检索结果-南通市图书馆

Novel NIR-Ⅱfluorescent probes for biliary atresia imaging

Acta Pharmaceutica Sinica B 2023年第11期13卷 4578-4590页

作者： Xiaodong Zeng Yuqin Liao Xue Qiao Ke Liang Qiusi Luo mingbo deng Yishen Liu Weijing Zhang Xuechuan Hong Yuling Xiao State Key Laboratory of Virology Department of CardiologyZhongnan Hospital of Wuhan UniversitySchool of Pharmaceutical SciencesWuhan UniversityWuhan 430071China State Key Laboratory of Drug Research&Center of Pharmaceutics Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug DiscoveryYantai 264117China Key Laboratory of Biodiversity and Environment on the Qinghai-Tibetan Plateau Ministry of EducationSchool of Ecology and EnvironmentTibet UniversityLhasa 850000China Shenzhen Institute of Wuhan University Shenzhen 518057China School of Pharmacy Yantai UniversityYantai 264005China School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Biliary atresia is a rare infant disease that predisposes patients to liver transplantation and death if not treated in time.However,early diagnosis is challenging because the clinical manifestations and laboratory tests of biliary atresia overlap with other cholestatic diseases.Therefore,it is very important to develop a simple,safe and reliable method for the early diagnosis of biliary atresia.Herein,a novel NIR-Ⅱfluorescence probe,HZL2,with high quantum yield,excellent biocompatibility,low cytotoxicity and rapid excretion through the liver and gallbladder was developed based on the oil/water partition coefficient and permeability.A simple fecal sample after injection of HZL2 can be used to efficiently identify the success of the mouse model of biliary atresia for the first time,allowing for an early diagnosis of the disease.This study not only developed a simple and safe method for the early diagnosis of biliary atresia with great potential in clinical translation but also provides a research tool for the development of pathogenesis and therapeutic medicines for biliary atresia.

关键词： Biliary atresia Fluorescence imaging Second near-infrared window Early diagnosis Hepatobiliary excretion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

P2P Energy Trading Considering Prosumer Preference and System Risk

引用

CSEE Journal of Power and Energy Systems 2024年第3期10卷 1179-1194页

作者： Xinyu He Ping Dong mingbo Liu Xuewei Huang Wenli deng Ruijin He School of Electric Power Engineering South China University of TechnologyGuangzhou 510640China IEEE

As an important means of mobilizing demand-side resources,peer-to-peer(P2P)energy trading has drawn more and more attention from scholars.This paper constructs a P2P energy trading framework considering prosumers’trading partner preferences(TPPs)and system risk.At first,we build the P2P trading models of prosumers equipped with different distributed energy resources(DERs),and TPP models.Secondly,to solve the established energy trading problem,a fully distributed double-consensus alternating direction method of multipliers(DC-ADMM)is proposed,which can achieve transaction consensus when considering market players’TPPs.Then,a risk-based security constrained economic dispatch(RBSCED)model based on AC power flow is established for the first time,by which a distribution system operator(DSO)checks system security and obtains risk-based locational marginal prices(RLMPs).Moreover,double-regulated price signals related to RLMPs which contain grid utilization prices(GUPs)and DSO’s retail prices realize management of players’transactions.In the end,the proposed method is applied to an IEEE33 bus distribution system.Results show the proposed method effectively reduces system risk and ensures secure operation of system without direct management.

关键词： Double-consensus ADMM grid utilization price price signal risk-based locational marginal price trading partner preference

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Interfacial Reaction of Ti6Al4V Lattice Structure-Reinforced VW92 Alloy Matrix Composites

引用

Acta Metallurgica Sinica(English Letters) 2024年第3期37卷 570-576页

作者： Haijun Wang Renju Cheng Xianhua Chen mingbo Yang Daiyi deng Lirui Liu Yongfeng Zhou Yanlong Ma Kaihong Zheng Fusheng Pan College of Materials Science and Engineering Chongqing University of TechnologyChongqing 400054China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Institute of New Materials Guangdong Academy of SciencesGuangzhou 510650China

A novel melting infiltration by ultrasonic vibration was investigated and applied to fabricate Ti6Al4V(TC4)lattice structure-reinforced Mg-10Gd-2Y-1Zn-xZr(refer to VW92 hereafter,x=0,0.5 wt%)alloy matrix composites.The edge-to-edge matching model indicates that the well-matching and possible orientation relationships(ORs)between theα-Mg andα-Ti,[10-10]_(α-Mg)//[11-23]_(α-Ti) in(0002)_(α-Mg)//(10-10)_(α-Ti) possesses the smallest misfit of 0.4%(f_(r)),and thus theα-Mg grains can nucleate on the TC4 lattice structure.Interfacial reaction occurred in the TC4/VW92+0.5 wt%Zr composites,and the reaction product was confirmed to be Al_(2)Zr_(3),AlZr_(2) andα-Ti(Zr)particles formed by continuous solution of Zr-Ti.Among the interfacial products,the AlZr_(2) phase is a brittle phase with high-volume fraction,which is not conducive to the load transfer.But generally speaking,theα-Ti(Zr)and theα-Mg tend to form a coherent interface,which is beneficial for improving the interfacial bonding strength of composites.

