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Broadening environmental research in the era of accurate protein structure determination and predictions

Frontiers of Environmental Science & Engineering 2024年第7期18卷 169-178页

作者： mingda zhou Tong Wang Ke Xu Han Wang Zibin Li Wei-xian Zhang Yayi Wang State Key Laboratory of Pollution Control and Resources Reuse Shanghai Institute of Pollution Control and Ecological SecurityCollege of Environmental Science and EngineeringTongji UniversityShanghai 200092China Translational Research Institute of Brain and Brain-Like Intelligence Shanghai Fourth People's HospitalSchool of MedicineTongji UniversityShanghai 200434China

The deep-learning protein structure prediction method AlphaFold2 has garnered enormous attention beyond the realm of structural biology,for its groundbreaking contribution to solving the"protein foiding problem"In this perspective,we explore the connection between protein structure studies and environmental research,delving into the potential for addressing specific environmental *** are promising for environmental applications because of the functional diversity endowed by their structural ***,structural studies on proteins with environmental significance remain ***,we present the opportunity to study proteins by advancing experimental determination and deep-learning prediction ***,the latest progress in environmental research via cryogenic electron microscopy is *** allows us to determine the structure of protein complexes in their native state within cells at molecular resolution,revealing environmentally-associated structural *** the remarkable advancements in computational power and experimental resolution,the study of protein structure and dynamics has reached unprecedented depth and *** advancements will undoubtedly accelerate the establishment of comprehensive environmental protein structural and functional *** opportunities for protein engineering exist to enable innovative solutions for environmental applications,such as the degradation of persistent contaminants,and the recovery of valuable metals as well as rare earth elements.

关键词： Environmental proteins Protein structure Cryogenic electron microscopy Protein structure prediction Protein engineering Artificial Intelligence

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Ethanol electrooxidation on Pd/C nanoparticles in alkaline media

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Journal of Energy Chemistry 2016年第1期25卷 71-76页

作者： Fangfang Zhang Debi zhou mingda zhou College of Chemistry and Chemical Engineering Central South University

Carbon-supported Pd nanoparticles were prepared by microwave heating-glycol reduction method, and characterized by a wide array of experimental techniques including X-ray diffraction spectroscopy（XRD） and transmission electron microscopy（TEM）. The electrooxidation behaviors of ethanol on the Pd/C electrode in alkaline media were investigated using cyclic voltammetry（CV）, chronoamperometry（CA）, electrochemical impedance spectroscopy（EIS） and single cell performance methods. Pd/C electrode for ethanol oxidation showed high electro-catalytic activity and long term stability. However, it is observed that the current density decreases with the increasing of the potential and negative impedance presents in the potential from-0.1 to0.1 V. The decreasing current density and the negative impedance could be due to the adsorbed intermediates species that inhibited the further oxidation of ethanol. Based on the chemical reaction analysis and EIS spectra, equivalent circuits relating to various potential zones have been obtained. These results reveal the dynamic adsorption of intermediates species on Pd surfaces. Significantly, it is clarified that the adsorption behavior begins from the maximum catalysis of electro-catalysis and ends in the formation of the palladium（II） oxide layer on the electrode surface.

关键词： Catalyst Adsorption behavior Ethanol oxidation Negative impedance

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Air target intention recognition and causal effect analysis combining uncertainty information reasoning and potential outcome framework

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Chinese Journal of Aeronautics 2024年第1期37卷 287-299页

作者： Yu ZHANG Fanghui HUANG Xinyang DENG mingda LI Wen JIANG School of Electronics and Information Northwestern Polytechnical UniversityXi’an 710129China

Recognizing target intent is crucial for making decisions on the ***,the imperfect and ambiguous character of battlefield situations challenges the validity and causation analysis of classical intent recognition *** with the challenge,a target intention causal analysis paradigm is proposed by combining with an Intervention Retrieval(IR)model and a Hybrid Intention Recognition(HIR)*** target data acquired by the sensors are modelled as Basic Probability Assignments(BPAs)based on evidence theory to create uncertain ***,the HIR model is utilized to recognize intent for a tested sample from uncertain ***,the intervention operator under the evidence structure is utilized to perform attribute intervention on the tested *** retrieval is performed in the sample database based on the IR model to generate the intention distribution of the pseudo-intervention samples to analyze the causal effects of individual sample *** simulation results demonstrate that our framework successfully identifies the target intention under the evidence structure and goes further to analyze the causal impact of sample attributes on the target intention.

