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A Robust N-Terminal Pro-Brain Natriuretic Peptide Assay for Clinical Diagnosis of Heart Failure in Elderly Patients

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Journal of Analysis and Testing 2024年第1期8卷 74-82页

作者： xue gong Jiangling Wu Jiajia Zhang Zhongwei Jiang Yi Wang pu Zhang Engineering Research Center for Biotechnology of Active Substances(Ministry of Education) Chongqing Key Laboratory of Green Synthesis and ApplicationsCollege of ChemistryChongqing Normal UniversityChongqing 401331China Chongqing Research Center for Pharmaceutical Engineering College of PharmacyChongqing Medical UniversityChongqing 400016China Department of Clinical Laboratory University Town Hospital of Chongqing Medical UniversityChongqing 401331China

Heart failure(HF)is a clinical hallmark of cardiovascular syndrome leading to substantial morbidity,repeated hospitalization,and enormous healthcare *** elderly populations continue to increase,biomarker-guided diagnosis and treatment for age-related cardiac decline have become *** evidence demonstrates that N-terminal proBNP(NT-proBNP)can provide a unique window into the diagnosis and risk stratification with ***,a simple yet robust aptasensor is developed for on-site recognizing the NT-proBNP by its targeting aptamer,thus achieving the accurate diagnosis of *** aptasensing system is prepared by absorbing the fluorophore-labeled aptamer strand onto the graphene oxide(GO),leading to efficient quenching without possible off-site signal *** aptamer strand can specifically identify target NT-proBNP molecules via a versatile conformational transformation,resulting in the desorption of the aptamer-NTproBNP complexes from GO and re-generation fluorescence signal,thus allowing sensitive detection of NT-proBNP in 37 clinical blood *** advantage of the high specificity of aptamer-guaranteed recognitions of NT-proBNP,this aptasensor system readily achieves better diagnostic performance for HF than commercially adopted chemiluminescence immunoassay(Siemens,CLIA)in hospitals in terms of accuracy(89.2%vs 83.8%),specificity(89.5%vs 84.2%),and positive predictive value(88.9%vs 83.3%).This work provides a stable option for the diagnosis and treatment of elderly HF-related diseases inclinics.

关键词： NT-proBNP Graphene oxide Aptamer Heart failure Clinical diagnosis

Simple and cost-effective methods for precise analysis of trace element abundances in geological materials with ICP-MS

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Science Bulletin 2017年第4期62卷 277-289页

作者： Shuo Chen Xiaohong Wang Yaoling Niu pu Sun Meng Duan Yuanyuan Xiao Pengyuan Guo Hongmei gong Guodong Wang Qiqi xue Institute of Oceanology Chinese Academy of SciencesQingdao 266071China Laboratory for Marine Geology Qingdao National Laboratory for Marine Science and TechnologyQingdao 266061China University of Chinese Academy of Sciences Beijing 100049China Department of Earth Sciences Durham UniversityDurham DH1 3LEUK School of Earth Science and Mineral Resources China University of GeosciencesBeijing 100083China

Inductively coupled plasma mass spectrometry （ICP-MS） is the most commonly used technique to deter- mine the abundances of trace elements in a wide range of geological materials. However, incomplete sample digestion, isobaric interferences and instrumental drift remain obvious problems that must be overcome in order to obtain precise and accurate results, For this reason, we have done many experi- ments and developed a set of simple, cost-effective and practical methods widely applicable for precise and rapid determination of trace element abundances in geological materials using ICP-MS. Commonly used high-pressure digestion technique is indeed effective in decomposing refractory phases, but this inevitably produces fluoride complexes that create new problems. We demonstrate that the fluoride complexes formed during high-pressure digestion can be readily re-dissolved using high-pressure vessel at 190 ℃ for only 2 h for 50 mg sample. In the case of isobaric interferences, although oxide （e.g., MO^＋/M^＋） and hydroxide （e.g., MO^＋/M^＋） productivity is variable between runs, the （MO^＋/M^＋）/（CeO^＋/Ce^＋） and （MOH^＋/M^＋）/（CeO^＋/Ce^＋） ratios remain constant, making isobaric interference correction for all other elements of interest straightforward, for which we provide an easy-to-use off-line procedure. We also show that mass-time-intensity drift curve is smooth as recognized previously, for which the correction can be readily done by analyzing a quality-control （QC） solution and using off-line Excel VBA procedure without internal standards. With these methods, we can produce data in reasonable agreement with rec- ommended values of international rock reference standards with a relative error of 〈8% and precision generally better than 5%. Importantly, compared to the widely used analytical practice, we can effectively save 〉60% of time （e.g., 〈24 h vs. 〉60 h）.

