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Impacts of Nutlin-3a and exercise on murine double minute 2-enriched glioma treatment

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Neural Regeneration Research 2025年第4期20卷 1135-1152页

作者： Yisheng Chen Zhongcheng Fan Zhiwen Luo Xueran Kang Renwen Wan Fangqi Li Weiwei Lin Zhihua Han Beijie Qi Jinrong Lin Yaying Sun Jiebin huang Yuzhen Xu Shiyi Chen Department of Sport Medicine Huashan HospitalFudan UniversityShanghaiChina Department of Orthopedic Surgery Hainan Province Clinical Medical CenterHaikou Affiliated Hospital of Central South University Xiangya School of MedicineHaikouHainan ProvinceChina Department of Basic Medicine Shanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Neurosurgery Second Affiliated Hospital of Zhejiang University School of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina Department of Orthopedics Shanghai General HospitalSchool of Medicine Shanghai Jiao Tong UniversityShanghaiChina Department of Infectious Diseases Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghaiChina Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina

Recent research has demonstrated the impact of physical activity on the prognosis of glioma patients,with evidence suggesting exercise may reduce mortality risks and aid neural *** role of the small ubiquitin-like modifier(SUMO)protein,especially post-exercise,in cancer progression,is gaining attention,as are the potential anti-cancer effects of *** used machine learning to create the exercise and SUMO-related gene signature(ESLRS).This signature shows how physical activity might help improve the outlook for low-grade glioma and other *** demonstrated the prognostic and immunotherapeutic significance of ESLRS markers,specifically highlighting how murine double minute 2(MDM2),a component of the ESLRS,can be targeted by *** underscores the intricate relationship between natural compounds such as nutlin-3 and immune *** comprehensive CRISPR screening,we validated the effects of specific ESLRS genes on low-grade glioma *** also revealed insights into the effectiveness of Nutlin-3a as a potent MDM2 inhibitor through molecular docking and dynamic ***-3a inhibited glioma cell proliferation and activated the p53 *** efficacy decreased with MDM2 overexpression,and this was reversed by Nutlin-3a or *** using a low-grade glioma mouse model highlighted the effect of physical activity on oxidative stress and molecular pathway ***,both physical exercise and Nutlin-3a administration improved physical function in mice bearing tumors derived from MDM2-overexpressing *** results suggest the potential for Nutlin-3a,an MDM2 inhibitor,with physical exercise as a therapeutic approach for glioma *** research also supports the use of natural products for therapy and sheds light on the interaction of exercise,natural products,and immune regulation in cancer treatment.

关键词： exercise and SUMO-related gene signatures(ESLRS) glioblastoma management low-grade glioma natural bioactives neural regeneration physical exercise

统筹发展和安全中的“民参军”——二战后大国技术发展模式及其启示

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国际安全研究 2025年第1期43卷 4-29,155页

作者：黄琪轩李文见上海交通大学国际与公共事务学院上海200030 上海市创新政策评估研究中心上海交通大学政治经济研究院

促进发展和维护安全是世界各国追求的两项重要目标,而技术的军民融合则是连接发展和安全的重要纽带。二战后,苏联、日本与美国的军民融合实践,分别代表了“旋转耗散”“旋转上升”“旋转下降”以及“旋转环绕”四种大国技术发展模式。... 详细信息

促进发展和维护安全是世界各国追求的两项重要目标,而技术的军民融合则是连接发展和安全的重要纽带。二战后,苏联、日本与美国的军民融合实践,分别代表了“旋转耗散”“旋转上升”“旋转下降”以及“旋转环绕”四种大国技术发展模式。这四种模式的不同成效表明,要成功地实现军民技术融合,统筹发展和安全,关键在于“民参军”。“民参军”为军用技术提供了负反馈的制约、互补能力的积累以及持续的资金来源。苏联的困境在于缺乏“民参军”,大量军用技术难以外溢到民用部门,最终导致军用部门也缺乏持续的资金支持。日本的经验是技术从民用部门扩散到军用部门,民用部门推动了军民两用技术的发展。20世纪80年代前的美国,服务安全的军用技术逐步外溢到服务发展的民用部门;在此之后,军用技术与民用技术相互渗透,交叉影响。二战后大国技术的发展模式及军民技术融合的成败为中国推动军民融合、统筹发展和安全提供了重要借鉴。

