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Angioarchitecture and CD133^+ tumor stem cell distribution in intracranial hemangiopericytoma A comparative study with meningioma

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Neural Regeneration Research 2011年第34期6卷 2687-2693页

作者： Zhongguo Zhang mingguang zhao Zaihua Xu Zhenquan Song Department of Neurosurgery Northern Hospital Shenyang 110840 Liaoning Province China Surgical Department of Colorectal Cancer Liaoning Provincial Cancer Hospital Shenyang 110042 Liaoning Province China

Angioarchitecture plays an important role in the malignant development of intracranial hemangiopericytoma. It remains poorly understood whether high frequency of hemorrhage during clinical surgery for intracranial hemangiopericytoma is associated with angioarchitecture. The present study utilized hematoxylin-eosin staining, and immunohistochemical staining with epithelial membrane antigen, vimentin, CD34, von Willebrand factor （vWF） and CD133 to observe characteristics of angioarchitecture. In addition, silver stains were used to demonstrate changes in reticular fibers in the wall of vessel channels in intracranial hemangiopericytoma and meningioma. Five patterns of angioarchitecture were identified in intracranial hemangiopericytoma, namely tumor cell islands, vasculogenic mimicry, mosaic blood vessels, sprouting angiogenesis, and intussusceptive angiogenesis. Several CD133＋ tumor cells were found to form tumor cell islands. A connection between vWF ^＋ and vWF channels was detected in the pattern of intussusceptive angiogenesis, and some vimentin^＋ tumor cells were embedded in the periodic acid-Schiff positive channel wall. Incomplete threads of reticular fibers formed the walls of larger pseudo-vascular channels and some tumor clumps or scattered tumor cells were detected ＂floating＂ in them. The angioarchitecture, specific markers and reticular fibers of intracranial hemangiopericytoma were significantly different from meningioma. Angioarchitecture provides a functional vascular network for vascular evolution in intracranial hemangiopericytoma and contributes to significant intra-operative bleeding.

关键词： intracranial hemangiopericytoma angioarchitecture tumor cell islands vasculogenic mimicry mosaic blood vessels, sprouting angiogenesis intussusceptive angiogenesis meningioma CD133

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Effects of gentamicin on choline acetyltransferase expression in paraolivary nucleus neurons of guinea pigs

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Neural Regeneration Research 2008年第11期3卷 1229-1232页

作者： mingguang zhao Xiaochen Wang Yong Liang Peng Xie Xuejun Guo Jinjiang Li WeiWang Department of Neurosurgery General Hospital of Shenyang Military Area Command of Chinese PLA Shenyang 110016 Liaoning Province China Department of Medical Branch General Hospital of Shenyang Military Area Command of Chinese PLA Shenyang 110016 Liaoning Province China

BACKGROUND： It is generally accepted that gentamicin can damage the cochlear nerve and acoustic nerve. In recent years, scholars have focused on neuronal changes and neurochemical information in the brainstem primary auditory center. OBJECTIVE： To explore morphological changes of choline acetyltransferase （ChAT）-positive neurons in the paraolivary nucleus （PON） of guinea pigs, and the effect on hearing following gentamicin injection. DESIGN, TIME AND SETTING： Randomized grouping and morphological observational study was performed at Animal Experimental Center of General Hospital of Shenyang Military Area Command of Chinese PLA from January to August 2007. MATERIALS： A total of 48 healthy guinea pigs were randomly divided into model （n = 40） and control （n = 8） groups. The model group was divided into five subgroups at five time points of 1 and 3 days, 1, 2, and 3 weeks. METHODS： Guinea pigs in the model group were intraperitoneally injected with gentamicin, and those in the control group were intraperitoneally injected with the same volume of saline. MAIN OUTCOME MEASURES： Auditory brainstem-evoked potential was used to record auditory threshold; distribution and morphological changes of ChAT-positive neurons in the PON were observed with immunohistochemistry; section area and gray value of ChAT-positive neurons were measured with Quantimet 570 image-analyzing system. RESULTS： ChAT-positive neurons were diffusedly distributed in the PON. The majority was composed of large, round cells, with positive neurites that could be clearly observed. Following gentamicin injection, the positive neurons displayed an irregular outline, and their neurites began to shorten and disappear. The gray value increased with prolonged gentamicin administration （P 〈 0.05）. In addition, the somatic cross-sectional area was enlarged in the model group at 1 and 3 days after injection （P 〈 0.05）, whereas cell number significantly decreased at ;three weeks after injection （P 〈 0.05）. Starting a

关键词： choline acetyltransferase gentamicin guinea pigs paraolivary nucleus

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Expression of angiogenic factors in cerebral arteriovenous malformations

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Neural Regeneration Research 2007年第3期2卷 138-141页

作者： mingguang zhao Youli Chen Zhenquan Song Yongzhong Gao Peiyu Pu Xuezhong Wei Department of Neurosurgery General Hospital of Shenyang Military Area Command of Chinese PLA Shenyang 110016 Liaoning Province China Department of Neurosurgery General Hospital of Tianjin Medical University Tianjin 300052 China

