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我国药品审评中药品监管科学研究工作进展与思考

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中国食品药品监管 2024年第4期 4-13页

作者：余明丽温宝书白玉国家药品监督管理局药品审评中心

药品监管科学是基于科学证据和患者用药需求做出科学决策的过程,其发展进程关乎患者用药可及性和药物创新研发成果转化及时性。本文对我国药品审评中药品监管科学发展历程和工作进展进行概述和分析,同时参考欧美药品监管科学发展经验,... 详细信息

药品监管科学是基于科学证据和患者用药需求做出科学决策的过程,其发展进程关乎患者用药可及性和药物创新研发成果转化及时性。本文对我国药品审评中药品监管科学发展历程和工作进展进行概述和分析,同时参考欧美药品监管科学发展经验,提出下一步工作思考,以期优化药品监管科学顶层设计和工作模式,推动我国药品审评技术标准体系的完善。

关键词：药品监管科学发展历程工作进展药品审评技术标准体系

Dense copper azide synthesized by in-situ reaction of assembled nanoporous copper microspheres and its initiation performance

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Defence Technology（防务技术） 2022年第6期18卷 1065-1072页

作者： Xing-yu Wu ming-yu li Qing-xuan Zeng Qing-xia yu State Key Laboratory of Explosion and Technology Beijing Institute of TechnologyBeijing100081PR China

Copper azide with high density was successfully synthesized by in-situ reaction of nanoporous copper(NPC)precursor with HN_(3) *** with pore size of about 529 nm has been prepared by electroless plating using polystyrene(PS)as *** copper shells thickness of NPC was controlled by adjusting the PS loading *** effects of copper shell on the morphology,structure and density of copper azide were *** conversion increased from 87.12%to 95.31%when copper shell thickness decrease from 100 to 50 ***,the density of copper azide prepared by 529 nm NPC for 24 h was up to 2.38 g/cm^(3).The hollow structure of this NPC was filled by swelling of copper azide which guaranteed enough filling volume for keeping the same shape as well as improving the charge ***,HNS-IV explosive was successfully initiated by copper azide with minimum charge thickness of 0.55 mm,showing that copper azide prepared has excellent initiation performance,which has more advantages in the application of miniaturized explosive systems.

关键词： Nanoporous copper Electroless plating In-situ reaction Copper azide

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书院制育人模式下高校学生社区党建研究

湖北开放职业学院学报 2024年第13期37卷 142-144,147页

作者：于明礼徐治初苏州科技大学江苏苏州215000

书院制育人模式作为新时代高校改革的“试验田”,其生活社区育人属性不断得到彰显,正日益成为高校党建工作的重要实践阵地。研究以书院制育人模式下学生社区为实践平台,探索学生社区党建工作思路方法,以期总结经验,形成范式,为新时期高... 详细信息

书院制育人模式作为新时代高校改革的“试验田”,其生活社区育人属性不断得到彰显,正日益成为高校党建工作的重要实践阵地。研究以书院制育人模式下学生社区为实践平台,探索学生社区党建工作思路方法,以期总结经验,形成范式,为新时期高校党建工作提供新思路。书院制育人模式下学生社区党建工作具有体制保障、空间保障和师资保障等优势,从组织建设、思政教育、学生管理、文化建设等四个方面探索学生社区党建育人融入书院育人模式的实施路径,对进一步加强高校党的建设、创新高校党建教育形式及发挥党建引领和党建育人实效具有重要现实意义与实践价值。

关键词：书院制学生社区高校党建

A mini review on oxidative dehydrogenation of propane over boron nitride catalysts

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Petroleum Science 2023年第4期20卷 2488-2498页

作者： Zhu Fu De-Zheng li li-Dai Zhou yu-ming li Jia-Wen Guo yu-Qiao li Hui-Min liu Qi-Jian Zhang School of Chemical and Environmental Engineering Liaoning University of TechnologyJinzhouLiaoning121001China State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing102249China

Oxidative dehydrogenation of propane is an attractive route for the synthesis of propylene due to its favorable thermodynamic and kinetic characteristics, however, it is challenging to realize high selectivity towards propylene. Recently, it has been discovered that boron nitride (BN) is a promising catalyst that affords superior selectivity towards propylene in oxidative dehydrogenation of propane. Summarizing the progress and unravelling the reaction mechanism of BN in oxidative dehydrogenation of propane are of great significance for the rational design of efficient catalysts in the future. Herein, in this review, the underlying reaction mechanisms of oxidative dehydrogenation of propane over BN are extracted;the developed BN catalysts are classified into pristine BN, functionalized BN, supported BN and others, and the applications of each category of BN catalysts in oxidative dehydrogenation of propane are summarized;the challenges and opportunities on oxidative dehydrogenation of propane over BN are pointed out, aiming to inspire more studies and advance this research field.

关键词： Oxidative dehydrogenation of propane Boron nitride Propylene Reaction mechanism

Diophantine equations and Fermat's last theorem for multivariate(skew-)polynomials

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Applied Mathematics(A Journal of Chinese Universities) 2024年第1期39卷 159-173页

作者： PAN Jie JIA yu-ming li Fang School of Mathematical Sciences Zhejiang UniversityHangzhou 310058China Henan Experimental High School Zhengzhou 450003China

Fermat’s Last Theorem is a famous theorem in number theory which is diﬃcult to ***,it is known that the version of polynomials with one variable of Fermat’s Last Theorem over C can be proved very *** aim of this paper is to study the similar problems about Fermat’s Last Theorem for multivariate(skew)-polynomials with any characteristic.

