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Anti-inflammatory effect of cannabinoid agonist WIN55, 212 on mouse experimental colitis is related to inhibition of p38MAPK

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World Journal of Gastroenterology 2016年第43期22卷 9515-9524页

作者： Ya-Jing Feng Yong-Yu Li Xu-Hong Lin Kun Li ming-hua cao Department of Pathophysiology Tongji University School of Medicine Department of Center ICU East Hospital Tongji University School of Medicine

AIM To investigate the anti-inflammatory effect and the possible mechanisms of an agonist of cannabinoid(CB) receptors, WIN55-212-2(WIN55), in mice with experimental colitis, so as to supply experimental evidence for its clinical use in future. METHODS We established the colitis model in C57BL/6 mice by replacing the animals' water supply with 4% dextran sulfate sodium(DSS) for 7 consecutive days. A colitis scoring system was used to evaluate the severity of colon local lesion. The plasma levels of proinflammatory cytokines, such as tumor necrosis factor-alpha(TNF-α) and interleukin-6(IL-6), and the myeloperoxidase(MPO) activity in colon tissue were measured. The expressions of cannabinoid receptors, claudin-1 protein, p38 mitogen-activated protein kinase(p38MAPK) and its phosphorylated form(p-p38) in colon tissue were determined by immunohistochemistry and Western blot. In addition, the effect of SB203580(SB), an inhibitor of p38, was investigated in parallel experiments, andthe data were compared with those from intervention groups of WIN55 and SB alone or used together. RESULTS The results demonstrated that WIN55 or SB treatment alone or together improved the pathological changes in mice with DSS colitis, decreased the plasma levels of TNF-α, and IL-6, and MPO activity in colon. The enhanced expression of claudin-1 and the inhibited expression of p-p38 in colon tissues were found in the WIN55-treated group. Besides, the expression of CB1 and CB2 receptors was enhanced in the colon after the induction of DSS colitis, but reduced when p38 MAPK was inhibited. CONCLUSION These results confirmed the anti-inflammatory effect and protective role of WIN55 on the mice with experimental colitis, and revealed that this agent exercises its action at least partially by inhibiting p38 MAPK. Furthermore, the results showed that SB203580, affected the expression of CB1 and CB2 receptors in the mouse colon, suggesting a close linkage and cross-talk between the p38 MAPK signaling

关键词： Inflammatory bowel disease Endogenous cannabinoid system p38MAPK Experimental colitis Claudin-1

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p38 MAPK inhibition alleviates experimental acute pancreatitis in mice

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Hepatobiliary & Pancreatic Diseases International 2015年第1期14卷 101-106页

作者： ming-hua cao Jing Xu Hai-Dong Cai Zhong-Wei Lv Ya-Jing Feng Kun Li Chun-Qiu Chen Yong-Yu Li Department of Pathophysiology Institute of Digestive Disease Tongji University School of Medicine The Seventh People's Hospital of Shanghai The Tenth People's Hospital of Shanghai Tongji University School of Medicine

BACKGROUND： The mitogen-activated protein kinases （MAPKs） signaling pathway is involved in inflammatory process. However,the mechanism is not clear. The present study was to investigate the role of p38 MAPK in acute pancreatitis in ***： Mice were divided into 4 groups： saline control; acute pancreatitis induced with repeated injections of cerulein; control plus p38 MAPK inhibitor SB203580; and acute pancreatitis plus SB203580. The pancreatic histology, pancreatic enzymes, cytokines, myeloperoxidase activity, p38 MAPK and heat shock protein （HSP） 60 and 70 were ***： Repeated injections of cerulein resulted in acute pancreatitis in mice, accompanying with the activation of p38 MAPK and overexpression of HSP60 and HSP70 in the pancreatic tissues. Treatment with SB203580 significantly inhibited the activation of p38 MAPK, and furthermore, inhibited the expression of HSP60 and HSP70 in the pancreas, the inflammatory cytokines in the serum, and myeloperoxidase activity in the ***： The p38 MAPK signaling pathway is involved in the regulation of inflammatory response and the expression of HSP60 and HSP70 in acute pancreatitis.

