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Atypical Adams-Oliver syndrome with typical ocular signs of familial exudative vitreoretinopathy

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International Journal of Ophthalmology(English edition) 2022年第8期15卷 1249-1253页

作者： En-Zhong Jin Lyu-zhen Huang ming-wei Zhao Hong Yin Department of Ophthalmology Ophthalmology&Optometry CenterPeking University People’s HospitalBeijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroidal DiseasesBeijing 100044China

AIM:To report an atypical Adams-Oliver syndrome(AOS)family with typical ocular signs of familial exudative vitreoretinopathy(FEVR).METHODS:A patient with visible avascular area and obvious non-perfusion zone in the peripheral retina with systemic signs of AOS was *** and personal characteristics were collected for the patient and his *** sequencing and ophthalmic examinations including fluorescein angiography were all performed for the whole ***:Two novel mutations of DOCK6(c.1396C>T and c.4796G>A)were identified in the proband and his family,and two compound heterozygous mutations were revealed in the proband and his *** patient and his sister showed physical deformities and mental abnormalities while FEVR mimicking retinal disorder can also be *** remarkable ocular or systemic abnormality can be observed for their *** retinal non-perfusion area,obvious abnormal vascularization or even retinal fold were observed in the proband and his sister,while only small avascular zone was identified for their ***:This is the first genetic authenticated AOS case mimicked as FEVR with genetic sequencing of a *** the patients with ocular phenotype of FEVR,further examination should be performed if the systemic or mental abnormalities exist.

关键词： Adams-Oliver syndrome familial exudative vitreoretinopathy gene sequencing DOCK6 mutation

Adsorption-Desorption Characteristics of Chlorimuron-Ethyl in Soils

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Agricultural Sciences in China 2007年第11期6卷 1359-1368页

作者： ZHANG wei WANG Jin-jun ZHANG Zhong-ming QIN zhen College of Plant Protection Southwest University Chongqing 400716 P.R.China Institute of the Control of Agrochemical of Sichuan Province Chengdu 610041 P.R.China

The adsorption-desorption characteristics of chlorimuron-ethyl in soils were investigated to provide the basic data for evaluating the safety in field and the risk to water resource. The adsorption-desorption experiment was conducted by the batch equilibration and HPLC techniques; furthermore, data were analyzed with 5 mathematic models to describe the characteristics and mechanism of adsorption-desorption and translocation of the herbicide in soils. The results showed that the adsorption-desorption isotherms of chlorimuron-ethyl fitted for the Freundlich model well, and the physical reaction presents the main contribution during the adsorption-desorption process. The adsorption values （Kads-f） of chlorimuron-ethyl in 8 types of soil ranged from 0.798 to 6.891. The isotherms of 2# （Jiangxi clay） and 3# （Jiangxi sand loam） soils belong to the S-type curve, while the isotherms of another 6 type soils belong to the L-type isotherm. The results of desorption indicated that the hysteresis phenomena appeared during the desorption process, and the hysteresis coefficients （H） of the herbicides in 8 soils varied from 0.259-0.980. Furthermore, Kads-f and desorption values （Kads-f） increased with the OM （%） and the clay content increasing, while the values decreased with the soils pH increasing. The H values decreased with the OM and the clay content increasing, and increased with the soils pH increasing. It can be concluded that the low adsorption abilities of chlorimuron-ethyl in test soils and un-reversible adsorption existed in the process, which will induce the great translocation of the herbicide after application in field. It can be transported to ground or groundwater causing risk to environments. The physical and chemical properties of soils, including the OM, the clay content, and the pH of soil were the dominating factors during the adsorption-desorption.