关键词：统筹发展和安全技术发展模式军民融合民参军

A novel flexible nerve guidance conduit promotes nerve regeneration while providing excellent mechanical properties

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Neural Regeneration Research 2025年第7期20卷 2084-2094页

作者： Tong Li Quhan Cheng Jingai Zhang Boxin Liu Yu Shi Haoxue Wang Lijie huang Su Zhang Ruixin Zhang Song Wang Guangxu Lu Peifu Tang Zhongyang Liu Kai Wang Department of Orthopedics the Fourth Medical Center of Chinese PLA General HospitalBeijingChina Department of Training and Sports Medicine Characteristic Medical Center of Chinese People’s Armed Police ForceTianjinChina Medical School of Chinese PLA BeijingChina Key Laboratory of Bioactive Materials for the Ministry of Education College of Life SciencesNankai UniversityTianjinChina Department of Orthopedics Tianjin HospitalTianjinChina Department of Rehabilitation Medicine Er Quan Hospital of PAPWuxiJiangsu ProvinceChina

Autografting is the gold standard for surgical repair of nerve defects>5 mm in length;however,autografting is associated with potential complications at the nerve donor *** an alternative,nerve guidance conduits may be *** ideal conduit should be flexible,resistant to kinks and lumen collapse,and provide physical cues to guide nerve *** designed a novel flexible conduit using electrospinning technology to create fibers on the innermost surface of the nerve guidance conduit and employed melt spinning to align ***,we prepared disordered electrospun fibers outside the aligned fibers and helical melt-spun fibers on the outer wall of the electrospun fiber *** presence of aligned fibers on the inner surface can promote the extension of nerve cells along the *** helical melt-spun fibers on the outer surface can enhance resistance to kinking and compression and provide *** novel conduit promoted nerve regeneration and functional recovery in a rat sciatic nerve defect model,suggesting that it has potential for clinical use in human nerve injuries.

关键词： aligned fibers anti-kinking helical fibers nerve guidance conduit nerve regeneration peripheral nerve injury topological guidance

生物医学领域碳纳米材料10年研究前沿与热点

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中国组织工程研究 2025年第4期29卷 752-760页

作者：党小雯黄海量黄雷王亚洁山东中医药大学康复医学院山东省济南市250355

背景:生物医学领域碳纳米材料的研究蓬勃发展,相关科研成果逐年增加,但此领域的年发文量、国家、机构、作者的研究情况及研究热点与趋势等内容的可视化分析相对匮乏。目的:展现生物医学领域碳纳米材料研究现状,揭示主要的研究主体,探索... 详细信息

背景:生物医学领域碳纳米材料的研究蓬勃发展,相关科研成果逐年增加,但此领域的年发文量、国家、机构、作者的研究情况及研究热点与趋势等内容的可视化分析相对匮乏。目的:展现生物医学领域碳纳米材料研究现状,揭示主要的研究主体,探索研究热点及发展趋势,为此领域未来发展提供参考。方法:以Web of Science核心集数据库为文献来源,检索2012-2023年生物医学领域碳纳米材料的相关文献,运用Citespace软件以国家、机构、作者、关键词、共被引为节点生成知识图谱并进行可视化分析。结果与结论:①共纳入2932篇文献,碳纳米材料在医学领域年发文量多且增长速度较快;美国发文量较多;中国是该领域的新兴力量,发文量虽然最多,但研究水平和影响力还有待提高;中国科学院是最大的合作网络机构,主要以国内机构为合作对象,缺少与国外知名单位的合作。②关键词分析显示,碳点的绿色合成方式及应用是近年来的研究热点;其次碳纳米材料与癌症光疗、免疫疗法相结合的新方法是未来研究中的重点方向。③共被引动态发展趋势提示,组织工程是生物医学领域碳纳米材料的热点研究主题,主要包括碳纳米材料对于心脏和神经组织修复和再生的研究以及作为3D和4D生物打印的生物墨水添加剂。④未来随着生物医学领域朝着以治疗为中心的精准方向发展,科研人员应加快创建科学有效的碳纳米材料与科技、新型聚合物或有机分子及新治疗方法等结合形成的碳基体系,发挥碳纳米材料的最大效应。

关键词：碳纳米材料生物医学可视化共被引文献计量学生物安全性研究热点癌症组织工程 Citespace

“一带一路”倡议对中国沿线城市旅游经济发展的影响效应 ——基于双重差分模型的实证分析

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华东经济管理 2025年第1期39卷 31-40页

作者：高亚佳黄裕洪浙江省“八八战略”创新发展研究院浙江杭州310012 中共新昌县委党校科研室浙江新昌312500 华南师范大学经济与管理学院广东广州510006

