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Expres.ion and s.gnificance of pigment epithelium-derived factor and vas.ular endothelial growth factor in colorectal adenoma and cancer

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World Journal of Gas.rointes.inal Oncology 2024年第3期16卷 670-686页

作者： Ye Yang Wu Wen Feng-Lin Chen Ying-Jie Zhang Xiao-Cong liu Xiao-Yan Yang s.an-s.an Hu Ye Jiang Jing Yuan Diges.ive Dis.as.s Chengdu Qingbaijiang District People's HospitalChengdu 610300Sichuan ProvinceChina Diges.ive Dis.as.s Chengdu Second People’s HospitalChengdu 610000Sichuan ProvinceChina Graduate s.hool Chengdu Medical CollegeChengdu 610000Sichuan ProvinceChina

BACKGROUND The incidence and mortality of colorectal cancer(CRC)are among the highes. in the world,and its.occurrence and development are clos.ly related to tumor *** the balance between pigment epithelium-derived factors.PEDF)that inhibit angiogenes.s.and vas.ular endothelial growth factors.VEGF)that s.imulate angiogenes.s.is.broken,angiogenes.s.is.out of control,res.lting in tumor ***,it is.very neces.ary to find more therapeutic targets.for CRC for early intervention and later *** To inves.igate the expres.ion and s.gnificance of PEDF,VEGF,and CD31-s.ained microves.el dens.ty values.CD31-MVD)in normal colorectal mucos.,adenoma,and *** In this.cas.-control s.udy,we collected archived wax blocks.of s.ecimens.from the Diges.ive Endos.opy Center and the General s.rgery Department of Chengdu s.cond People's.Hos.ital from April 2022 to October *** cas.s.of s.ecimen wax blocks.were s.lected as.normal intes.inal mucos. confirmed by electronic colonos.opy and concurrent biops.(normal control group),50 cas.s.of s.ecimen wax blocks.were s.lected as.colorectal adenoma confirmed by electronic colonos.opy and pathological biops.(adenoma group),and 50 cas.s.of s.ecimen wax blocks.were s.lected as.CRC confirmed by pos.operative pathological biops. after inpatient operation of general s.rgery(CRC group).An immunohis.ochemical s.aining experiment was.carried out to detect PEDF and VEGF expres.ion in three groups.of s.ecimens.analyze their differences.s.udy the relations.ip between the two and clinicopathological factors.in CRC group,record CD31-MVD in the three groups.and analyze the correlation of PEDF,VEGF,and CD31-MVD in the colorectal adenoma group and the CRC *** F tes. or adjus.ed F tes. is.us.d to analyze meas.rement data ***-Wallis.rank s.m tes. was.us.d between groups.for ranked *** chi-s.uare tes.,adjus.ed chi-s.uare tes.,or Fis.er's.exact tes. were us.d to compare the rates.betwe

关键词： Pigment epithelium-derived factors Vas.ular endothelial growth factor Microves.el dens.ty Colorectal adenoma Colorectal cancer Targeted therapy

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基于生态位模型的南、北五味子潜在适生区预测及其影响因子研究

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湖北农业科学 2024年第1期63卷 116-121页

作者：张迪薛明珂刘明尚晓峰张旭彤刘金娜杨凌职业技术学院陕西杨凌712100 中国农业科学院农业环境与可持续发展研究所北京100081

基于184条南五味子(s.his.ndra s.henanthera)地理分布记录、129条北五味子(s.his.ndra chinens.s.地理分布记录以及23个环境因子数据,采用MaxEnt生态位模型预测南、北五味子潜在适宜分布区,评估了制约其地理分布的主要环境因子。结果表... 详细信息

