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Role of deubiquitinase JOSD2 in the pathogenesis of esophageal squamous cell carcinoma

World Journal of Gastroenterology 2024年第6期30卷 565-578页

作者： Wen-Peng Wang Dan Shi Duo Yun Jun Hu Jie-Fu Wang Jia liu Yan-Peng Yang ming-rui li Jun-FengWang Da-Lu Kong Department of Colorectal Oncology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin’s Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin 300060China Department of Gastrointestinal Surgery Tianjin Nan Kai HospitalTianjin Medical UniversityTianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM RepairInstitute of Integrative Medicine for Acute Abdominal DiseasesTianjin 300100China Department of Oncology The First Hospital of HohhotHohhot 010000Inner Mongolia Autonomous RegionChina Department of Endocrinology Dazhou Central HospitalDazhou 635000Sichuan ProvinceChina

BACKGROUND Esophageal squamous cell carcinoma(ESCC)is a deadly malignancy with limited treatment ***(DUBs)have been confirmed to play a crucial role in the development of malignant ***2 is a DUB involved in con-trolling protein deubiquitination and influencing critical cellular processes in *** To investigate the impact of JOSD2 on the progression of *** Bioinformatic analyses were employed to explore the expression,prognosis,and enriched pathways associated with JOSD2 in *** transduction was utilized to manipulate JOSD2 expression in ESCC cell lines(KYSE30 and RESULTS )Preliminary research indicated that JOSD2 was highly expressed in ESCC tissues,which was associated with poor *** analysis demonstrated that JOSD2 was upregulated in ESCC cell lines compared to normal esophageal ***2 knockdown inhibited ESCC cell activity,including proliferation and colony-forming ***,JOSD2 knockdown decreased the drug resistance and migration of ESCC cells,while JOSD2 overexpression enhanced these *** vivo xenograft assays further confirmed that JOSD2 promoted tumor proliferation and drug resistance in ***,JOSD2 appears to activate the MAPK/ERK and PI3K/AKT signaling *** spectrometry was used to identify crucial substrate proteins that interact with JOSD2,which identified the four primary proteins that bind to JOSD2,namely USP47,IGKV2D-29,HSP90AB1,and *** JOSD2 plays a crucial role in enhancing the proliferation,migration,and drug resistance of ESCC,suggesting that JOSD2 is a potential therapeutic target in ESCC.

关键词： Esophageal squamous cell carcinoma JOSD2 Ubiquitination Biomarker Targeted therapy Drug resistance

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Multi-objectives nonlinear structure optimization for actuator in trajectory correction fuze subject to high impact loadings

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Defence Technology（防务技术） 2021年第4期17卷 1338-1351页

作者： Jiang-hai Hui Min Gao ming li ming-rui li Hui-hui Zou Gang Zhou Northwest Institute of Nuclear Technology Xi’an710025China Shijiazhuang Campus Army Engineering UniversityShijiazhuang050003China

This paper presents an actuator used for the trajectory correction fuze,which is subject to high impact loadings during launch.A simulation method is carried out to obtain the peak-peak stress value of each component,from which the ball bearings are possible failures according to the ***,three schemes against impact loadings,full-element deep groove ball bearing and integrated raceway,needle roller thrust bearing assembly,and gaskets are utilized for redesigning the actuator to effectively reduce the bearings’***,multi-objectives optimization still needs to be conducted for the gaskets to decrease the stress value further to the yield *** gasket’s structure parameters and three bearings’peak-peak stress are served as the four optimization variables and three objectives,*** Latin hypercube design is used for generating sample points,and Kriging model selected according to estimation result can establish the relationship between the variables and objectives,representing the simulation which is ***,two optimization algorithms work out the Pareto solutions,from which the best solutions are selected,and verified by the simulation to determine the gaskets optimized structure *** can be concluded that the simulation and optimization method based on these components is effective and efficient.

关键词： Actuator Trajectory correction fuze Impact loadings Optimized Latin hypercube design Kriging model Optimization algorithm

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Rigid elliptical cross-section ogive-nose projectiles penetration into concrete targets

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Defence Technology（防务技术） 2021年第3期17卷 800-811页

作者： Xiang-hui Dai Ke-hui Wang ming-rui li Jian Duan Bing-wen Qian Gang Zhou Laboratory of Intense Dynamic Loading and Effect Northwest Institute of Nuclear TechnologyXi’anShaanxi710024PR China

The elliptical cross-section ogive-nose projectile(ECOP) has recently attracted attention because it is well suited to the flattened shape of earth-penetrating weapons. However, the penetration performance of ECOPs has not been completely understood. The objective of this study was to investigate the penetration performance of ECOPs into concrete targets using a theoretical method. A general geometric model of ECOPs was introduced, and closed-form penetration equations were derived according to the dynamic cavity-expansion theory. The model was validated by comparing the predicted penetration depths with test data, and the maximum deviation was 15.8%. The increment in the penetration depth of the ECOP was evaluated using the proposed model, and the effect of the majoreminor axis ratio on the increment was examined. Additionally, the mechanism of the penetration-depth increment was investigated with respect to the caliber radius head, axial stress, and resistance.

