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Copy number variation profile-based genomic typing of premenstrual dysphoric disorder in Chinese

Journal of Genetics and Genomics 2021年第12期48卷 1070-1080页

作者： Hong Xue Zhenggang Wu Xi Long Ata Ullah Si Chen Wai-Kin Mat Peng Sun ming-Zhou Gao Jie-qiong Wang Hai-Jun Wang Xia Li Wen-Jun Sun ming-qi qiao Shandong University of Traditional Chinese Medicine JinanShandong 250355China Division of Life Science and Applied Genomics Center Hong Kong University of Science and TechnologyHong KongChina School of Basic Medicine and Clinical Pharmacy China Pharmaceutical UniversityNanjingJiangsu 210009China HKUST Shenzhen Research Institute NanshanShenzhen 518057China Guangzhou HKUST Fok Ying Tung Research Institute Science and Technology BuildingNansha Information Technology ParkNanshaGuangzhou 511458China

Premenstrual dysphoric disorder(PMDD) affects nearly 5% of women of reproductive age. Symptomatic heterogeneity, together with largely unknown genetics, has greatly hindered its effective treatment. In the present study, analysis of genomic sequencing-based copy number variations(CNVs) called from 100 kb white blood cell DNA sequence windows by means of semisupervized clustering led to the segregation of patient genomes into the D and V groups, which correlated with the depression and invasion clinical types,respectively, with 89.0% consistency. Application of diagnostic CNV features selected using the correlation-based machine learning method enabled the classification of the CNVs obtained into the D group, V group, total patient group, and control group with an average accuracy of 83.0%. The power of the diagnostic CNV features was 0.98 on average, suggesting that these CNV features could be used for the molecular diagnosis of the major clinical types of PMDD. This demonstrated concordance between the CNV profiles and clinical types of PMDD supported the validity of symptom-based diagnosis of PMDD for differentiating between its two major clinical types, as well as the predominantly genetic nature of PMDD with a host of overlaps between multiple susceptibility genes/pathways and the diagnostic CNV features as indicators of involvement in PMDD etiology.

关键词： Clinical subtyping Genomic sequencing Machine learning Recurrent copy number variation Replication phase Semisupervized

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GPS: graph contrastive learning via multi-scale augmented views from adversarial pooling

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Science China(Information Sciences) 2025年第1期68卷 145-158页

作者： Wei JU Yiyang GU Zhengyang MAO Ziyue qiao Yifang qiN Xiao LUO Hui XIONG ming ZHANG School of Computer Science National Key Laboratory for Multimedia Information ProcessingPeking University Artificial Intelligence Thrust The Hong Kong University of Science and Technology Department of Computer Science University of California

Self-supervised graph representation learning has recently shown considerable promise in a range of fields, including bioinformatics and social networks. A large number of graph contrastive learning approaches have shown promising performance for representation learning on graphs, which train models by maximizing agreement between original graphs and their augmented views(i.e., positive views). Unfortunately, these methods usually involve pre-defined augmentation strategies based on the knowledge of human experts. Moreover, these strategies may fail to generate challenging positive views to provide sufficient supervision signals. In this paper, we present a novel approach named graph pooling contrast(GPS) to address these *** by the fact that graph pooling can adaptively coarsen the graph with the removal of redundancy, we rethink graph pooling and leverage it to automatically generate multi-scale positive views with varying emphasis on providing challenging positives and preserving semantics, i.e., strongly-augmented view and weakly-augmented view. Then, we incorporate both views into a joint contrastive learning framework with similarity learning and consistency learning, where our pooling module is adversarially trained with respect to the encoder for adversarial robustness. Experiments on twelve datasets on both graph classification and transfer learning tasks verify the superiority of the proposed method over its counterparts.

关键词： graph representation learning graph neural networks graph contrastive learning graph augmentations graph pooling

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工人群体生活事件与愤怒郁怒相关性流行病学调查

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中西医结合学报 2011年第3期9卷 281-286页

作者：高冬梅乔明琦山东中医药大学基础医学院山东济南250355

目的:提出"生活事件是引发愤怒郁怒情志反应的始发因素"新假说,探讨生活事件与愤怒郁怒的相关性,以期了解在当今社会中引发愤怒、郁怒情绪的主要生活事件。方法:采用流行病学横断面调查的方法,根据怒的流行特点及相关资料,选取济南、青... 详细信息