关键词： Inductively coupled plasma mass spectrometry High-pressure digestion Oxide and hydroxide interferences Instrumental drift Correction methods Trace elements

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非对称情形下R&D竞争项目的策略性投资

数学物理学报（A辑） 2008年第5期28卷 794-801页

作者：薛明皋龚朴华中科技大学管理学院财务金融系武汉430074

在非对称情形下,考虑具有技术不确定和未来收益不确定的竞争研究与开发(R&D)项目的不可逆策略性投资.利用期权博弈理论和随机优化方法给出了高效研发公司(主导者)的最优投资阈值和最优投资规则的解析表达式,并证明了由于两公司的竞争使... 详细信息

在非对称情形下,考虑具有技术不确定和未来收益不确定的竞争研究与开发(R&D)项目的不可逆策略性投资.利用期权博弈理论和随机优化方法给出了高效研发公司(主导者)的最优投资阈值和最优投资规则的解析表达式,并证明了由于两公司的竞争使投资阈值下降.其次讨论了两公司的混合投资策略,并给出每个公司执行投资期权的概率和两公司同时执行投资期权的概率.在最后给出了数值模拟算例来说明该文结论的合理性.

关键词： R&D投资期权博弈投资阈值占先策略混合策略

首次穿过边界概率及其在金融中的应用(英文)

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经济数学 2004年第4期21卷 283-295页

作者：薛明龚朴华中科技大学管理学院财务金融系武汉430074

本文把数学和管理科学有机结合 ,为数学应用提出问题 ,得出新结果 ,推广了 *** Harrison(1985 ) [1] 第 4 3页的命题 2 7,并给出了在金融中的应用 .

关键词：概率,投资,鞅,首达时,破产临界值

Integrated Transcriptome and Small RNA Sequencing Analyses Reveals Insights into the Molecular Mechanism of Seed Germination in Mung Bean

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Phyton-International Journal of Experimental Botany 2023年第6期92卷 1793-1812页

作者： Yanyan pu Liwen Wang Leilei Li Yujun Si Shubin Xie Yunzhe Cong Dong Wang Yongchao gong Rumei Tian xue Chen Xiaoyan Zhang Min Liu Hanfeng Ding Nana Li Institute of Crop Germplasm Resources Shandong Academy of Agricultural SciencesJinan250100China State Key Laboratory of Crop Biology Shandong Agricultural UniversityTai’an271018China College of Life Science Shandong Normal UniversityJinan250014China Weifang Academy of Agricultural Sciences Weifang261000China

During the life cycle of a plant,seed germination is *** ingestion of water,the dry seeds resumed energy metabolism and cellular *** dissect the complex mechanisms at the very beginning of seed germination,two approaches including transcriptome and small RNA sequencing were conducted during the water imbibition process of mung bean seeds compared with dry *** transcriptome sequencing analysis identified 10,108 differentially expressed genes(DEGs)between dry and imbibed mung bean *** enrichment analyses demonstrated numerous DEGs involved in hormone signaling pathways,carbohydrate,and energy *** of the total DEGs,129 genes were investigated to involve in abscisic acid,gibberellin,and ethylene pathways,with 56 genes involved in glycolysis and TCA *** the analysis of small RNA sequencing among different samples,there were 284 miRNAs found in the imbibed and dried seeds of mung bean containing 213 known and 71 novel *** comparison between the two types of seeds,51 miRNAs were differentially *** integrated analyses of transcriptome and miRNAome data showed that 23 DEGs are the putative target genes of 8 miRNAs including miR156,miR171b-3p,miR166e-3p,miR169-1,***-PCR was used to validate several DEGs and *** data suggested that the seed imbibition process is regulated by a variety of DEGs and ***,we hope to gain a deeper insight into how mung bean seeds germinate in order to optimize seed growth.

