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3D digital-image correlation insight into generalized relaxation behavior of sandstone under stress and pore pressure coupling

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2516-2536页

作者： Cancan Chen Heping Xie Jiang Xu Seisuke Okubo Shoujian Peng Cunbao li minghui li State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering Shenzhen UniversityShenzhen518060China Guangdong Provincial Key Laboratory of Deep Earth Sciences and Geothermal Energy Exploitation and Utilization Institute of Deep Earth Sciences and GreenEnergyCollege of Civil and Transportation EngineeringShenzhen UniversityShenzhen518060China State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing400044China

The occurrence of geological hazards and the instability of geotechnical engineering structures are closely related to the time-dependent behavior of ***,the idealization boundary condition for constant stress in creep or constant strain in relaxation is not usually attained in natural geological ***,generalized relaxation tests that explore the simultaneous changes of stress and strain with time under different stress levels with constant pore-water pressure are conducted in this *** results show that in area Ⅰ,area Ⅱ,and area Ⅲ,the stress and strain both change synchronously with time and show similar evolutionary laws as the strain-time curve for creep or the stress-time curve for *** the applied stress level surpasses the δ_(ci) or δ_(cd) threshold,the variations in stress and strain and their respective rates of change exhibit a significant *** radial deformation and its rate of change exhibit greater sensitivity in response to stress *** apparent strain deforms homogeneously at the primary stage,and subsequently,gradually localizes due to the microcrack development at the secondary ***,interconnection of the microcracks causes the formation of a shear-localization zone at the tertiary *** strain-time responses inside and outside the localization zone are characterized by local strain accumulation and inelastic unloading during the secondary and tertiary stages,*** width of the shear-localization zone is found to range from 4.43 mm to 7.08 mm and increased with a longer *** electron microscopy(SEM)reveals a dominant coalescence of intergranular cracks on the fracture surface,and the degree of physiochemical deterioration caused by water-rock interaction is more severe under a longer *** brittle sandstone’s time-dependent deformation is essentially controlled by microcrack development during generalized relaxation,and its expectancy-life is dete

关键词： Generalized relaxation Stress level Direction coefficient Major-strain field Microcrack damage Stress threshold

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Human brain organoid:trends,evolution,and remaining challenges

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Neural Regeneration Research 2024年第11期19卷 2387-2399页

作者： minghui li Yuhan Yuan Zongkun Hou Shilei Hao liang Jin Bochu Wang Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqingChina Southwest Hospital/Southwest Eye Hospital Third Military Medical University(Army Medical University)ChongqingChina School of Biology and Engineering/School of Basic Medical Sciences Guizhou Medical UniversityGuiyangGuizhou ProvinceChina

Advanced brain organoids provide promising platforms for deciphering the cellular and molecular processes of human neural development and *** various studies and reviews have described developments and advancements in brain organoids,few studies have comprehensively summarized and analyzed the global trends in this area of *** identify and further facilitate the development of cerebral organoids,we utilized bibliometrics and visualization methods to analyze the global trends and evolution of brain organoids in the last 10 ***,annual publications,countries/regions,organizations,journals,authors,co-citations,and keywords relating to brain organoids were *** hotspots in this field were also systematically ***,current applications for brain organoids in neuroscience,including human neural development,neural disorders,infectious diseases,regenerative medicine,drug discovery,and toxicity assessment studies,are comprehensively *** that end,several considerations regarding the current challenges in brain organoid research and future strategies to advance neuroscience will be presented to further promote their application in neurological research.

关键词： bibliometric analysis brain organoids cerebral organoids global trends neuroscience

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Screening of Streptomyces strains helping arbuscular mycorrhizal symbiosis against pepper(Capsicum annuum L.)Phytophthora blight

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Pedosphere 2024年第2期34卷 438-446页

作者： Xin WANG Yifan liU Baiping HE minghui li Xiangui liN Fuyong WU Junli HU State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China Key Laboratory of Plant Nutrition and the Agri-environment in Northwest China Ministry of Agriculture and Rural AffairsCollege of Natural Resources and EnvironmentNorthwest A&F UniversityYangling 712100China University of Chinese Academy of Sciences Beijing 100049China

Mycorrhiza helper bacteria(MHB)can promote the formation and functioning of arbuscular mycorrhizal(AM)symbiosis,but their role and application potential in coping with soil-borne diseases are still unclear.A 14-week greenhouse pot experiment was conducted to obtain several actinomycete strains helping AM symbiosis in suppressing the Phytophthora blight of pepper(Capsicum annuum L.),using a soil inoculated with Phytophthora capsici after *** Streptomyces strains,including ***,***,***,***,and ***,as well as the AM fungus(Funneliformis caledonium)were *** Phytophthora blight severity reached 66%at full productive stage in the uninoculated control,and inoculation of ***,***,and *** alone significantly decreased(Plight *** to the feature of enhancing disease-suppression by AM symbiosis,both *** and *** were confirmed as MHB strains ***,*** had a stronger performance in directly accelerating mycorrhization,while *** was also an antagonist to the pathogenic ***,*** with the independent disease-suppression function was not an MHB strain *** redundancy analyses demonstrated that when AM fungus was present,root mycorrhizal colonization replaced soil pH becoming the main factor affecting pepper Phytophthora ***,*** and *** seemed to have the value of preparation and application in the future to help AM symbiosis against pepper Phytophthora blight.