关键词： Elliptical cross-section Projectile Penetration Concrete target Dynamic cavity-expansion

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High-precision high-voltage detuning system for HIAF-SRing electron target

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Nuclear Science and Techniques 2023年第5期34卷 125-138页

作者： Kai-ming Yan ming-rui li Yun-Bin Zhou Xiao-ming Ma Jin-Bin Shangguan Zhong-Kui Huang Xiao-Jun Wang Mei-Tang Tang Jie Gao Hou-Ke Huang Da-Qin Gao li-Jun Mao Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China

The development of a detuning system for the precision control of electron energy is a major challenge when electron targets are used in ion-storage ***,a high-precision,high-voltage,detuning system was developed for the electron target of a high-intensity heavy-ion accelerator facility-spectrometer ring(HIAF-SRing)to produce accurate electron-ion relative energies during *** system consists of auxiliary,and high-voltage detuning power *** front stage of the auxiliary power supply adopts an LCC resonant converter operating in the soft-switching state and an LC filter for a sinusoidal waveform output in the *** detuning power supply is a high-voltage pulse amplifier(HVPA)connected with a high-voltage DC(HVDC)module in *** this paper,the design and development of the detuning system are described in detail,and the test bench is *** test results demonstrated that the detuning system conforms to the technical specifications of the dielectronic recombination(DR)***,a Fe15+DR spectrum was measured using the detuning *** experimental data demonstrated a good experimental resolution and verified the reliability and feasibility of the design.

关键词： Detuning system Storage ring Dielectronic recombination

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A novel hybrid thermodynamic model for pore size distribution characterisation for shale

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Petroleum Science 2022年第3期19卷 963-978页

作者： Ze-Zhang Song Abide Abula Jun-Yi Zhao Guang-Di liu ming-rui li Dai-lin Yang Yun-Long Wang State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing102249China College of Geosciences China University of PetroleumBeijing102249China The Exploration Department of the Changqing Oilfield Company PetroChinaXi'anShaanxi710021China Research Institute of Petroleum Exploration and Development Southwest Oil and Gas Field CompanyPetroChinaChengduSichuan 610041China

Scholars often see the gas adsorption technique as a straight-to-interpret technique and adopt the pore size distribution(PSD)given by the gas adsorption technique directly to interpret pore-structure-related *** oversimplification of interpreting shale PSD based on monogeometric thermodynamic models leads to apparent bias to the realistic pore *** work aims at establishing a novel thermodynamic model for shale PSD *** simplified the pore space into two geometric types—cylinder-shaped and ***,Low-temperature Nitrogen Adsorption data were analyzed utilizing two monogeometric models(cylindrical and slit)to generate PSD_(cyl).and PSD_(slit);Secondly,pore geometric segmentation was carried out using Watershed by flooding on typical SEM images to obtain the ratio of slit-shaped(∅_(s))and cylinder-shaped pores(∅_(c)).Combining the results of the two,we proposed a novel hybrid *** performed pyrolysis,XRD,FE-SEM observation,quantitative comparison with the results obtained by the DFT model,and fractal analysis to discuss the validity of the obtained PSD_(Hybrid).The results showed that:the hybrid model proposed in this work could better reflect the real geometry of pore space and provide a more realistic PSD;compared with thermodynamic monogeometric models,PSD obtained from the hybrid model are closer to that from the DFT model,with an improvement in the deviation from the DFT model from 5.06%to 68.88%.The proposed hybrid model has essential application prospects for better interpretation of shale pore *** is also worth noting that we suggest applying the proposed hybrid model for PSD analysis in the range of 5-100 nm.

