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3D multiphysic simulations of energy field and material process in radial ultrasonic rolling electrochemical micromachining

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Chinese Journal of Aeronautics 2022年第3期35卷 494-508页

作者： minghuan wang Yongchao SHANG Changshun LIU Jiajie wang Jinsong ZHENG Xufeng XU College of Mechanical Engineering Zhejiang University of TechnologyHangzhou 310023ZhejiangChina Key Laboratory of Special Purpose Equipment and Advanced Processing Technology of Ministry of Education Zhejiang University of TechnologyHangzhou 310023ZhejiangChina

The radial ultrasonic rolling electrochemical micromachining(RUR-EMM)combined rolling electrochemical micromachining(R-EMM)and ultrasonic vibration was studied in this *** fundamental understanding of the machining process especially the interaction between multiphysics in the interelectrode gap(IEG)was investigated and discussed by the finite element *** multiphysics coupling model including flow field model,Joule heating model,material dissolution model and vibration model was built.3D multiphysics simulation based on micro dimples process in RUR-EMM and R-EMM was *** results showed that the electrolyte flowed into and out IEG periodically,gas bubbles were easy to squeeze out and the gas void fraction deceased about 16%to 54%,the maximum current density increased by 1.36 times in RUR-EMM than in R-EMM in one vibration period of *** application of the ultrasonic vibration increased the electrolyte temperature about 1.3–4.4%in *** experiments of the micro dimple process denoted better corrosion consistency of array dimples in RUR-EMM,there was no island at the micro dimple bottom which always formed in R-EMM,and an aggregated deviation of less than 8.7%for the micro dimple depth and 4%for the material removal amount between theory and experiment was obtained.

关键词： 3D Multiphysics simulation Electrochemical micromachining Energy field Material process Micro dimple Ultrasonic vibration

Updated Understanding of the Glial-Vascular Unit in Central Nervous System Disorders

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Neuroscience Bulletin 2023年第3期39卷 503-518页

作者： Di Yao Ruoying Zhang Minjie Xie Fengfei Ding minghuan wang Wei wang Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pharmacology School of Basic Medical SciencesFudan UniversityShanghai 200032China Key Laboratory of Neurological Diseases of the Chinese Ministry of Education School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

The concept of the glial-vascular unit(GVU)was raised recently to emphasize the close associations between brain cells and cerebral vessels,and their coordinated reactions to diverse neurological insults from a“glio-centric”*** is a multicellular structure composed of glial cells,perivascular cells,and perivascular *** component is closely linked,collectively forming the *** central roles of glial and perivascular cells and their multi-level interconnections in the GVU under normal conditions and in central nervous system(CNS)disorders have not been elucidated in ***,we comprehensively review the intensive interactions between glial cells and perivascular cells in the niche of perivascular space,which take part in the modulation of cerebral blood flow and angiogenesis,formation of the blood-brain barrier,and clearance of neurotoxic ***,we discuss dysfunctions of the GVU in various neurological diseases,including ischemic stroke,spinal cord injury,Alzheimer’s disease,and major depression *** addition,we highlight the possible therapies targeting the GVU,which may have potential clinical applications.

关键词： Glial-vascular unit Perivascular space Blood-brain barrier Glymphatic system Ischemic stroke Spinal cord injury Alzheimer's disease Major depression disorder

Digoxin Ameliorates Glymphatic Transport and Cognitive Impairment in a Mouse Model of Chronic Cerebral Hypoperfusion

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Neuroscience Bulletin 2022年第2期38卷 181-199页

作者： Jie Cao Di Yao Rong Li Xuequn Guo Jiahuan Hao Minjie Xie Jia Li Dengji Pan Xiang Luo Zhiyuan Yu minghuan wang Wei wang Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Respiratory Medicine Quanzhou First Hospital Affiliated to Fujian Medical UniversityQuanzhou 362000China Key Laboratory of Neurological Diseases of the Chinese Ministry of Education School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

The glymphatic system plays a pivotal role in maintaining cerebral *** cerebral hypoperfusion,arising from small vessel disease or carotid stenosis,results in cerebrometabolic disturbances ultimately manifesting in white matter injury and cognitive ***,whether the glymphatic system serves as a potential therapeutic target for white matter injury and cognitive decline during hypoperfusion remains ***,we established a mouse model of chronic cerebral hypoperfusion via bilateral common carotid artery *** found that the hypoperfusion model was associated with significant white matter injury and initial cognitive impairment in conjunction with impaired glym・phatic system *** glymphatic dysfunction was associated with altered cerebral perfusion and loss of aquaporin 4 *** of digoxin rescued changes in glymphatic transport,white matter structure,and cognitive *** of glymphatic functions by treatment with the AQP4 inhibitor TGN-020 abolished this protective effect of digoxin from hypoperfusion *** research yields new insight into the relationship between hemodynamics,glymphatic transport,white matter injury,and cognitive changes after chronic cerebral hypoperfusion.