关键词： actinomycete strain blight severity Funneliformis caledonium mycorrhiza helper bacteria Phytophthora capsici root mycorrhizal colonization soil-bornedisease

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Resolving controversies surrounding carbon sinks from carbonate weathering

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Science China Earth Sciences 2024年第9期67卷 2705-2717页

作者： Xiaoyong BAI Sirui ZHANG Pete SMITH Chaojun li lian XIONG Chaochao DU Yingying XUE Zilin li Mingkang LONG minghui li Xiaoyun ZHANG Shu YANG Qing LUO Xiaoqian SHEN State Key Laboratory of Environmental Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China University of Chinese Academy of Sciences Beijing 100049China Institute of Biological and Environmental Sciences University of AberdeenAberdeen AB243UUUK College of Resources and Environmental Engineering Guizhou UniversityGuiyang 550025China School of Geography and Environmental Sciences Guizhou Normal UniversityGuiyang 550025China CAS Center for Excellence in Quaternary Science and Global Change Xi’an 710061China

The importance of carbonate weathering carbon sinks(CCSs)is almost equal to that of vegetation photosynthesis in the global carbon ***,CCSs have become controversial in formulating carbon neutral policies to deal with global climate problems in various countries,since the carbonate dissolution is *** order to address these controversies,we reviewed recent advances in understanding CCSs and examined the outstanding controversies surrounding *** have analyzed the five controversies,revealing the existence of CCSs,quantifying their magnitude,clarifying their spatiotemporal pattern,and documenting how they have increased and how they evolved under the background of global *** addressing these five controversies,we help to bring clarity to the role of CCSs in the carbon cycle of global terrestrial ecosystems.

关键词： Carbon sink Carbonate weathering Carbon cycle Climate change Anthropogenic driver

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An Efficient Multifunctional Soluble Catalyst for li-O_(2) Batteries

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CCS Chemistry 2024年第7期6卷 1810-1820页

作者： Shuochao Xing Zhengcai Zhang Yaying Dou minghui li Jing Wu Zhang Zhang Zhen Zhou Interdisciplinary Research Center for Sustainable Energy Science and Engineering(IRC4SE2) School of Chemical EngineeringZhengzhou UniversityZhengzhou 450001 Key Laboratory of Advanced Energy Materials Chemistry Ministry of EducationCollege of ChemistryNankai UniversityTianjin 300071

Aprotic lithium-oxygen(li-O_(2))batteries have a high theoretical energy density,but they face challenges such as cathode blockage,high charge overpotential,and poor cycling *** are caused by sluggish reaction kinetics and severe parasitic *** the performance of li-O_(2) batteries necessitates the development of efficient *** catalysts not only augment both the oxygen reduction reaction(ORR)and the oxygen evolution reaction(OER)but also inhibit undesirable parasitic *** this work,we demonstrated for the first time a multifunctional soluble catalyst of iridium(III)acetylacetonate(Ir(acac)_(3))that could speed up oxygen ***(acac)_(3) regulated the ORR pathway and the reactivity of superoxide radical species by forming a reversible intermediate complex(Ir(acac)_(3)-O_(2)^(−)).During charging,Ir(acac)_(3) acted as a redox mediator and aided in li_(2)O_(2) decomposition by reacting with superoxide ***,as demonstrated by operando UV-visible spectroscopy,the lower charge potential significantly reduced the generation of highly reactive singlet oxygen(^(1)O_(2))*** a result,the Ir(acac)_(3)-mediated li-O_(2) battery showed low overpotential,large capacity,and stable *** study offers a new approach to achieving efficient li-O_(2) batteries and provides an opportunity to suppress parasitic reactions.