关键词： acute pancreatitis p38 MAPK heat shock protein

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lncRNA SNHG4 enhanced gastric cancer progression by modulating miR-409-3p/CREB1 axis

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Oncology research 2025年第1期33卷 185-198页

作者： Zhouyang Cheng Yuchen hua Yang cao Jun Qin Department of General Surgery Affiliated Hospital of Nantong University Nantong 226001 China. Department of Surgery Affiliated Hospital of Nantong University Medical School of Nantong University Nantong 226001 China. Department of Operation Affiliated Hospital of Nantong University Nantong 226001 China.

Objective:Gastric cancer (GC) is a globally common cancer characterized by high incidence and mortality worldwide. Advances in the molecular understanding of GC provide promising targets for GC diagnosis and therapy. Long non-coding RNAs (lncRNAs) and their downstream regulators are regarded to be implicated in the progression of multiple types of malignancies. Studies have shown that the lncRNA small nucleolar RNA host gene 4 (SNHG4) serves as a tumor promoter in various malignancies, while its function in GC has yet to be characterized. Therefore, our study aimed to explore the role and underlying mechanism of SNHG4 in GC.Methods:We used qRT-PCR to analyze SNHG4 expression in GC tissues and cells. Kaplan-Meier analysis was used to assess the correlation between SNHG4 expression and the survival rate of GC patients. Cellular function experiments such as CCK-8, BrdU, colony formation, flow cytometry analysis, and transwell were performed to explore the effects of SNHG4 on GC cell proliferation, apoptosis, cell cycle, migration, and invasion. We also established xenograft mouse models to explore the effect of SNHG4 on GC tumor growth. Mechanically, dual luciferase reporter assay was used to verify the interaction between SNHG4 and miR-409-3p and between miR-409-3p and cAMP responsive element binding protein 1 (CREB1).Results:The results indicated that SNHG4 was overexpressed in GC tissues and cell lines, and was linked with poor survival rate of GC patients. SNHG4 promoted GC cell proliferation, migration, and invasion while inhibiting cell apoptosis and cell cycle arrest . The experiment indicated that SNHG4 facilitated GC tumor growth. Furthermore, SNHG4 was demonstrated to bind to miR-409-3p. Moreover, CREB1 was directly targeted by miR-409-3p. Rescue assays demonstrated that miR-409-3p deficiency reversed the suppressive impact of SNHG4 knockdown on GC cell malignancy. Additionally, miR-409-3p was also revealed to inhibit GC cell proliferation, migration, and

关键词： Gastric cancer MicroRNA-409-3p (miR-409-3p) Small nucleolar RNA host gene 4 (SNHG4) cAMP responsive element binding protein 1 (CREB1)

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Universal design of three-dimensional porous graphene-iron based promotors for kinetically rationalized lithium-sulfur chemistry

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Journal of Energy Chemistry 2025年第1期100卷 192-200页

作者： hua Gao Yunfeng Zhang Menglei Wang Ruoxuan Yang Shuai Feng Xuan cao Yaping Zhang Zhongyuan Lu Yingze Song State Key Laboratory of Environment-Friendly Energy Materials School of Materials and Chemistry Southwest University of Science and Technology School of Material Science and Engineering Henan University of Technology College of Chemistry and Chemical Engineering Taishan University

Lithium-sulfur （Li-S） batteries are widely deemed to be one of the most potential candidates for future secondary batteries because of their remarkable energy ***,notorious polysulfide shuttling and retarded sulfur reaction kinetics pose significant obstacles to the further application of Li-S *** rationally designed highly active electrocatalysts can facilitate polysulfide conversion,the universal and scalable synthesis strategies need to be ***,a universal synthetic strategy to construct a series of three-dimensional （3D） porous graphene-iron （3DGr-Fe） based electrocatalysts involving 3DGr-FeP,3DGr-Fe3C,and 3DGr-Fe3Se4is exploited for manipulating the Li-S redox *** has been observed that the implementation of a 3D porous Gr architecture leads to the well-designed conductive networks,while the uniformly dispersed iron nanoparticles introduce an abundance of active sites,fostering the lithium polysulfide conversion,thereby bolstering the overall electrochemical *** Li-S battery with the 3DGr-Fe based electrocatalyst exhibits remarkable capacity retention of 94.8%upon 100 times at 0.2 ***,the soft-packaged Li-S pouch cell based on such a 3DGr-Fe electrocatalyst delivers superior capacity of 1060.71 mA h g-1and guarantees for the continuous 30 min work of fan *** investigation gives comprehensive insights into the design,synthesis,and mechanism of 3DGr-Fe based electrocatalysts with high activity toward efficient and durable Li-S batteries.