关键词： TC4 VW92 composites TC4 lattice structure Interfacial reaction Mismatch

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Efficacy and safety of low-dose cyclophosphamide combined with lenvatinib, pembrolizumab and TACE for unresectable hepatocellular carcinoma:A single-center, prospective,single-arm clinical trial

引用

Chinese Journal of Cancer Research 2024年第2期36卷 114-123页

作者： Yupeng Ren Yuxuan Li mingbo Cao Yongchang Tang Feng Yuan Gaoyuan Yang Zhiwei He Zheng Shi Xiaorui Su Zhicheng Yao Meihai deng Department of Hepatobiliary Surgery the Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630China Department of General Surgery Qilu HospitalShandong UniversityJinan 250012China Department of Hepatobiliary Surgery the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China Department of Hepatobiliary and Pancreatic Surgery the Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630China

Objective: Unresectable hepatocellular carcinoma(uHCC) continues to pose effective treatment options. The objective of this study was to assess the efficacy and safety of combining low-dose cyclophosphamide with lenvatinib, pembrolizumab and transarterial chemoembolization(TACE) for the treatment of uHCC.Methods: From February 2022 to November 2023, a total of 40 patients diagnosed with uHCC were enrolled in this small-dose, single-center, single-arm, prospective study. They received a combined treatment of low-dose cyclophosphamide with lenvatinib, pembrolizumab, and TACE. Study endpoints included progression-free survival(PFS), objective response rate(ORR), and safety assessment. Tumor response was assessed using the modified Response Evaluation Criteria in Solid Tumors(mRECIST), while survival analysis was conducted through KaplanMeier curve analysis for overall survival(OS) and PFS. Adverse events(AEs) were evaluated according to the National Cancer Institute Common Terminology Criteria for Adverse Events(version 5.0).Results: A total of 34 patients were included in the study. The median follow-up duration was 11.2 [95% confidence interval(95% CI), 5.3-14.6] months, and the median PFS(mPFS) was 15.5(95% CI, 5.4-NA) months.Median OS(mOS) was not attained during the study period. The ORR was 55.9%, and the disease control rate(DCR) was 70.6%. AEs were reported in 27(79.4%) patients. The most frequently reported AEs(with an incidence rate >10%) included abnormal liver function(52.9%), abdominal pain(44.1%), abdominal distension and constipation(29.4%), hypertension(20.6%), leukopenia(17.6%), constipation(17.6%), ascites(14.7%), and insomnia(14.7%). Abnormal liver function(14.7%) had the most common grade 3 or higher AEs.Conclusions: A combination of low-dose cyclophosphamide with lenvatinib, pembrolizumab, and TACE is safe and effective for u HCC, showcasing a promising therapeutic strategy for managing uHCC.

关键词： Hepatocellular carcinoma lenvatinib low-dose cyclophosphamide pembrolizumab transarterial chemoembolization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Real-Time 3D Ultrasound Imaging System Based on a Hybrid Reconstruction Algorithm

引用

Chinese Journal of Electronics 2024年第1期33卷 245-255页

作者： Yifei LYU Yu SHEN mingbo ZHANG Junchen WANG School of Mechanical Engineering and Automation Beihang University The First Medical Center General Hospital of Chinese PLA

As a safe and convenient imaging technology in clinical routine diagnosis, ultrasound imaging can provide real-time 2D images of internal tissues and organs. To realize real-time 3D image reconstruction, pixel nearest neighbor interpolation(PNN) reconstruction algorithm and Bezier interpolation algorithm are combined into a hybrid reconstruction algorithm. On this basis, a real-time interactive 3D ultrasound imaging system is developed.Through temporal calibration and spatial calibration, the six degrees of freedom poses of 2D ultrasound images can be accurately collected. The 3D volume reconstructed by the proposed 3D reconstruction algorithm is visualized by volume rendering. A multi-thread software system allows parallel operation of data acquisition, 3D reconstruction,volume visualization and other functions. 3D imaging experiments on a 3D printing femur model, a neck phantom and the neck of human volunteers were performed for systematic evaluation. When the reconstruction voxel size was set to be(0.53 mm3, 1.03 mm3, 1.53 mm3), the reconstruction errors of the femur and trachea model were respectively(0.23 mm, 0.31 mm, 0.56 mm) and(0.62 mm, 0.88 mm, 1.41 mm). Clinical feasibility was demonstrated by application of the 3D ultrasound imaging on the neck of human volunteers.

