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A highly stable terbium metal-organic framework for efficient detection of picric acid in water

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Chinese Chemical Letters 2021年第10期32卷 3095-3098页

作者： Zi-Ying Li Zhao-Quan Yao Rui Feng ming-hua sun Xiao-Tian Shan Zi-Hao Su Wei Li Xian-He Bu TKL of Metal and Molecule Based Material Chemistry&School of Materials Science and Engineering Tianjin 300350China State Key Laboratory of Elemento-Organic Chemistry College of ChemistryTianjin 300071China

A highly stable fluorescent terbium MOF(Tb_(4)(paip)_(6)·1.2 H_(2) O,paip = 5-(1 H-pyrazole-4-yl)isophthalate)showing a sharp green emission(545 nm) and a quantum yield of 21.0% was successfully *** compound is shown to be a recyclable sensor for detecting picric acid in aqueous solution with both high sensitivity and selectivity,attributed to the electron transfer quenching mechanism.

关键词： Metal-organic framework Detection Nitro aromatics Picric acid Fluorescent

Crop Yield,N Uptake and Nitrates in a Fluvo-Aquic Soil Profile

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Pedosphere 2004年第1期14卷 131-136页

作者： ZHANGShu-Xiang LIXiu-Ying LIXiao-Ping YUANFeng-ming YAOZhao-hua sunYong-Lin ZHANGFu-Dao InstituteofSoilsandFertilizers ChineseAcademyofAgriculturalSciencesBeijing100081（China）

The effects of different chemical fertilizer combinations (N, P and K) oncrop yield, N uptake and nitrate distribution and accumulation to a depth of 100 cm were studied ina cinnamon fluvo-aquic soil profile (Beijing) with a continuous winter wheat-summer maize croppingsystem for nine years. The experiment consisted of 7 treatments: no fertilizer control (CK); Nalone, N in combination with K (NK), P (NP), and P and K (NPK and N1PK); and P and K in combinationwithout N (PK). The rate of N was 150 kg ha^(-1) for the N treatments except Treatment N1PK withhigher N rate (195 kg ha^(-1)), and the rates of P (P_2O_5) and K (K2O) were 75 and 37.5 kg ha^(-1),respectively. The applications of N combined with P and K (NK, NP and NPK) resulted in higher cropyields than a single application of N. The yields followed the order: NPK > NP > N1PK > PK > NK > N> CK for winter wheat, and NPK > N1PK > NP > NK > N > PK > CK for summer maize. Supplement of N withP or K, or both P and K resulted in a higher average N uptake of the two crops, which was in adecreasing order NPK > NP > N1PK > NK > N > PK > CK. The combinations also increased apparent Nrecovery more than N alone and CK. The nitrate content in the profile was thus reduced more in thecombination treatments. The nitrate accumulation in the soil profiles followed the order: N > NK >N1PK > NPK > NP > CK > PK. Higher N uptake by the adequately fertilized crops (Treatment NPK)reduced nitrate accumulation in the profile and thus reduced nitrate leaching. The optimum N:P:Kratio was thus of paramount importance in increasing yields and N uptake of crops and reducingnitrate leaching losses.

关键词： fertilizer combination N uptake nitrate distribution and accumulation yield

CAF-derived exosome-miR-3124-5p promotes malignant biological processes in NSCLC via the TOLLIP/TLR4-MyD88-NF-κB pathway

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Oncology Research 2025年第1期33卷 133-148页

作者： TAO sun QINGhua SONG hua LIU Department of Respiratory and Critical Care Medicine Affiliated Hospital of Nantong UniversityMedical School of Nantong UniversityNantong226001China Department of Emergency The People’s Hospital of RugaoNantong226500China Department of Haematology The People’s Hospital of RugaoNantong226500China

Background:Lung cancer is a life-threatening disease that occurs worldwide,but is especially common in *** crucial role of the tumour microenvironment(TME)in non-small cell lung cancer(NSCLC)has attracted recent ***-associated fibroblasts(CAFs)are the main factors that contribute to the TME function,and CAF exosomes are closely linked to ***:The expression levels of miR-3124-5p and Toll-interacting protein(TOLLIP)were analysed by bioinformatics prediction combined with RT-qPCR/Western Blot *** were isolated and identified from clinical NSCLC *** electron microscopy and Western Blot were used to identify exosomes from these *** in proliferation(CCK-8 and clone formation),migration(wound healing),and invasion(transwell)of NSCLC cells were *** Luciferase reporter test was applied to clarify the binding of miR-3124-5p to *** TOLLIP/TLR4/MyD88/NF-κB pathway proteins were determined using Western blot ***:MiR-3124-5p is overexpressed in clinical tissues and cells of ***-3124-5p was dramatically enriched in CAF-derived *** experiments revealed that CAFs delivered miR-3124-5p into NSCLC cells via exosomes,stimulating cancer cell ***-3124-5p acted as a sponge to negatively regulate TOLLIP expression,which activated the TLR4/MyD88/NF-κB axis to promote the occurrence and development of *** salvage tests were performed to determine whether CAF-exosome-derived miR-3124-5p plays a pro-cancer role in NSCLC by affecting the TOLLIP signalling ***:These results provide an interesting direction for the diagnosis and therapy of NSCLC.

