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World Journal of Clinical Cases 2021年第3期9卷 607-613页

作者： Yi-Ding Xiao ming-zi zhang Ang Zeng Department ofPlastic Surgery Peking Union Medical College HospitalBeijing 100730China

BACKGROUND Microcystic adnexal carcinoma(MAC)is a rare malignant tumor of the skin that is commonly found on the *** grows slowly and has a low mortality ***,for various reasons,including strong histological invasiveness,clinical inexperience and inadequate procedure design,immediate or permanent facial deformity may occur after surgical *** SUMMARY This article describes a middle-aged female artist who was diagnosed with MAC on the left upper *** declined the recommended treatment plan,which included two-stage reconstruction,skin grafting,or surgery that could have resulted in obvious facial dysfunction or esthetic *** accurately designed a personalized procedure involving a“jigsaw puzzle advancement flap”for the patient based on the lesion location and the estimated area of skin *** procedure was successful;both pathological R0 resection and immediate and long-term esthetic reconstruction effects were *** This study suggests that when treating facial MAC or other skin malignancies,a surgical team should have sufficient plastic surgery-related knowledge and *** optimal surgical plan for an individual is needed to achieve good facial esthetics and functional recovery and shorten the treatment course.

关键词： Microcystic adnexal carcinoma Esthetic reconstruction Jigsaw puzzle advancement flap Plastic surgery Reconstruction Esthetics Case report

Application of SSOR-PCGM with improved iteration format in FEM simulation of massive concrete

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Water Science and Engineering 2011年第3期4卷 317-328页

作者： Lin HAN zi-ming zhang Zhi-qiang NI College of Mechanics and Materials Hohai University Nanjing 210098 P. R. China

In this study, for the purpose of improving the efficiency and accuracy of numerical simulation of massive concrete, the symmetric successive over relaxation-preconditioned conjugate gradient method （SSOR-PCGM） with an improved iteration format was derived and applied to solution of large sparse symmetric positive definite linear equations in the computational process of the finite element analysis. A three-dimensional simulation program for massive concrete was developed based on SSOR-PCGM with an improved iteration format. Then, the programs based on the direct method and SSOR-PCGM with an improved iteration format were used for computation of the Guandi roller compacted concrete （RCC） gravity dam and an elastic cube under free expansion. The comparison and analysis of the computational results show that SSOR-PCGM with the improved iteration format occupies much less physical memory and can solve larger-scale problems with much less computing time and flexible control of accuracy.

关键词： massive concrete symmetric successive over relaxation-preconditioned conjugate gradient method (SSOR-PCGM) improved iteration Jbrmat .finite element method (FEM) numerical simulation

NUDT5 promotes the growth,metastasis,and Warburg effect of IDH wild-type glioblastoma multiforme cells by upregulating TRIM47

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Asian Pacific Journal of Tropical Biomedicine 2024年第2期14卷 82-92页

作者： zi-Fa zhang Shu-ming Liu Neurosurgery Department Shanxi Bethune HospitalTaiyuanShanxi Province030022China Shanxi Academy of Medical Sciences TaiyuanShanxi province030022China Emergency Department Taiyuan People’s HospitalTaiyuanShanxi Province030021China

Objective:To explore the regulatory mechanism of NUDT5 in glioblastoma multiforme(GBM).Methods:GEPIA database was used to predict the expressions of NUDT5 and tripartite motif family proteins 47(TRIM47)in GBM ***-qPCR and Western blot analyses were performed to examine NUDT5 expression in GBM ***-229 cell proliferation,migration as well as invasion were estimated by CCK-8,colony formation,wound healing,and Transwell assays following interference with *** assay,L-lactic acid kit,glucose detection kit,and ATP detection kit were applied for the detection of glycolysis-related ***-immunoprecipitation experiment was carried out to verify the relationship between NUDT5 and ***:GEPIA database showed that NUDT5 expression was significantly increased in GBM *** the expression of NUDT5 in GBM cells significantly suppressed the viability,proliferation,invasion,migration,and glycolysis of GBM ***,TRIM47 was highly expressed in GBM cells and interacted with *** of TRIM47 partially reversed the inhibitory effect of NUDT5 downregulation on the proliferation,metastasis,and glycolysis of GBM ***:NUDT5 promotes the growth,metastasis,and Warburg effect of GBM cells by upregulating *** NUDT5 and TRIM47 can be used as targets for GMB treatment.

