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Partial Anomalous Pulmonary Venous Connection and the Nature of Associated Sinus Venosus Defect

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Congenital Heart Disease 2022年第2期17卷 201-214页

作者： Ling Sun Chengcheng Pang Xiaoyan Wang mingguo xu Zhiwei Zhang Shushui Wang Department of Pediatric Cardiology Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangdong Cardiovascular InstituteGuangdong Provincial Key Laboratory of South China Structural Heart DiseaseGuangzhouChina Department of Pediatric Cardiology Chengdu Women’s and Children’s Central HospitalThe Affiliated Women’s and Children’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduChina Department of Pediatric Cardiology Shenzhen Children’s HospitalShenzhenChina

Background:Partial anomalous pulmonary venous connection(PAPVC)is frequently associated with atrial septal defect(ASD),especially sinus venosus defect(SVD).Although Waggstaffe described the pathology of SVDs in 1868,the exact anatomic features and the nature of SVD remains *** with no posterior atrial rim were observed in recent ***,no studies suggested that absence of the residual posterior atrial septal tissue might be the key feature of *** aims of this study were to investigate if absence of posterior rim of atrial septum played a crucial role in patients with ***:From January 2011 to December 2019,256 children with PAPVC combined ASD and 878 children with isolated ASD who underwent corrective cardiac surgery were consecutively *** review of preoperative transthoracic echocardiography,computed-tomography images and surgical findings were performed by experienced pediatric *** subtypes of PAPVC,locations and types of ASD,and presence of posterior atrial rim of associated ASD were ***:PAPVC was right-sided in 244 children,left-sided in 6 children,and bilateral in 6 *** PAPVC cases,ASD without posterior atrial rim existed in 226 SVD *** without posterior atrial septum only existed in cases with one or more right pulmonary veins returning to right atrium(RA)or to RA-superior vena cava *** cases with isolated ASD,there were 3 SVD,and the other 875 cases were secundum ***:ASD without posterior atrial rims was associated with one or more right pulmonary veins returning to RA or RA-superior venous cava(SVC)*** SVD,the key feature is that the defect is in the posterior of the interatrial septum with no posterior septal rim,rather than adjacent to the SVC or to the inferior vena cava.

关键词： Partial anomalous pulmonary venous connection sinus venosus atrial septal defect echocardiography right atrium inferior vena cava

外泌体源性微小RNA在儿童心血管系统疾病治疗中的研究进展

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中华实用儿科临床杂志 2022年第5期37卷 393-397页

作者：蓝晶晶徐明国遵义医科大学珠海校区珠海519041 深圳市儿童医院心血管内科深圳518000

近年来研究人员对于外泌体相关研究的热度逐渐提高,外泌体源性微小RNA(exo-miRNA)已作为极具潜力的非侵入性生物标志物广泛用于早期临床诊断研究中。血液中含大量血小板、动脉内皮细胞和其他细胞类型释放的外泌体,且外泌体外部膜还具有... 详细信息

近年来研究人员对于外泌体相关研究的热度逐渐提高,外泌体源性微小RNA(exo-miRNA)已作为极具潜力的非侵入性生物标志物广泛用于早期临床诊断研究中。血液中含大量血小板、动脉内皮细胞和其他细胞类型释放的外泌体,且外泌体外部膜还具有保护exo-miRNA等内容物免受生物酶水解、稳定存在于人体体液中的独特优势,这些特点使外泌体及exo-miRNA在心血管疾病早期诊断、促进细胞再生、心脏保护等方面发挥出巨大作用。现就外泌体的结构和生物发生方式、exo-miRNA的作用机制及其在儿童心血管相关疾病治疗中的研究进展进行综述。

关键词：外泌体微小RNA 心血管疾病研究进展儿童

多项式方程区间内求根基于R^2空间的3次裁剪方法

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计算机辅助设计与图形学学报 2014年第11期26卷 1923-1929页

