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Decision making module based on stochastic magnetic tunnel junctions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 202-209页

作者： Yifan Miao Li zhao Yajun Zhang zhe Yuan Center for Advanced Quantum Studies and Department of Physics Beijing Normal University Institute for Nanoelectric Devices and Quantum Computing Fudan University Interdisciplinary Center for Theoretical Physics and Information Sciences Fudan University

In biological neural systems, noise is ubiquitous but does not affect the correct decisions made in the complex cognitive ***-making in biological neural system is typically achieved by accumulating input information over a period of *** by recent developments in neurosciences, we design a decision-making module based on spintronic devices, utilizing superparamagnetic tunnel junctions as artificial neurons. The feasibility of this decision-making module is verified through circuit simulations. Taking a multi-layer perceptron as an example, the module significantly improves the accuracy of the perceptron in the handwritten digit recognition task. Furthermore, the spintronic decision-making module offers advantages over the conventional pooling methods, such as adaptive decision time, high performance and the absence of analog-to-digital conversion. The decision-making module is flexible to be integrated into artificial neural networks and provides a general yet effective solution to enhance performance against device noise.

关键词： neuromorphic computing spintronics magnetic tunnel junction neural networks

Effect of danhong injection combined with nadroparin calcium on serum CyS-C, CRP, IL-6, vWF, ET and VEGF in patients with acute coronary syndrome

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Journal of Hainan Medical University 2017年第16期23卷 5-8页

作者： Xun-Jian Hu ming-zhe zhao Zhong-Qi Wu Hui-Ying Huai Department of Cardiology the Third People's Hospital of JiangsuJiangyin214442 China

Objective: To study the effect of danhong injection combined with nadroparin calcium on serum CyS-C, CRP, IL-6, vWF, ET and VEGF in patients with acute coronary syndrome. Methods: A total of 80 patients with acute coronary syndrome in our hospital from July 2014 to July 2017 were enrolled in this study. The subjects were divided into the control group (n=40) and the treatment group (n=40) randomly. The control group was treated with xuesaitong injection combined with nadroparin calcium;the treatment group was treated with danhong injection combined with nadroparin calcium. The two groups were treated for 2 weeks. The serum CyS-C, CRP, IL-6, vWF, ET and VEGF levels of the two groups before and after treatment were compared. Results: There were no significantly differences of the serum CyS-C, CRP, IL-6, vWF, ET and VEGF levels of the two groups before treatment. The serum CyS-C, CRP, IL-6, vWF, ET and VEGF levels of the two groups after treatment were significantly lower than before treatment, and that of the treatment group were significantly better than that of the control group. Conclusion: Danhong injection combined with nadroparin calcium can significantly reduce the serum CyS-C, CRP, IL-6, vWF, ET and VEGF levels of patients with acute coronary syndrome, and it was worthy clinical application.

关键词： Danhong injection Nadroparin calcium Acute coronary syndrome CyS-C CRP IL-6 vWF ET VEGF

Rapid and scalable preparation of highly quaternized polymer networks to achieve efficient simultaneous adsorption of iodide and pertechnetate

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Science China Chemistry 2025年第01期 337-349页

作者： Meiyun Xu Song Gu Fulong Chen zhe zhao Peng Liu Daoben Hua State Key Laboratory of Radiation Medicine and Protection School of Radiological and Interdisciplinary Sciences (RAD-X) Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions Soochow University

The efficient separation of fission products,such as TcO4-and I-,holds strategic significance for the management of radioactive wastes and environmental *** this study,we propose an ultrafast strategy for scalable preparation of a highly quaternized organic network to facilitate efficient and synchronous separation of iodide and *** network can be prepared within a few minutes at room temperature,using polyethylenimine and 1,2,4,5-tetrakis（bromomethyl）benzene as building *** chlorine replacement,the network,abundantly decorated with quaternary ammonium groups （Cl@QPN）,exhibits an ultrahigh positive charge density of 7.6 mmol/*** enables the rapid and efficient enrichment of target anions through strong electrostatic Coulomb *** a result,Cl@QPN exhibits significantly higher adsorption rate constants of 0.830 g/（mg min） for ReO4-（a nonradioactive surrogate of TcO4-） and 0.677 g/（mg min） for I-compared to other ***,it possesses high adsorption capacities,reaching 1,681 mg/g for ReO4-and 917.4 mg/g for I-.Cl@QPN also demonstrates good selectivity towards target ions and shows efficient adsorption for99TcO4-.Additionally,Cl@QPN exhibits high dynamic processing capacities,handling up to 3,100 and 7,400 kg of simulated streams per kilogram of material for I-and ReO4-,respectively.

