic steatohepatitis induced by high fat diet according to histological analysis. Furthermore, increased TC, ALT, MDA, and LEP in NAFLD were significantly ameliorated by pre-treatment and treatment with sulfate chitosan derivatives. Furthermore, increased TG, AST, and TNF-α in NAFLD were significantly ameliorated by treatment with sulfate chitosan derivatives. Sulfate chitosan derivatives have good pre-treatment and therapeutic effect on NAFLD.

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