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Transport signatures of the topological surface state induced by the size effect in superconductor β-PdBi_(2)

Science China(Physics,Mechanics & Astronomy) 2023年第7期66卷 94-101页

作者： Ankang Zhu Zheng Chen Yuyan han Mengcheng Zhu Huanhuan Wang Minglong han Liang Li Xue Liu Guolin Zheng Xiangde Zhu Wenshuai Gao mingliang Tian Information Materials and Intelligent Sensing Laboratory of Anhui Province Institutes of Physical Science and Information TechnologyAnhui UniversityHefei 230601China Anhui Province Key Laboratory of Condensed Matter Physics at Extreme Conditions High Magnetic Field LaboratoryChinese Academy of SciencesHefei 230031China Key Laboratory of Materials Physics Institute of Solid State PhysicsChinese Academy of SciencesHefei 230601China School of Physics and Optoelectronics Engineering Anhui UniversityHefei 230031China

The superconductivity and nontrivial topological electronic state are key hallmarks of topological ***,we focus on the transport signals of possible topological surface state in the topological superconductor candidate β-PdBi_(2) nanoflake with a thickness of 21 *** resistance demonstrates a semiconductor-metal transition followed by an upturned behavior as the temperature decreases.A large and unsaturated longitudinal magnetoresistance(MR),accompanied by distinct Shubnikov-de Hass oscillation in Hall resistance,is *** analysis of Hall resistance reveals that the carriers present the characteristics of relativistic particles with small effective mass and extremely high *** angle-dependent quantum oscillations demonstrate a two-dimensional Fermi surface topology.A giant anisotropic MR as large as 98%is detected when rotating the magnetic *** results provide the possible transport signals of a nontrivial topological electronic state,establishing a further understanding of the topological properties of the low-dimensional topological superconductor candidate β-PdBi_(2).

关键词： magnetotransport surface state low-dimensional

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Engineered Bacillus subtilis alleviates intestinal oxidative injury through Nrf2-Keap1 pathway in enterotoxigenic Escherichia coli(ETEC) K88-infected piglet

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第6期24卷 496-509页

作者： Chaoyue WEN Hong ZhanG Qiuping GUO Yehui DUAN Sisi CHEN Mengmeng han Fengna LI mingliang JIN Yizhen WANG Institute of Feed Science Key Laboratory of Animal Feed and Nutrition of Zhejiang ProvinceKey Laboratory of Molecular Animal NutritionMinistry of EducationKey Laboratory of Animal Nutrition and Feed Science in Eastern ChinaMinistry of AgricultureCollege of Animal SciencesZhejiang UniversityHangzhou 310058China Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process CAS Key Laboratory of Agro-Ecological Processes in Subtropical RegionNational Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry ProductionInstitute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125China College of Advanced Agricultural Science University of Chinese Academy of SciencesBejing 100039China

Engineered probiotics can serve as therapeutics based on their ability of produce recombinant immune-stimulating *** this study,we built the recombinant Bacillus subtilis WB800 expressing antimicrobial peptide KR32(WB800-KR32)using genetic engineering methods and investigated its protective effects of nuclear factor-E2-related factor 2(Nrf2)-Kelch-like ECH-associated protein 1(Keap1)pathway activation in intestinal oxidative disturbance induced by enterotoxigenic Escherichia coli(ETEC)K88 in weaned ***-eight weaned piglets were randomly distributed into four treatment groups with seven replicates fed with a basal *** feed of the control group(CON)was infused with normal sterilized saline;meanwhile,the ETEC,ETEC+WB800,and ETEC+WB800-KR32 groups were orally administered normal sterilized saline,5×10^(10)CFU(CFU:colony forming units)WB800,and 5×10^(10)CFU WB800-KR32,respectively,on Days 1-14 and all infused with ETEC K881×10^(10)CFU on Days *** results showed that pretreatment with WB800-KR32 attenuated ETEC-induced intestinal disturbance,improved the mucosal activity of antioxidant enzyme(catalase(CAT),superoxide dismutase(SOD),and glutathione peroxidase(GPx))and decreased the content of malondialdehyde(MDA).More importantly,WB800-KR32 downregulated genes involved in antioxidant defense(GPx and SOD1).Interestingly,WB800-KR32 upregulated the protein expression of Nrf2 and downregulated the protein expression of Keap1 in the ***800-KR32 markedly changed the richness estimators(Ace and Chao)of gut microbiota and increased the abundance of Eubacterium_rectale_ATCC_33656 in the *** results suggested that WB800-KR32 may alleviate ETEC-induced intestinal oxidative injury through the Nrf2-Keap1 pathway,providing a new perspective for WB800-KR32 as potential therapeutics to regulate intestinal oxidative disturbance in ETEC K88 infection.