关键词： Fermat's last theorem polynomial ring skew polynomial ring

Scaling laws governing the elastic properties of 3D graphenes

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Science China(Technological Sciences) 2024年第6期67卷 1748-1756页

作者： li ming LU Guo yu HaoDong li MengLei ZHENG FaWei Centre for Quantum Physics Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurement(MOE)School of PhysicsBeijing Institute of TechnologyBeijing100081China Beijing Key Lab of Nanophotonics&Ultrafine Optoelectronic Systems School of PhysicsBeijing Institute of TechnologyBeijing100081China Laboratory of Computational Physics Institute of Applied Physics and Computational MathematicsBeijing100088China Department of Physics Capital Normal UniversityBeijing100048China

In this study,we comprehensively investigated the scaling law for elastic properties of three-dimensional honeycomb-like graphenes(3D graphenes)using hybrid neural network potential-based molecular dynamics simulations and theoretical *** elastic constants were obtained as functions of honeycomb hole size,denoted by the graphene wall length *** five independent elastic constants in the large-L limit are proportional to L^(-1).The associated coefficients are combinations of elastic constants of two-dimensional ***-order terms including L^(-2)and L^(-3)emerge for finite L *** have three origins,the distorted areas close to the joint lines of 3D graphenes,the variation in solid angles between graphene plates,and the bending distortion of graphene ***,the chirality becomes essential with decreasing L because the joint line structures are different between the armchair and zigzag-type 3D *** findings provide insights into the elastic properties of graphene-based superstructures and can be used for further studies on graphene-based materials.

关键词： scaling law neural network elastic properties 3D graphene

Construction technology for deep tunnels crossing superhigh-temperature fault zones with high water surges

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Frontiers of Structural and Civil Engineering 2024年第8期18卷 1267-1280页

作者： Yong ZHAO Tingyu ZHU li yu ming LU Sichuan–Xizang Railway Co. Ltd.Linzhi 860000China School of Civil Engineering Southwest Jiaotong UniversityChengdu 610036China

The harsh environment in tunnels with high geothermal temperatures and humidity can adversely impact machinery,personnel,and *** main causes of specific problems are the unknown mechanisms of local geothermal formation,inappropriate temperature control measures,and insufficient systematic *** this study,three work sections relating to a high geothermal tunnel are:the tunnel face,middle-of-tunnel section,and outside-oftunnel section.A cooling strategy is proposed to offer technical support in achieving comprehensive cooling,overall as well as for each of the ***,a comprehensive geological survey explores the mechanism and exact location of the heat ***,grouting and centralized drainage measures are used to control the heat release of hot *** ventilation,ice chillers and other applicable measures are used to control the ambient ***,a monitoring and early warning system is established to prevent *** cooling strategy has been applied in the field with good results.

关键词： high geothermal tunnels cooling strategy comprehensive cooling measures safety and security

Influence of carbonization temperature on cobalt-based nitrogendoped carbon nanopolyhedra derived from ZIF-67 for nonoxidative propane dehydrogenation

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Petroleum Science 2023年第1期20卷 559-568页

作者： yu-ming li Zi-Ye liu Qi-Yang Zhang Ya-Jun Wang Guo-Qing Cui Zhen Zhao Chun-ming Xu Gui-yuan Jiang State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing102249China

Propylene is a significant basic material for petrochemicals such as polypropylene,propylene oxide,*** abundant propane supply from shale gas,propane dehydrogenation(PDH)becomes extensively attractive as an on-purpose propylene production route in recent ***-doped carbon(NC)nanopolyhedra supported cobalt catalysts were synthesized in one-step of ZIF-67 pyrolysis and investigated further in ***,TEM and N_(2) adsorption-desorption were used to study the influence of carbonization temperature on as-prepared NC supported cobalt *** temperature is found to affect the cobalt phase and nitrogen species of the *** the positive correlation was established between Co0 proportion and space time yield of propylene,indicating that the modulation of carbonization temperature could be important for catalytic performance.

关键词： Propane dehydrogenation ZIF-67 Nitrogen-doped carbon Cobalt

Near real-time gravitational wave data analysis of the massive black hole binary with TianQin

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 175-186页

作者： Hong-yu Chen Xiang-yu Lyu En-Kun li Yi-ming Hu MOE Key Laboratory of TianQin Mission TianQin Research Center for Gravitational Physics&School of Physics and AstronomyFrontiers Science Center for TianQinGravitational Wave Research Center of CNSASun Yat-sen University(Zhuhai Campus)Zhuhai 519082China

Space-borne gravitational wave(GW)detectors can detect the merger of massive black *** early warning and localization of GW events before merging can be used to inform electromagnetic telescopes and conduct multimessenger ***,this requires real-time data transmission and analysis *** geocentric orbit of the space-borne GW detector Tian Qin makes it possible to conduct real-time data *** this study,we develop a search and localization pipeline for massive black hole binaries(MBHBs)with Tian Qin under both regular and real-time data transmission *** demonstrate that,with real-time data transmission,MBHBs can be accurately localized on the *** the approaching merger,each analysis can be finished in only 40 *** an MBHB system at a distance of 1 Gpc,if we receive data every hour,then we can pinpoint its location to within less than 1 deg^(2)on the final day before the merger.

关键词： gravitational wave detectors and experiments black holes data analysis algorithms and implementation data management