Gene×environment interaction in major depressive disorder
作者机构：Bio-X InstitutesKey Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders(Ministry of Education)Shanghai Jiao Tong UniversityShanghai 200240China Tianjin Medical University Cancer Institute and HospitalTianjin Medical UniversityTianjin 300060China Institute of Advanced TechnologyWestlake Institute for Advanced StudyHangzhou 310024Zhejiang ProvinceChina School of EngineeringWestlake UniversityHangzhou 310024Zhejiang ProvinceChina
出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)
年 卷 期：2021年第9卷第31期
页 面：9368-9375页
核心收录：
学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学]
主 题：Major depressive disorder Gene×environment interaction Diathesis-Stress model Differential susceptibility Theory Stressful life events Childhood adversities
摘 要：Major depressive disorder(MDD)is a multifactorial disorder,where multiple susceptibility genes interact with environmental factors,predisposing individuals to the development of the *** this article,we reviewed different gene×environment interaction(G×E)studies shifting from a candidate gene to a genome-wide *** environmental factors,childhood adversities and stressful life events have been suggested to exert crucial impacts on ***,the diathesis-stress conceptualization of G×E has been challenged by the differential susceptibility ***,we summarized several limitations of G×E studies and suggested how future G×E studies might reveal complex interactions between genes and environments in MDD.
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