关键词： Glioblastoma multiforme NUDT5 TRIM47 Growth Metastasis Warburg effect

Clinical features and treatment options for mitral regurgitation in elderly inpatients

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Journal of Geriatric Cardiology 2018年第6期15卷 428-433页

作者： Rui-Qi ZHUGE Xiao-Pei HOU Xi-Ling QI Yong-Jian WU ming-zi zhang Department of Cardiology Fuwai Hospital National Center for Cardiovascular Disease Peking Union Medical College Chinese Academy of Medical Sciences Beijing China Department of Plastic Surgery Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing China

Objective To summarize clinical characteristics and treatment strategy of Chinese elderly mitral regurgitation （MR） inpatients under the current guidelines, and to identify factors related to treatment options in them. Methods A single center retrospective study was conducted in which patients hospitalized in Fuwai hospital from May ist of 2014 to April 30 of 2015 with moderate to severe MR assessed by transthoraeic echocardiography were enrolled consecutively （n = 1741）. Patients 〉 60 years old were grouped as elderly group （n = 680） and patients 〈 60 years were grouped as control group （n = 1061）. The elderly group was categorized into two subgroups based on surgical status. Results The mean age of the elderly group was 66.98 i 5.94 years. The most common reason of MR in elderly group was degenerative MR （41.18%）. Atherosclerotic risk factors such as hypertension, diabetes or hyperlipidaemia were more commonly observed in elderly group than the control group （45.44% vs. 25.17%, P 〈 0.001; 19.56% vs. 8.48%, P 〈 0.001; 35.29% vs. 19.51%, P 〈 0.001）. Elderly group had higher Enroscore Ⅱ score （5.54 ± 2.42 vs. 3.15 ± 1.66）, greater left ventricular end diastolic diameter （LVEDD）（57.72±12.3 vs. 57.33 ± 10.19 ram） and a lower surgery rate （54.71% vs. 63.91%）; P 〈 0.05. Age, left ventricular ejection fraction （LVEF）, regurgitation grade, Eu- roScore-Ⅱ high risk stratification and having diabetes were identified as factors associated with therapy decisions in elderly MR patients. Conclusions Valve surgery was denied in 45.29% of elderly MR inpatients. Older age, impaired LVEF, lower regurgitation grade, Euro- Score-Ⅱ high risk stratification, and having diabetes were factors most significantly associated with surgery denial among elderly Chinese inpatients with MR.

关键词： Clinical features Elderly patients Mitral regurgitation Treatment

Improvement in antibacterial ability and cell cytotoxicity of Ti-Cu alloy by anodic oxidation

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Rare Metals 2022年第2期41卷 594-609页

作者： Shuang Cao zi-ming zhang Jia-Qi zhang Ren-Xian Wang Xiao-Yan Wang Lei Yang Da-Fu Chen Gao-Wu Qin Er-Lin zhang School of Materials Science and Engineering Key Laboratory for Anisotropy and Texture of MaterialsEducation Ministry of ChinaNortheastern UniversityShenyang 110819China Departments of Immunology College of Basic MedicineJiamusi UniversityJiamusi 154007China Laboratory of Bone Tissue Engineering Beijing Laboratory of Biomedical MaterialsBeijing Research Institute of Orthopaedics and TraumatologyBeijing Jishuitan HospitalBeijing 100035China School of Metallurgy Northeastern UniversityShenyang 110819China Research Center for Metallic Wires Northeastern UniversityShenyang 110819China

Ti-Cu alloy has potential to be used in plastic surgery and dental implants due to its strong antibacterialproperties,high strength and good corrosion *** this paper,Ti-5Cu was anodic-oxidized to enhance the surface *** influence of the oxidation on the corrosion resistance,antibacterial properties and biological properties was investigated.X-ray diffraction(XRD)and X-ray photoelectron spectroscopy(XPS)results showed that a double-layer oxide coating with dense inner layer and porous outside layer was formed on Ti-Cu *** oxide coating consisted mainly of TiO2,CuzO and small amount of CuO,improved the corrosion resistance of Ti-Cu alloy by one order of magnitude due to the formation of the dense oxide inner layer,but high Cu ion release was *** plate count results showed that the antibac-terial activity of Ti-Cu sample was improved to≥99%due to the comprehensive function of CuO and Cu_(2)O in the coating and Cu^(2+)*** test results showed that thecoating exhibited good cell compatibility,the porous sur-face structure improved the adhesion of cells,and Cu ion release promoted the cell proliferation.