关键词： chlorimuron-ethyl adsorption-desorption Freundlich model hysteresis physical and chemical properties of soils

胶质瘤磁共振IVIM与DSC灌注成像的相关性研究

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中国医学计算机成像杂志 2017年第5期23卷 490-494页

作者：任彦庞浩鹏谢骞狄宁宁金腾陈宏邱天明姚振威冯晓源刘含秋复旦大学附属华山医院放射科复旦大学附属华山医院病理科复旦大学附属华山医院神经外科

目的:研究胶质瘤磁共振体素内不相干运动(IVIM)成像与动态磁敏感对比增强(DSC)灌注相关性。方法:94例经手术病理证实的成人胶质瘤,术前均行IVIM和DSC磁共振扫描并计算肿瘤区域IVIM相关灌注参数快弥散(Dfast),快弥散分数(PF),rCBF,rCBV... 详细信息

目的:研究胶质瘤磁共振体素内不相干运动(IVIM)成像与动态磁敏感对比增强(DSC)灌注相关性。方法:94例经手术病理证实的成人胶质瘤,术前均行IVIM和DSC磁共振扫描并计算肿瘤区域IVIM相关灌注参数快弥散(Dfast),快弥散分数(PF),rCBF,rCBV值及其相应标化值nDfast、nPF、nrCBF和nrCBV,并进行相关统计学分析。结果:Dfast与rCBV和rCBF均呈正相关,ρ分别为0.396和0.328;nDfast与nrCBV和nrCBF均呈正相关,ρ分别为0.466和0.390(所有P<0.001)。结论:胶质瘤磁共振IVIM灌注参数Dfast与nrCBV密切相关,是无需外源性对比剂示踪的非侵入性活体评价胶质瘤灌注的潜在标记物。

关键词：胶质瘤弥散加权成像体素内不相干运动磁敏感对比增强

Influence of Information Technology on Social Spatial Behaviors of Urban Residents——Case of Nanjing City in China

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Chinese Geographical Science 2008年第4期18卷 316-322页

作者： zhen Feng wei Zongcai School of Geographic and Oceanographic Sciences Nanjing University Nanjing 210093 China Guangzhou Urban Planning ＆ Design Survey Research Institute Guangzhou 510060 China

Taking Nanjing as a case, the paper explains the spatial behavior differences existing in the information technology use among different groups of residents and households, by virtue of analyzing the survey data of urban households in the 11 districts of Nanjing, from the social, spatial, life and other non-technical angles. Also it makes various analyses and evaluation quantitatively and qualitatively on the social and spatial effect of information technology. The results show that the new technology is changing the social spatial behaviors of urban residents. New behavioral spaces of urban family such as telecommuting, email and QQ have begun to emerge. With the help of Internet, the communication scope of families has expanded greatly, and more new forms of publicizing community information have begun to emerge. Telecommunication contact forms have been developing swiftly, and their frequencies of contact have been increasing dramatically.

关键词： information technology households social and spatial behavior social and spatial effect Nanjing

Source,migration,distribution,toxicological effects and remediation technologies of arsenic in groundwater in China

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China Geology 2023年第3期6卷 476-493页

作者： zhen Wang Hua-ming Guo Hai-yan Liu wei-min Zhang MOE Key Laboratory of Groundwater Circulation and Environmental Evolution China University of Geosciences(Beijing)Beijing 100083China School of Water Resources and Environment Engineering East China University of TechnologyNanchang 330032China School of Water Resources and Environment China University of Geosciences(Beijing)Beijing 100083China