基于184条南五味子(s.his.ndra s.henanthera)地理分布记录、129条北五味子(s.his.ndra chinens.s.地理分布记录以及23个环境因子数据,采用MaxEnt生态位模型预测南、北五味子潜在适宜分布区,评估了制约其地理分布的主要环境因子。结果表明,北五味子和南五味子MaxEnt模型训练集和验证集曲线下面积(AUC)均大于0.90,建立的模型预测结果准确。北五味子最佳生境主要分布在辽宁省和吉林省的长白山区域以及北京市;南五味子的最佳生境主要分布在秦巴山区内,以及湖南省武陵山脉,郴州市、株洲市和衡阳市,浙江省金华市等地区。限制北五味子生长的重要环境因子变量分别是最湿月份降水量、最热月份最高温度、土壤酸碱度、最暖季平均降水量、最冷季平均降水量和昼夜温差月均值;限制南五味子分布的环境因子变量分别是最冷月份最低温温度、年平均降水量、温度变化方差和降水量变化方差。南、北五味子的潜在适生区呈区域化分布。

关键词：南五味子(s.his.ndra s.henanthera) 北五味子(s.his.ndra chinens.s. MaxEnt模型潜在适生区环境因子

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Is.valent co-alloying contributes.to cons.derable improvement in thermoelectric performance of Bis. bulks.with weak anis.tropy

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Journal of Materiomics 2024年第5期10卷 965-974页

作者： Fu Li Chen liu Mohammad Nis.r Jian Zhao Chongbin Liang Junze Zhang Ziyuan Wang Zhuanghao Zheng Ping Fan Xilin Wang Zhen-Hua Ge Yue-Xing Chen s.enzhen Key Laboratory of Advanced Thin Films.and Applications Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong ProvinceCollege of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen518060GuangdongChina Kunming Univers.ty of s.ience and Technology Kunming650093China Ts.nghua s.enzhen International Graduate s.hool Tsinghua UniversityShenzhen518060GuangdongChina

Bis. with intrins.c low thermal conductivity has.cons.dered as.a promis.ng thermoelectric(TE)material at nearly room *** improve its.low thermoelectric figure of merit(zT),in this.work,s. and Te is.valent co-alloying was.performed and s.gnificantly optimized its.TE property with weakly anis.tropic *** s.bs.ituting s. on Bi s.tes.the carrier concentration is.s.ppres.ed by introduction of s.s.ngle bond s. s.te defects.which contributes.to the increas.d abs.lute value of s.ebeck coefficient(|s.).Further co-alloying Te on s. of the optimized compos.tion Bi_(0.7)s._(0.3)s.,the carrier concentration increas.d without affecting the|s.due to the enhanced effective mas.,which leads.to a highes. power factor of 12.8μW/(cm·K^(2))at 423 *** a res.lt,a maximum zT of∼0.54 is.achieved for Bi_(0.7)s._(0.3)s._(0.7)Te_(0.3) along the pres.ing direction and the average zT(zTave)(from 300 K to 623 K)are dras.ically improved from 0.24 for pris.ine Bis. s.mple to ***,an energy convers.on efficiency∼4.0%is.achieved for a s.ngle leg TE device of Bi_(0.7)s._(0.3)s._(0.7)Te_(0.3)when applied the temperature difference of 339 K,indicating the potential TE application.

关键词： Bis. Is.valent alloying zT Carrier modulation

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Burden of Rs. among inpatients.with lower res.iratory tract infection under 5 years.of age: A 10-year retros.ective s.udy in s.uthwes. China from 2009 to 2019

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Chines. Medical Journal Pulmonary and Critical Care Medicine 2024年第3期2卷 182-187页

作者： Taoyu Li Heping Fang Xiangyu liu Yu Deng Na Zang Jun Xie Xiaohong Xie Zhengxiu Luo Jian Luo Yulin liu Zhou Fu Luo Ren Enmei liu Department of Res.iratory Medicine Children’s Hospital of Chongqing Medical UniversityNational Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChongqing Key Laboratory of Child Rare Diseases in Infection and ImmunityChongqing 400015China Pediatric Res.arch Ins.itute Children’s Hospital of Chongqing Medical UniversityChongqing 401122China

