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Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-En Xu ming-Lei Wu ji-Chuan Liu Zi-Ling Shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

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Role of nutrition in diabetes mellitus and infections

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World Journal of Clinical Cases 2025年第3期13卷 1-8页

作者： Xue-Lu Yu Li-Yun Zhou Xiao huang Xin-Yue Li ming-Ke Wang ji-Shun Yang Naval Medical Center of PLA Naval Medical UniversityShanghai 200052China

In this editorial,we have commented on the article that has been published in the recent issue of World Journal of Clinical *** authors have described a case of unilateral thyroid cyst and have opined that the acute onset of infection may be linked to diabetes mellitus(DM).We have focused on the role of nutrition in the association between DM and *** with DM are at a high risk of infection,which could also be attributed to nutrition-related *** interventions for patients with diabetes are mainly based on a low-calorie diet,which can be achieved by adhering to a low-carbohydrate ***,dietary fiber supplementation is recommended to maintain the diversity of the gut ***,high-quality protein can prevent the increased risk of infection due to *** of vitamins C,vitamins A,vitamins D,and folic acid improves blood sugar control and facilitates immune *** deficiencies augment the risk of infection,but the relationship with diabetes is mostly U-shaped and a good intake should be maintained.

关键词： Diabetes mellitus Infection Macronutrients Vitamins Minerals

Self-assembled carbon monoxide nanoprodrug for chemiexcitationtriggered synergistic chemotherapy against breast cancer

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Science China Chemistry 2025年

作者： Shunfei Cui Yiyao Pan Chenzhe Ma Bin Qi Qingqiang Min ming Li Huabing Chen Hengte Ke Xingyue ji jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development College of Pharmaceutical ScienceSoochow University

Carbon monoxide（CO） has recently been well-established as a promising therapeutic modality against cancer. The development of transition-metal-free and tumor-targeted delivery platforms for CO is highly demanded but remains very sporadic. Herein, we developed a polyprodrug system for the co-delivery of CO and a chemotherapeutic agent combretastin A-4（CA-4） to the tumor site based on a chemiexcitation mechanism. Such a poly-prodrug successfully achieved the co-activation of CO and CA-4 in response to H2O2at the tumor site both in vitro and in vivo. Importantly, a synergist effect between CO and CA-4 was observed in suppressing tumor growth in a mouse tumor model. It is anticipated that such a poly-prodrug system could be potentially adapted for the co-delivery of CO and another drug payload for combinational therapy for other indications.

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Surface micro-arrays enhancing electromagnetic interference shielding of polydimethylsiloxane/multiwalled carbon nanotubes nanocomposites

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Nano Research 2025年第1期18卷 508-519页

作者： Ke jiang Zhi Chen ji Yu Chen Zheng Shan huang ming Wang Chongqing Key Laboratory of Soft-Matter Material Manufacturing School of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China School of Mechanics Civil Engineering and ArchitecturesNorthwestern Polytechnical UniversityXi’an 710072China jieyang Branch of Chemistry and Chemical Engineering Guangdong Laboratory(Rongjiang Laboratory) Jieyang 515200China

Herein,the electromagnetic shielding performance of surface concave-convex(SC)and zig-zag micro-arrays was studied by using a simulation prediction and a three-dimensional(3D)printing custom ***,surface stripe concaveconvex(SSC)and surface cylindrical concave-convex(SCC)micro-arrays with or without zig-zag micro-arrays are designed,and their shielding performance is simulated in multi-bands(C-,X-band).The multiwalled carbon nanotubes/polydimethylsiloxane composites(MWCNT/PDMS)with different SC structures and different electrical conductivity are molded in acrylonitrile-butadiene-styrene copolymer(ABS)molds which are printed by a 3D *** results show that the electromagnetic interference shielding effectiveness(EMI SE)of the samples can be enhanced by constructing the SC micro-arrays with zig-zag micro-arrays,and improving with the increase of conductivity and *** addition,the shielding mechanism of the SC-MWCNT/PDMS composites is investigated and discussed by an electromagnetic simulation.