目的:提出"生活事件是引发愤怒郁怒情志反应的始发因素"新假说,探讨生活事件与愤怒郁怒的相关性,以期了解在当今社会中引发愤怒、郁怒情绪的主要生活事件。方法:采用流行病学横断面调查的方法,根据怒的流行特点及相关资料,选取济南、青岛两市工人群体为目标人群,由经过专门培训的调查人员,使用事先设计好的调查工具进行调查。调查对象填写一般情况问卷、状态-特质怒表达量表2(State-trait Anger Expression Inventory-2,STAXI-2)和生活事件量表(Life Events Scale,LES)调查问卷。应用二分类反应变量的logistic回归统计愤怒、郁怒工人与生活事件的相关性。结果:在愤怒工人中,事件"性生活不满意或独身"(OR:2.877)和"对现职工作不满意"(OR:3.308)与愤怒情绪呈正相关。在此基础上进一步分析,这一组生活事件是愤怒工人产生愤怒情绪的主要危险因素,提示工人对上述生活事件如处理不当,极易产生愤怒情绪。在郁怒工人中,事件"自己(爱人)流产"(OR:2.209)、"对现职工作不满意"(OR:2.054)和"与上级关系紧张"(OR:2.714)与郁怒情绪呈正相关。在此基础上进一步分析,这一组事件是郁怒工人产生郁怒情绪的主要危险因素,提示工人对上述生活事件如处理不当,极易产生郁怒情绪。而事件"结婚"与郁怒呈负相关,提示工人群体面临这一事件的刺激,不易产生郁怒情绪,可能产生其他情绪。结论:研究结果为新假说提供了流行病学调查第一手资料,这将拓展中医情志内伤病因学,从病因学角度为愤怒、郁怒产生及其发病机制提供相关理论依据和数据支持,为七情内伤学说增添新内容。

关键词：情志怒愤怒郁怒生活事件横断面研究流行病学方法

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MTO装置新型催化剂实验研究

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化工管理 2021年第12期 46-47页

作者：齐明巧宁波富德能源有限公司浙江宁波315204

我国的能源结构在近些年来仍未有较大的变化,当前乃至未来很长一段时间内,占据我国能源消耗主要地位的仍然是煤炭资源。同时,乙烯和丙烯是各类化工材料的重要原料,是衡量一个国家化工业水平的重要标志。现有传统工艺制备的乙烯主要来自... 详细信息

我国的能源结构在近些年来仍未有较大的变化,当前乃至未来很长一段时间内,占据我国能源消耗主要地位的仍然是煤炭资源。同时,乙烯和丙烯是各类化工材料的重要原料,是衡量一个国家化工业水平的重要标志。现有传统工艺制备的乙烯主要来自石脑油的裂解,乙烯联产和催化裂化就能够制备丙烯,这就需要消耗大量的石油。近些年石油价格上涨以及供应不稳定都会对乙烯、丙烯的制备产生影响。随着煤制烯烃技术的工业化,烯烃需求与石油供应的矛盾得到了一定的缓解。文章主要介绍了MTO的催化剂和反应机理,并对新型催化剂实验研究进行评价,并且在煤化工厂运行中,总结了MTO技术的工业化缺陷及可能改革前进的问题所在。

关键词：催化剂甲醇制烯烃工业试验煤化工

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Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury

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Neural Regeneration Research 2025年第10期20卷 2807-2822页

作者： Xizi Song Ruixin Li Xiaolei Chu qi Li Ruihua Li qingwen Li Kai-Yu Tong Xiaosong Gu Dong ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Haihe Laboratory of Brain-Machine Interface and Human-Machine Fusion TianjinChina Department of Rehabilitation Tianjin University Tianjin HospitalTianjinChina Department of Hand Microsurgery Tianjin University Tianjin HospitalTianjinChina School of Exercise and Health Tianjin University of SportTianjinChina Department of Biomedical Engineering the Chinese University of Hong KongHong Kong Special Administrative RegionChina

Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and *** on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target *** has led to restrictions on current therapeutic *** this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target *** peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal *** nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury *** damage to target organs can occur,including skeletal muscle atrophy and sensory receptor *** then provide a brief review of the research advances in therapeutic approaches to peripheral nerve *** main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical ***,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ ***,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.

关键词： central nervous system central peripheral target organ multilevel pathological analysis nerve regeneration peripheral nerve injury peripheral nervous system target organs therapeutic approach

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Self-assembled carbon monoxide nanoprodrug for chemiexcitationtriggered synergistic chemotherapy against breast cancer

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Science China Chemistry 2025年

作者： Shunfei Cui Yiyao Pan Chenzhe Ma Bin qi qingqiang Min ming Li Huabing Chen Hengte Ke Xingyue Ji Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development College of Pharmaceutical ScienceSoochow University

Carbon monoxide（CO） has recently been well-established as a promising therapeutic modality against cancer. The development of transition-metal-free and tumor-targeted delivery platforms for CO is highly demanded but remains very sporadic. Herein, we developed a polyprodrug system for the co-delivery of CO and a chemotherapeutic agent combretastin A-4（CA-4） to the tumor site based on a chemiexcitation mechanism. Such a poly-prodrug successfully achieved the co-activation of CO and CA-4 in response to H2O2at the tumor site both in vitro and in vivo. Importantly, a synergist effect between CO and CA-4 was observed in suppressing tumor growth in a mouse tumor model. It is anticipated that such a poly-prodrug system could be potentially adapted for the co-delivery of CO and another drug payload for combinational therapy for other indications.

