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Three-phase Enriched Environment Improves Post-stroke Gait Dysfunction via Facilitating Neuronal Plasticity in the Bilateral Sensorimotor Cortex:A Multimodal MRI/PET Analysis in Rats

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Neuroscience Bulletin 2024年第6期40卷 719-731页

作者： Yun Lu Ziyue lin mingcong li Yuming Zhuang Binbin Nie Jianfeng Lei Yuanyuan Zhao Hui Zhao School of Traditional Chinese Medicine Capital Medical UniversityBeijing100069China Beijing Key Lab of TCM Collateral Disease Theory Research Beijing100069China Beijing Engineering Research Center of Radiographic Techniques and Equipment Institute of High Energy PhysicsChinese Academy of SciencesBeijing100049China Medical Imaging Laboratory of Core Facility Center Capital Medical UniversityBeijing100069China

The three-phase Enriched Environment(EE)paradigm has been shown to promote post-stroke functional improvement,but the neuronal mechanisms are still *** this study,we applied a multimodal neuroimaging protocol combining magnetic resonance imaging(MRI)and positron emission tomography(PET)to examine the effects of post-ischemic EE treatment on structural and functional neuroplasticity in the bilateral sensorimotor *** were subjected to permanent middle cerebral artery *** motor function of the rats was examined using the DigiGait *** was applied to investigate the EE-induced structural modifications of the bilateral sensorimotor cortex.[^(18)F]-fluorodeoxyglucose PET was used to detect glucose *** oxygen level-dependent(BOLD)-functional MRI(fMRI)was used to identify the regional brain activity and functional connectivity(FC).In addition,the expression of neuroplasticity-related signaling pathways including neurotrophic factors(BDNF/CREB),axonal guidance proteins(Robo1/Slit2),and axonal growth-inhibitory proteins(NogoA/NgR)as well as downstream proteins(RhoA/ROCK)in the bilateral sensorimotor cortex were measured by Western *** results showed the three-phase EE improved the walking *** T2 mapping imaging and diffusion tensor imaging demonstrated that EE benefited structure integrity in the bilateral sensorimotor ***-MRI fused images showed improved glucose metabolism in the corresponding regions after EE ***,the BOLD-based amplitude of low-frequency fluctuations showed that EE increased spontaneous activity in the bilateral motor cortex and ipsilateral sensory *** addition,FC results showed increased sensorimotor connectivity in the ipsilateral hemisphere and increased interhemispheric motor cortical connectivity and motor cortical-thalamic connectivity following EE *** addition,a strong correlation was found between increased functional connectivity and improv

关键词： Enriched environment Gait function Neuronal plasticity Structural integrity Glucose metabolism Functional connectivity Microenvironmental molecules Axonogenesis

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源-网-荷-储一体化技术在园区配电系统中的应用

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电力系统装备 2024年第2期 36-37,122页

作者：李明聪温州设计集团有限公司浙江温州325000

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大规模分布式资源应用使得传统的园区配电系统安全经济运行面临着重大的挑战,针对该问题,分析了源-网-荷-储园区的整体架构,以及园区内源-网-荷-储协同调控的机理特性,并梳理了源-网-荷-储园区协同应用模式和相关应用技术,总结了源-网-荷-储园区协同模式的作用。

关键词：源-网-荷-储一体化技术协同应用模式园区配电系统

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青海省长江源区近十年水资源状况与产业发展的关联分析

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青海科技 2024年第1期31卷 168-173页

作者：李明聪巢世军周玉碧青海省青藏高原特色生物资源研究重点实验室中国科学院西北高原生物研究所西宁810008 中国科学院大学北京100049 青海省环境科学研究设计院有限公司西宁810007

以青海省长江源区林牧渔畜产业与水资源利用为研究对象,发掘2013-2022年青海省长江源区林牧渔畜产业发展与水资源之间的变化趋势。应用时间序列分析、灰色关联分析等多元数据分析方法,分析了青海省长江源区林牧渔畜产业发展与水资源的... 详细信息