关键词： Titanium-copper alloy Anodic oxidation Corrosion resistance Antibacterial activity Cell adhesion Surface modification

Dynamics of Microbial Activity Related to N Cycling in Cd-Contaminated Soil During Growth of Soybean

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Pedosphere 2007年第3期17卷 383-388页

作者： YANG Ye CHEN Ying-Xu TIAN Guang-ming zhang zi-Jian Department of Environmental Engineering Zhejiang University Hangzhou 310029 （China） Appraisal Center for Environment and Engineering SEP Beijing 100012 （China）

The potential influences of cadmium (Cd) on the biochemical processes of the soil nitrogen (N) cycle, along with the dynamics of ammonification, nitrification, and denitrification processes in the rhizosphere and non-rhizosphere (bulk soil), respectively, were investigated in a Cd-stressed system during an entire soybean growing season. In terms of Cd pollution at the seedling stage, the ammonifying bacteria proved to be the most sensitive microorganisms, whereas the effects of Cd on denitrification were not obvious. Following the growth of soybeans, the influences of Cd on ammonification in the bulk soil were: toxic impacts at the seedling stage, stimulatory effects during the early flowering stage, and adaptation to the pollutant during the podding and ripening stages. Although nitrification and denitrification in the bulk soil decreased throughout the entire growth cycle, positive adaptation to Cd stress was observed during the ripening stage. Moreover, during the ripening stage, denitrification in the bulk soil under high Cd treatment (20 mg kg-1) was even higher than that in the control, indicating a probable change in the ecology of the denitrifying microbes in the Cd-stressed system. Changes in the activity of microbes in the rhizosphere following plant growth were similar to those in the non-rhizosphere in Cd treatments; however, the tendency of change in the rhizosphere seemed to be more moderate. This suggested that there was some mitigation of Cd stress in the rhizosphere.

关键词： cadmium microbial activity nitrogen cycle rhizosphere

Supramolecular polymer network constructed by a functionalized polyimidazolium salt derived from metal-carbene template approach

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Science China Chemistry 2024年第4期67卷 1224-1228页

作者： ming-ming Gan zi-En zhang Yi-Fan zhang Heng zhang Li-Ying Sun Ying-Feng Han Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education Xi’an Key Laboratory of Functional Supramolecular Structure and MaterialsCollege of Chemistry and Materials ScienceNorthwest UniversityXi’an 710127China

In this study,we present a supramolecular templating approach for constructing polyimidazolium salt containing crown ether and cyclobutane *** strategy involves the formation of metal-carbene templates,photochemical cycloaddition,and subsequent demetallation of metal *** by the host-guest chemistry between crown ether units and ammonium salts,we successfully fabricated a supramolecular polymer SPN1,which features imidazolium receptors and cyclobutane *** obtained SPN1 demonstrates outstanding reversible stimulus-response,antibacterial behavior and conductivity.

关键词： metal-carbene template crown ether polyimidazolium salt host-guest chemistry

Effect of hydrogen intervention on refractory wounds after radiotherapy:A case report

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World Journal of Clinical Cases 2022年第21期10卷 7545-7552页

作者： Peng-Xiang Zhao Rui-Liu Luo Zheng Dang You-Bin Wang Xu-Juan zhang zi-Yi Liu Xiao-Hu Wen Meng-Yu Liu ming-zi zhang Yao Mawulikplimi Adzavon Xue-Mei Ma Faculty of Environment and Life Science Beijing International Science and TechnologyCooperation Base of Antivirus DrugBeijing University of TechnologyBeijing 100124China Department of Plastic Surgery Peking Union Medical College HospitalBeijing 100032China