关键词： Non-small cell lung cancer(NSCLC) Cancer-associated fibroblasts(CAFs) Exosomes miR-3124-5p Toll-interacting protein(TOLLIP)

多b值下表观弥散系数值对肺部良、恶性病变的诊断效能

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中国现代医学杂志 2016年第12期26卷 67-72页

作者：孙明华刘斌安徽医科大学第一附属医院放射科安徽合肥230022

目的探讨不同b值扩散加权成像图像对肺部不同病变的鉴别效能。方法对62例电子计算机断层扫描检查发现肺部占位性病变的患者,进行常规磁共振T1加权像、T2加权像及扩散加权成像扫描(测得病变表观弥散系数值采用t检验及方差分析,比较肺部... 详细信息

目的探讨不同b值扩散加权成像图像对肺部不同病变的鉴别效能。方法对62例电子计算机断层扫描检查发现肺部占位性病变的患者,进行常规磁共振T1加权像、T2加权像及扩散加权成像扫描(测得病变表观弥散系数值采用t检验及方差分析,比较肺部良恶性病变及不同病理类型肺癌在不同b值下的表观弥散系数值是否有差异,并根据受试者工作特征曲线衡量相应的鉴别效能),分析肺部良恶性病变及不同病理类型肺癌在不同b值下的鉴别诊断效能。结果 62例患者均经病理证实,小细胞肺癌6例,11例鳞状细胞癌,8例高分化腺癌,13例低分化腺癌及24例良性病变。当b值取800 s/mm^2时,高分化腺癌、中低分化腺癌、小细胞肺癌及鳞癌的表观弥散系数值分别为(1.80±0.14)×10^(-3)mm^2/s、(1.09±0.15)×10^(-3)mm^2/s、(0.80±0.10)×10-3 mm^2/s及(1.19±0.18)×10^(-3)mm^2/s;b值分别为200 s/mm^2、500 s/mm^2和800 s/mm^2时,肺部良性病变表观弥散系数值分别为:(2.18±0.27)×10^(-3)mm^2/s、(2.06±0.16)×10^(-3)mm^2/s和(1.84±0.21)×10^(-3)mm^2/s;恶性病变表观弥散系数值分别为(1.49±0.36)×10^(-3)mm^2/s、(1.33±0.38)×10-3 mm^2/s和(1.22±0.36)×10-3 mm^2/s,肺部良恶性病变的表观弥散系数值差异有统计学意义(P<0.01)。结论同一b值(b=200 s/mm^2、500 s/mm^2和800 s/mm^2)下,表观弥散系数值对肺部良恶性病变及不同病理类型肺癌均有鉴别意义,且b=800 s/mm^2时,高分化腺癌及中低分化腺癌鉴别效能最大。

关键词：磁共振成像扩散加权成像肺癌鉴别效能

克癌新丸对裸鼠结肠癌细胞HCT116移植瘤生长的抑制作用

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中国药学杂志 2017年第18期52卷 1609-1613页

作者：李华云李芹刘明华孙琴西南医科大学附属医院四川泸州646000 西南医科大学药学院四川泸州646000 西南医科大学附属中医医院药物研究中心四川泸州646000

目的观察克癌新丸对裸鼠人结肠癌细胞HCT116移植瘤生长及肿瘤血管生成的抑制作用。方法复制裸鼠人结肠癌HCT116移植瘤模型,随机分为阴性对照组(Ns)、阳性对照组(贝伐单抗注射液,5 mg·kg^(-1),腹腔注射给药)和克癌新丸低、中、高3个剂量... 详细信息

