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Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-En Xu ming-Lei wu Ji-Chuan Liu Zi-Ling Shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

钙(Ⅱ)对铁锰氧化物催化氧化去除氨氮的影响

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中国给水排水 2016年第23期32卷 10-15页

作者：刘杰黄廷林郭英明武俊槟张帆西安建筑科技大学环境与市政工程学院陕西西安710055

利用已持续运行2年的石英砂滤柱中试系统，通过改变进水中离子的种类及其浓度，考察了不同高浓度离子对石英砂滤料表面活性铁锰氧化物滤膜催化氧化水中氨氮性能的影响。结果表明：高浓度钠离子、钾离子、氯离子、硫酸根离子、碳酸氢根... 详细信息

利用已持续运行2年的石英砂滤柱中试系统，通过改变进水中离子的种类及其浓度，考察了不同高浓度离子对石英砂滤料表面活性铁锰氧化物滤膜催化氧化水中氨氮性能的影响。结果表明：高浓度钠离子、钾离子、氯离子、硫酸根离子、碳酸氢根离子对滤料去除氨氮性能基本没有影响，去除率均达到了87％以上。高浓度钙离子对滤料去除氨氮性能影响很大，当进水氯化钙浓度为1000mg／L时，去除率降低到了51％。停止投加钙离子后，滤料去除氨氮的性能可在8—9h内恢复。对滤料表面进行微观表征后发现钙的含量大幅上升，降低了滤料的比表面积、孔体积，影响了滤料与氨氮污染物的接触，造成对氨氮去除率的下降。

关键词：活性滤膜接触氧化钙离子氨氮

Analytical Results of Steady-State Populations in Multiphoton Electromagnetically Induced Transparency

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Communications in Theoretical Physics 2004年第12期 887-890页

作者： YANG Xiao-Xue,~(1,2) LUO Jin-ming,~2 wu ying~(1,2,3)~1State Key Laboratory for Laser Technique,Huazhong University of Science and Technology,wuhan 430074,China~2Physics Department,Huazhong University of Science and Technology,wuhan 430074,China~3Center for Cold Atom Physics,the Chinese Academy of Sciences,wuhan 430071,China

We present the explicit analytical expressions of the steady-state probability amplitudes and populationsof atom levels in N-photon electromagnetically induced transparency for an arbitrary positive integer N.

关键词： electromagnetically induced transparency multi-wave mixing

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TGP在煎炸油质量评价中的应用研究

粮食与油脂 2017年第6期30卷 91-93页

作者：仇兆倩曹文明吴莹陈凤香上海良友(集团)有限公司技术中心上海200333 丰益(上海)生物技术研发中心有限公司上海200137 上海市粮食科学研究所上海200333

现有煎炸油质量评价指标存在特征指标专一性不强、适用范围有限等缺陷。对煎炸油中极性组分与TGP相关性进行研究,结果表明,极性组分与TGP随煎炸时间的延长呈线性增加关系。通过试验得出多次使用的煎炸老油中TGP含量远高于新鲜煎炸油,用... 详细信息

现有煎炸油质量评价指标存在特征指标专一性不强、适用范围有限等缺陷。对煎炸油中极性组分与TGP相关性进行研究,结果表明,极性组分与TGP随煎炸时间的延长呈线性增加关系。通过试验得出多次使用的煎炸老油中TGP含量远高于新鲜煎炸油,用TGP含量评价煎炸油质量具有可行性。相较PCs指标,TGP的稳定性更能使其客观反应油脂的新鲜程度。

关键词： TGP 煎炸油极性组分

氧化甘油三酯聚合物含量在冷榨油鉴别中的应用研究

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粮食与油脂 2018年第3期31卷 34-36页

作者：陈凤香曹文明吴莹朱天仪上海市粮食科学研究所上海200333

以氧化甘油三酯聚合物(TGP)为内源性指标依据,对多个不同品牌的冷榨芝麻油和不同来源的精炼芝麻油、特级初榨橄榄油和精炼橄榄油中TGP含量进行比较研究。结果发现,冷榨油与精炼油在TGP上有极显著性差异(P<0.01),冷榨油的TGP含量均小于0.... 详细信息

以氧化甘油三酯聚合物(TGP)为内源性指标依据,对多个不同品牌的冷榨芝麻油和不同来源的精炼芝麻油、特级初榨橄榄油和精炼橄榄油中TGP含量进行比较研究。结果发现,冷榨油与精炼油在TGP上有极显著性差异(P<0.01),冷榨油的TGP含量均小于0.15%,而精炼油中的TGP含量均大于1.0%,用TGP的含量来鉴别冷榨油和精炼油具有可行性。