关键词： Pore size distribution Monogeometric thermodynamic model The hybrid model Pore structure Shale

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A study of novel real-time power balance strategy with virtual asynchronous machine control for regional integrated electric-thermal energy systems

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Science China(Technological Sciences) 2024年第7期67卷 2074-2086页

作者： WANG rui li ming-Jia WANG YiBo SUN QiuYe ZHANG PinJia College of Information Science and Engineering Northeastern UniversityShenyang 110819China School of Mechanical Engineering Beijing Institute of TechnologyBeijing 100081China Department of Electrical Engineering Tsinghua UniversityBeijing 100084China

The development of regional integrated electric-thermal energy systems(RIETES) is considered a promising direction for modern energy supply systems. These systems provide a significant potential to enhance the comprehensive utilization and efficient management of energy resources. Therein, the real-time power balance between supply and demand has emerged as one pressing concern for system stability operation. However, current methods focus more on minute-level and hour-level power optimal scheduling methods applied in RIETES. To achieve real-time power balance, this paper proposes one virtual asynchronous machine(VAM) control using heat with large inertia and electricity with fast response speed. First, the coupling timescale model is developed that considers the dynamic response time scales of both electric and thermal energy systems. Second, a real-time power balance strategy based on VAM control can be adopted to the load power variation and enhance the dynamic frequency response. Then, an adaptive inertia control method based on temperature variation is proposed, and the unified expression is further established. In addition, the small-signal stability of the proposed control strategy is validated. Finally, the effectiveness of this control strategy is confirmed through MATLAB/Simulink and HIL(Hardware-in-the-Loop) experiments.

关键词： regional integrated electric-thermal energy systems real-time power balance virtual asynchronous machine adaptive inertia small-signal stability

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Effectiveness of Acupoint Application in Patients with Pharyngeal Pain: Evidence from CHUNBO, A Prospective Real-World Study

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Chinese Journal of Integrative Medicine 2024年第1期30卷 18-24页

作者： MA Hang-kun WANG Yi-ming GUO Man-ping li Chen-fei li rui GAO rui Emergency Department Xiyuan Hospital Affiliated to China Academy of Chinese Medical SciencesBeijing(100091)China National Medical Products Administration for Laboratory of Clinical Research and Evaluation of Traditional Chinese Medicine Beijing(100091)China National Clinical Research Center for Chinese Medicine Cardiology Beijing(100091)China Postdoctoral Workstation of Yabao Pharmaceutical Group Co. Ltd.YunchengShanxi Province(044602)China

Objective: To assess the outcomes after acupoint application in patients with pharyngeal pain in a real-world settings, and analyze the characteristics of effective population and prescription characteristics of acupoint application. Methods: Based on CHUNBO platform, patients with pharyngeal pain who were candidates for acupoint application on the basis of physician-evaluation, were enrolled in a nationwide, prospective, 69-week multicenter observational study from August 2020 to February 2022. Propensity score matching(PSM) was used to match the confounding factors and the association rules were used to analyze the characteristics of effective population and prescription characteristics of acupoint application. Outcome assessments included the disappearance rate of pharyngeal pain(within 3, 7, and 14 days), disappearance time of pharyngeal pain, as well as adverse events. Results: Of 7,699 enrolled participants, 6,693(86.9%) received acupoint application and 1,450(21.7%) with non-acupoint application. After PSM, there were 1,004 patients each in the application group(AG) and non-application group(NAG). The disappearance rate of pharyngeal pain in the AG at 3, 7, and 14 days were all higher than those in the NAG(Plication group with tonsil diseases was 2.19 times higher than that in the NAG(Plied to RN 8 most frequently(support 84.39%). A total of 1,324(17.2%) patients experienced AEs, and mainly occurred in the AG, with s

关键词： acupoint application Chinese medicine pharyngeal pain multicentre effectiveness characters real-world study

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Hybrid improper ferroelectricity and phase transition behavior of li_(2)Nd_(2)Ti_(3)O_(10)ceramics with A-site ordered triple-layer Ruddlesden-Popper structure

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Journal of Materiomics 2024年第1期10卷 145-153页

作者： Bi Hui Zhang Diming Xu rui Ze Guo Lu liu Xiao Qiang liu Xiang ming Chen Laboratory of Dielectric Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou310058China Key Laboratory of Multifunctional Materials and Structures Ministry of EducationSchool of Electronic Science and EngineeringXi'an Jiaotong UniversityXi'an710049China

Hybrid improper ferroelectricity has been extensively reported through theoretical prediction and experimental investigation in the oxides with Ruddlesden-Popper(R-P)***,the experimentally reported ferroelectric materials based on triple-layer R-P structures are rare,and the weak ferroelectricity impedes its practical *** the present work,the single-phase li_(2)Nd_(2)Ti_(3)O_(10)ceramics with A-site cation ordered triple-layer R-P structure was obtained by spark plasma sintering technique,and the crystal structure of P2_(1)ab symmetry was revealed by neutron powder diffraction and transmission electron microscope ***,the switchable ferroelectricity in li_(2)Nd_(2)Ti_(3)O_(10)ceramics has been observed at room temperature,and the saturated polarization-electric field hysteresis loop was obtained with P_(r)=0.4μC/cm^(2)under the electric field of 250 kV/*** phase transition behavior of li_(2)Nd_(2)Ti_(3)O_(10)oxides was revealed by the temperature-dependence Raman and dielectric spectra combined with the piezoelectric property.