BACKGROUND Patients with keloids who receive radiotherapy(RT)after surgery can develop refractory wounds that cannot be healed by the patient's own repair *** chronic wounds are uneven and complex due to persistent abscess and *** external intervention,they can easily result in local tissue necrosis or,in severe cases,large area tissue resection,amputation,and even *** SUMMARY This article describes the use of hydrogen to treat a 42-year-old female patient with a chronic wound on her left *** patient had a skin graft that involved implanting a dilator under the skin of her left shoulder,and then transferring excess skin from her shoulder onto scar tissue on her *** skin grafting was followed by two rounds of RT,after which the shoulder wound had difficulty *** six months,the patient was treated with 2 h of hydrogen inhalation(HI)therapy per day,in addition to application of sterile gauze on the wound and periodic *** also performed one deep,large,sharp debridement to enlarge the wound *** wound healed completely within 6 mo of beginning the HI *** After HI therapy,the patient showed superior progress in reepithelialization and wound repair,with eventual wound closure in 6 mo,in comparison with the previous failures of hyperbaric oxygen and recombinant bovine basic fibroblast growth factor *** work showed that HI therapy could be a new strategy for wound healing that is cleaner,more convenient,and less expensive than other therapies,as well as easily accessible for further application in clinical wound care.

关键词： Hydrogen Inhalation therapy Wound healing Reepithelialization Refractory wounds Case report

Integrating machine learning and CALPHAD method for exploring low-modulus near-β-Ti alloys

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Rare Metals 2024年第1期43卷 309-323页

作者： Hao Zou Yue-Yan Tian Li-Gang zhang Ren-Hao Xue zi-Xuan Deng ming-ming Lu Jian-Xin Wang Li-Bin Liu School of Computer Science and Engineering Central South UniversityChangsha 410083China School of Materials Science and Engineering Central South UniversityChangsha 410083China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China

Traditional theoretical and empirical calculation methods can guide the design of β-and metastable β-alloys for bio-titanium. However, it is still difficult to obtain novel near-β-Ti alloys with low modulus. This study developed a method that combines machine learning with calculation of phase diagrams(CALPHAD) to facilitate the design of near-β-Ti alloys. An elastic modulus database of Ti–Nb–Zr–Mo–Ta–Sn system was constructed first, and then three features(the electron to atom ratio, mean absolute deviation of atom mass, and mean electronegativity) were selected as the key factors of modulus by performing a three-step feature selection. With these features, a highly accurate model was built for predicting the modulus of near-β-Ti alloys. To further ensure the accuracy of modulus prediction, machine learning with the elastic constants calculated was leveraged by CALPHAD database. The root mean square error of the well-trained model can be as low as 6.75 GPa. Guided by the prediction of machine learning and CALPHAD, three novel near-β-Ti alloys with elastic modulus below 50 GPa were successfully designed in this study. The best candidate alloy(Ti–26Nb–4Zr–4Sn–1Mo–Ta) exhibits an ultra-low modulus(36.6 GPa) after cold rolling with a thickness reduction of 20%. Our method can greatly save time and resources in the development of novel Ti alloys, and experimental verifications have demonstrated the reliability of this method.

关键词： Near-β-Ti alloy Machine learning Calculation of phase diagram Low-modulus alloy Feature selection

Application of the grid computing technology for fault diagnosis

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材料与冶金学报 2007年第1期6卷 77-80页

作者： WANG ming-zan zhang zi-ye School of Mechanical Engineering and Automation Northeastern University Shenyang 110004 China

Introduced the basic principle and structure of the grid computing technology,as well as the application combined with the fault diagnosis expert *** forward that use grid node to construct integrated fault diagnosis system based on object model,experience rule,neural network model and practice,so that the aptitude and efficiency of the diagnosis system is *** on the method of applying the grid architecture in fault diagnosis based on *** also puts forward the method of fault diagnosis in *** is made up of grid nodes,which are used for spectrum diagnosis and data tendency *** web Service program,can realize accessing and grid calculating between clients and ***,presented the system control flow.

关键词：故障诊断网格计算网络服务专家系统开放式网络结构