关键词： Engineered probiotics Intestine Oxidative injury Weaned piglets Nuclear factor-E2-related factor 2(Nrf2)-Kelch-like ECH-associated protein 1(Keap1)pathway

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Single-molecule imaging reveals the stoichiometry change of epidermal growth factor receptor during transactivation by β_2-adrenergic receptor

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Science China Chemistry 2017年第10期60卷 1310-1317页

作者： mingliang Zhang Kangmin He Jimin Wu Nan Li Jinghe Yuan Wei Zhou Zi Ye Zijian Li han Xiao Zhizhen Lv Youyi Zhang Xiaohong Fang Institute of Vascular Medicine of Third Hospital Ministry of Health Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides Beijing Key Laboratory of Cardiovascular Receptors and Academy for Advanced Interdisciplinary Studies Peking University Beijing National Laboratory for Molecular Sciences Key Laboratory of Molecular Nanostructures and Nanotechnology Institute of ChemistryChinese Academy of Sciences

Stimulation of G protein-coupled receptors(GPCRs) can lead to the transactivation of the epidermal growth factor receptors(EGFR). The cross-communication between the two signaling pathways regulates several important physiological or pathological processes. However, the molecule mechanism underlying EGFR transactivation remains poorly understood. Here, we aim to study the GPCR-mediated EGFR transactivation process using the single-molecule fluorescence imaging and tracking *** found that although EGFR existed as monomers at the plasma membrane of resting cells, they became dimers and thus diffused slower following the activation of β2-adrenergic receptor(β2-AR) by isoproterenol(ISO). We further proved thatβ2-AR-mediated changes of EGFR in stoichiometry and dynamics were mediated by Src kinase. Thus, the observations obtained via the single-molecule imaging and tracking methods shed new insights into the molecular mechanism of EGFR transactivation at single molecule level.

关键词： transactivation epidermal growth factor receptor(EGFR) β2-adrenergic receptor(β2-AR) single molecule imaging

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A FAST CONVERGING SPARSE RECONSTRUCTION ALGORITHM IN GHOST IMAGING

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Journal of Electronics(China) 2012年第6期29卷 617-620页

作者： Li Enrong Chen mingliang Gong Wenlin Wang Hui han Shensheng Key Laboratory for Quantum Optics and Center for Cold Atom Physics of CAS Shanghai Institute of Optics and Fine MechanicsChinese Academy of Sciences

A fast converging sparse reconstruction algorithm in ghost imaging is presented. It utilizes total variation regularization and its formulation is based on the Karush-Kuhn-Tucker (KKT) theorem in the theory of convex optimization. Tests using experimental data show that, compared with the algorithm of Gradient Projection for Sparse Reconstruction (GPSR), the proposed algorithm yields better results with less computation work.

关键词： Compressive sensing Ghost Imaging (GI) Sparse reconstruction Karush-Kuhn-Tucker (KKT) condition Gradient projection

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基于改进DEAHP法的高比例可再生能源系统脆弱性评估

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电工技术 2024年第2期 87-93页

作者：田彪韩孟祺穆明亮伊瑞鹏张琳李丽丽邹平市科技局合作交流中心山东滨州256600 山东师范大学附属中学山东济南250000 国网山东省电力公司滨州供电公司山东滨州256600 国网山东省电力公司博兴县供电公司山东滨州256600