关键词： 3D ultrasound imaging Free-hand reconstruction Spatial calibration

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

An Elite-Class Teaching-Learning-Based Optimization for Reentrant Hybrid Flow Shop Scheduling with Bottleneck Stage

引用

Computers, Materials & Continua 2024年第4期79卷 47-63页

作者： Deming Lei Surui Duan mingbo Li Jing Wang College of Automation Wuhan University of TechnologyWuhan430070China

Bottleneck stage and reentrance often exist in real-life manufacturing processes;however,the previous research rarely addresses these two processing conditions in a scheduling problem.In this study,a reentrant hybrid flow shop scheduling problem(RHFSP)with a bottleneck stage is considered,and an elite-class teaching-learning-based optimization(ETLBO)algorithm is proposed to minimize maximum completion time.To produce high-quality solutions,teachers are divided into formal ones and substitute ones,and multiple classes are formed.The teacher phase is composed of teacher competition and teacher teaching.The learner phase is replaced with a reinforcement search of the elite class.Adaptive adjustment on teachers and classes is established based on class quality,which is determined by the number of elite solutions in class.Numerous experimental results demonstrate the effectiveness of new strategies,and ETLBO has a significant advantage in solving the considered RHFSP.

关键词： Hybrid flow shop scheduling reentrant bottleneck stage teaching-learning-based optimization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Identification of the Worst-case Static Voltage Stability Margin Interval of AC/DC Power System Considering Uncertainty of Renewables

引用

CSEE Journal of Power and Energy Systems 2024年第3期10卷 974-987页

作者： Wanbin Liu Shunjiang Lin Yuerong Yang mingbo Liu Qifeng Li School of Electric Power Engineering South China University of TechnologyGuangzhou 510640China Guangdong Key Laboratory of Clean Energy Technology South China University of TechnologyGuangzhou 511458China Department of Electrical and Computer Engineering University of Central FloridaOrlandoFL 32816USA CSEE IEEE

Calculation of static voltage stability margin(SVSM)of AC/DC power systems with lots of renewable energy sources(RESs)integration requires consideration of uncertain load growth and renewable energy generation output.This paper presents a bi-level optimal power flow(BLOPF)model to identify the worst-case SVSM of an AC/DC power system with line commutation converter-based HVDC and multi-terminal voltage sourced converter-based HVDC transmission lines.Constraints of uncertain load growth’s hypercone model and control mode switching of DC converter stations are considered in the BLOPF model.Moreover,uncertain RES output fluctuations are described as intervals,and two three-level optimal power flow(TLOPF)models are established to identify interval bounds of the system worst-case SVSM.The two TLOPF models are both transformed into max–min bi-level optimization models according to independent characteristics of different uncertain variables.Then,transforming the inner level model into its dual form,max–min BLOPF models are simplified to single-level optimization models for direct solution.Calculation results on the modified IEEE-39 bus AC/DC case and an actual large-scale AC/DC case in China indicate correctness and efficiency of the proposed identification method.

关键词： AC/DC power system control mode switching convex relaxation dual programming multi-level optimization optimal power flow static voltage stability margin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Alternative relay regulates the adenosine triphosphatase activity of Locusta migratoria striated muscle myosin

引用

Insect Science 2024年第2期31卷 435-447页

作者： Jie Hao Chang Liu Ning Zhang Jing Li Tong Ni mingbo Qu Xiang-dong Li State Key Laboratory oflntegrated Management of lnsect Pests and Rodents Insttute of ZoologyChinese Academy of SciencesBejingChina University of Chinese Academy of Sciences BejingChina School of Bioengeering Dalian University of TechnologyDalianChina