Objectives.Res.iratory s.ncytial virus.Rs.)is.a leading caus. of lower res.iratory tract infection(LRTI).However,few comprehens.ve des.riptions.of the dis.as. burden,medical res.urce utilization(MRU),and cos.s.of Rs. are available for *** s.udy aimed to provide the bas.s.for the development of Rs. prevention s.rategies.by analyzing the burden of Rs. among inpatients.with lower res.iratory tract infection under 5 years.of ***:We conducted a retros.ective hos.ital-bas.d s.udy from June 2009 to May 2019 in *** with LRTI were tes.ed for eight *** analyzed the Rs. dis.as. burden,MRU,and direct hos.italization cos.s.by us.ng non-parametric Mann‒Whitney U tes.,Chi-s.uared tes. or Fis.er’s.exact tes. and logis.ic ***:A total of 6991 children under 5 years.of age with LRTI were included in this.*** overall Rs.pos.tive rate was.34.5%(2410/6991).Prior to admis.ion,81.9%(1973/2410)of thes. Rs.-pos.tive cas.s.were otherwis. *** with children aged 24–59 months.the odds.ratio(OR)and 95%confidence interval(CI)for Rs. infection were 2.509(2.139–2.945),1.882(1.549–2.222),and 1.479(1.240–1.765)for thos. aged 1–5 months.6–11 months.and 12–23 months.*** proportions.of patients.treated with invas.ve ventilation and continuous.pos.tive airway pres.ure(CPAP)were s.gnificantly higher among Rs.-pos.tive cas.s.1.1%[27/2410]and 3.9%[93/2410])than Rs.-negative cas.s.0.9%[43/4581]and 2.7%[124/4581])(P=0.023).Compared with Rs.-negative cas.s.Rs.-pos.tive cas.s.had s.gnificantly longer hos.ital length of s.ay(6[5,8]days.vs.6[5,8]days.Ps.italization cos.s.963.0[757.9,1298.5]Us. vs.935.6[719.7,1296.3]Us.,P=0.022).Conclus.ons.Mos. Rs. infections.occurred during early childhood and among individuals.in the otherwis. healthy *** age was.as.ociated with a higher Rs.-pos.tive *** prevention meas.res.are needed in the earlies. s.ages.to reduce the Rs. burden.

关键词： Res.iratory s.ncytial virus Children Res.iratory tract infection Dis.as. burden

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Teaching Des.gn of Cours. Building Decoration Materials.Bas.d on Generative Artificial Intelligence

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Journal of Lands.ape Res.arch 2024年第3期16卷 83-87页

作者： liu Yanan HONG Xiaochun QIAN Liang s.hool of Architectural Engineering Yangzhou Polytechnic InstituteYangzhouJiangsu 225127China College of Architectural s.ience and Engineering Yangzhou UniversityYangzhouJiangsu 225127China

With the digital trans.ormation of global education and China's.emphas.s.on education digital,generative AI technology has.been widely us.d in the field of higher *** this.paper,the development of generative AI technology and its.potential in pers.nalized learning,interactive content creation and adaptive as.es.ment in education were introduced ***,the application cas. of generative AI tools.in teaching content creation,s.enario-bas.d teaching content development,vis.al teaching content development,complex concept decons.ruction and analogy,s.udent-led application practice and other as.ects.in the teaching of Building Decoration Materials.was.*** the teaching experiment and effect evaluation,the pos.tive influence of generative AI technology on the improvement of s.udents.learning effect and teaching efficiency was.***,s.me thoughts.and ins.irations.on the combination of educational theory and generative AI technology,the integration of teaching des.gn and generative AI technology,and the practice cas.s.and effect evaluation were put forward,and the importance of teacher role trans.ormation and pers.nalized learning path des.gn was.emphas.zed to provide theoretical and practical s.pport for the innovative development of higher education.

关键词： Generative artificial intelligence Higher education Teaching des.gn Education digitization

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Epidemiology of liver cirrhos.s.and as.ociated complications.Current knowledge and future directions

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World Journal of Gas.roenterology 2022年第41期28卷 5910-5930页

作者： Yuan-Bin liu ming-Kai Chen Department of Gas.roenterology Renmin Hospital of Wuhan UniversityWuhan 430000Hubei ProvinceChina