作者：陈小雕徐明国叶阳天段晓慧杭州电子科技大学计算机学院杭州310018

多项式方程的求根问题在求交、最近距离计算等方面有着广泛的应用.3次裁剪求根方法充分利用了Bernstein基函数较好的计算稳定性,避免了数值迭代求解的不稳定性,同时具有4次收敛的速度.不同于传统的基于R1空间内的3次裁剪方法,提出了基... 详细信息

多项式方程的求根问题在求交、最近距离计算等方面有着广泛的应用.3次裁剪求根方法充分利用了Bernstein基函数较好的计算稳定性,避免了数值迭代求解的不稳定性,同时具有4次收敛的速度.不同于传统的基于R1空间内的3次裁剪方法,提出了基于R2空间内的3次裁剪方法.首先引入R2空间中一条曲线(t,f(t)),在该曲线给定的区间上选取3个点,并计算这3个点及其对应的切向;然后求解3次多项式曲线Ai(u),满足同时插值这3个点及其中2个点处的切向;最后选择适当的重新参数化函数φ(t),使得Ai(φ(t))和f(t)之间具有5次逼近阶.若给定的参数区间Φ充分小,A1(φ(t))和A2(φ(t))可以在区间Φ内直接包住f(t),从而节省了用于求解包围多项式的大量计算.实例结果表明,该方法具有更好的逼近效果、更快的收敛速度和更高的计算效率.

关键词：多项式求根 3次剪裁稳定性 R^2空间收敛阶

外周血细胞参数对川崎病临床预测作用的研究进展

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中华实用儿科临床杂志 2020年第13期35卷 1027-1030页

作者：吴业媚徐明国遵义医科大学珠海校区广东珠海519041

外周血细胞参数,如中性粒细胞/淋巴细胞、血小板计数/淋巴细胞和平均血小板体积/淋巴细胞是系统性炎症标志物,对心血管疾病、肿瘤、全身炎性反应等疾病的发生、疗效和预后的判断有预测意义。目前已有研究表明,中性粒细胞百分比、血清清... 详细信息

外周血细胞参数,如中性粒细胞/淋巴细胞、血小板计数/淋巴细胞和平均血小板体积/淋巴细胞是系统性炎症标志物,对心血管疾病、肿瘤、全身炎性反应等疾病的发生、疗效和预后的判断有预测意义。目前已有研究表明,中性粒细胞百分比、血清清蛋白、C反应蛋白、红细胞比容、血小板计数、血清钠、总胆红素、氨基末端脑钠肽前体(NT-proBNP)等是预测川崎病患儿冠状动脉病变或免疫球蛋白抵抗的常见独立危险因素。近期研究表明,外周血细胞参数对川崎病患儿冠状动脉病变和免疫球蛋白抵抗有预测价值。因血常规廉价、操作简单易行而具有广泛的临床应用前景。现就外周血细胞参数预测川崎病患儿冠状动脉病变及免疫球蛋白抵抗的研究进展进行综述。

关键词：川崎病中性粒细胞/淋巴细胞血小板计数/淋巴细胞平均血小板体积/淋巴细胞冠状动脉病变静脉用免疫球蛋白抵抗

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心电图在川崎病急性期的应用研究进展

中华实用儿科临床杂志 2020年第6期35卷 472-474页

作者：欧振恒徐明国刘琮深圳市儿童医院心血管内科 518038

川崎病是一种急性血管炎症性疾病,冠状动脉损伤及心肌炎是其常见的并发症,尤其在急性期可表现出不同程度的心肌损伤,在心电图上可表现出多种异常。心电图作为一种无创的电生理检查手段,对川崎病的早期诊断及治疗预后评估均有重要意义。... 详细信息