BACKGROUND： In the process of vascularization, vascular endothelial growth factor （VEGF）, angiopoietin-2 and Tie2 are involved in the migration, differentiation and proliferation of vascular endothelial cells, and stimulate the rapid angiogenesis; Tiel and angiopoietin-1 play important roles in facilitating the formation of vascular lumen and maintaining the integrity of vascular wall. Thus the distributions and expressions may be associated with the occurrence of cerebral arteriovenous malformation. OBJECTIVE： To observe the biological effects of angiogenic factors in the occurrence and development of cerebral arteriovenous malformation. DESIGN： An observational comparative experiment. SETTINGS： Department of Neurosurgery, General Hospital of Shenyang Military Area Command of Chinese PLA; Department of Neurosurgery, General Hospital of Tianjin Medical University. PARTICIPANTS： Fresh samples of complete cerebral arteriovenous malformations resected in 47 patients were collected from the Department of Neurosurgery, General Hospital of Tianjin Medical University from August 1999 to May 2001, including 22 males and 25 females, the mean age was 34.5 years. Informed consents were obtained from all the patients or their relatives. The initial symptom was hemorrhage in 28 cases. All the patients were classified according to the clinical imaging data and Spetzler-Martin grading standard, including 11 cases of grade Ⅰ, 17 cases of grade Ⅱ, 11 cases of grade Ⅲ, and 8 cases of grade Ⅳ - Ⅴ. Normal brain tissues resected by decompression due to trauma were taken from 8 patients as controls, including 5 males and 3 females, aging 12 - 65 years. METHODS： ① The expressions of VEGF, Tie receptors, angiopoietin-1, angiopoietin-2, proto-oncogene c-myc and proliferating cell nuclear antigen（PCNA） in the samples of cerebral arteriovenous malformation were detected with immunohistochemical method. Under light microscope, the positively stained rat-anti-human factor Ⅷ-related antigens （sp

关键词： cerebral arteriovenous malformations angiogenesis factor proto-oncogenes proliferating cell nuclear antigen

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网络化制造环境下企业联盟的置信度研究

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中国机械工程 2005年第22期16卷 2015-2018页

作者：赵明光易红东南大学

针对网络化制造环境下企业联盟合作伙伴的选择问题,提出了置信度的概念及其计算方法,建立并验证了伙伴选择的置信度评判模型;对联盟成立后总联盟置信度的算法进行了研究,提出了大型联盟置信度的简化算法。基于置信度的评判模型,更能体... 详细信息

针对网络化制造环境下企业联盟合作伙伴的选择问题,提出了置信度的概念及其计算方法,建立并验证了伙伴选择的置信度评判模型;对联盟成立后总联盟置信度的算法进行了研究,提出了大型联盟置信度的简化算法。基于置信度的评判模型,更能体现伙伴选择的实质,为企业联盟的合理组建提供了有效的策略支持。

关键词：企业联盟置信度评判模型原型系统

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网络化制造环境下企业联盟的项目进度监控策略研究

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中国机械工程 2006年第14期17卷 1480-1483页

作者：赵明光易红淮海工学院连云港222005 东南大学南京210096

提出企业联盟中各级盟员执行进度的计算方法,该计算方法用进度曲线的形式来获取盟员的进度信息;提出以任务实施计划图、进度计算、进度汇报和进度监控为主流程的进度监控策略,该策略可以简练地反映出多级子项目的动态进度和盟员生产资... 详细信息

提出企业联盟中各级盟员执行进度的计算方法,该计算方法用进度曲线的形式来获取盟员的进度信息;提出以任务实施计划图、进度计算、进度汇报和进度监控为主流程的进度监控策略,该策略可以简练地反映出多级子项目的动态进度和盟员生产资源的变化状况。

关键词：网络化制造企业联盟进度算法进度监控

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基于Web的数据采集系统在沥青混合料马歇尔稳定度试验仪上的应用

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机床与液压 2006年第9期34卷 176-177,232页

作者：赵明光淮海工学院机械工程系江苏连云港222005

介绍了计算机控制式沥青混合料马歇尔稳定度试验仪的基本结构及其控制系统的设计与实现。针对远程服务的需要,提出了基于CORBA的网络化实施方案。运行结果表明,该试验仪安全可靠,功能丰富,提高了该项试验的工作效率,降低了工作强度。

关键词：沥青混合料马歇尔稳定度数据采集远程服务

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液阻、液容对开关阀流量特性影响的仿真研究

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工程机械 2007年第3期38卷 41-44+87-88页

作者：赵明广方庆琯安徽工业大学

开关阀的应用越来越广泛,而液阻、液容的存在严重影响了开关阀的流量特性。对液阻、液容进行了分析,并建立了液阻和液容理论模型,给出了其理论计算公式及仿真模块图。对液阻、液容和开关阀组成的液压系统进行模型分析,建立了考虑液阻、... 详细信息

开关阀的应用越来越广泛,而液阻、液容的存在严重影响了开关阀的流量特性。对液阻、液容进行了分析,并建立了液阻和液容理论模型,给出了其理论计算公式及仿真模块图。对液阻、液容和开关阀组成的液压系统进行模型分析,建立了考虑液阻、液容的开关阀动态模型,并利用Matlab/Simulink建立了液压系统仿真模块图,通过设置不同参数对开关阀液压系统进行仿真,定性地分析了液阻、液容对开关阀流量特性的影响。仿真结果可以为开关阀的应用提供相关参考。

关键词：液阻液容开关阀计算机仿真

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