关键词： li-O_(2)battery soluble catalyst superoxide species organometallics singlet oxygen

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Boosting synergism of chemo- and immunotherapies via switching paclitaxel-induced apoptosis to mevalonate metabolism-triggered ferroptosis by bisphosphonate coordination lipid nanogranules

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Acta Pharmaceutica Sinica B 2024年第2期14卷 836-853页

作者： Ge Song minghui li Shumin Fan Mengmeng Qin Bin Shao Wenbing Dai Hua Zhang Xueqing Wang Bing He Qiang Zhang Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems School of Pharmaceutical SciencesPeking UniversityBeijing 100191China State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Department of Medical Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer HospitalBeijing 100142China

Conventional chemotherapy based on cytotoxic drugs is facing tough challenges recently following the advances of monoclonal antibodies and molecularly targeted *** is critical to inspire new potential to remodel the value of this classical therapeutic ***,we fabricate bisphosphonate coordination lipid nanogranules(BC-LNPs)and load paclitaxel(PTX)to boost the chemo-and immuno-therapeutic synergism of cytotoxic *** in BC-LNPs@PTX,a bisphosphonate to block mevalonate metabolism,works as both the structure and drug constituent in nanogranules,where alendronate coordinated with calcium ions to form the particle *** synergy of alendronate enhances the efficacy of paclitaxel,suppresses tumor metastasis,and alters the cytotoxic *** from the paclitaxel-induced apoptosis,the involvement of alendronate inhibits the mevalonate metabolism,changes the mitochondrial morphology,disturbs the redox homeostasis,and causes theaccumulation of mitochondrial ROS and lethal lipid peroxides(LPO).These factors finally trigger the ferroptosis of tumor cells,an immunogenic cell death mode,which remodels the suppressive tumor immune microenvironment and synergizes with ***,by switching paclitaxel-induced apoptosis to mevalonate metabolism-triggered ferroptosis,BC-LNPs@PTX provides new insight into the development of cytotoxic drugs and highlights the potential of metabolism regulation in cancer therapy.

关键词： Bisphosphonate coordinationlipid nanogranules Ferroptosis Mevalonatemetabolism Mitochondrial metabolism Nano-systematic biology

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Storage, form, and influencing factors of karst inorganic carbon in a carbonate area in China

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Science China Earth Sciences 2024年第3期67卷 725-739页

作者： Chaochao DU Xiaoyong BAI Yangbing li Qiu TAN Cuiwei ZHAO Guangjie LUO Luhua WU Fei CHEN Chaojun li Chen RAN Sirui ZHANG lian XIONG Fengjiao SONG Biqin XIAO Zilin li Yingying XUE Mingkang LONG Qing LUO Xiaoyun ZHANG minghui li Xiaoqian SHEN Shu YANG State Key Laboratory of Environmental Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China School of Geography and Environmental Sciences Guizhou Normal UniversityGuiyang 550001China CAS Center for Excellence in Quaternary Science and Global Change Xi'an 710061China Guizhou Provincial Key Laboratory of Geographic State Monitoring of Watershed Guizhou Normal CollegeGuiyang 550018China College of Resources and Environmental Engineering Guizhou UniversityGuiyang 550025China

Carbonate rock chemical weathering carbon sinks reduce the rate of increase of the atmospheric CO_(2) concentration and global warming. However, uncertainty still exists in the estimation results of carbonate rock chemical weathering carbon sink fluxes(CCSF), and the contributions of climate change and ecological restoration to the CCSF are not clear. To this end, we compiled published site data on ion concentrations in different watersheds in China and used a classical thermodynamic dissolution model to reassess the potential and spatial and temporal patterns of the CCSF in China from 1991 to 2020. We quantified the contributions of temperature(MAT), precipitation(MAP), evapotranspiration(ET), soil water(SM), and the normalized difference vegetation index(NDVI) to the CCSF. The results revealed that(1) China's CCSF was 22.76 t CO_(2)km^(-2)yr^(-1), which was higher than the global average(15.77 t CO_(2)km^(-2)yr^(-1)). The total carbonate rock chemical weathering carbon sink(CCS) was 4772.67×10^(4)t CO_(2), contributing 14.91% of the global CCS through a carbonate rock area of 252.98×10^(4)km^(-2).(2) China's CCSF decreased gradually from southeast to northwest, with values of 33.14, 12.93, and7.27 t CO_(2)km^(-2)yr^(-1)in the southern karst, Qinghai-Tibetan karst, and northern karst regions, respectively.(3) The overall CCSF in China exhibited an increasing trend from 1991 to 2020, with a rate of increase of 0.16 t CO_(2)km^(-2)yr^(-1).(4) The contributions of the MAP, MAT, ET, SM, and NDVI to the CCSF were 63.3%, 3.02%, 27.5%, 3.1%, and 3.05%, respectively. Among them, the increase in precipitation was the main contributor to the increase in the CCSF in China over the last 30 years, while the enhancement of ET offset part of the positive contribution of the increase in precipitation to the CCSF. In conclusion, the results of this study provide a systematic quantification of the magnitude, the patterns, and the influencing factors of CCS over a long time series in

关键词： Carbonate rocks Carbon sinks Patterns Influencing factors Thermodynamic dissolution modeling