关键词： Chronic cerebral hypoperfusion Cognitive impairment Digoxin Glymphatic system White matter injury

Targeting polarized phenotype of microglia via IL6/JAK2/ STAT3 signaling to reduce NSCLC brain metastasis

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Signal Transduction and Targeted Therapy 2022年第3期7卷 869-880页

作者： Yu Jin Yalin Kang minghuan wang Bili Wu Beibei Su Han Yin Yang Tang Qianxia Li Wenjie Wei Qi Mei Guangyuan Hu Veronika Lukacs-Kornek Jian Li Kongming Wu Xianglin Yuan Wei wang Department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030 Hubei ProvinceChina Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030 Hubei ProvinceChina Institute of Experimental Immunology University Clinic of Rheinische Friedrich-Wilhelms-UniversityBonnGermany

Tumor-associated macrophages have emerged as crucial factors for *** are indispensable components of the brain microenvironment and play vital roles in brain metastasis(BM).However,the underlying mechanism of how acti... 详细信息

关键词： metastasis JAK2 NSCLC STAT3

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航空制导炸弹轨迹快速优化研究

西北工业大学学报 2016年第6期34卷 963-968页

作者：聂聪张科张明环王佩西北工业大学航天学院陕西西安710072 航天飞行动力学国家级重点实验室陕西西安710072

针对制导炸弹对地攻击的垂直打击的弹道特点,研究了多约束条件下的轨迹优化问题,提出了一种基于hp自适应Radau伪谱法(hp-RPM)的迭代求解策略。该方法允许不同区间的插值多项式的阶次不同,并以轨迹曲率作为重新分配配点以提高区间求解精... 详细信息

针对制导炸弹对地攻击的垂直打击的弹道特点,研究了多约束条件下的轨迹优化问题,提出了一种基于hp自适应Radau伪谱法(hp-RPM)的迭代求解策略。该方法允许不同区间的插值多项式的阶次不同,并以轨迹曲率作为重新分配配点以提高区间求解精度的依据,当各配点处的计算精度达到设定的误差允许范围时,迭代停止。以某航空制导炸弹为对象进行轨迹快速优化,仿真结果表明,该方法能够在多约束条件下快速生成满足要求的轨迹,且解的Hamilton函数满足最优性条件,与常规方法相比,平均增程效果达到11.45%。

关键词：制导炸弹轨迹优化残差 hp自适应 Radau伪谱法

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基于液体棱镜的光开关

中国激光 2015年第6期42卷 319-324页

作者：姚黎晓王琼华刘超王明欢四川大学电子信息学院四川成都610065

光开关是实现多光路电子切换器件的重要组成元件。提出一种基于液体棱镜的光开关，该光开关由一个液体棱镜与一个双孔挡光板组成。初始状态下，液一液界面为凸面形状，入射光经过液体棱镜后会聚到挡光板中央，被挡光板阻挡反射吸收，表... 详细信息

光开关是实现多光路电子切换器件的重要组成元件。提出一种基于液体棱镜的光开关，该光开关由一个液体棱镜与一个双孔挡光板组成。初始状态下，液一液界面为凸面形状，入射光经过液体棱镜后会聚到挡光板中央，被挡光板阻挡反射吸收，表现为光关状态。当把电压施加在液体棱镜单侧时，为光开状态。并且当在两侧同时施加电压时，液一液界面形变为凹面形状，入射光束发生发散，此时表现为同时光开状态。实验结果表明，该器件在自适应液体光开关中具有较快的响应时间（上升时间：～85ms；下降时间：～140ms）以及较高的光衰减度（～965：1）特性。提出的光开关在光阀、可调光衰减器以及光路由器等方面有着潜在的应用价值。

关键词：光学设计光开关电湿润液体棱镜

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纳秒脉冲微细电化学加工的理论及试验

机械工程学报 2007年第1期43卷 208-213页

作者：张朝阳朱荻王明环南京航空航天大学机电工程学院南京210016

根据电化学反应原理,探讨纳秒脉冲电化学加工的特点及其实现微细加工的机理。建立纳秒脉冲微细电化学加工的理论模型,并分析电解液浓度、加工间隙、脉冲参数和加工电压等因素对微细电解加工的影响作用。构建微细电化学加工系统,包括微... 详细信息