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One-stop strategy for treatment of atrial fibrillation:feasibility and safety of combining catheter ablation and left atrial appendage closure in a single procedure

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Chinese Medical Journal 2020年第12期133卷 1422-1428页

作者： Mu Chen Zhi-Quan Wang Qun-Shan Wang Jian Sun Peng-Pai Zhang Xiang-Fei Feng Wei Li Ying Yu Bo Liu Bin-Feng Mo Rui Zhang Mei Yang Chang-Qi Gong ming-zhe zhao Yi-Chi Yu Yan zhao Qiu-Fen Lu Yi-Gang Li Department of Cardiology Xinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200092China

Background:Catheter ablation is effective in restoring sinus rhythm and left atrial appendage closure(LAAC)is increasingly used for stroke prevention in patients with atrial fibrillation(AF).We aimed to observe the feasibility and safety of performing AF ablation and LAAC in a single(one-stop)***:Consecutive AF patients who underwent the combined procedure of AF ablation and LAAC with WATCHMAN device between March 2017 and September 2018 were prospectively *** and intra-procedural parameters were ***-month and subsequent 1-year follow-up were performed in all and earlier-enrolled subjects,***:A total of 178 AF patients(94 males,68.9±8.1 years)underwent the one-stop procedure with CHA2DS2-VASc score 3.3±1.5 and HAS-BLED score 1.6±1.0,*** vein isolation was achieved in all patients while additional linear ablation was applied if the operator deemed necessary,yielding immediate ablation success rate of 98.9%(176/178).In the subsequent LAAC,satisfactory seal(residual leak<5 mm)was achieved in all *** stroke and four cardiac perforations occurred *** 3-month follow-up,sinus rhythm and satisfactory seal were maintained in 153/178(86.0%)and 178/178(100%)patients,*** stroke and one delayed cardiac tamponade occurred,while no device-related thrombus or device migration was *** the 1-year follow-up for the earlier enrolled subjects,52/72(72.2%)of the patients maintained sinus *** was no stroke or systemic embolism ***:Combining catheter ablation and LAAC in a single procedure can be successfully and safely performed in non-valvular AF patients of Chinese population.

关键词： Atrial fibrillation Left atrial appendage closure Catheter ablation Stroke WATCHMAN One-stop procedure

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun zhao De-En Xu ming-Lei Wu Ji-Chuan Liu Zi-Ling Shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

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性激素负反馈作用在男性不育诊疗中的应用

生殖医学杂志 2017年第8期26卷 743-748页

作者：曾勇宋明哲赵明叶丽君蔡靖深圳中山泌尿外科医院深圳518045 深圳中山泌尿外科医院生殖医学中心深圳518045 深圳中山生殖与遗传研究所深圳518045 深圳中山泌尿外科医院检验科深圳518045

下丘脑-垂体-睾丸轴对男性的生殖功能起着关键性作用,下丘脑和垂体共同参与调控睾丸的甾体激素合成与精子发生;复杂的刺激和反馈机制通过神经腺成分来控制激素的合成和分泌。下丘脑和垂体均有大量雄、雌激素的受体,同时受睾酮及其芳香... 详细信息

下丘脑-垂体-睾丸轴对男性的生殖功能起着关键性作用,下丘脑和垂体共同参与调控睾丸的甾体激素合成与精子发生;复杂的刺激和反馈机制通过神经腺成分来控制激素的合成和分泌。下丘脑和垂体均有大量雄、雌激素的受体,同时受睾酮及其芳香化产物(包括雌激素)的负反馈调节。利用男性生殖内分泌轴系中的负反馈作用,通过给予抗雌激素药物或芳香化酶抑制剂,可减弱睾酮及其芳香化产物的持续负反馈调节作用,增加内源性促性腺激素的分泌,而且还能去除雌激素对生精的副作用,恢复生精或提高精液质量。

关键词：负反馈性激素内分泌男性不育

Norcantharidin:A potential antiangiogenic agent for gallbladder cancers in vitro and in vivo

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外科研究与新技术 2013年第1期 58-58页

作者： JING-TAO ZHANG YUE-ZU FAN CHUN-QIU CHEN zhe-ming zhao WEI SUN Department of Surgery Tongji HospitalTongji University School of Medicine Department of Surgery Shanghai Tenth People's HospitalTongji University