关键词： Mung bean transcriptome differentially expressed genes miRNA regulatory network

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具有破产约束的最优投资决策模型

经济数学 2007年第1期24卷 1-9页

作者：薛明皋龚朴华中科技大学管理学院财务金融系武汉430074

本文给出了追求目标行为的投资决策模型,将投资目标系统化为这个扩散过程的两个吸收壁(Barriers),而文[1]的模型没有考虑破产,仅有一个吸收壁.在投资目标行为设定中,不仅要考虑目标完成水平,而且也要考虑破产,因为不破产是完成目标水平... 详细信息

本文给出了追求目标行为的投资决策模型,将投资目标系统化为这个扩散过程的两个吸收壁(Barriers),而文[1]的模型没有考虑破产,仅有一个吸收壁.在投资目标行为设定中,不仅要考虑目标完成水平,而且也要考虑破产,因为不破产是完成目标水平的前提条件,所以不应该被忽略.根据现有文献的实证结果导出投资回报率满足的扩散过程.本文首先描述所要解决的实际问题,设置在计划时间内要达到的目标,最后给出这个事件的概率解析表达式.

关键词：破产概率投资风险鞅停时概率测度破产临界值 R&D投资

Exotic origin of the Chinese continental shelf: new insights into the tectonic evolution of the western Pacific and eastern China since the Mesozoic

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Science Bulletin 2015年第18期60卷 1598-1616页

作者： Yaoling Niu Yi Liu Qiqi xue Fengli Shao Shuo Chen Meng Duan Pengyuan Guo Hongmei gong Yan Hu Zhenxing Hu Juanjuan Kong Jiyong Li Jinju Liu pu Sun Wenli Sun Lei Ye Yuanyuan Xiao Yu Zhang Institute of Oceanology Chinese Academy of Sciences Department of Earth Sciences Durham University School of Earth Science and Resources China University of Geosciences Institute of Deep Sea Science and Engineering Chinese Academy of Sciences School of Earth Sciences Lanzhou University

The effect of paleo-Pacific subduction on the geological evolution of the western Pacific and continental China is likely complex. Nevertheless, our analysis of the distribution of Mesozoic granitoids in the eastern continental China in space and time has led us to an interesting conclusion： The basement of the continental shelf beneath East and South China Seas may actually be of exotic origin geologically unrelated to the continental lithosphere of eastern China. By accepting the notion that the Jurassic- Cretaceous granitoids in the region are genetically associated with western Pacific subduction and the concept that subduction may cease to continue only if the trench is being jammed, then the termination of the granitoid magmatism throughout the vast region at -88±2 Ma manifests the likelihood of ＂sudden＂, or shortly beforehand （- 100 Ma）, trench jam of the Mesozoic western Pacific subduction. Trench jam happens if the incoming ＂plate＂ or portion of the plate contains a sizeable mass that is too buoyant to subduct. The best candidate for such a buoyant and unsubductable mass is either an oceanic plateau or a micro-continent. We hypothesize that the basement of the Chinese continental shelf represents such an exotic, buoyant and unsubductable mass, rather than seaward extension of the continental lithosphere of eastern China. The locus of the jammed trench （i.e., the suture） is predictably located on the shelf in the vicinity of, and parallel to, the arc-curved coastal line of the southeast continental China. It is not straightforward to locate the locus in the northern section of the East China Sea shelf because of the more recent （〈20 Ma） tectonic re-organization associated with the opening of the Sea of Japan. We predict that the trench jam at - 100 Ma led to the re-orientation of the Pacific plate motion in the course of NNW direction as inferred from the age-progressive Emperor Seamount Chain of Hawaiian hotspot origin （its oldest unsubdued Meiji and Detroi

