检索结果-南通市图书馆

Establishment of predictive models and determinants of preoperative gastric retention in endoscopic retrograde cholangiopancreatography

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2024年第8期16卷 2574-2582页

作者： Ying Jia Hao-Jun Wu Tang Li Jia-Bin Liu Ling Fang zi-ming Liu Department of Thyroid Surgery West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Division of Biliary Tract Surgery Department of General SurgeryWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Division of General Surgery West China Hospital-Chengdu Shangjin NanfuWest China HospitalChengdu 611730Sichuan ProvinceChina

BACKGROUND Study on influencing factors of gastric retention before endoscopic retrograde cholangiopancreatography(ERCP)background:With the wide application of ERCP,the risk of preoperative gastric retention affects the smooth progress of the *** study found that female,biliary and pancreatic malignant tumor,digestive tract obstruction and other factors are closely related to gastric retention,so the establishment of predictive model is very important to reduce the risk of *** A retrospective analysis was conducted on 190 patients admitted to our hospital for ERCP preparation between January 2020 and February *** baseline clinical data were collected using an electronic medical record *** were randomly matched in a 1:4 ratio with data from 190 patients during the same period to establish a validation group(n=38)and a modeling group(n=152).Patients in the modeling group were divided into the gastric retention group(n=52)and non-gastric retention group(n=100)based on whether gastric retention occurred *** data of patients in the validation group and identify factors influencing preoperative gastric retention in ERCP patients.A predictive model for preoperative gastric retention in ERCP patients was constructed,and calibration curves were used for *** receiver operating characteristic(ROC)curve was analyzed to evaluate the predictive value of the *** We found no statistically significant difference in general data between the validation group and modeling group(P>0.05).The comparison of age,body mass index,hypertension,and diabetes between the two groups showed no statistically significant difference(P>0.05).However,we noted statistically significant differences in gender,primary disease,jaundice,opioid use,and gastrointestinal obstruction between the two groups(P<0.05).Mul-tivariate logistic regression analysis showed that gender,primary disease,jaundice,opioid use,and gastrointestina

关键词： Cholangiopancreatography Gastric retention Influencing factors Predictive model Endoscope

Tumor recurrence and survival prognosis in patients with advanced gastric cancer after radical resection with radiotherapy and chemotherapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2024年第6期16卷 1660-1669页

作者： Shuang-Fa Nie Chen-Yang Wang Lei Li Cheng Yang zi-ming Zhu Jian-Dong Fei Department of General Surgery The First Affiliated Hospital of Hebei North UniversityZhangjiakou 75000Hebei ProvinceChina Department of Gastrointestinal Surgery Zhongshan Hospital of Fudan UniversityShanghai 200032China

BACKGROUND Advanced gastric cancer is a common malignancy that is often diagnosed at an advanced stage and is still at risk of recurrence after radical surgical ***,as one of the important treatment methods for gastric cancer,is of great significance for improving the survival rate of ***,the tumor recurrence and survival prognosis of gastric cancer patients after radio-therapy and chemotherapy are still *** To analyze the tumor recurrence after radical radiotherapy and chemotherapy for advanced gastric cancer and provide more in-depth guidance for *** A retrospective analysis was performed on 171 patients with gastric cancer who received postoperative adjuvant radiotherapy and chemotherapy in our hospital from 2021 to *** Kaplan-Meier method was used to calculate the recurrence rate and survival rate;the log-rank method was used to analyze the single-factor prognosis;and the Cox model was used to analyze the prognosis associated with multiple *** The median follow-up time of the whole group was 63 months,and the follow-up rate was 93.6%.Stage Ⅱ and Ⅲ patients accounted for 31.0%and 66.7%,*** incidences of Grade 3 and above acute gastrointestinal reactions and hematological adverse reactions were 8.8%and 9.9%,respectively.A total of 166 patients completed the entire chemoradiotherapy regimen,during which no adverse reaction-related deaths *** terms of the recurrence pattern,17 patients had local recurrence,29 patients had distant metastasis,and 12 patients had peritoneal implantation *** 1-year,3-year,and 5-year overall survival(OS)rates were 83.7%,66.3%,and 60.0%,*** 1-year,3-year,and 5-year disease-free survival rates were 75.5%,62.7%,and 56.5%,*** analysis revealed that T stage,peripheral nerve invasion,and the lymph node metastasis rate(LNR)were independent prognostic factors for *** Postoperative intensity-