关键词： surface micro-arrays electrical properties electromagnetic interference(EMI)shielding three-dimensional(3D)printing

Nitrogen addition promotes soil carbon accumulation globally

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Science China Life Sciences 2025年第1期 284-293页

作者： Xuemei Yang Suhui Ma Erhan huang Danhua Zhang Guoping Chen jiangling Zhu Chengjun ji Biao Zhu Lingli Liu jingyun Fang Institute of Ecology College of Urban and Environmental Sciencesand Key Laboratory for Earth Surface Processes of the Ministry of EducationPeking University Ministry of Education Key Laboratory for Transboundary Ecosecurity of Southwest China School of Ecology and Environmental ScienceYunnan University State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of Sciences

Soil is the largest carbon(C) reservoir in terrestrial ecosystems and plays a crucial role in regulating the global C cycle and climate *** nitrogen(N) deposition has been widely considered as a critical factor affecting soil organic carbon(SOC) storage, but its effect on SOC components with different stability remains unclear. Here, we analyzed extensive empirical data from 304 sites worldwide to investigate how SOC and its components respond to N addition. Our analysis showed that N addition led to a significant increase in bulk SOC(6.7%), with greater increases in croplands(10.6%) and forests(6.0%) compared to grasslands(2.1%). Regarding SOC components, N addition promoted the accumulation of plant-derived C(9.7%–28.5%) over microbial-derived C(0.2%), as well as labile(5.7%) over recalcitrant components(–1.2%), resulting in a shift towards increased accumulation of plant-derived labile C. Consistently, N addition led to a greater increase in particulate organic C(11.9%) than mineral-associated organic C(3.6%), suggesting that N addition promotes C accumulation across all pools, with more increase in unstable than stable pools. The responses of SOC and its components were best predicted by the N addition rate and net primary productivity. Overall, our findings suggest that N enrichment could promote the accumulation of plant-derived and non-mineral associated C and a subsequent decrease in the overall stability of soil C pool, which underscores the importance of considering the effects of N enrichment on SOC components for a better understanding of C dynamics in soils.

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A versatile synthetic strategy towards rare earth based metal-organic frameworks

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Science China Chemistry 2025年

作者： Quan Shi Yun-Hao Xu ming-Hui Chen Peng Zhao Wen-Bo Deng ji Xiong Kai Guo Ya-Qing Feng Bao Zhang School of Chemical Engineering and Technology Tianjin University Tianjin Collaborative Innovation Center of Chemical Science and Engineering Guangdong Laboratory Chemistry & Fine Chemical Industry jieyang Center

Rare earth metal-organic frameworks (RE-MOFs) have drawn wide attention owing to diverse network structures and various application ***,due to the unpredictable formation of the nodes,it is still challenging to design novel RE-MOFs.A novel versatile strategy was developed employing a RE-acetate complex (RE2(CH3COO)6·4H2O) as a precursor to construct RE-MOFs.2D RE-MOFs (RE-DBP) and 3D RE-MOFs (RE-TCPP) could be obtained by using dicarboxylic porphyrin ligands H2DBP and tetracarboxylic porphyrin ligands H2TCPP,*** RE-MOFs were further synthesized to verify the universality of the *** crystalline RE-MOFs could also be prepared at room temperature via the developed strategy,which could significantly promote large-scale preparation and practical application of *** proof of the concept,the performance of porphyrin-based RE-MOFs was investigated in the photocatalytic cycloaddition of CO2with *** the RE-DBP(Co) MOFs,Tb-DBP(Co) exhibited the best photocatalytic performance,which was also greater than that of the corresponding 3D MOF Tb-TCPP(Co) due to the optimal 2D structure and thus the accelerated photogenerated charge separation and transfer *** work not only provides a novel versatile strategy to design and develop RE-MOFs,but also proposes a promising approach for the potential bulk production of RE-MOFs at room temperature.

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聚乙二醇与二甲基亚砜促进HCV体外感染树鼩肝细胞的作用

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世界华人消化杂志 2001年第6期9卷 631-634页

作者：闵峰郝飞刘冰刘国栋黄纪明王宇明宋闽宁中国人民解放军174医院传染科福建省厦门市361003 中国人民解放军第三军医大学西南医院感染科重庆市400038 中国人民解放军520医院传染科

目的观察聚乙二醇(PEG)与二甲基亚砜(DMSO)在HCV体外感染树鼩肝细胞中的作用。方法我们采用两步灌流法分离树鼩肝细胞,并用L15培养基予以培养,培养3d接种HCV-RNA阳性血清,在接种感染血清前90min 加40g·L^1PEG与15g·L^1,然后再接种HCV-... 详细信息