关键词： Hybrid improper ferroelectricity A-site ordered Ruddlesden-Popper structure Phase transition behavior

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Genetic and Epigenetic Diversities Shed light on Domestication of Cultivated Ginseng （Panax ginseng）

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Molecular Plant 2015年第11期8卷 1612-1622页

作者： ming-rui li Fena-Xue Shi Yu-Xin Zhou Ya-ling li Xin-Feng Wang Cui Zhang Xu-Tong Wang Bao liu Hong-Xing Xiao lin-Feng li Key Laboratory of Molecular Epigenetics of Ministry of Education Northeast Normal University #5268 Renmin Street Changchun 130024 China Institute of Grassland Science Northeast Normal University Key Laboratory of Vegetation Ecology Ministry of Education Changchun 130024 China

Chinese ginseng （Panaxginseng） is a medically important herb within Panax and has crucial cultural values in East Asia. As the symbol of traditional Chinese medicine, Chinese ginseng has been used as a herbal remedy to restore stamina and capacity in East Asia for thousands of years. To address the evolutionary origin and domestication history of cultivated ginseng, we employed multiple molecular approaches to investigate the genetic structures of cultivated and wild ginseng across their distribution ranges in northeastern Asia. Phylogenetic and population genetic analyses revealed that the four cultivated ginseng landraces, COMMON, BIANTIAO, SHIZHU, and GAOli （also known as Korean ginseng）, were not domesticated independently and Fusong Town is likely one of the primary domestication centers. In addition, our results from population genetic and epigenetic analyses demonstrated that cultivated ginseng maintained high levels of genetic and epigenetic diversity, but showed distinct cytosine methylation patterns compared with wild ginseng. The patterns of genetic and epigenetic variation revealed by this study have shed light on the domestication history of cultivated ginseng, which may serve as a framework for future genetic improvements.

关键词： Panax ginseng domestication traditional Chinese medicine cytosine methylation genetic and epigenetic diversity

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Enhanced electrochemical performance of li_(1.3)Al_(0.3)Ti_(1.7)(PO_(4))_(3) solid electrolyte by anion doping

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Nano Research 2024年第3期17卷 1465-1472页

作者： Jingrui Kang Xu Guo rui Gu Honglei Hao Yi Tang Jiahui Wang li Jin Hongfei li Xiaoyong Wei Electronic Materials Research Laboratory Key Laboratory of the Ministry of Education&International Center for Dielectric ResearchSchool of Electronic and Information EngineeringXi’an Jiaotong UniversityXi’an 710049China School of Energy and Materials Shanghai Key Laboratory of Engineering Materials Application and EvaluationShanghai Polytechnic UniversityShanghai 201209China

Nowadays,the majority of the studies on the substitution are focused on cations(such as Y^(3+),Ti^(4+),P^(5+),etc.)in li_(1.3)Al_(0.3)Ti_(1.7)(PO_(4))_(3)(LATP),while there are few studies on the substitution of anion O^(2-).In this work,the modified LATP with a series of liCl(LATPClx,x=0.1,0.2,0.3,0.4)additives is prepared to enhance ionic *** successful introduction of Cl-makes the length of the c axis decrease from 20.822(2)to 20.792(1)Å,and the bulk conductivity of 2.13×10^(-3) S·cm^(-1) is achieved in LATPCl_(0.3).Moreover,the Al/Ti-O1/Cl1 and Al/Ti-O_(2)/Cl_(2) distance decrease,while the li1-O_(2)/Cl_(2) distance *** ions migrate more easily in the nanochannel of *** addition,the liCl additive increases the relative density and the grain boundary conductivity of LATPClx ***,a higher ionic conductivity of 2.12×10^(–4) S·cm^(-1) and a low activation energy of 0.30 eV are obtained in LATPCl_(0.3).Correspondingly,the symmetric cell exhibits a low overpotential of±50 mV for over 200 h in LATPCl_(0.3).The solid-state li|LATPCl_(0.3)|NCM811(NCM811=liNi0.8Co0.1Mn0.1O_(2))battery exhibits high initial capacity 185.1 mAh·g^(-1) with a capacity retention rate of 95.4%after 100 cycles at 0.5 *** result suggests that liCl additive is an effective strategy to promote electrochemical properties of LATP solid electrolyte and can be considered for reference to other inorganic solid electrolytes systems.

关键词： li_(1.3)Al_(0.3)Ti_(1.7)(PO_(4))_(3)(LATP)solid electrolyte anion doping ionic conductivity cyclic performance

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