以青海省长江源区林牧渔畜产业与水资源利用为研究对象,发掘2013-2022年青海省长江源区林牧渔畜产业发展与水资源之间的变化趋势。应用时间序列分析、灰色关联分析等多元数据分析方法,分析了青海省长江源区林牧渔畜产业发展与水资源的关联性。研究表明,青海省长江源区水资源量呈现平稳周期性变化,且呈现上升的趋势;青海省长江流域的水资源与该区域的林牧渔畜产业中的畜牧业的关联度较强,且与玉树州经济发展关联度较强。

关键词：水资源长江源区关联性分析林牧渔畜产业

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基于白光干涉技术的表面微观形貌测量方法

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计量与测试技术 2024年第9期51卷 109-111,114页

作者：李铭聪刘盼史建华中国航空制造技术研究院

本文从测量原理和技术特性的角度出发,分析了扫描显微镜法、光学干涉法、激光散射法和共焦显微法等非接触测量方法的适用范围。同时,根据白光干涉法的干涉特性和工作原理,研究了其常用的信号处理算法、数据处理和参数评定过程,并对表面... 详细信息

本文从测量原理和技术特性的角度出发,分析了扫描显微镜法、光学干涉法、激光散射法和共焦显微法等非接触测量方法的适用范围。同时,根据白光干涉法的干涉特性和工作原理,研究了其常用的信号处理算法、数据处理和参数评定过程,并对表面三维微观形貌、表面粗糙度、划痕深度进行测量与评价。实验证明:该方法在表面三维微观形貌精确测量中具有显著优势,且精度较高,可为其质量评定提供技术支撑。

关键词：白光干涉技术非接触测量表面三维微观形貌数据处理参数评定

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补阳还五汤改善脑缺血大鼠血流灌注的多模态磁共振成像研究

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环球中医药 2024年第9期17卷 1691-1697页

作者：李慢中庄雨明林子越李明聪姜德春赵晖首都医科大学附属北京世纪坛医院药学部临床合理用药评价北京市重点实验室 100038 首都医科大学中医药学院

目的利用多模态磁共振成像(magnetic resonance imaging,MRI)技术纵向观察补阳还五汤对脑缺血大鼠侧支循环及血流灌注的影响。方法采用线栓法建立永久性中动脉栓塞致脑缺血大鼠模型。将造模成功的24只大鼠随机分为模型组、补阳还五汤高... 详细信息

目的利用多模态磁共振成像(magnetic resonance imaging,MRI)技术纵向观察补阳还五汤对脑缺血大鼠侧支循环及血流灌注的影响。方法采用线栓法建立永久性中动脉栓塞致脑缺血大鼠模型。将造模成功的24只大鼠随机分为模型组、补阳还五汤高剂量组(16.6 g/kg)、补阳还五汤低剂量组(8.3 g/kg),每组8只,以及假手术组(8只),共分4组。各给药组大鼠在造模后24小时灌胃给药,连续给药15天。假手术组和模型组大鼠给予等量生理盐水。分别在给药后第7天和15天进行多模态MRI扫描。利用T2加权成像检测脑梗死体积,磁共振血管成像检测颅内动脉信号,动脉自旋标记检测缺血边缘血流灌注。结果与假手术组大鼠比较,缺血7天和15天后,模型组大鼠缺血侧前动脉(anterior cerebral artery,ACA)、颈内动脉(internal carotid artery,ICA)、后动脉(posterior cerebral artery,PCA)血管信号强度显著降低(P<0.05,P<0.001),基底动脉(basilar artery,BA)信号强度显著升高(P<0.001),缺血边缘血流灌注明显降低(P<0.001)。与模型组比较,补阳还五汤高、低剂量治疗均可明显减少缺血7天后脑梗死体积(P<0.05),降低缺血7天和15天BA信号强度(P<0.05,P<0.01),并升高缺血15天后缺血边缘的血流灌注(P<0.001)。此外,补阳还五汤高剂量治疗还可以降低缺血15天后脑梗死体积(P<0.01),并升高ACA及ICA信号强度(P<0.05);补阳还五汤低剂量还可以升高缺血7天后缺血边缘的血流灌注(P<0.05)。结论补阳还五汤可促进颅内关键动脉侧支循环建立,改善脑血流灌注,降低脑梗死体积,保护脑组织。