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陕北黄土区深剖面不同土地利用方式下土壤水分和温度的分布特征

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应用生态学报 2024年第9期35卷 2552-2560页

作者：李明辉李秧秧樊军中国科学院水利部水土保持研究所黄土高原土壤侵蚀与旱地农业国家重点实验室陕西杨凌712100 中国科学院大学北京100049 西北农林科技大学黄土高原土壤侵蚀与旱地农业国家重点实验室陕西杨凌712100

研究不同土地利用方式对深剖面土壤水分和温度时空动态的影响,揭示不同植被覆盖对区域水热资源的调控效应,可为优化土地管理和植被恢复提供理论依据。本研究以黄土高原北部六道沟流域不同土地利用方式为研究对象,于2022年对0~1000 cm土... 详细信息

研究不同土地利用方式对深剖面土壤水分和温度时空动态的影响,揭示不同植被覆盖对区域水热资源的调控效应,可为优化土地管理和植被恢复提供理论依据。本研究以黄土高原北部六道沟流域不同土地利用方式为研究对象,于2022年对0~1000 cm土层土壤含水量和温度进行动态监测,分析4种土地利用方式下(林地、草地、农地和荒草地)土壤水分和温度的时间变化规律和垂直剖面分布特征。结果表明:研究区不同土地利用方式之间的土壤水分和温度分布特征差异显著。2022年生长季(4—10月),4种土地利用方式0~1000 cm土层土壤总储水量由高到低依次为:大豆农地(1393 mm)、荒草地(1374 mm)、柠条林地(1218 mm)和苜蓿草地(557 mm)。柠条林地和大豆农地在0~300 cm、荒草地在0~500 cm、苜蓿草地在0~200 cm土壤水分变化较大,深层土壤水分均变化较小。土地利用方式对土壤温度的影响主要表现在0~200cm土层,最深可达300 cm。2022年4种土地利用方式的降水入渗补充深度在200 cm之内。柠条林地和苜蓿草地的土壤水分消耗深度均为200 cm,大豆农地和荒草地的土壤水分消耗深度为100 cm。植被变化显著影响了土壤深剖面水热过程。

关键词：深剖面土地利用方式土壤水分土壤温度

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审计委员会背景下我国国家审计体制改革思路探讨

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经济与管理评论 2024年第1期40卷 148-160页

作者：李明辉南京大学商学院江苏南京210093

在各级党的审计委员会组建以后,审计委员会的功能定位、地方审计机关的报告关系、审计委员会的领导内容等方面,有待进一步确立和完善。对于审计委员会背景下审计机关的报告关系,有双重报告模式、监察委员会模式等五种不同方案,相应地,... 详细信息

在各级党的审计委员会组建以后,审计委员会的功能定位、地方审计机关的报告关系、审计委员会的领导内容等方面,有待进一步确立和完善。对于审计委员会背景下审计机关的报告关系,有双重报告模式、监察委员会模式等五种不同方案,相应地,审计委员会的职能定位也有所不同。相比之下,借鉴监察体制改革的做法,审计机关由人大产生、在党委审计委员会和上级审计机关双重领导下实施审计监督,是一种较优选择。同时,审计委员会的功能及其对审计机关的具体领导内容和形式也要依据上述定位加以明确。这一研究,可以为我国进一步深化审计体制改革提供参考。

关键词：国家审计审计体制审计委员会

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客户超额商誉与审计师变更

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系统管理学报 2024年第4期33卷 1100-1118页

作者：叶超李明辉南京林业大学经济管理学院南京210037 南京大学商学院南京210093

超额商誉不仅蕴藏着经营风险,而且往往与财务报表错报风险相联系,从而增加审计师面临的风险,那么,超额商誉是否会对审计契约的稳定性产生影响?利用2007~2019年A股非金融类上市公司的数据,考察了上市公司超额商誉对审计师变更的影响,发... 详细信息

超额商誉不仅蕴藏着经营风险,而且往往与财务报表错报风险相联系,从而增加审计师面临的风险,那么,超额商誉是否会对审计契约的稳定性产生影响?利用2007~2019年A股非金融类上市公司的数据,考察了上市公司超额商誉对审计师变更的影响,发现超额商誉与审计师变更之间存在显著正向关系,并且,这种影响主要存在于客户控制风险与法律风险较高的情况。进一步检验发现,公司的超额商誉与其审计师辞聘以及向上变更的概率显著正相关,而与其向下变更的可能性之间不存在显著关联。此外,机制检验发现,超额商誉会增加公司的经营风险和财务报表错报风险,进而引发审计师变更。这一研究从审计契约稳定性的角度拓展了关于审计师对客户超额商誉风险的态度与应对的文献。

关键词：超额商誉审计契约审计师变更

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