Our objective was to explore the antiangiogenic activity of norcantharidin ( NCTD ) as an angiogenic inhibitor for gallbladder cancers. In vitro and in vivo experiments to determine the effects of NCTD on HUVECs,chicken CAM capillaries and gallbladder cancer xenograft angiogenesis in nude mice were respectively done. The MTT method was used to assay the cytotoxicity of NCTD on HUVECs. Immunofluorescence was used to evaluate HUVEC apoptosis. The scraping line method,Matrigel invasion assay and tube formation assay were used to detect the migration,invasion and tube formation of HUVECs. A digital camera was used to observe chicken CAM capillaries. Experiments with NCTD in a xenograft model were used to observe the effect of NCTD on xenograft growth and survival of mice with xenografts. CD34 immunohistochemistry,flow cytometry and micro-MRA were used, respectively,to determine MVD,cell apoptosis and hemodynamic analysis of the xenografts. Immunohistochemistry and RT-PCR were used,respectively,to detect the expression of VEGF,Ang-2,TSP,TIMP-2 proteins/mRNAs of the xenografts. The xenograft MVD associated with tumor volume,the PCNA/apoptosis ratio and related-protein expression was evaluated simultaneously. We found that NCTD effectively inhibited the proliferation,migration,invasion and capillary-like tube formation of HUVECs in vitro; it reduced angiogenesis and directly destroyed the formed CAM capillaries in vivo. In the experiments in mice,NCTD not only inhibited significantly xenograft proliferation and growth,prolonged survival time of mice with xenografts,decreased the xenograft MVD and vascular perfusion,but also,similarly to ES,decreased significantly the expression of VEGF or Ang-2 protein/mRNA, increased the expression of TSP or TIMP-2 protein/mRNA. Moreover,the xenograft MVD was positively related with tumor volume,PCNA/apoptosis ratio,and VEGF or Ang-2 expression,respectively ( all P < 0. 05) ,but negatively correlated with TSP or TIMP-2 expression ( both P

关键词： NCTD TSP Norcantharidin TIMP

A versatile synthetic strategy towards rare earth based metal-organic frameworks

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Science China Chemistry 2025年

作者： Quan Shi Yun-Hao Xu ming-Hui Chen Peng zhao Wen-Bo Deng Ji Xiong Kai Guo Ya-Qing Feng Bao Zhang School of Chemical Engineering and Technology Tianjin University Tianjin Collaborative Innovation Center of Chemical Science and Engineering Guangdong Laboratory Chemistry & Fine Chemical Industry Jieyang Center

Rare earth metal-organic frameworks (RE-MOFs) have drawn wide attention owing to diverse network structures and various application ***,due to the unpredictable formation of the nodes,it is still challenging to design novel RE-MOFs.A novel versatile strategy was developed employing a RE-acetate complex (RE2(CH3COO)6·4H2O) as a precursor to construct RE-MOFs.2D RE-MOFs (RE-DBP) and 3D RE-MOFs (RE-TCPP) could be obtained by using dicarboxylic porphyrin ligands H2DBP and tetracarboxylic porphyrin ligands H2TCPP,*** RE-MOFs were further synthesized to verify the universality of the *** crystalline RE-MOFs could also be prepared at room temperature via the developed strategy,which could significantly promote large-scale preparation and practical application of *** proof of the concept,the performance of porphyrin-based RE-MOFs was investigated in the photocatalytic cycloaddition of CO2with *** the RE-DBP(Co) MOFs,Tb-DBP(Co) exhibited the best photocatalytic performance,which was also greater than that of the corresponding 3D MOF Tb-TCPP(Co) due to the optimal 2D structure and thus the accelerated photogenerated charge separation and transfer *** work not only provides a novel versatile strategy to design and develop RE-MOFs,but also proposes a promising approach for the potential bulk production of RE-MOFs at room temperature.

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Molecular Dynamics Analysis of the Effect of Laser and Defects on the Micro-Structure of Fused Silica

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Journal of Electronic Science and Technology 2020年第2期18卷 159-168页

作者： Li Li ming-Wen Zhang zhe-zhen zhao School of Physics University of Electronic Science and Technology of ChinaChengdu 610054

In this work, the classic molecular dynamics simulations are employed to investigate the atomic structural modification of fused silica with defects as laser irradiation. The dynamics evolution of the atomic structure of fused silica is modeled during energy deposition. The structure parameters such as pair distribution functions(PDFs), bond angle distributions(BADs), and the coordination number are given. The calculated results reveal that fused silica undergoes significant changes in terms of Si-O, Si-Si, and O-O bond lengths, Si-O-Si and O-Si-O bond angles, and the Si and O coordination numbers during laser irradiation. The effects of different surface defects on the microstructure of fused silica are discussed too. The simulation results of molecular dynamics may help to understand the role of defects in the radiation effect of fused silica.

关键词： deposition. silica fused