根据电化学反应原理,探讨纳秒脉冲电化学加工的特点及其实现微细加工的机理。建立纳秒脉冲微细电化学加工的理论模型,并分析电解液浓度、加工间隙、脉冲参数和加工电压等因素对微细电解加工的影响作用。构建微细电化学加工系统,包括微细加工机床、纳秒脉冲电源、电解液循环系统、运动控制部分和加工检测部分。试验研究了超短脉冲的电压幅值和脉冲宽度对侧面加工间隙的影响,结果表明减小脉冲宽度和降低加工电压可以提高微细电解加工的精度。在自制的微细电化学机床上,实现工具电极和工件微结构的连续加工。将加工间隙控制在5μm以内,加工出中间有20μm×30μm×30μm棱台的微型腔和30μm槽宽的十字形孔,分析加工起始点对成形精度的影响,并提出解决方法。试验证明纳秒脉冲微细电解加工可以很好地满足微机电系统(Micro e1ectro-mechanical system,MEMS)微器件的加工要求。

关键词：微细电化学加工纳秒脉冲极间间隙加工精度

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电化学腐蚀法加工微圆柱体

机械工程学报 2006年第6期42卷 128-132页

作者：王明环朱荻张朝阳南京航空航天大学机电学院南京航空航天大学机电学院南京 210016

基于电化学腐蚀原理加工微机械加工中使用的微圆柱体,对微细圆柱体成形的机理进行详细的分析。通过对腐蚀过程进行理论建模,利用对电压和腐蚀时间的控制来决定腐蚀后微圆柱体成形的形状以及圆柱体直径尺寸大小。同时,对影响微圆柱体成... 详细信息

基于电化学腐蚀原理加工微机械加工中使用的微圆柱体,对微细圆柱体成形的机理进行详细的分析。通过对腐蚀过程进行理论建模,利用对电压和腐蚀时间的控制来决定腐蚀后微圆柱体成形的形状以及圆柱体直径尺寸大小。同时,对影响微圆柱体成形的试验参数进行详细的分析,如对电压的控制、电流的变化、电解液浓度的影响、腐蚀时间决定的微圆柱体直径大小等,最后得出微圆柱体成形的规律。理论模型计算结果与试验结果进行比较,证明了理论建模的正确性。利用此种方法试验加工出总长1 180μm,前端较细处长300 μm,直径6μm的钨微细圆柱体结构,长径比达到50:1,并可以在微细加工作为工具电极使用。

关键词：电化学腐蚀微圆柱体微细加工

随机参数扰动在一次山地暴雨集合预报中的对比研究

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气象 2021年第8期47卷 953-965页

作者：熊洁李俊王明欢中国气象局武汉暴雨研究所暴雨监测预警湖北省重点实验室武汉430205

基于WRF v3.9模式使用随机参数扰动MYNN边界层方案和RUC陆面过程方案参数对我国西南山地一次特大暴雨模拟,对比评估出山地暴雨集合预报中针对MYNN边界层、RUC陆面过程方案随机参数扰动的较优设置,主要结论如下:随机扰动MYNN边界层方案(S... 详细信息

基于WRF v3.9模式使用随机参数扰动MYNN边界层方案和RUC陆面过程方案参数对我国西南山地一次特大暴雨模拟,对比评估出山地暴雨集合预报中针对MYNN边界层、RUC陆面过程方案随机参数扰动的较优设置,主要结论如下:随机扰动MYNN边界层方案(SPPM)和RUC陆面过程方案(SPPR)参数试验,扰动的主要是地面和模式低层的变量,扰动能量从模式低层逐步向高层发展,两者相比扰动边界层方案能获得更大的扰动能量;较去空间相关尺度而言,SPPM方案对去时间相关参数的变化更敏感,而SPPR方案由于其扰动能量总体偏小,去空间和时间相关参数的变化对其集合预报性能影响相对较小;SPPM方案中去时间相关选择6 h,去空间尺度选择70 km可以获得较好的集合预报技巧,SPPR方案中相对而言去时间相关选择6 h,去空间尺度选择50 km可以获得较好的集合预报技巧。

关键词：随机参数扰动边界层参数化方案陆面过程参数化方案山地暴雨