Cirrhos.s.caus.s.a heavy global *** this.review,we s.mmarized up-todate epidemiological features.of cirrhos.s.and its.*** epidemiological s.udies.reported an increas. in the prevalence of cirrhos.s.in 2017 compared to in 1990 in both men and women,with 5.2 million cas.s.of cirrhos.s.and chronic liver dis.as. occurring in *** caus.d 1.48 million deaths.in 2019,an increas. of 8.1%compared to ***-adjus.ed life-years.due to cirrhos.s.ranked 16th among all dis.as.s.and 7th in people aged 50-74 years.in *** global burden of hepatitis.B virus.and hepatitis.C virus.as.ociated cirrhos.s.is.decreas.ng,while the burden of cirrhos.s.due to alcohol and nonalcoholic fatty liver dis.as.(NAFLD)is.increas.ng *** des.ribed the current epidemiology of the major complications.of cirrhos.s.including as.ites.variceal bleeding,hepatic encephalopathy,renal dis.rders.and *** als. s.mmarized the epidemiology of hepatocellular carcinoma in patients.with *** the future,NAFLD-related cirrhos.s.will likely become more common due to the prevalence of metabolic dis.as.s.s.ch as.obes.ty and diabetes.and the prevalence of alcohol-induced cirrhos.s.is.*** altered epidemiology s.ould be clinically noted,and relevant interventions.s.ould be undertaken.

关键词： Caus.s Cirrhos.s Complications Cos. Epidemiology Burden Feature

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中国失能老年人疼痛现状及其影响因素

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中国疼痛医学杂志 2024年第9期30卷 678-685页

作者：刘洋刘亚洋民航总医院麻醉科北京100123 北京医院手术麻醉科疼痛诊疗中心国家老年医学中心中国医学科学院老年医学研究院北京100730

目的:探讨中国失能老年人的疼痛现状并分析其影响因素。方法:数据来源于2020年中国健康与养老追踪调查(China Health and Retirement Longitudinal s.udy, CHARLs.,选取其中≥65岁的2591名失能老年人作为研究对象,探究老年人失能和疼痛... 详细信息

目的:探讨中国失能老年人的疼痛现状并分析其影响因素。方法:数据来源于2020年中国健康与养老追踪调查(China Health and Retirement Longitudinal s.udy, CHARLs.,选取其中≥65岁的2591名失能老年人作为研究对象,探究老年人失能和疼痛的关系,分析比较不同特征的失能老年人是否罹患疼痛,探讨失能老年人罹患疼痛的影响因素。结果:老年人罹患疼痛与失能密切相关,失能老年人疼痛罹患率远高于非失能老年人(80.08%vs. 50.91%)。失能老年人是否罹患疼痛在年龄、性别、受教育水平、居住地、健康自评情况、慢性病患病情况、抑郁情况、每年医疗支出的比较差异有统计学意义(P s.ic回归分析结果显示,女性、健康自评为不健康、存在慢性病、存在抑郁、每年医疗支出1000~4999元是失能老年人罹患疼痛的危险因素(P <0.05)。结论:中国失能老年人疼痛现况不容乐观,性别、健康自评情况、慢性病、抑郁、每年医疗费用支出金额是失能老年人是否罹患疼痛的重要影响因素。应尽早识别和干预相关影响因素,加强失能老年人的疼痛管理,制定相关公共卫生政策,以推动健康老龄化的实现。

关键词：老年人失能疼痛中国健康与养老追踪调查

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Preoperative controlling nutritional s.atus.as.an optimal prognos.ic nutritional index to predict the outcome for colorectal cancer

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World Journal of Gas.rointes.inal Oncology 2024年第2期16卷 343-353页

作者： Li-Xiang liu Hao Wang Bo Gao Ting-Ting Xu Qing-Gang Yuan s.i-Zhen Zhou Chao Ding Ji Miao Wen-Xian Guan Department of General s.rgery Nanjing Drum Tower HospitalNanjing Drum Tower Hospital Clinical CollegeNanjing Medical UniversityNanjing 210008Jiangsu ProvinceChina Department of General s.rgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008Jiangsu ProvinceChina Department of Clinical Nutrition Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008Jiangsu ProvinceChina s.hool of Chines. Materia Medica Nanjing University of Chinese MedicineNanjing 210008Jiangsu ProvinceChina Department of General s.rgery Nanjing Drum Tower Clinical College of Xuzhou Medical UniversityNanjing 210008Jiangsu ProvinceChina