关键词：冷榨油精炼油氧化甘油三酯聚合物高效体积排阻凝胶色谱

Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing Yao Chubing Long Pengcheng Yi Jiali Song Luojia wu Wei Wan Xiuqin Rao Yue Lin Gen Wei Jun ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

An Efficient Boron Source Activation Strategy for the Low‑Temperature Synthesis of Boron Nitride Nanotubes

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Nano-Micro Letters 2025年第1期17卷 548-558页

作者： ying Wang Kai Zhang Liping Ding Liyun wu Songfeng E Qian He Nanyang Wang Hui Zuo Zhengyang Zhou Feng Ding Yue Hu Jin Zhang Yagang Yao National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesJiangsu Key Laboratory of Artificial Functional Materialsand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093People’s Republic of China School of Electronic Information and Artificial Intelligence Shaanxi University of Science&TechnologyXian 710000People’s Republic of China College of Bioresources Chemical and Materials Engineering Shaanxi University of Science&TechnologyXian 710000People’s Republic of China Key Laboratory of Carbon Materials of Zhejiang Province College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325000People’s Republic of China Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhen 518000People’s Republic of China College of Chemical and Molecular Engineering Peking UniversityBeijing 100871People’s Republic of China

Lowering the synthesis temperature of boron nitride nanotubes(BNNTs)is crucial for their *** primary reason for adopting a high temperature is to enable the effective activation of highmelting-point solid *** this study,we developed a novel approach for efficiently activating boron by introducing alkali metal compounds into the conventional MgO–B *** approach can be adopted to form various low-melting-point AM–Mg–B–O growth *** growth systems have improved catalytic capability and reactivity even under low-temperature conditions,facilitating the synthesis of BNNTs at temperatures as low as 850℃.In addition,molecular dynamics simulations based on density functional theory theoretically demonstrate that the systems maintain a liquid state at low temperatures and interact with N atoms to form BN *** findings offer novel insights into the design of boron activation and are expected to facilitate research on the low-temperature synthesis of BNNTs.

关键词： Boron nitride nanotubes Low-temperature Boron activation Density functional theory

Magnetic properties of α-Fe_2O_3 nanopallets

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Rare Metals 2019年第1期38卷 14-19页

作者： ying-ying Xu Long Wang Tong wu Rong-ming Wang Beijing Key Laboratory for Magneto-Photoelectrical Composite and Interface Science School of Mathematics and PhysicsUniversity of Science and Technology Beijing Department of Equipment Manufacture Zhongshan Torch Polytechnic Division of Energy and Environmental Measurement National Institute of Metrology

It is the result of a systemic study about uniform hematite nanopallets with length of about 100 nm, width of about 30 nm, and thickness of less than 10 nm. The sample has superparamagnetic(SPM) properties above the blocking temperature of ～16 K. The temperature dependence of magnetization was well fitted by Bloch T^(3/2) law considering the dipolar interaction of the particles. The field dependence of magnetization was fitted with revised Langevin *** magnetization of the weak ferromagnetic(WF) canted spins contributes to the linear portion in the high field region;the surface uncompensated spins and the parasitic ferromagnetic moments due to the canted spins both contribute to the particle moments and the superparamagnetic behavior.

关键词： α-Fe2O3 nanopallets Magnetic property Superparamagnetic behavior Canted spins

Applications of covalent organic frameworks(COFs)：From gas storage and separation to drug delivery

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Chinese Chemical Letters 2017年第6期28卷 1135-1143页

作者： ming-Xue wu ying-Wei Yang International Joint Research Laboratory of Nano-Micro Architecture Chemistry (NMAC) College of Chemistry Jilin University Changchun 130012 China

Covalent organic frameworks（COFs） are an emerging class of porous covalent organic structures whose backbones were composed of light elements（B,C,N,O,Si） and linked by robust covalent bonds to endow such material with desirable properties,i.e.,inherent porosity,well-defined pore aperture,ordered channel structure,large surface area,high stability,and *** expected,the abovementioned properties of COFs broaden the applications of this class of materials in various fields such as gas storage and separation,catalysis,optoelectronics,sensing,small molecules adsorption,and drug *** this review,we outlined the synthesis of COFs and highlighted their applications ranging from the initial gas storage and separation to drug delivery.

关键词： Covalent organic frameworks Drug delivery Porous materials Synthesis