川崎病是一种急性血管炎症性疾病,冠状动脉损伤及心肌炎是其常见的并发症,尤其在急性期可表现出不同程度的心肌损伤,在心电图上可表现出多种异常。心电图作为一种无创的电生理检查手段,对川崎病的早期诊断及治疗预后评估均有重要意义。随着研究的深入,川崎病早期的心电图表现及电生理意义逐渐被认识,现对近年来国内外研究川崎病急性期心电改变及临床意义进行回顾及总结,就心电图在川崎病诊治的应用进展进行综述。

关键词：川崎病心电图 QT离散度 T波心律失常

Riverine sulfate sources and behaviors in arid environment,Northwest China:Constraints from sulfur and oxygen isotopes

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Journal of Environmental Sciences 2024年第3期137卷 716-731页

作者： Yifu xu Wenjing Liu Bing xu Zhifang xu Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Innovation Academy for Earth Science Chinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China

The fate of riverine sulfate ion (SO_(4)^(2-)) and its environmental effects in arid environment are difficult to evaluate due to its complicated sources and strongly coupled behaviors with water cycle which is significantly modified by *** understand the sulfur cycle in aquatic systems in arid environment,the chemical and sulfur and oxygen isotopic compositions (δ^(34)S_(SO4)and δ^(18)O_(SO4)) of major rivers around the Badain Jaran Desert,northwestern China,were *** rivers had averaged SO_(4)^(2-)content at 1336μmol/L,over 10times higher than the global *** δ^(34)S_(SO4)and δ^(18)O_(SO4)values ranged from-5.3‰to+11.8‰and+1.6‰to+12.8‰,*** end-member analysis and the inverse model showed that riverine sulfate was mainly derived from evaporites dissolution (0-87%),sulfide oxidation (13%-100%) and precipitation (0-33%),indicating heterogeneity in sulfur sources and behaviors along the river drainage with the lithology variations and climate *** isotopic tools combining with hydro-chemistry compositions could be applied to reveal sulfur cycle in arid *** on the calculation,sulfide oxidation plays the primary role in the headwater and upstream in the Qilian-Mountains area,where sulfide is widely *** the proportion of evaporites dissolution contributing to riverine sulfate is much higher in downstream in a drier ***,less precipitation and higher temperature can lead to more intensive evaporation,affecting the process of sulfide oxidation and enhancing the rates of evaporites dissolution and sulfate precipitation in the basin.

关键词： Sulfur and oxygen isotopes Source apportionment Inverse model Arid environment Inland rivers Northwestern China

HtoH连续护理模式在老年慢性病患者中的应用效果

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国际护理学杂志 2020年第1期39卷 159-162页

作者：李君南阳市中心医院 473000

目的探讨HtoH连续护理模式在老年慢性病患者中的临床应用效果。方法采用随机数字表法将该院2016年1月至2017年2月收治老年慢性病患者226例分为观察组和对照组,各113例。对照组给予常规护理,观察组在常规护理的基础上给予系统的综合护理... 详细信息

目的探讨HtoH连续护理模式在老年慢性病患者中的临床应用效果。方法采用随机数字表法将该院2016年1月至2017年2月收治老年慢性病患者226例分为观察组和对照组,各113例。对照组给予常规护理,观察组在常规护理的基础上给予系统的综合护理干预以及出院后为期6个月以健康宣教为核心的HtoH连续护理。6个月后观察两组患者的服药依从性、精神状态、生活自理能力(Activity Daily Life,ADL)、健康知识掌握情况。结果观察组患者的服药依从性显著高于对照组,差异有统计学意义(P<0.05);焦虑(Self-raling Anxiety Scale,SAS)和抑郁(Self-rating Depression Scale,SDS)自评量表得分均低于对照组,生活自理能力得分高于对照组,差异有统计学意义(均P<0.05);健康知识掌握得分高于对照组,差异有统计学意义(P<0.05)。结论HtoH连续护理模式可帮助老年慢性病患者了解并掌握疾病相关知识,有利于改善患儿的焦虑、抑郁状态,提高患者的服药依从性,提升其生活自理能力。