由于可再生能源间歇性和随机性的运行特点以及不稳定的输出特性与不可控的源动力,电网接入可再生能源时在结构和运行上不可避免地会出现某些难以预料的脆弱特性。通过建立系统多场景规划模型,综合多个角度共同评估电网元件的脆弱性,提... 详细信息

由于可再生能源间歇性和随机性的运行特点以及不稳定的输出特性与不可控的源动力,电网接入可再生能源时在结构和运行上不可避免地会出现某些难以预料的脆弱特性。通过建立系统多场景规划模型,综合多个角度共同评估电网元件的脆弱性,提出了带有不确定测度的脆弱性评估方法。此方法能够有效识别电网中存在的薄弱节点和支路,可为运行分析人员和调度人员提供电网安全预警信息。

关键词：可再生能源电力系统脆弱性数据包络分析层次分析法抗干扰能力

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许氏平鲉蛋白激酶B(SsAkt)基因的克隆及其mRNA在细菌胁迫后的表达规律

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渔业科学进展 2024年第1期45卷 47-59页

作者：李兆龙王腾腾韩慧宗陈钰臻王斐张明亮孙硕解维俊姜海滨上海海洋大学水产与生命学院上海201306 山东省海洋资源与环境研究院山东烟台264006

为研究蛋白激酶B(Akt)在许氏平鲉(Sebastes schlegelii)应答细菌胁迫过程中的作用,本研究应用PCR技术对许氏平鲉Akt基因(SsAkt)的编码区序列进行了克隆和特征分析,并应用实时荧光定量PCR技术检测了健康许氏平鲉各组织和细菌胁迫后肾脏... 详细信息

为研究蛋白激酶B(Akt)在许氏平鲉(Sebastes schlegelii)应答细菌胁迫过程中的作用,本研究应用PCR技术对许氏平鲉Akt基因(SsAkt)的编码区序列进行了克隆和特征分析,并应用实时荧光定量PCR技术检测了健康许氏平鲉各组织和细菌胁迫后肾脏、血液和肝脏中SsAktm RNA的表达规律。结果显示,SsAkt的开放阅读框(ORF)的长度为1440 bp,编码479个氨基酸,预测其蛋白的相对分子质量为55.80 k Da,理论等电点(p I)为5.64。SMART分析显示,Ss Akt蛋白含有丝氨酸/苏氨酸蛋白激酶家族的3个特征性保守结构域和2个磷酸化位点。同源比对发现,Ss Akt与鱼类的同源性较高,与尖嘴鲈(Lates calcarifer)的相似度最高,为99.37%。组织表达分析显示,SsAkt在许氏平鲉健康组织(血液、鳃、肝脏、肌肉、肾脏、脾脏、肠、脑和心脏)中均有表达,在肾脏、脑和血液中的相对表达量较高。许氏平鲉响应细菌胁迫的表达结果显示,藤黄微球菌(Micrococcus luteus)感染后,SsAkt在3种组织中的表达明显上调,呈先上升后下降的趋势;鳗弧菌(Vibrio anguillarum)感染后,SsAkt在3种组织中呈现不同的表达趋势:在肾脏中,SsAkt的表达趋势为先上升后下降又上升再下降,而在血液和肝脏中的表达趋势为先上升后下降。以上研究表明,SsAkt响应了外源微生物对许氏平鲉的胁迫,在抵御外源微生物免疫应答过程中发挥重要作用。本研究结果为许氏平鲉的免疫机理研究奠定了基础。

关键词：许氏平鲉蛋白激酶B Akt 基因克隆表达规律

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Microwave induced in-situ formation of SiC nano wires on SiCNO ceramic aerogels with excellent electromagnetic wave absorption performance

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Journal of Advanced Ceramics 2021年第5期10卷 1140-1151页

作者： Keke YUAN Daoyang han Junfang LIANG Wanyu ZHAO mingliang LI Biao ZHAO Wen LIU Hongxia LU Hailong WANG Hongliang XU Gang SHAO Rui ZhanG School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China The 27th Research Institute of China Electronic Technology Group Corporation Zhengzhou 450047China Henan Key L aboratory of Aeronautical Material and Application Technology School of Materials Science and EngineeringZhengzhou University of AeronauticsZhengzhou 450046China School of Materials Science and Engineering Luoyang Institute of Science and TechnologyLuoyang 471023China