关键词： Causal effect analysis Hybrid intention recognition Intervention retrieval Target intention Uncertainty reasoning

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How Effective are Decentralized Anti-poverty Programs?

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China & World Economy 2024年第4期32卷 85-113页

作者： Shuai Chen mingda Cheng Jie-Sheng Tan-Soo China Academy for Rural Development and School of Public Affairs Zhejiang UniversityChina Jiangxi Caitong Supply Chain Financial Group Co. Ltd.Jiangxi Financial Holding Group Co.Ltd.China Lee Kuan Yew School of Public Policy National University of SingaporeSingapore

This study examines the effectiveness of China's National Poor Counties(NPC)program,a decentralized anti-poverty initiative,by analyzing five rounds of individual-level panel data from 1988 to *** impact of two waves of the NPC program(1994 and 2001)is evaluated utilizing a panel fixed-effects regression *** results indicate substantial positive effects,with residents in NPC counties experiencing a 47 percent income increase,3.1 percent higher employment rates,and a 5.7 percent rise in household expenditure from 1988 to 2008,in comparison with non-NPC ***,the program benefited vulnerable populations,dispelling concerns about"elite capture."The study also reveals that evolving policy focus has played a pivotal role in sustaining the effects of the program over *** 1994 round prioritized low-skilled employment,and the 2001 wave emphasized productivity enhancement through skills *** findings highlight the continued efficacy of decentralized anti-povertyefforts.

关键词： decentralization elite capture National Poor Counties program poverty

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乘子法在多组分光度分析中的应用

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分析化学 1999年第6期27卷 715-718页

作者：周明达文莉邓凯佳刘建华湖南医科大学基础医学院湖南医科大学基础医学院长沙410078

报道了将乘子法用于样品中多组分的分光光度法同时测定;介绍了乘子法的原理和计算步骤.对复方新诺明模拟样中磺胺甲噁唑、甲氧苄氨嘧啶测定的平均回收率分别为99.79%、100.67%;RSD分别为0.45%、0.95%(n=9).测定了5个批号复方新诺明片剂... 详细信息

报道了将乘子法用于样品中多组分的分光光度法同时测定;介绍了乘子法的原理和计算步骤.对复方新诺明模拟样中磺胺甲噁唑、甲氧苄氨嘧啶测定的平均回收率分别为99.79%、100.67%;RSD分别为0.45%、0.95%(n=9).测定了5个批号复方新诺明片剂和针剂的含量,结果满意.

关键词：乘子法紫外分光光度法复方新诺明磺胺甲(口恶)唑甲氧苄胺嘧啶

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A synergetic strategy of NIR-Ⅱ squaraine dyes with ultrahigh photothermal conversion efficiency for photothermal therapy

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Science China Chemistry 2024年第2期67卷 612-621页

作者： Yigang Wang Guomin Xia Junhui Wang mingda Wang Weihan Guo Manman Tan Leilei Si Yang Yang Hua Wang Hongming Wang Institute for Advanced Study and School of Chemistry and Chemical Engineering Nanchang UniversityNanchang330031China State Key Laboratory of Molecular Reaction Dynamics and Dynamics Research Center for Energy and Environmental Materials Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian116023China The Second Affiliated Hospital of Nanchang University Nanchang330031China

Recent research on photothermal therapy(PTT) has sparked significant interest in the development of new organic photothermal agents(PTAs),ranging from single-molecule to aggregated ***,controlling aggregation pathways for PTAs with ultrahigh photothermal conversion efficiency(PCE) remains a major ***,a two-pronged approach utilizing “Haggregation” and “intramolecular motion” was employed to enhance the PCE of an acceptor-substituted squaraine dye(NSQs).The C2vmolecular symmetry of the NSQs,which possess a ground state dipole moment(μg),promotes H-dimeric aggregates through dipole-dipole *** triphenylethylene or diphenylamine groups were added to this H-dimeric *** was done to enhance intramolecular motions for heat generation and also to extend conjugation,which redshifted the optical absorption and balanced the blue-shift induced by *** this technique,an organic PTA with NIR-II absorption was developed,and its nanoparticle achieved a remarkable PCE of 86.3% under 1,064 nm laser *** transient absorption spectroscopy and quantum mechanical calculations demonstrated the accelerated internal conversion process in NIR-II PTAs for rapid heat *** NSQs nanoparticles exhibit superior photothermal therapeutic properties for in vivo photoacoustic imaging-guided PTT,demonstrating the potential of bottom-up design to enable synergistic engineering strategies towards efficient phototheranostic agents.