关键词： Redox reactions

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S空位及非金属掺杂单层Bi_(2)S_(2)Se的第一性原理研究

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原子与分子物理学报 2025年第1期42卷 127-134页

作者：张建华王敏陈畅曹倩徐银湖北大学资源环境学院武汉430062

Bi_(2)S_(2)Se是一种新兴的具有优异光电性能的材料,因此受到了广泛的关注.本研究采用第一性原理方法和开源程序,研究了本征单层Bi_(2)S_(2)Se以及掺杂非金属元素X(X=P,Cl,Br和I)和S空位的体系的电子结构和光学特性.计算结果表明,改性... 详细信息

Bi_(2)S_(2)Se是一种新兴的具有优异光电性能的材料,因此受到了广泛的关注.本研究采用第一性原理方法和开源程序,研究了本征单层Bi_(2)S_(2)Se以及掺杂非金属元素X(X=P,Cl,Br和I)和S空位的体系的电子结构和光学特性.计算结果表明,改性后出现了晶格缺陷.含S空位和P、Cl、Br掺杂体系的带隙减少,而I掺杂体系的带隙增加.同时,含S空位和Cl、Br、I掺杂体系的费米能级穿过导带底,而P掺杂体系的费米能级穿过价带顶.所有改性体系在费米能级附近都出现了缺陷能级或杂质能级,表现出较高的可见光吸收能力和散射能力,改性体系的对可见光的吸收能力和散射能力有所增加.

关键词： Bi_(2)S_(2)Se 掺杂电子结构光学性质第一性原理

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A tumor down-regulated gene NOR1 induced by hypoxia promote apoptosis in nasopharyngeal carcinoma cell 6-10B

A tumor down-regulated gene NOR1 induced by hypoxia promote ...

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第四届中国肿瘤学术大会暨第五届海峡两岸肿瘤学术会议

作者： Yang Jue-Ou Fang Song-Qing Xiang Bo Peng Shu-Ping Wu ming-hua cao Li huang Chen Liu hua-Ying Luo Xiao-ming Zhou ming Li Gui-Yuan Cancer Research Institute of Central South University Xiang-Yale School of Medicine,110# Xiang-Ya Road, Changsha, Hunan, 410078, China Pathology department of the 2nd Xiang-Yale Hospital of Central South University Changsha, Hunan, P.R.China

＜正＞Objective: NOR1, a nasopharyngeal cancer-related novel gene, has the characteristic of reductase, may be a novel member of nitroreductases .Hypoxia which is a common feature of solid tumors could change the cy-tosol redox state during its forming .The aim of the study was to determine the relation between NOR1 expression and tumor hypoxia. Methods: We detected the expression of NOR1 in cancer and noncancerous tissues with combination of tissue array and in situ hybridization （ISH）. NOR1 was induced with hypoxia and hypoxia mimetics CoC12 in 6-10B and the effects of overexpressed NOR1 on 6-10B were determined. Results: We found the expression level of NOR1 in cancer of nasopharyngeal, liver, stomach, colon, rectum were significantly lower than those in their corresponding benign tissue（P ＜0.05）. But, we failed to indicate the correlation between tumor clinical pathology stages and the expression level of NOR1 in NPC, lung, colon and rectum （P ＞0.05 ）. NOR1 was up regulated after induced by hypoxia, it could decrease proliferation of the cell and the ability to form colonies in soft agar, and NOR1 could promote apoptosis in 6-10B. Conclusion: Our results suggested that the NOR1 could suppress the tumor growth by participating in the cancer cell apoptosis in the process of early tumor.