Electromagnetic absorption(EMA)materials with light weight and harsh environmental robustness are highly desired and crucially important in the stealth of high-speed ***,meeting these two requirements is always a great challenge,which excluded the most attractive lightweight candidates,such as carbon-based *** this study,SiC_(nw)-reinfbrced SiCNO(SiC_(nw)/SiCNO)composite aerogels were fabricated through the in-situ growth of SiC_(nw) in polymer-derived SiCNO ceramic aerogels by using catalyst-assisted microwave heating at ultra-low temperature and in short *** phase composition,microstructure,and EMA property of the SiC_(nw)/SiCNO composite aerogels were systematically *** results indicated that the morphology and phase composition of SiC_(nw)/SiCNO composite aerogels can be regulated easily by varying the microwave treatment *** composite aerogels show excellent EMA property with minimum reflection loss of -23.9 dB@13.8 GHz,-26.5 dB@10.9 GHz,and -20.4 dB@14.5 GHz and the corresponding effective bandwidth of 5.2 GHz,3.2 GHz,and 4.8 GHz at 2.0 mm thickness for microwave treatment at 600℃,800℃,and 1000℃,respectively,which is much better than that of SiCN ceramic *** superior EMA performance is mainly attributed to the improved impedance matching,multireflection,multi-interfacial polarization,and micro current caused by migration of hopping electrons.

关键词： polymer-derived SiCNO ceramic aerogel SiC nanowires(SiC_(nw)) microwave heating electromagnetic absorption(EMA)performance

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N-(2-Phenoxy)ethyl imidazo[1,2-a]pyridine-3-carboxamides containing various amine moieties:Design,synthesis and antitubercular activity

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Chinese Chemical Letters 2020年第2期31卷 409-412页

作者： Linhu Li Apeng Wang Bin Wang mingliang Liu Kai Lv Zeyu Tao Chao Ma Xican Ma Bing han Aoyu Wang Yu Lu Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Limin Chemical Co. Ltd.Xinyi 221422China Beijing Key Laboratory of Drug Resistance Tuberculosis Research Department of PharmacologyBeijing Tuberculosis and Thoracic Tumor Research InstituteBeijing Chest HospitalCapital Medical UniversityBeijing 100149China

Seven 2,6-disubstituted N-(2-phenoxy)ethyl imidazo[1,2-a]pyridine-3-carboxamide series containing various amine moieties were designed and synthesized as new anti-TB *** of them show excellent in vitro activity against both drug-sensitive MTB strain H37Rv and two MDR-MTB clinical isolates(MIC:<0.002-0.030 μg/mL).Compounds 2f,5e and 5g display acceptable safety and pharmacokinetic profiles,opening a new direction for further development.

关键词： N-(2-Phenoxy)ethyl imidazo[1,2-α]pyridine Design Synthesis Antimycobacterial activity

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基于抗炎效应成分指数的金银花配方颗粒质量评价研究

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中草药 2024年第8期55卷 2630-2640页

作者：贾金浩陈小菲李寒冰李伟霞王晓艳张辉张明亮汪彬韩冰纪秋如肖小河唐进法河南中医药大学药学院河南郑州450046 河南中医药大学第一附属医院药学部河南省中药临床应用、评价与转化工程研究中心河南省中药临床药学中医药重点实验室河南郑州450000 中国人民解放军总医院第五医学中心北京100039

目的以抗炎为例,建立基于效应成分指数(effect-constituents index,ECI)的金银花配方颗粒质量一致性评价方法。方法采用超高效液相色谱法测定22批次不同标准(国标/企标)的金银花配方颗粒样品中9种具有抗炎活性的单体成分(新绿原酸、绿... 详细信息