Groundwater with high arsenic(As) content seriously threatens human life and health. Drinking high-As groundwater for a long time will lead to various pathological changes such as skin cancer, liver cancer,and kidney cancer. High-As groundwater has become one of the most serious environmental geological problems in China and even internationally. This paper aims to systematically summarize the sources,migration, distribution, toxicological effects, and treatment techniques of As in natural groundwater in China based on a large number of literature surveys. High-As groundwater in China is mainly distributed in the inland basins in arid and semi-arid environments and the alluvial and lacustrine aquifers in river deltas in humid environments, which are in neutral to weakly alkaline and strongly reducing *** content of As in groundwater varies widely, and As(Ⅲ) is the main form. The main mechanism of the formation of high-As groundwater in China is the reduced dissolution of Fe and Mn oxides under the action of organic matter and primary microorganisms, alkaline environment, intense evaporation and concentration, long-term water-rock interaction, and slow groundwater velocity, which promote the continuous migration and enrichment of As in groundwater. There are obvious differences in the toxicity of different forms of As. The toxic of As(Ⅲ) is far more than As(V), which is considered to be more toxic than methyl arsenate(MMA) and dimethyl arsenate(DMA). Inorganic As entering the body is metabolized through a combination of methylation(detoxification) and reduction(activation) and catalyzed by a series of methyltransferases and reductases. At present, remediation methods for high-As groundwater mainly include ion exchange technology, membrane filtration technology, biological treatment technology, nanocomposite adsorption technology, electrochemical technology, and so on. All the above remediation methods still have certain limitations, and it is urgent to d

关键词： High arsenic groundwater Source and distribution Enrichment mechanism Skin cancer Liver cancer Kidney cancer Toxicological effect Remediation technology Ecological geological survey engineering Hydrogeological survey engineering

Optimal design of hot rolling process for C-Mn steel by combining industrial data-driven model and multi-objective optimization algorithm

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Journal of Iron and Steel Research International 2018年第7期25卷 700-705页

作者： Si-wei Wu Xiao-guang Zhou Jia-kuang Ren Guang-ming Cao zhen-yu Liu Nai-an Shi State Key Laboratory of Rolling and Automation Northeastern University Shenyang 110819 Liaoning China Continuous Rolling Plant of No. 3 Steelmaking of Angang Co. Ltd. Anshan 114021 Liaoning China

A successful mechanical property data-driven prediction model is the core of the optimal design of hot rolling process for hot-rolled strips. However, the original industrial data, usually unbalanced, are inevitably mixed with fluctuant and abnormal values. Models established on the basis of the data without data processing can cause misleading results, which cannot be used for the optimal design of hot rolling process. Thus, a method of industrial data processing of C-Mn steel was proposed based on the data analysis. The Bayesian neural network was employed to establish the reliable mechanical property prediction models for the optimal design of hot rolling process. By using the multi-objective optimization algorithm and considering the individual requirements of costumers and the constraints of the equipment, the optimal design of hot rolling process was successfully applied to the rolling process design for Q345B steel with 0.017% Nb and 0.046% Ti content removed. The optimal process design results were in good agreement with the industrial trials results, which verify the effectiveness of the optimal design of hot rolling process.

关键词： Industrial data Data processing - Mechanical property Optimal design Hot rolling process C-Mn steel

Injection of stored nucleotides from single-walled carbon nanotubes

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第10期11卷 709-713页

作者： zhen-hai LI wei YANG Applied Mechanics Laboratory Department of Engineering Mechanics Tsinghua University Beijing 100084 China University Office Zhejiang University Hangzhou 310058 China

We investigate the possibility of injection of a nucleotide via single-walled carbon nanotubes (SWNTs). The collapse process of an SWNT with a large radius may proceed like falling dominoes. The characteristics of a large radius SWNT are utilized to drive the nucleotide movement in the SWNT, or even to inject the stored nucleotide out of the SWNT. In this process, the lateral section of the collapsed SWNT resembles a dumbbell. Occasionally, the nucleotide in the SWNT will be inbreathed into one of the two dumbbell ends, leading to interference with the injection process. To investigate the random nature of the injection process, a series of simulations on SWNT with different lengths were carried out. It was found that the injection probability was not influenced by the tube length. Freezing the nucleotide at the beginning, or modifying the SWNT at the outlet, may serve to facilitate the injection process, as indicated by the rise in the injection probability.