关键词： HtoH连续护理慢性病服药依从性生活自理能力

Laboratory evaluation of high-friction thin overlays for pavement preservation

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Frontiers of Structural and Civil Engineering 2024年第6期18卷 936-948页

作者： Ouming xu Rentao xu Lintong JIN School of Highway Chang’an UniversityXi’an 710064China School of Materials Science and Engineering Chang’an UniversityXi’an 710061China

Traditional asphalt concrete(AC)and stone matrix asphalt(SMA),which are used as thin asphalt overlays,are common maintenance strategies to enhancing ride quality,skid resistance,and ***,several studies have used a novel asphalt mixture known as a high-friction thin overlay(HFTO)to improve surface ***,it remains uncertain whether the laboratory properties of HFTO differ significantly from those of conventional *** study aims to evaluate the laboratory properties of HFTO mixtures and compare them with those of AC and *** mixtures with nominal maximum size of 9.5 mm were produced in the laboratory,and performance tests were conducted,including wheel tracking test,low temperature flexural creep test,moisture susceptibility test,Cantabro Abrasion Test,Marshall Test,sand patch test,British pendulum test,and indoor tire-rollingdown *** results showed that the HFTO exhibited a lower tire/pavement noise than the AC and ***,HFTO had superior high-temperature stability,larger macro texture,and higher skid resistance in comparison to those of AC,but lower than those of ***,HFTO mixtures may be considered a suitable replacement for traditional AC mixtures in regions where skid resistance and noise reduction are concerns.

关键词： road engineering pavement maintenance high friction thin overlay performance skid resistance tire/pavement noise

Aldehyde oxidase mediated enantioselective metabolic health risk of dinotefuran

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Science China Chemistry 2024年第6期67卷 2079-2091页

作者： Liwei xu Xinxin xu Hua Kuang Chuanlai xu Xiaoling Wu State Key Laboratory of Food Science and Resources Jiangnan UniversityWuxi214122China International Joint Research Laboratory for Biointerface and Biodetection and School of Food Science and Technology Jiangnan UniversityWuxi214122China Collaborative Innovation center of Food Safety and Quality Control in Jiangsu Province Jiangnan UniversityWuxi214122China

Chiral pollutants often pose significant differential environmental health *** this study,the biotransformation of chiral dinotefuran(DIN)and its enantioselective metabolic toxicity mechanisms have been systemically ***,reversedphase chromatography-high resolution mass spectrometry was developed to quantify the content of DIN R/S chiral enantiomer with pg level sensitivity,revealing a lower elimination rate constant(K_(e))of S-DIN(0.730 h^(-1))than R-DIN(0.746 h^(-1)).Secondly,the interaction mechanism between DIN metabolism and important endogenous bioactive molecules,such as aldehyde oxidase(AOX)and neurotransmitters,was *** DIN nitro-group was converted into a guanidine group by the reducing site of nearby flavin adenine dinucleotide(FAD)in AOX with the preferred higher affinity of ***,the endogenous tryptophan(Trp)aldehyde metabolic intermediate,5-hydroxyindoleacetaldehyde(5-HIAL),provides a persistent electron donor for DIN reduction via the oxidation-catalyzed site in AOX,resulting in remarkable up-regulation of monoamine neurotransmitters such as serotonin and ***,the higher level of neurotransmitters further mediated dysregulation of oxylipin homeostasis via the serotonergic pathway,where S-DIN exhibited more pronounced liver lipid damage and environmental health risk with the accumulated lipid biomarkers,oxidized triglyceride(OxTG)and oxidized sphingomyelin(OxSM).This study elucidates the AOX-mediated enantioselectivity metabolic pathway of DIN,providing a new analytical method for chiral pollutants and paves the way for their health risk assessments.

关键词： neonicotinoid dinotefuran enantiomer aldehyde oxidase metabolomics health risk