目的以抗炎为例,建立基于效应成分指数(effect-constituents index,ECI)的金银花配方颗粒质量一致性评价方法。方法采用超高效液相色谱法测定22批次不同标准(国标/企标)的金银花配方颗粒样品中9种具有抗炎活性的单体成分(新绿原酸、绿原酸、隐绿原酸、断马钱子酸、断氧化马钱子苷、木犀草苷、异绿原酸B、异绿原酸A、异绿原酸C)含量,采用环氧合酶-2(cyclooxygenase-2,COX-2)试剂盒测定上述样品的抗炎效价和相关单体成分的半数抑制浓度(half inhibitory concentration,IC_(50)),进而整合分析获取上述各个成分的抗炎效价权重系数,通过权重系数和效价整合计算得到ECI,最后通过细胞实验验证所构建的ECI的可行性。结果抗炎成分含量测定结果显示,9种单体成分含量存在较大的差异,其中国标批次(S1~S11)和企标批次(S12~S22)在单体成分的含量高低也存在显著差异,如国标批次(S8)中绿原酸的含量是企标批次(S16)中该成分含量的3.3倍(43.06 vs 12.98 mg/g)。国标(S1~S11)样品的整体稳定性与企标(S12~S22)样品相差不大(RSD_(国标)=211.55,RSD_(企标)=215.71)。生物效价测定方法通过了方法学考察,结果显示国标样品的抗炎效价和稳定性比企标更好(效价_(国标)=100.28~106.35 U/m L,效价_(企标)=88.06~95.49 U/m L;RSD_(国标)=1.98,RSD_(企标)=2.56)。ECI理论计算结果显示该方法结果与实验结果一致,能够反映金银花配方颗粒样品的药效关系(ECI_(国标)=10.82~14.11,ECI_(企标)=9.32~12.58;RSD_(国标)=9.51,RSD_(企标)=10.02)。相关性分析显示单一指标性成分的含量与抗炎效价之间正相关性较好的是绿原酸(r=0.644),其次是木犀草苷(r=0.581),说明这2个成分在抗炎活性中起主要作用。结论以抗炎为例,建立基于效应成分指数的金银花配方颗粒质量评价方法。可应用于多批次不同标准(国标/企标)的金银花配方颗粒的质量一致性评价,为其他具有类似抗炎作用的中药配方颗粒的质量评价研究及应用提供科学参考。

关键词：质量评价效应成分指数抗炎金银花配方颗粒新绿原酸绿原酸隐绿原酸断马钱子酸断氧化马钱子苷木犀草苷异绿原酸B 异绿原酸A 异绿原酸C

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Non-Monotonic Evolution of Carrier Density and Mobility under Thermal Cycling Treatments in Dirac Semimetal Cd_(3)As_(2) Microbelts

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Chinese Physics Letters 2021年第4期38卷 91-95页

作者： Zheng Chen Min Wu Yequn Liu Wenshuai Gao Yuyan han Jianhui Zhou Wei Ning mingliang Tian Anhui Province Key Laboratory of Condensed Matter Physics at Extreme Conditions High Magnetic Field LaboratoryChinese Academy of SciencesHefei 230031China Department of Physics University of Science and Technology of ChinaHefei 230026China Analytical Instrumentation Center State Key Laboratory of Coal ConversionInstitute of Coal ChemistryChinese Academy of SciencesTaiyuan 030001China Department of Physics School of Physics and Materials ScienceAnhui UniversityHefei 230601China

Tunable carrier density plays a key role in the investigation of novel transport properties in three-dimensional topological *** demonstrate that the carrier density,as well as the mobility,of Dirac semimetal Cd_(3)As_(2) nanoplates can be effectively tuned via in situ thermal treatment at 350 K for one hour,resulting in non-monotonic evolution by virtue of the thermal cycling *** upward shift of Fermi level relative to the Dirac nodes blurs the surface Fermi-arc states,accompanied by an anomalous phase shift in the oscillations of bulk states,due to a change in the topology of the ***,the oscillation peaks of bulk longitudinal magnetoresistivity shift at high fields,due to their coupling to the oscillations of the surface Fermi-arc *** work provides a thermal control mechanism for the manipulation of quantum states in Dirac semimetal Cd_(3)As_(2) at high temperatures,via their carrier density.

关键词： density. Dirac Fermi

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