拓展和深化旅游合作是共建“一带一路”的重要内容。文章基于2009—2020年中国271个地级市的面板数据,构建双重差分模型实证考察“一带一路”倡议对沿线城市旅游经济发展的影响及潜在机制。研究发现,“一带一路”倡议对沿线城市旅游经... 详细信息

拓展和深化旅游合作是共建“一带一路”的重要内容。文章基于2009—2020年中国271个地级市的面板数据,构建双重差分模型实证考察“一带一路”倡议对沿线城市旅游经济发展的影响及潜在机制。研究发现,“一带一路”倡议对沿线城市旅游经济发挥显著的促进效应,这一影响效应在东部城市、大城市及历史文化名城中更为突出;机制分析表明,“一带一路”倡议通过完善数字信息基础设施、推动技术创新、优化产业结构和提高服务供给水平等渠道推动城市旅游经济发展。研究结论可以为中国通过共建“一带一路”倡议促进旅游高质量发展提供理论依据和政策启示。

关键词： “一带一路”倡议旅游经济高质量发展区域经济双重差分模型

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磁性纳米材料与磁场效应加速骨损伤修复

中国组织工程研究 2025年第4期29卷 827-838页

作者：肖放黄雷王琳华中科技大学同济医学院附属协和医院组织工程与再生医学研究中心湖北省武汉市430022 华中科技大学同济医学院附属协和医院检验科湖北省武汉市430022

背景:磁性纳米材料具有促进干细胞成骨分化和抑制破骨细胞形成等生物活性,并在磁场协同下有效促进损伤骨组织愈合,在骨损伤修复中具有广阔的应用前景。目的:综述磁性纳米材料与磁场促进骨修复的作用机制,及其在骨损伤修复领域的研究进... 详细信息

背景:磁性纳米材料具有促进干细胞成骨分化和抑制破骨细胞形成等生物活性,并在磁场协同下有效促进损伤骨组织愈合,在骨损伤修复中具有广阔的应用前景。目的:综述磁性纳米材料与磁场促进骨修复的作用机制,及其在骨损伤修复领域的研究进展。方法:在PubMed和Web of Science数据库中进行相关文献检索,检索词为“magnetic nanomaterials,magnetic field,bone repair,bone tissue engineering,stem cell,osteoblast,osteoclast”。检索文献时限为2003-2023年,将其进行筛选和分析,最终纳入98篇文献进行分析。结果与结论:①磁性纳米材料具有促成骨细胞分化、抑制破骨细胞形成和调节免疫微环境等生物效应;此外,磁性纳米材料可调节组织工程支架的机械性能和表面形貌等理化性质,并赋予其磁性,有利于调控干细胞的黏附、增殖与成骨分化。②磁场具有调控细胞内多条信号通路发挥促成骨细胞分化、抑制破骨细胞形成和刺激血管生成等生物学效应,从而加速损伤的骨组织愈合。③磁性纳米材料与磁场的联合应用,通过激活机械转导、增加细胞内磁性纳米粒子含量、增强微磁场效应等加速骨损伤修复,为骨组织工程的研究提供了新的思路。④磁场在临床骨折、骨质疏松症和骨关节炎疾病的治疗中展现出确切疗效,促进骨组织生长、减轻骨质流失和缓解疼痛,改善患者的生活质量。⑤磁性纳米材料与磁场在骨损伤修复与再生中应用潜力大,但磁性纳米材料、磁场和细胞之间的相互作用机制尚未完全阐明,而且磁场调控细胞内分子事件的关键参数,包括磁场类型、强度、频率、作用时间和作用方式等,以及特定磁场对骨细胞的精确生物效应和潜在机制仍有待明确。⑥未来需要进一步关注其对损伤组织微环境中的破骨细胞、神经、血管和免疫细胞的影响,而关于磁性材料用于人体安全性问题,有待系统性研究其分布、代谢以及急性和慢性毒性等。

关键词：磁性纳米材料磁场骨修复骨组织工程干细胞成骨细胞破骨细胞

Cerebral fat embolism following autologous fat injection in facial reconstruction:A case report

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World Journal of Clinical Cases 2025年第2期13卷 50-58页