关键词：补阳还五汤脑缺血大鼠血流灌注磁共振成像动脉自旋标记

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Effects of long-term fertilization with different substitution ratios of organic fertilizer on paddy soil

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Pedosphere 2022年第4期32卷 637-648页

作者： Weifeng SONG Aiping SHU Jiai liU Wenchong SHI mingcong li Wenxue ZHANG Zuzhang li Guangrong liU Fusheng YUAN Shuxin ZHANG Zengbing liU Zheng GAO State Key Laboratory of Crop Biology Shandong Agricultural UniversityTai'anChina College of life Sciences Shandong Agricultural UniversityTai'anChina Institute of Soil and Fertilizer&Resource and Environment/National Engineering and Technology Research Center for Red Soil Improvement Nanchang330200China

In recent years,the abuse of chemical fertilizers has caused numerous environmental problems,such as soil acidification and *** chemical fertilizers with organic fertilizers can effectively alleviate these ***,the effects of alternative organic fertilizers remain *** explore the effects of organic fertilizer substitution on rice yield and paddy soil physicochemical properties and bacterial community structure,we conducted a 5-year experiment using different proportions of organic fertilizer substitution in a double-cropping rice field in Jiangxi,*** results showed that replacing chemical fertilizers with organic fertilizers can reduce soil acidification,increase soil organic matter content,nutrient contents,and enzyme activities,improve soil physicochemical properties and microbial community,and enhance soil *** organic substitution also had positive effects on rice *** findings enhance our understanding of the effects of different alternative organic fertilization methods and have important theoretical significance for the promotion of the use of organic fertilizers in the future.

关键词： bacterial community double-cropping rice organic matter rice yield soil acidification,soil property

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Recent Progress in Optical Sensors Based on MXenes Quantum Dots and MXenes Nanosheets

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Journal of Analysis and Testing 2024年第1期8卷 95-113页

作者： Chunxiao lin Xinhong Song Weilan Ye Ting liu mingcong Rong li Niu Guangzhou Key Laboratory of Sensing Materials and Devices/Center for Advanced Analytical Science/School of Chemistry and Chemical Engineering Guangzhou UniversityGuangzhou 510006China College of Ocean Science and Engineering Shanghai Maritime UniversityShanghai 201306China

In recent years,MXenes,as a new promising two-dimensional material,have received extensive attentions in the fields of environmental remediation,catalysts,sensors,and energy *** broaden the applications of MXenes in sensing,MXenes nanosheets(MNSs) and MXenes quantum dots(MQDs) are prepared by physical etching or chemical *** are monolayered or multilayered MXenes nanosheets within several nanometers in height,and can serve as the perfect reaction substrate and fluorescence *** are spherical,fluorescent MXenes QDs within several nanometers in size,which possess favorable stability and photo *** the distinct features such as high conductivity,favorable hydrophilicity,biocompatibility,abundant surface functional groups,and easy functionalization,MNSs and MQDs show potential applications in the fields of anti-counterfeiting,environmental monitoring,biosensing and *** review focuses on the research of MNS s/MQDs-based optical sensors,including colorimetric sensors,fluorescence sensors,electrochemiluminescence sensors,surface plasmon resonance sensors,and surface-enhanced Raman scattering ***,the current challenges and prospects concerning MNSs/MQDs-based optical sensing techniques are discussed.

关键词： MXenes quantum dots Fluorescence Colorimetry Electrochemiluminescence Surface plasmon resonance

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On Energy Assessment of Titanium Alloys Belt Grinding Involving Abrasive Wear Effects

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Chinese Journal of Mechanical Engineering 2023年第6期36卷 185-196页

作者： mingcong li Shudong Zhao Heng li Yun Huang Lai Zou Wenxi Wang College of Mechanical and Vehicle Engineering Chongqing UniversityChongqing 400044China State Key Laboratory of Mechanical Transmissions Chongqing UniversityChongqing 400044China