目的观察克癌新丸对裸鼠人结肠癌细胞HCT116移植瘤生长及肿瘤血管生成的抑制作用。方法复制裸鼠人结肠癌HCT116移植瘤模型,随机分为阴性对照组(Ns)、阳性对照组(贝伐单抗注射液,5 mg·kg^(-1),腹腔注射给药)和克癌新丸低、中、高3个剂量组(200,400和800 mg·kg^(-1),灌胃给药),给药结束后剥取瘤体并称重,常规石蜡切片,采用免疫组化法分析瘤体内微血管密度(microvessel density,MVD)和血管内皮生长因子(vascular endothelial growth factor,VEGF)表达的影响。结果克癌新丸明显抑制裸鼠移植瘤的生长,各治疗组给药后肿瘤体积、相对肿瘤体积和相对肿瘤增殖率明显下降,与对照组比较,P<0.05;克癌新丸治疗组微血管分布较稀疏,MVD值由对照组的(59.62±18.83)分别减少至(55.56±12.63),(46.72±11.57)和(41.35±10.27)。克癌新丸治疗组阳性表达率由对照组的(78.46±16.53)%下降至(58.64±14.19)%,(49.27±13.29)%和(43.68±11.71)%。结论克癌新丸能明显抑制裸鼠HCT116移植瘤的生长,降低移植瘤微血管密度MVD,下调瘤组织VEGF的表达,揭示其抗肿瘤作用与减少血管生成有关。

关键词：克癌新丸 HCT116 微血管密度血管内皮生长因子

Low‑Temperature Oxidation Induced Phase Evolution with Gradient Magnetic Heterointerfaces for Superior Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第1期17卷 191-204页

作者： Zizhuang He Lingzi Shi Ran sun Lianfei Ding Mukun He Jiaming Li hua Guo Tiande Gao Panbo Liu School of Chemistry and Chemical Engineering Northwestern Polytechnical UniversityXi’an 710129People’s Republic of China School of Marine Science and Technology Northwestern Polytechnical UniversityXi’an 710072People’s Republic of China

Gradient magnetic heterointerfaces have injected infinite vitality in optimizing impedance matching,adjusting dielectric/magnetic resonance and promoting electromagnetic(EM)wave absorption,but still exist a significant challenging in regulating local phase ***,accordion-shaped Co/Co_(3)O_(4)@N-doped carbon nanosheets(Co/Co_(3)O_(4)@NC)with gradient magnetic heterointerfaces have been fabricated via the cooperative high-temperature carbonization and lowtemperature oxidation *** results indicate that the surface epitaxial growth of crystal Co_(3)O_(4) domains on local Co nanoparticles realizes the adjustment of magnetic-heteroatomic components,which are beneficial for optimizing impedance matching and interfacial ***,gradient magnetic heterointerfaces simultaneously realize magnetic coupling,and long-range magnetic ***,the synthesized Co/Co_(3)O_(4)@NC absorbents display the strong electromagnetic wave attenuation capability of−53.5 dB at a thickness of 3.0 mm with an effective absorption bandwidth of 5.36 GHz,both are superior to those of single magnetic domains embedded in carbon *** design concept provides us an inspiration in optimizing interfacial polarization,regulating magnetic coupling and promoting electromagnetic wave absorption.

关键词： Magnetic heterointerfaces Phase evolution Interfacial polarization Magnetic coupling Electromagnetic wave absorption

Neuroprotective potential for mitigating ischemia-reperfusion-induced damage

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Neural Regeneration Research 2025年第8期20卷 2199-2217页

作者： Zi Ye Runqing Liu Hangxing Wang Aizhen Zuo Cen Jin Nan Wang Huiqi sun Luqian Feng hua Yang The Clinical Medical College Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Infectious Diseases Department of Internal MedicinePeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina School of Medical Imaging Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Gastroenterology First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina The Second Clinical Medical College Lanzhou UniversityLanzhouGansu ProvinceChina Department of Neurosurgery Affiliated Hospital of Guizhou Medical UniversityGuiyangGuizhou ProvinceChina

Reperfusion following cerebral ischemia causes both structural and functional damage to brain tissue and could aggravate a patient's condition;this phenomenon is known as cerebral ischemia-reperfusion *** studies have elucidated the neuroprotective role of the sirtuin protein family(Sirtuins)in modulating cerebral ischemia-reperfusion ***,the potential of utilizing it as a novel intervention target to influence the prognosis of cerebral ischemia-reperfusion injury requires additional *** this review,the origin and research progress of Sirtuins are summarized,suggesting the involvement of Sirtuins in diverse mechanisms that affect cerebral ischemia-reperfusion injury,including inflammation,oxidative stress,blood-brain barrier damage,apoptosis,pyroptosis,and *** therapeutic avenues related to Sirtuins that may improve the prognosis of cerebral ischemia-reperfusion injury were also investigated by modulating Sirtuins expression and affecting representative pathways,such as nuclear factor-kappa B signaling,oxidative stress mediated by adenosine monophosphate-activated protein kinase,and the forkhead box *** review also summarizes the potential of endogenous substances,such as RNA and hormones,drugs,dietary supplements,and emerging therapies that regulate Sirtuins *** review also reveals that regulating Sirtuins mitigates cerebral ischemia-reperfusion injury when combined with other risk *** Sirtuins show promise as a potential target for the treatment of cerebral ischemiareperfusion injury,most recent studies are based on rodent models with circadian rhythms that are distinct from those of humans,potentially influencing the efficacy of Sirtuinstargeting drug ***,this review provides new insights into the role of Sirtuins in the pathology and treatment of cerebral ischemia-reperfusion injury.