关键词： squaraine dyes second near-infrared window H-aggregation intramolecular motion photothermal therapy

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Therapeutic sponge prevents postoperative breast cancer recurrence by sustainably dissociating into CD44-targeted nanoplatform

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Nano Research 2024年第3期17卷 1792-1803页

作者： Junhui Sui mingda Zhao Zhihao Guo Jiafeng Li Jie Chen Hongli Chen Jie Liang Yong Sun Xingdong Zhang Yujiang Fan National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China Beijing Tide Pharmaceutical Co. Ltd.Beijing 100176China The Key Laboratory of Biomedical Material School of Life Science and TechnologyXinxiang Medical UniversityXinxiang 453003China Coal Mining Branch China Coal Research InstituteBeijing 100028China School of Ophthalmology&Optometry Eye HospitalWenzhou Medical UniversityWenzhou 325027China

Locoregional recurrence and distant metastasis of breast cancer still pose a significant risk for patients’*** address the clinical challenge,functional absorbable sponges(HA-SH/PP-Dox/Lap/COL I(HCNPs))were constructed by biomimetic extracellular matrix of collagen I/hyaluronic acid complex conjugated with doxorubicin/lapatinib(Dox/Lap)-loaded *** HCNPs sponge exhibited excellent clotting ability and blood absorption ***,Dox/Lap-loaded nanoparticles were synchronously endowed with a large number of oligo hyaluronic acid segments after degradation,which thus enhanced the ability of targeting into CD44-overexpressed tumor *** implantable HCNPs sponge in resected cavity of postoperative 4T1 models inhibited the spread of scattered tumor cells by absorbing the inevitable *** importantly,CD44 targeted nanoparticle with suitable Dox/Lap proportion continuously released from sponge to kill tumor cells of surrounding HCNPs and those remaining at surgical margin,thus prevented local recurrence as well as distant ***,the functional HCNPs sponge might provide a safer and more effective strategy for postoperative treatment of cancer.

关键词： therapeutic sponge scattered tumor cells recurrence and metastasis CD44-targeted nanoparticles breast cancer

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Mechanisms of vacuolar phosphate efflux supporting soybean root hair growth in response to phosphate deficiency

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Journal of Integrative Plant Biology 2024年第9期66卷 1983-1999页

作者： Zhong Shan Yanli Chu Guangfang Sun Rui Chen Jun Yan Qiwei He Yingna Liu Bin Wang mingda Luan Wenzhi Lan School of Life Sciences Nanjing UniversityNanjing 210023China Institute of Future Agriculture Northwest A&F UniversityYangling 712100China

Phosphorus is an essential macronutrient for plant growth and *** response to phosphate(Pi)deficiency,plants rapidly produce a substitutive amount of root hairs;however,the mechanisms underlying Pi supply for root hair growth remain ***,we observed that soybean(Glycine max)plants maintain a consistent level of Pi within root hairs even under external Pi *** therefore investigated the role of vacuole-stored Pi,a major Pi reservoir in plant cells,in supporting root hair growth under Pi-deficient *** findings indicated that two vacuolar Pi efflux(VPE)transporters,GmVPE1 and GmVPE2,remobilize vacuolar stored Pi to sustain cytosolic Pi content in root hair *** analysis showed that double mutants of GmVPE1 and GmVPE2 exhibited reduced root hair growth under low Pi ***,GmVPE1 and GmVPE2 were highly expressed in root hairs,with their expression levels significantly upregulated by low Pi *** analysis revealed that GmRSL2(ROOT HAIR DEFECTIVE 6-like 2),a transcription factor involved in root hair morphogenesis,directly binds to the promoter regions of GmVPE1 and GmVPE2,and promotes their expressions under low Pi ***,mutants lacking both GmRSL2 and its homolog GmRSL3 exhibited impaired root hair growth under low Pi stress,which was rescued by overexpressing either GmVPE1 or *** together,our study has identified a module comprising vacuolar Pi exporters and transcription factors responsible for remobilizing vacuolar Pi to support root hair growth in response to Pi deficiency in soybean.