关键词： Tumor recurrence Survival prognosis Advanced gastric cancer Radical resection Retrospective study

Prediction model establishment and validation for enteral nutrition aspiration during hospitalization in patients with acute pancreatitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2024年第8期16卷 2583-2591页

作者： Ping Hou Hao-Jun Wu Tang Li Jia-Bin Liu Quan-Qing Zhao Hong-Jiang Zhao zi-ming Liu Division II of General Surgery West China Hospital-Chengdu Shangjin NanfuWest China HospitalSichuan UniversityChengdu 611730Sichuan ProvinceChina Division of Biliary Tract Surgery West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Hepatobiliary and Pancreatic Surgery West China Hospital-Chengdu Shangjin NanfuWest China HospitalSichuan UniversityChengdu 611730Sichuan ProvinceChina Department of Thyroid Surgery West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Oncology West China Hospital-Chengdu Shangjin NanfuWest China HospitalSichuan UniversityChengdu 611730Sichuan ProvinceChina Division of Biliary Tract Surgery Department of General SurgeryWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Acute pancreatitis(AP)is a disease caused by abnormal activation of pancreatic enzymes and can lead to self-digestion of pancreatic tissues and dysfunction of other *** nutrition plays a vital role in the treatment of AP because it can meet the nutritional needs of patients,promote the recovery of intestinal function,and maintain the barrier and immune functions of the ***,the risk of aspiration during enteral nutrition is high;once aspiration occurs,it may cause serious complications,such as aspiration pneumonia,and suffocation,posing a threat to the patient’s *** study aims to establish and validate a prediction model for enteral nutrition aspiration during hospitalization in patients with *** To establish and validate a predictive model for enteral nutrition aspiration during hospitalization in patients with *** A retrospective review was conducted on 200 patients with AP admitted to Chengdu Shangjin Nanfu Hospital,West China Hospital of Sichuan University from January 2020 to February *** data were collected from the electronic medical record *** were randomly divided into a validation group(n=40)and a modeling group(n=160)in a 1:4 ratio,matched with 200 patients from the same time *** modeling group was further categorized into an aspiration group(n=25)and a non-aspiration group(n=175)based on the occurrence of enteral nutrition aspiration during *** and multivariate logistic regression analyses were performed to identify factors influencing enteral nutrition aspiration in patients with AP during hospitalization.A prediction model for enteral nutrition aspiration during hospitalization was constructed,and calibration curves were used for *** operating characteristic curve analysis was conducted to evaluate the predictive value of the *** There was no statistically significant difference in general data between the validation and mode

关键词： Acute pancreatitis Hospitalization Enteral nutrition Predictive model Aspiration

Neosophoflavonoids A–C, A class of highly oxidized hybrid flavonoids from Sophora flavescens with antidiabetic effects

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第10期35卷 295-298页

作者： Xu Zhang Jiang Li Kai-Zhou Lu Ya-Nan Yang Jian-Shuang Jiang Xiang Yuan zi-ming Feng Fei Ye Pei-Cheng Zhang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and PekingUnionMedical CollegeBeijing100050China