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Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu Wei Wu Ying Wang Yan Sun Lingxiao Deng Melissa Walker Chen Chen Heqiao Dai qi Han Ying Ding Yongzhi Xia George Smith Rui Li Nai-Kui Liu Xiao-ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

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Poly(acrylonitrile-co-3-aminocarbonyl-3-butenoic acid methyl ester):A better precursor material for carbon fiber than acrylonitrile terpolymer

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Chinese Chemical Letters 2014年第9期25卷 1275-1278页

作者： An-qi Ju Meng-Juan Li Miao Luo ming-qiao Ge Key Laboratory of Eco-textiles Ministry of EducationJiangnan University College of Textile & Clothing Jiangnan University School of Pharmacy East China University of Science and Technology

In order to improve the stabilization and spinnability of polyacrylonitrile, a bifunctional comonomer containing both ester and amide groups was synthesized to prepare poly（acrylonitrile-co-3- aminocarbonyl-3-butenoic acid methyl ester） [P（AN-co-ABM）] copolymers used as the carbon fiber precursor instead of poly（acrylonitrile-acrylamide-methyl acrylate） [P（AN-AM-MA）] terpolymer. The differential scanning calorimetry and thermogravimetry results show that the stabilization of P（AN-co- ABM） have been remarkably improved by ABM compared with P（AN-AM-MA） terpolymer, such as lower initiation temperature, broadened exothermic peak and smaller activation energy. Moreover, the spinnability of P（AN-co-ABM） is also improved by ABM due to the lubrication of ester groups in ABM. This study clearly shows that P（AN-co-ABM） copolymer is a better material for use as a carbon fiber precursor than P（AN-AM-MA） terpolymer.

关键词： Polymerization Stabilization DSC Spinnability Carbon fiber

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Fe_(n)Mo_(38-n)(n=0-38)及Fe_(n)Mo_(55-n)(n=0-55)双金属团簇的结构演化和基态能量

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原子与分子物理学报 2025年第3期42卷 85-93页

作者：郑琪琪陈轩程彪段海明新疆大学物理科学与技术学院乌鲁木齐830017

基于半经验的Gupta多体势,采用遗传算法及分子动力学淬火算法,系统研究了(FeMo)m(m=38及55)双金属团簇的基态结构及其能量.结果表明:对于Fe_(n)Mo_(38-n)(n=0-38)团簇,随Fe原子数的增加,Fe原子优先占据团簇表面再占据内部,其基态构型存... 详细信息

基于半经验的Gupta多体势,采用遗传算法及分子动力学淬火算法,系统研究了(FeMo)m(m=38及55)双金属团簇的基态结构及其能量.结果表明:对于Fe_(n)Mo_(38-n)(n=0-38)团簇,随Fe原子数的增加,Fe原子优先占据团簇表面再占据内部,其基态构型存在类O_(h)结构、类I_(h)结构和无序结构间的竞争.对于Fe_(n)Mo_(55-n)(n=0-55)团簇,随Fe原子数的增加,Fe原子优先占据团簇中心位置,再依次占据表面顶点、棱边和次外层,双金属团簇基态构型主要体现为在Mackay二十面体基础上的结构畸变.Fe_(24)Mo_(14),Fe_(13)Mo_(42)和Fe_(43)Mo_(12)为幻数结构团簇,研究发现双金属团簇幻数成因不能通过单质团簇常用的平均配位数和平均键长模型解释,它更多的归咎于组分效应导致的结构高对称性.

关键词：双金属团簇结构和能量淬火算法遗传算法

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Fe_(n)Co_(55-n)与Co_(n)Mo_(55-n)(n=0~55)团簇基态的能量与结构演化

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原子与分子物理学报 2025年第5期42卷 57-66页

作者：程彪郑琪琪陈轩段海明新疆大学物理科学与技术学院乌鲁木齐830049

采用半经验的Gupta多体势函数结合遗传算法及分子动力学淬火算法,系统研究了Co_(n)Mo_(55-n)(n=0~55)与Fe_(n)Co_(55-n)(n=0~55)团簇的基态结构与能量.通过分析基态结构的相似函数、质心间距、平均键长、平均原子配位数、平均结合能、... 详细信息

采用半经验的Gupta多体势函数结合遗传算法及分子动力学淬火算法,系统研究了Co_(n)Mo_(55-n)(n=0~55)与Fe_(n)Co_(55-n)(n=0~55)团簇的基态结构与能量.通过分析基态结构的相似函数、质心间距、平均键长、平均原子配位数、平均结合能、混合能与二阶差分能.探究了团簇基态的结构特征及稳定性与团簇所含元素种类及组分的关联.结果表明:对Co-Mo混合团簇,随Co原子数目增加,Co原子依次占据团簇中心与最外层顶点,混合团簇逐渐出现组分偏析与无序现象;对Fe-Co混合团簇,基态结构主体上均体现为围绕Mackay二十面体构型的结构畸变,随Fe原子含量增加,Fe原子先占据团簇外表面顶点位置直到全部包裹Co原子,逐渐形成核壳式结构;Co_(13)Mo_(42)与Fe_(42)Co_(13)是幻数结构团簇,研究发现组分效应导致的团簇高对称性相比团簇平均键长与平均原子配位数更能解释幻数结构的成因.

关键词：遗传算法淬火算法双金属团簇基态结构

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