Locust(Locusta migratoria)has a single striated muscle myosin heavy chain(Mhc)gene,which contains 5 clusters of alternative exclusive exons and 1 differently included penultimate exon.The alternative exons of Mhc gene encode 4 distinct regions in the myosin motor domain,that is,the N-terminal SH3-like domain,one lip of the nucleotide-binding pocket,the relay,and the converter.Here,we investigated the role of the alternative regions on the motor function of locust muscle myosin.Using Sf9-baculovirus protein expression system,we expressed and purified 5 isoforms of the locust muscle myosin heavy meromyosin(HMM),including the major isoform in the thorax dorsal longitudinal flight muscle(FL1)and 4 isoforms expressed in the abdominal intersegmental muscle(AB1 to AB4).Among these 5 HMMs,FL1-HMM displayed the highest level of actin-activated adenosine triphosphatase(ATPase)activity(hereafter referred as ATPase activity).To identify the alternative region(s)responsible for the elevated ATPase activity of FL1-HMM,we produced a number of chimeras of FL1-HMM and AB4-HMM.Substitution with the relay of AB4-HMM(encoded by exon-14c)substantially decreased the ATPase activity of FL1-HMM,and conversely,the relay of FL1-HMM(encoded by exon-14a)enhanced the ATPase activity of AB4-HMM.Mutagenesis showed that the exon-14a-encoded residues Gly474 and Asn509 are responsible for the elevated ATPase activity of FL1-HMM.Those results indicate that the alternative relay encoded by exon-14a/c play a key role in regulating the ATPase activity of FL1-HMM and AB4-HMM.

关键词： alternative splicing ATPase Locusta migratoria molecular motor muscle myosin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Drag reduction characteristics of recirculation flow at rocket base in an RBCC engine under ramjet/scramjet mode

引用

Chinese Journal of Aeronautics 2024年第3期37卷 104-115页

作者： Menglei LI mingbo SUN Peibo LI Daoning YANG Bin AN Yizhi YAO Jikai CHEN Taiyu WANG Jiaoru WANG Hypersonic Technology Laboratory National University of Defense TechnologyChangsha 410073China Department of Aerospace Science and Technology Space Engineering UniversityBeijing 101416China

To reduce the drag generated by the recirculation flow at the rocket base in a RocketBased Combined Cycle(RBCC)engine operating in the ramjet/scramjet mode,a novel annular rocket RBCC engine based on a central plug cone was proposed.The performance loss mechanism caused by the recirculation flow at the rocket base and the influence of the plug cone configuration on the thrust performance were studied.Results indicated that the recirculation flow at the rocket base extended through the entire combustor,which creates an extensive range of the"low-kineticenergy zone"at the center and leads to an engine thrust loss.The plug cone serving as a surface structure had a restrictive effect on the internal flow of the engine,making it smoothly transit at the position of the large separation zone.The model RBCC engine could achieve a maximum thrust augmentation of 37.6%with a long plug cone that was twice diameter of the inner isolator.However,a shorter plug cone that was half diameter of the inner isolator proved less effective at reducing the recirculation flow for a supersonic flow and induced an undesirable flow fraction that diminished the thrust performance.Furthermore,the effectiveness of the plug cone increased with the flight Mach number,indicating that it could further broaden the operating speed range of the scramjet mode.

关键词： Rocket-based combined cycle Ramjet/scramjet mode Plug cone Drag reduction k-x SST turbulent model

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Molecule aging induced by electron attacking

引用

Journal of Energy Chemistry 2024年第6期93卷 519-525,I0013页

作者： Ping Song Yining Dong Xue Gong mingbo Ruan Baoxin Ni Xuanhao Mei Kun Jiang Weilin Xu State Key Laboratory of Electroanalytical Chemistry and Jilin Province Key Laboratory of Low Carbon Chemical Power Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022JilinChina School of Applied Chemistry and Engineering University of Science and Technology of Chin1Hefei 230026AnhuiChina Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Collaborative Innovation Center of Chemistry for Energy MaterialsDepartment of ChemistryFudan UniversityShanghai 200438China

Here we propose a new concept of"molecule aging":with some special treatment,a molecule could be"aged"by losing some unknown tiny particles or pieces from atoms in the molecule,Such"aging"or loss of unknown tiny particles does not change apparently its molecular structure or chemical composition,but some physicochemical properties could be changed irreversibly.We further confirm such"molecule aging"via a long-term electron attacking to age water(H_(2)O)molecules.The IR spectra show no structural difference between the fresh water and the aged one,while the NMR spectra show that the electron attacking can decrease the size of water clusters.Such facts indicate that the electron attacking indeed can"affect"the structure of water molecule slightly but without damaging to its basic molecule frame.Further exploration reveals that the hydrogen evolution reaction(HER)activity of the aged water molecule is lower than the fresh water on the same Pt/C electrocatalyst.The density functional theory calculations indicate that the shortened O-H bond in H_(2)O indeed can present lower HER activity,so the observed size decrease of water clusters from NMR probably could be attributed to the shortening of O-H bond in water molecules.Such results indicate significantly that the molecule aging can produce materials with new functions for new possible applications.

关键词： Aging of molecules Electron attacking Full width at half maxima Hydrogen evolution reaction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：