目的观察聚乙二醇(PEG)与二甲基亚砜(DMSO)在HCV体外感染树鼩肝细胞中的作用。方法我们采用两步灌流法分离树鼩肝细胞,并用L15培养基予以培养,培养3d接种HCV-RNA阳性血清,在接种感染血清前90min 加40g·L^1PEG与15g·L^1,然后再接种HCV-RNA阳性血清温育6h～8h,并收集不同时相的细胞和上清以逆转录-聚合酶链反应(PT-PCR)法检测其中HCV正负链RNA。结果未加PEG与DMSO时,细胞内正负链RNA首次检出是感染后d5,至d10仍可间断检出,培养上清正链首次检出是感染后d3,d10亦呈阳性;加PEG与DMSO时,细胞内负链首次检出是感染后d3,至d17仍可间断检出,细胞内正链首次检出是感染后d3,至d15仍可间断检出,培养上清正链RNA首次检出感染后d3,至d15亦呈阳性。结论加PEG与DMSO细胞内正负链RNA首次检出时间较早,检出率较高,持续时间较长。

关键词：肝细胞聚乙烯二醇类药理学二甲基亚砜 C型肝炎样病毒属

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树鼩肝细胞的分离和培养

世界华人消化杂志 2001年第6期9卷 627-630页

作者：闵峰郝飞刘冰刘国栋黄纪明蒋天伦中国人民解放军174医院传染科福建省厦门市361003 中国人民解放军第三军医大学西南医院感染科重庆市400038 中国人民解放军520医院传染科

目的观察体外培养的树鼩肝细胞形态结构和生物合成功能。方法采用体外两步灌流法分离树鼩肝细胞,用L15培养基予以培养,光、电镜下动态观察培养肝细胞形态结构,同时并检测不同时相点培养上清中清蛋白、总蛋白及甲胎蛋白的含量。结果该方... 详细信息

目的观察体外培养的树鼩肝细胞形态结构和生物合成功能。方法采用体外两步灌流法分离树鼩肝细胞,用L15培养基予以培养,光、电镜下动态观察培养肝细胞形态结构,同时并检测不同时相点培养上清中清蛋白、总蛋白及甲胎蛋白的含量。结果该方法分离的肝细胞经台盼蓝拒染试验证实肝细胞即时存活率达90％以上,1h～3h肝细胞开始壁并伸展,同时可见双核细胞,培养3d 10d肝细胞相互接触,布满视野,肝细胞维持此状态至培养18d,接种1d肝细胞合成清蛋白为6.8g·L^1·d^1,7d达峰值为12.8g·L^1·d^1,并维持至14d,以后逐渐减少至终止培养;培养1d肝细胞的甲胎蛋白分泌量处于较高水平为3.45mg·L^1·d^1·3d达峰值为6.23mg·L^1·d^1,以后逐渐减少,17d检测不出。结论体外培养的树鼩肝细胞具有良好的形态结构和生物合成功能,能够满足肝炎病毒体外培养的需要,也为我们深入研究肝炎病毒复制机制创造了实验条件。

关键词：肝细胞学细胞培养细胞分离蛋白质类

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液压柱塞泵运动副磨损特性研究综述

液压与气动 2017年第8期41卷 84-94页

作者：马纪明黄怡鸿郭健史逸尧宋岳恒北京航空航天大学中法工程师学院北京100191 海军驻南京地区航空军事代表室江苏南京211106

针对液压柱塞泵的3对主要运动副:柱塞-缸体副(柱塞副)、缸体-配流盘副(配流盘副)、斜盘-滑靴副(滑靴副),对国内外围绕3对运动副磨损特性相关的研究进行了汇总和总结。柱塞泵运动副间隙的润滑形式为粘弹性动力润滑(EHL),磨损特性与油膜... 详细信息

针对液压柱塞泵的3对主要运动副:柱塞-缸体副(柱塞副)、缸体-配流盘副(配流盘副)、斜盘-滑靴副(滑靴副),对国内外围绕3对运动副磨损特性相关的研究进行了汇总和总结。柱塞泵运动副间隙的润滑形式为粘弹性动力润滑(EHL),磨损特性与油膜、介质、污染、运动副材料及表面形貌等密切相关。主要介绍了柱塞泵运动副的润滑磨损理论研究,影响磨损特性的运动副油膜特性相关研究成果,以及适用于柱塞泵运动副的磨损模型。对比分析了柱塞泵磨损特性研究常用的解析方法、仿真方法、实验方法,介绍了每种方法的优势及局限性。最后对影响柱塞泵运动副磨损特性的关键因素进行了总结,给出了有待解决的问题及研究方案。

关键词：液压柱塞泵柱塞一缸体副缸体-配流盘副斜盘-滑靴副磨损仿真实验

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