Improved energy utilisation,precision,and quality are critical in the current trend of low-carbon green *** this study,three abrasive belts were prepared at various wear stages and characterised *** effects of abrasive belt wear on the specific grinding energy partition were investigated by evaluating robotic belt grinding of titanium plates.A specific grinding energy model based on subdivided tangential forces of cutting and sliding was developed for investigating specific energy and energy utilisation coefficient *** surface mor-phology and Abbott–Firestone curves of the belts were introduced to analyse the experimental findings from the per-spective of the micro cutting *** specific grinding energy increased with abrasive belt wear,especially when the belt was near the end of its ***,the belt wear could lead to a predominance change of sliding and chip formation *** highest EUC was observed in the middle of the belt life because of its retained sharp cutting edge and uniform distribution of the grit protrusion *** study provides guidance for balancing the energy consumption and energy utilization efficiency of belt grinding.

关键词： Belt grinding Wear Specific grinding energy Microtopography

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天津市负氧离子浓度变化特征分析及预测模型筛选

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天津科技 2024年第3期51卷 11-15页

作者：廖云琛李明聪吴洋张嘉霖孙树鹏尹紫薇天津市津南区气象局天津300350 天津市东丽区气象局天津300300

利用天津市梁庄子站(森林区)、市区站(居民区)2019年6月至2022年12月的负氧离子浓度数据、气象、环境要素数据,分析逐日负氧离子浓度不同时间尺度上的变化特征及其与不同要素之间的关系,并构建最优预测模型。结果表明:①森林区和居民区... 详细信息

利用天津市梁庄子站(森林区)、市区站(居民区)2019年6月至2022年12月的负氧离子浓度数据、气象、环境要素数据,分析逐日负氧离子浓度不同时间尺度上的变化特征及其与不同要素之间的关系,并构建最优预测模型。结果表明:①森林区和居民区负氧离子浓度均呈“一峰一谷”型日变化特征,森林区存在“两峰一谷”型月变化特征,而居民区不明显;②森林区负氧离子浓度为(春季,冬季)>秋季>夏季,居民区为夏季>春季>秋季>冬季;③居民区负氧离子浓度明显低于森林区,不同区域存在不同的影响要素;④构建森林区逐日负氧离子浓度预测模型更适合使用随机森林法,构建居民区逐日负氧离子浓度预测模型更适合使用随机梯度下降法。

关键词：负氧离子浓度气象要素预测模型机器学习

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Long-term Consumption of Highland Barley Tea Promotes Healthy Aging of Skeletal Muscle

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Food Science and Human Wellness 2024年

作者： li Yan Chenzhipeng Nie Qingwei Zheng mingcong Fan Waleed AL-Ansi Haifeng Qian li Wang State Key Laboratory of Food Science and Technology， School of Food Science and Technology， Jiangnan University

Highland barley tea (HBT) is made from roasted barley seeds and is abundant in β-glucan， amino acids， minerals， phenolics， and other natural active ingredients. These natural compounds found in whole grains have been shown to slow aging and positively affect skeletal muscle function. As a result， studying the effects of HBT on the skeletal muscle health of the elderly population is critical from a scientific and societal standpoint for improving their health status and reducing the medical burden on society. The antioxidant activity and the content of natural active substances were used as indicators to screen the optimal process of HBT brewing. The effects of long-term HBT consumption on aging in mice were investigated by using HBT as a substitute for drinking water in naturally aging mice for a 5-month intervention. Afterward， various factors were measured， such as basic physiological indices， inflammation， plasma metabolites， skeletal muscle function， and exercise capacity， to evaluate the effects of HBT on aging in mice. Long-term consumption of HBT reduced body and spleen weight， increased body weight percentage of skeletal muscle， and reduced plasma inflammation levels in aging mice. Metabolomic results showed increased plasma levels of the mitochondrial marker short-chain acylcarnitine and some amino acids. Additionally， there was a decrease in bile and long-chain acylcarnitine. The level of fibrosis in the gastrocnemius muscle of aging mice was suppressed， and the percentage of type I muscle fibers was increased， improving the endurance of the mice. Thus， long-term consumption of HBT may reduce body weight and increase skeletal muscle mitochondrial activity and exercise capacity in aging mice by reducing inflammation levels and alleviating mitochondrial damage.

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