关键词： Nasopharyngeal carcinoma (NPC) NOR1 hypoxia Apoptosis

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Interfacial Structures Governed Plastic Deformation Behaviors in Metallic Multilayers

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Acta Metallurgica Sinica(English Letters) 2016年第2期29卷 199-204页

作者： ming-Zhen Wei Zhen-hua cao Xiang-Kang Meng Institute of Materials Engineering National Laboratory of Solid State Microstructures College of Engineering and Applied Sciences Nanjing University Department of Physics School of Science Linyi University

In this work, we have investigated the mechanical properties of Cu/Ta, Ag/Cu and Ag/Nb multilayers with different heterogeneous interfaces. The results suggest that when individual layer thickness （h） is larger than 5-10 nm, the hardness/strength of three different multilayer systems has the similar length scale effect with decreasing layer thickness, while when h ≤ 5 nm, the three multilayer systems show remarkably different plastic deformation behaviors. The strength curves exhibit the variation trends of unchanging, softening and increasing corresponding to Cu/Ta, Ag/Cu and Ag/Nb multilayers, respectively. The microstructure analysis shows that three kinds of multilayers have totally different interfacial structures, which lead to the different strengthening or softening mechanisms.

关键词： Metallic multilayers Plastic deformation Interfacial structures Strengthening mechanism

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New insights into p53 functions through its target microRNAs

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Journal of Molecular Cell Biology 2014年第3期8卷 206-213页

作者： Jun-ming Liao Bo cao XiangZhou hua Lu Department of Biochemistry & Molecular Biology and Tutane Cancer Center Tulane University School of Medicine New Orleans LA 70112 USA

The tumor suppressor p53 pathway, whose alterations are highly associated with all types of human cancers, plays an essential role in preventingtumor development and progression mostly through its downstream target genes. Over the last decade, a growing list of p53 microRNA （miRNA） targets has been identified as additional downstream players of this pathway. Further studies ofthese miRNAs have revealed their more complicated regulations and functions in executing and/or regulating p53 activity. Here, we review the p53 miRNA targets identified thus far, and discuss how they fine-tune p53 stress responses, mediate the crosstalk between p53 and other signaling pathways, and expand the role of p53 in other human diseases in addition to cancers.

关键词： miRNA p53 tumorigenesis cancer

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基于改进联邦Kalman滤波的组合校准方法研究

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导航定位与授时 2016年第6期3卷 21-25页

作者：陈晶袁书明程建华曹新宇海军装备研究院北京100161 哈尔滨工程大学自动化学院哈尔滨150001

联邦滤波器广泛应用于多传感器信息融合领域,联邦滤波中的信息分配原则影响滤波精度。针对联邦Kalman滤波器进行改进,采用基于估计协方差阵奇异值动态确定信息分配系数。对子滤波器进行重置时,采用新的重置方法,保证了子滤波器误差协方... 详细信息

联邦滤波器广泛应用于多传感器信息融合领域,联邦滤波中的信息分配原则影响滤波精度。针对联邦Kalman滤波器进行改进,采用基于估计协方差阵奇异值动态确定信息分配系数。对子滤波器进行重置时,采用新的重置方法,保证了子滤波器误差协方差阵的对称性,确保Kalman滤波器的一致收敛稳定性。新的联邦滤波算法允许每个状态分量拥有不同的动态信息分配因子,从而改进了联邦滤波信息融合的精度。设计了SINS/GPS/电子罗盘组合导航系统,仿真结果说明,与传统联邦滤波算法相比,改进的联邦滤波器估计精度得到了提高,可以更好地对SINS误差进行校准,提高系统的精度。

关键词：信息分配信息融合联邦滤波组合校准

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Gaussian-curvature-derived invariants for isometry

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Science China(Information Sciences) 2013年第9期56卷 219-230页

作者： cao WeiGuo HU Ping LIU YuJie GONG ming LI hua Institute of Computing Technology Chinese Academy of Sciences Graduate University of Chinese Academy of Sciences School of Computer Science and Communication Engineering China University of Petroleum

Surface deformations without tearing or stretching, preserving the intrinsic properties, are called isometries. This paper presents a new definition of Gaussian curvature moments (GCMs) by the integral of n power of Gaussian curvature. Then a series of moment invariants, called Gaussian curvature moment invariants (GCMIs), are derived via GCMs. These moment invariants share many good properties under rigid transformations and isometric non-rigid transformations, and Gaussian-Bonnet theorem is a special case of GCMI. GCMIs are invariant under isometry and scaling transformations. We construct an invariant vector as a descriptor for a surface via GCMIs, and a modified χ2 distance is defined as a measure of similarity. Finally, experiments show that it is a reliable descriptor for isometric non-rigid shape.

关键词： rigid object non-rigid object isometry scale Gaussian curvature moment moment invariant

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