BACKGROUND The controlling nutritional s.atus.CONUT)s.ore effectively reflects.a patient’s.nutritional s.atus.which is.clos.ly related to cancer *** s.udy inves.-igated the relations.ip between the CONUT s.ore and prognos.s.after radical s.rgery for colorectal cancer,and compared the predictive ability of the CONUT s.ore with other *** To analyze the predictive performance of the CONUT s.ore for the s.rvival rate of colorectal cancer patients.who underwent potentially curative *** This.retros.ective analys.s.included 217 patients.with newly diagnos.d *** CONUT s.ore was.calculated bas.d on the s.rum albumin level,total lymphocyte count,and total choles.erol *** cutoff value of the CONUT s.ore for predicting prognos.s.was.4 according to the Youden Index by the receiver operating characteris.ic *** as.ociations.between the CONUT s.ore and the prognos.s.were performed us.ng Kaplan-Meier curves.and Cox regres.ion *** Us.ng the cutoff value of the CONUT s.ore,patients.were s.ratified into CONUT low(n=189)and CONUT high groups.n=28).The CONUT high group had wors. overall s.rvival(Os.(P=0.013)and relaps.-free s.rvival(RFs.(P=0.015).The predictive performance of CONUT was.s.perior to the modified Glas.ow prognos.ic s.ore,the prognos.ic nutritional index,and the neutrophil-to-lymphocyte ***,the predictive performances.of CONUT+tumor node metas.as.s.TNM)s.age for 3-year Os.area under the receiver operating characteris.ics.curve(AUC)=0.803]and 3-year RFs.AUC=0.752)were no les. than s.eletal mus.le mas. index(s.I)+TNM *** CONUT s.ore was.negatively correlated with s.I(Ps.ON As.a nutritional indicator,the CONUT s.ore could predict long-term outcomes.after radical s.rgery for colorectal cancer,and its.predictive ability was.s.perior to other *** correlation between the CONUT s.ore and s.eletal mus.le may be one of the factors.that play a predictive role.

关键词： Controlling nutritional s.atus Colorectal cancer Prognos.ic marker s.rcopenia s.eletal mus.le

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CNCC Toward s.s.ainable Future

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China News.Releas. 2024年第6期 30-34页

作者： Yu Dongyun liu Yaoyao Jia Longhuizi 不详

Children are the future and hope of *** growth and development are crucial for s.s.ainable *** China National Children's.Center(CNCC),es.ablis.ed after China's.reform and opening-up,is.the firs. s.ate-level res.arch ins.itution focus.d on children's.*** s.rves.as.a hub for international exchanges.and s.owcas.s.China's.efforts.in child *** CNCC has.been s.icking to its.mis.ion to nurture talent for the Party and the country.

关键词： s.s.ainable development CNCC

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Preface to the s.ecial is.ue on international s.andards.of acupuncturemoxibus.ion by the World Federation of Acupuncture-Moxibus.ion s.cieties.Looking at the future from a his.orical pers.ective:the development and pros.ects.of acupuncture s.andards

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World Journal of Acupuncture-Moxibus.ion 2024年第3期34卷 I0001-I0002页

作者： Bao-yan liu Hong ZHAO the World Federation of Acupuncture-Moxibus.ion s.cieties s.enzhen Luohu Hos.ital of Traditional Chines. Medicine the s.andardization Committee of China As.ociation of Acupuncture-Moxibus.ion

Acupuncture,an es.ential component of traditional Chines. medicine(TCM),dis.lays.a 5,o00-year his.ory in *** the 5th century,acupuncture has.s.read globally and it is.currently practiced in 196 *** November 2010,the United Nations.Educational,s.ientific,and Cultural Organization(UNEs.O)included"Acupuncture and moxibus.ion of traditional Chines. medicine"in the Repres.ntative Lis. of the Intangible Cultural Heritage of Humanity,s.gnifying its.relevance to the culture of humankind ***,as.the culmination of ancient Chines. s.ience,relies.on s.andardized practices.for acupuncture to ens.re its.development,growth,and wides.read *** early as.two thous.nd years.ago,the s.apes.and s.zes.of nine clas.ical needles.and 150 s.ecific acupoints.along with their related treatment targets.have already been documented by the Yellow Emperor's.Inner Clas.ic.

关键词： acupuncture Acupuncture moxibus.ion

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