关键词： mineral deficiency remobilization root remodeling transcriptional regulation

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基于惯导辅助地磁的手机室内定位系统设计

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传感技术学报 2015年第8期28卷 1249-1254页

作者：宋镖程磊周明达吴怀宇陈洋武汉科技大学冶金自动化与检测技术教育部工程研究中心武汉430081

目前的室内定位技术大都是需要建立足够多的信号节点,这种有源信号受建筑物干扰衰减快导致其定位精度不足。为了避免这些存在的问题,通过深入研究室内定位方法,提出了基于惯导辅助地磁匹配的适用于手机移动终端的室内定位方法。有别于... 详细信息

目前的室内定位技术大都是需要建立足够多的信号节点,这种有源信号受建筑物干扰衰减快导致其定位精度不足。为了避免这些存在的问题,通过深入研究室内定位方法,提出了基于惯导辅助地磁匹配的适用于手机移动终端的室内定位方法。有别于传统的室外定位系统,本文利用地球磁场在不同点的差异化信息,并通过选择适当的地磁匹配算法,可以实现不依赖于外部设备的移动个体室内定位,同时通过惯导辅助地磁的组合定位方式有效增加地磁信息匹配效率,能获得较高的室内定位的精度。最后设计了基于android平台的手机室内定位软件,可利用手机内置的传感器设备实现室内定位功能,仿真及实验显示该定位方法是有效的。

关键词：地磁应用传感器室内定位惯性导航 android

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Transcriptome Analysis of Inflorescence Development at the Five-Leaf Stage in Castor(Ricinus communis L.)

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Phyton-International Journal of Experimental Botany 2024年第4期93卷 713-723页

作者： Yong Zhao Yaxuan Jiang Li Wen Rui Luo Guorui Li Jianjun Di mingda Yin Zhiyan Wang Fenglan Huang Fanjuan Meng College of Life Science Baicheng Normal UniversityBaicheng137000China College of Life Science and Food Inner Mongolia University for the NationalitiesTongliao028000China College of Life Science Northeast Forestry UniversityHarbin150040China Key Laboratory of Castor Breeding of the State Ethnic Affairs Commission Inner Mongolia Minzu UniversityTongliao028043China Inner Mongolia Industrial Engineering Research Center of Universities for Castor Inner Mongolia Minzu UniversityTongliao028043China Inner Mongolia Key Laboratory of Castor Breeding and Comprehensive Utilization Inner Mongolia Minzu UniversityTongliao028000China Inner Mongolia Engineering Research Center of Industrial Technology Innovation of Castor Inner Mongolia Minzu UniversityTongliao028000China

The yield of castor is influenced by the type of inflorescence and the proportion of female ***,there are few studies on the genetic mechanism involved in the development and differentiation of castor *** this study,we performed transcriptomic analyses of three different phenotypes of inflorescences at the five-leaf *** comparison to the MI(complete pistil without willow leaves),290 and 89 differentially expressed genes(DEGs)were found in the SFI(complete pistil with willow leaves)and the BI(monoecious inflorescence),*** the DEGs,104 and 88 were upregulated in the SFI and BI,respectively,compared to the *** addition,186 DEGs and 1 DEG were downregulated in the SFI and BI compared to the ***,we conducted GO and KEGG enrichment analyses of the *** comparison to the MI,the SFI and BI exhibited the enrichment of functional branches in DEGs,specifically in pollen wall assembly,pollen development,and cellular component assembly involved in *** our study,RADL5 showed low expression levels between SFI-vs.-MI *** addition,we found that the expression of NAC in the SFI differed from that in MI and BI,and some genes related to hormonal signaling changed their expression levels during inflorescence *** results reveal the genetic mechanism of sex genotypes in castor,which will not only guide researchers in the breeding of castor but also provide a reference for genetic research on other flowering plants.

关键词： Ricinus communis L RNA-Seq inflorescence

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