作者： Xiu-Ying Chen Fa Shen Chang Cheng Yu-Han Wang Wen-Chao Cheng De-Zhi Yuan Wen huang Department of Neurology Chongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400000China Department of Neurology Xinqiao HospitalThe Army Medical University(Third Military Medical University)Chongqing 400000China

BACKGROUND Autologous fat injection in facial reconstruction is a common cosmetic *** cerebral fat embolism(CFE)as a complication is rare,it carries serious health *** SUMMARY We present a case of a 29-year-old female patient who developed acute CFE following facial fat filling *** the surgery,the patient experienced symptoms including headache,nausea,vomiting,and difficulty breathing,which was followed by neurological symptoms such as slurred speech and left-sided *** physical examination and auxiliary investigations,including blood tests,head and neck computed tomography angiography,and cranial magnetic resonance diffusion-weighted imaging,were performed upon *** clinical diagnosis was acute cerebral embolism following facial fat filling *** included measures to improve cerebral circulation,dehydration for intracranial pressure reduction,nutritional support,and rehabilitation therapy for left limb *** patient showed a significant improvement in symptoms after 2 weeks of *** recovered left limb muscle strength to grade 5,had clear speech,and experienced complete relief of *** Our case highlights the potential occurrence of severe complications in patients undergoing fat injection in facial *** prevent these complications,plastic surgeons should enhance their professional knowledge and skills.

关键词： Cerebral fat embolism Mechanical thrombectomy Thrombolysis Steroid therapy Symptomatic treatment Case report

锯齿形氮化铝纳米带负阻器件电子输运性质研究

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原子与分子物理学报 2025年第2期42卷 85-90页

作者：黄绛雪黄启俊何进王豪常胜武汉大学物理科学与技术学院武汉430072

低维纳米带材料因为其结构的特异性而呈现出新奇的物理性质.修饰纳米带的边缘能够调制其电子性质.本文运用基于密度泛函理论(DFT)的第一性原理计算方法,探究了锯齿形氮化铝纳米带(ZAlNNR)单边氟化、单边氯化以及单边氢化的电子结构和输... 详细信息

低维纳米带材料因为其结构的特异性而呈现出新奇的物理性质.修饰纳米带的边缘能够调制其电子性质.本文运用基于密度泛函理论(DFT)的第一性原理计算方法,探究了锯齿形氮化铝纳米带(ZAlNNR)单边氟化、单边氯化以及单边氢化的电子结构和输运特性.研究表明:锯齿型氮化铝纳米带可以通过以上手段实现能带结构的半导体-金属转换.计算电子输运特性,我们发现三种边缘修饰的器件均呈现出负微分电阻效应,其中AlN-F器件有最大峰谷电流比(PVCR),达到了1.78×10^(7),是硅烯纳米器件以及黑磷纳米器件的10^(6)倍.值得一提的是,相比于H-AlN-Cove纳米器件,AlN-F器件能够在更小的偏压范围内实现高PVCR.该结果为锯齿形氮化铝纳米带在低功耗纳米器件中的应用提供了广泛的前景.

关键词：锯齿形氮化铝纳米带电子输运负微分电阻效应第一性原理

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The Hilbert expansion of the Boltzmann equation in the incompressible Euler level in a channel

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Science China Mathematics 2025年第1期 39-88页

作者： Feimin huang Weiqiang Wang Yong Wang Feng Xiao Academy of Mathematics and Systems Science Chinese Academy of Sciences School of Mathematical Sciences University of Chinese Academy of Sciences Key Laboratory of Computing and Stochastic Mathematics (Ministry of Education) School of Mathematics and StatisticsHunan Normal University

The study of the hydrodynamic limit of the Boltzmann equation with physical boundary is a challenging problem due to the appearance of the viscous and Knudsen boundary *** this paper,the hydrodynamic limit from the Boltzmann equation with the specular reflection boundary condition to the incompressible Euler equations in a channel is *** on the multi-scaled Hilbert expansion,the equations with boundary conditions and compatibility conditions for interior solutions,and viscous and Knudsen boundary layers are derived under different scaling,***,some uniform estimates for the interior solutions,and viscous and Knudsen boundary layers are *** the help of the L2-L∞framework and the uniform estimates obtained above,the solutions to the Boltzmann equation are constructed by the truncated Hilbert expansion with multiscales,and hence the hydrodynamic limit in the incompressible Euler level is justified.

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