Angioarchitecture and CD133^+ tumor stem cell distribution in intracranial hemangiopericytoma A comparative study with meningioma

作     者：Zhongguo Zhang Mingguang Zhao Zaihua Xu Zhenquan Song 

作者机构：Department of Neurosurgery Northern Hospital Shenyang 110840 Liaoning Province China Surgical Department of Colorectal Cancer Liaoning Provincial Cancer Hospital Shenyang 110042 Liaoning Province China 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2011年第6卷第34期

页      面：2687-2693页

核心收录：

学科分类：0710[理学-生物学] 0907[农学-林学] 090705[农学-野生动植物保护与利用] 07[理学] 09[农学] 071002[理学-动物学] 

基　　金：the Science and Technology Projects in Liaoning Province  No. 2010225036 

主　　题：intracranial hemangiopericytoma angioarchitecture tumor cell islands vasculogenic mimicry mosaic blood vessels, sprouting angiogenesis intussusceptive angiogenesis meningioma CD133 

摘      要：Angioarchitecture plays an important role in the malignant development of intracranial hemangiopericytoma. It remains poorly understood whether high frequency of hemorrhage during clinical surgery for intracranial hemangiopericytoma is associated with angioarchitecture. The present study utilized hematoxylin-eosin staining, and immunohistochemical staining with epithelial membrane antigen, vimentin, CD34, von Willebrand factor （vWF） and CD133 to observe characteristics of angioarchitecture. In addition, silver stains were used to demonstrate changes in reticular fibers in the wall of vessel channels in intracranial hemangiopericytoma and meningioma. Five patterns of angioarchitecture were identified in intracranial hemangiopericytoma, namely tumor cell islands, vasculogenic mimicry, mosaic blood vessels, sprouting angiogenesis, and intussusceptive angiogenesis. Several CD133＋ tumor cells were found to form tumor cell islands. A connection between vWF ^＋ and vWF channels was detected in the pattern of intussusceptive angiogenesis, and some vimentin^＋ tumor cells were embedded in the periodic acid-Schiff positive channel wall. Incomplete threads of reticular fibers formed the walls of larger pseudo-vascular channels and some tumor clumps or scattered tumor cells were detected ＂floating＂ in them. The angioarchitecture, specific markers and reticular fibers of intracranial hemangiopericytoma were significantly different from meningioma. Angioarchitecture provides a functional vascular network for vascular evolution in intracranial hemangiopericytoma and contributes to significant intra-operative bleeding.