关键词： Nano injection Single-walled carbon nanotube (SWNT) Nucleotide

The ornithine-urea cycle involves fumaric acid biosynthesis in Aureobasidium pullulans ***,a green and eco-friendly process for fumaric acid production

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Synthetic and Systems Biotechnology 2023年第1期8卷 33-45页

作者： Xin wei Miao Zhang Guang-Yuan Wang Guang-Lei Liu zhen-ming Chi Zhe Chi College of Marine Life Sciences Ocean University of ChinaYushan RoadNo.5QingdaoChina Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and Technology266003China College of Life Science Shandong Province Key Laboratory of Applied MycologyQingdao Agricultural UniversityQingdao266109China

The current petroleum chemical methods for fumaric acid production can cause heavy pollution and global *** this study,the engineered strains of *** *** were found to be suitable for green fumaric acid *** and complementation of the relevant genes showed only the ornithine-urea cycle(OUC)was involved in high level fumarate biosynthesis which was controlled by the Ca^(2+)signaling *** of both the GOX gene encoding glucose oxidase and the PKS1 gene encoding the polyketide synthase for 3,5-dihydroxydecanoic acid biosynthesis and overexpression of the PYC gene encoding pyruvate carboxylase made the strain e-PYC produce 88.1±4.3 g/L of fumarate at flask level and 93.9±0.8 g/L of fumarate during the fed-batch *** a yeast-like fungal strain,it was very easy to cultivate *** *** DH177 and their mutants in the bioreactor and to edit its genomic DNAs to enhance fumarate *** was found that 2 mol of CO_(2) could be fixed during a maximal theoretical yield of 2 mol of fumarate per mole of glucose consumed in the ***,the OUC-mediated fumarate biosynthesis pathway in *** *** was a green and eco-friendly process for the global sustainable development and carbon neutrality.

关键词： Fumaric acid A.pullulans var.aubasidani Ornithine-urea cycle Ca^(2+)signaling pathway

Evidence-based appraisal in laparoscopic Nissen and Toupet fundoplications for gastroesophageal reflux disease

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World Journal of Gastroenterology 2010年第24期16卷 3063-3071页

作者： Shan, Cheng-Xiang Zhang, wei zheng, Xiang-Min Jiang, Dao-zhen Liu, Sheng Qiu, ming Second Mil Med Univ Changzheng Hosp Dept Minimally Invas Surg Shanghai 200003 Peoples R China

AIM: To demonstrate the optimal surgical procedure for gastroesophageal reflux disease. METHODS: The electronic databases of Medline, Elsevier, Springerlink and Embase over the last 16 years were searched. All clinical trials involved in the outcomes of laparoscopic Nissen fundoplication (LNF) and laparoscopic Toupet fundoplication (LTF) were identified. The data of assessment in benefits and adverse results of LNF and LTF were extracted and compared using metaanalysis. RESULTS: We ultimately identified a total of 32 references reporting nine randomized controlled trials, eight prospective cohort trials and 15 retrospective trials. These studies reported a total of 6236 patients, of whom 4252 (68.18%) underwent LNF and 1984 (31.82%) underwent LTF. There were no differences between LNF and LTF in patients' satisfaction, perioperative complications, postoperative heartburn, refluxrecurrence and reoperation. Both LNF and LTF enhanced the function of lower esophageal sphincter and improved esophagitis. The postoperative dysphagia, gasbloating syndrome, inability to belch and the need for dilatation after LNF were more common than after LTF. Subgroup analyses showed that dysphagia after LNF and LTF was similar in patients with normal esophageal peristalsis (EP), but occurred more frequently in patients with weak EP after LNF than after LTF. Furthermore, patients with normal EP after LNF still had a higher risk of developing dysphagia than did patients with abnormal EP after ***: Compared with LNF, LTF offers equivalent symptom relief and reduces adverse results.

关键词： Laparoscopic fundoplication Nissen, Toupet Gastroesophageal reflux disease Antireflux surgery Esophageal peristalsis Metaanalysis