关键词： apoptosis autophagy blood-brain barrier dietary supplements drug hormones inflammation neuroprotection oxidative stress prognosis pyroptosis reperfusion injury risk factors RNA therapeutics

2004至2013年中国大学生人格变迁的横断历史研究

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心理发展与教育 2017年第1期33卷 30-36页

作者：田园明桦黄四林孙铃北京师范大学发展心理研究所北京100875 中央财经大学心理学系北京100081

已有研究发现大学生的心理健康等心理状态随社会变迁而发生变化,那么作为个体内在特质的人格是如何随年代变化呢?本研究对2004至2013年65篇采用五因素人格量表的研究进行了横断历史分析,以揭示47029名大学生人格特质的变化趋势。结果发... 详细信息

已有研究发现大学生的心理健康等心理状态随社会变迁而发生变化,那么作为个体内在特质的人格是如何随年代变化呢?本研究对2004至2013年65篇采用五因素人格量表的研究进行了横断历史分析,以揭示47029名大学生人格特质的变化趋势。结果发现:(1)2004至2013年期间,大学生的人格五个因子得分与年代之间均呈现显著正相关,大学生人格特质发生了整体变化。(2)大学生的神经质、外向性、开放性和严谨性得分在10年期间均上升1个标准差以上,其d值在1.06~1.30之间,宜人性提高0.57个标准差。大学生在变得更加外向、开放、严谨和宜人的同时,情绪稳定性也更差。(3)男女大学生人格特质的变化既有共同趋势,又存在明显差异,男生的五个因子得分都显著上升,但是女生的开放性无变化,宜人性却有所下降。

关键词：人格 NEO-FFI 大学生横断历史研究元分析

Deciphering Water Oxidation Catalysts:The Dominant Role of Surface Chemistry over Reconstruction Degree in Activity Promotion

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Nano-Micro Letters 2025年第3期17卷 340-354页

作者： Li An Jianyi Li Yuanmiao sun Jiamin Zhu Justin Zhu Yeow Seow Hong Zhang Nan Zhang Pinxian Xi * Zhichuan JXu Chun‑hua Yan State Key Laboratory of Applied Organic Chemistry Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu ProvinceFrontiers Science Center for Rare IsotopesCollege of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000People’s Republic of China School of Materials Science and Engineering Nanyang Technological UniversitySingapore 639798Singapore Faculty of Materials Science and Energy Engineering Institute of Technology for Carbon NeutralityShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055People’s Republic of China Key Laboratory of Electromagnetic Materials and Devices National Center for International Research On Photoelectric and Energy MaterialsSchool of Materials and EnergyElectron Microscopy CenterYunnan UniversityKunming 650091People’s Republic of China State Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization Baotou Research Institute of Rare EarthsBaotou 014030People’s Republic of China Beijing National Laboratory for Molecular Sciences State Key Laboratory of Rare Earth Materials Chemistry and ApplicationsPKU‑HKU Joint Laboratory in Rare Earth Materials and Bioinorganic ChemistryPeking UniversityBeijing 100871People’s Republic of China

Water splitting hinges crucially on the availability of electrocatalysts for the oxygen evolution *** surface reconstruction has been widely observed in perovskite catalysts,and the reconstruction degree has been often correlated with the activity ***,a systematic study on the roles of Fe substitution in activation of perovskite LaNiO_(3)is *** substituting Fe content influences both current change tendency and surface reconstruction ***_(0.9)Fe_(0.1)O_(3)is found exhibiting a volcano-peak intrinsic activity in both pristine and reconstructed among all substituted perovskites in the LaNi_(1-x)Fe_(x)O_(3)(x=0.00,0.10,0.25,0.50,0.75,1.00)*** reconstructed LaNi_(0.9)Fe_(0.1)O_(3)shows a higher intrinsic activity than most reported NiFe-based ***,density functional theory calculations reveal that Fe substitution can lower the O 2p level,which thus stabilize lattice oxygen in LaNi0.9Fe0.1O3 and ensure its long-term ***,it is vital interesting that activity of the reconstructed catalysts relied more on the surface chemistry rather than the reconstruction *** effect of Fe on the degree of surface reconstruction of the perovskite is decoupled from that on its activity enhancement after surface *** finding showcases the importance to customize the surface chemistry of reconstructed catalysts for water oxidation.

关键词： Oxygen evolution reaction Perovskite oxides Doping Activation and reconstruction