关键词： Mesozoic granitoids in eastern ChinaExotic origin of Chinese continental shelf Trenchjam Transform plate boundary Basal hydrationweakening Lithosphere thinning Cratondestruction Mantle hydrous melting Crustalmelting Plate tectonics South China Sea

Online calculator for predicting the risk of malignancy in patients with pancreatic cystic neoplasms: A multicenter, retrospective study

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World Journal of Gastroenterology 2022年第37期28卷 5469-5482页

作者： Dong Jiang Zi-Xiang Chen Fu-Xiao Ma Yu-Yong gong Tian pu Jiang-Ming Chen xue-Qian Liu Yi-Jun Zhao Kun Xie Hui Hou Cheng Wang Xiao-Ping Geng Fu-Bao Liu Department of General Surgery The First Affiliated Hospital of Anhui Medical UniversityHefei 230000Anhui ProvinceChina Department of General Surgery The Second Affiliated Hospital of Anhui Medical UniversityHefei 230000Anhui ProvinceChina Department of General Surgery The First Affiliated Hospital of University of Science and Technology of ChinaHefei 230000Anhui ProvinceChina

BACKGROUND Efficient and practical methods for predicting the risk of malignancy in patients with pancreatic cystic neoplasms(PCNs)are *** To establish a nomogram-based online calculator for predicting the risk of malignancy in patients with *** In this study,the clinicopathological data of target patients in three medical centers were *** independent sample t-test,Mann–Whitney U test or chi-squared test were used as appropriate for statistical *** univariable and multivariable logistic regression analysis,five independent factors were screened and incorporated to develop a calculator for predicting the risk of ***,the concordance index(C-index),calibration,area under the curve,decision curve analysis and clinical impact curves were used to evaluate the performance of the *** Enhanced mural nodules[odds ratio(OR):4.314;95%confidence interval(CI):1.618–11.503,P=0.003],tumor diameter≥40 mm(OR:3.514;95%CI:1.138–10.849,P=0.029),main pancreatic duct dilatation(OR:3.267;95%CI:1.230–8.678,P=0.018),preoperative neutrophil-to-lymphocyte ratio≥2.288(OR:2.702;95%CI:1.008–7.244,P=0.048],and preoperative serum CA19-9 concentration≥34 U/mL(OR:3.267;95%CI:1.274–13.007,P=0.018)were independent risk factors for a high risk of malignancy in patients with *** the training cohort,the nomogram achieved a C-index of 0.824 for predicting the risk of *** predictive ability of the model was then validated in an external cohort(C-index:0.893).Compared with the risk factors identified in the relevant guidelines,the current model showed better predictive performance and clinical *** The calculator demonstrates optimal predictive performance for identifying the risk of malignancy,potentially yielding a personalized method for patient selection and decision-making in clinical practice.

关键词： Pancreatic cystic neoplasms Risk of malignancy Nomogram Model Prediction Calculator

弱的参数周期扰动对一非线性系统安全域的影响与分形侵蚀安全域的控制

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物理学报 2001年第5期50卷 841-846页

作者：龚璞林徐健学孙政策西安交通大学非线性动力学研究所西安710049

讨论了弱参数周期扰动对于非线性系统安全域的影响 ,在一定频率下的参数周期扰动将加速安全域的分形侵蚀 ,而在另一些频率的扰动下 ,将抑制安全域的分形侵蚀 ,并且存在着增进安全域的最优频率 .提出了用弱参数周期扰动控制受到分形侵蚀... 详细信息

讨论了弱参数周期扰动对于非线性系统安全域的影响 ,在一定频率下的参数周期扰动将加速安全域的分形侵蚀 ,而在另一些频率的扰动下 ,将抑制安全域的分形侵蚀 ,并且存在着增进安全域的最优频率 .提出了用弱参数周期扰动控制受到分形侵蚀的安全域的方法 ,并用Melnikov方法进行了分析 .最后讨论了这种控制安全域的方法在实际环境中当具有外加噪声时的鲁棒性 .

关键词：分形吸引域边界参数周期扰动控制非线性系统安全域分形侵蚀非线性振子工程动力学 Melnikov方法吸引子