Three highly oxidized hybrid flavonoids neosophoflavonoids A–C(1,2a,and 2b)were isolated from the roots of Sophora *** A possesses a unique highly oxidized heptacyclic6/6/6/6/6/6/5 *** B and C are isomers and share the same highly oxidized hexacyclic 6/6/6/6/6/6 *** planar structures were elucidated from 1D/2D nuclear magnetic resonance(NMR),ultraviolet spectroscopy(UV),infrared spectroscopy(IR),and high resolution electrospray ionization mass spectroscopy(HRESIMS)*** absolute configurations were determined by thorough GIAO13C NMR(DP4+)calculation protocol and electronic circular dichroism(ECD)calculation *** plausible biosynthetic routes for the compounds were also *** compounds exhibited significant protein tyrosine phosphatase-1B(PTP1B)inhibitory activity with half maximal inhibitory concentration(IC_(5)0)values 3.94±0.01,0.38±0.13,and 0.70±0.01μmol/L,*** addition,compared to a positive control fenofibrate(Feno)at 20μmol/L,compounds 2a and 2b exhibited stronger inhibitory effects on lipid accumulation in the oleic acid(OA)-induced cell model at 5 and 10μmol/L.

关键词： Sophora flavescens Highly oxidized hybrid flavonoids Neosophoflavonoids A-C PTP1B inhibition Lipid accumulation inhibition

Biological scaffold as potential platforms for stem cells:Current development and applications in wound healing

在线全文

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2024年第4期16卷 334-352页

作者： Jie-Yu Xiang Lin Kang zi-ming Li Song-Lu Tseng Li-Quan Wang Tian-Hao Li Zhu-Jun Li Jiu-Zuo Huang Nan-Ze Yu Xiao Long Department of Plastic and Reconstructive Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Biomedical Engineering Facility Institute of Clinical MedicinePeking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100021China

Wound repair is a complex challenge for both clinical practitioners and *** approaches for wound repair have several *** cell-based therapy has emerged as a novel strategy to address this issue,exhibiting significant potential for enhancing wound healing rates,improving wound quality,and promoting skin ***,the use of stem cells in skin regeneration presents several ***,stem cells and biomaterials have been identified as crucial components of the wound-healing *** therapy involving the development of biocompatible scaffolds,accompanying cells,multiple biological factors,and structures resembling the natural extracellular matrix(ECM)has gained considerable *** scaffolds encompass a range of biomaterials that serve as platforms for seeding stem cells,providing them with an environment conducive to growth,similar to that of the *** scaffolds facilitate the delivery and application of stem cells for tissue regeneration and wound *** article provides a comprehensive review of the current developments and applications of biological scaffolds for stem cells in wound healing,emphasizing their capacity to facilitate stem cell adhesion,proliferation,differentiation,and paracrine ***,we identify the pivotal characteristics of the scaffolds that contribute to enhanced cellular activity.

关键词： Stem-cell-based therapy Biological scaffolds Wound healing Extracellular matrix mimicry Cellular activities enhancement Scaffold characteristics

Photoinduced Floquet higher-order Weyl semimetal in C_(6) symmetric Dirac semimetals

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics B 2024年第6期33卷 109-117页

作者：许欣欣王梓名许东辉陈垂针 Institute for Advanced Study and School of Physical Science and Technology Soochow UniversitySuzhou 215006China Department of Physics and Chongqing Key Laboratory for Strongly Coupled Physics Chongqing UniversityChongqing 400044China Center of Quantum Materials and Devices Chongqing UniversityChongqing 400044China

Topological Dirac semimetals are a parent state from which other exotic topological phases of matter, such as Weyl semimetals and topological insulators, can emerge. In this study, we investigate a Dirac semimetal possessing sixfold rotational symmetry and hosting higher-order topological hinge Fermi arc states, which is irradiated by circularly polarized light. Our findings reveal that circularly polarized light splits each Dirac node into a pair of Weyl nodes due to the breaking of time-reversal symmetry, resulting in the realization of the Weyl semimetal phase. This Weyl semimetal phase exhibits rich boundary states, including two-dimensional surface Fermi arc states and hinge Fermi arc states confined to six ***, by adjusting the incident direction of the circularly polarized light, we can control the degree of tilt of the resulting Weyl cones, enabling the realization of different types of Weyl semimetals.

关键词： Dirac semimetals Weyl semimetals periodic driving higher-order topology

Adipose-derived stem cells in diabetic foot care:Bridging clinical trials and practical application

在线全文

学校读者我要写书评

暂无评论

World Journal of Diabetes 2024年第6期15卷 1162-1177页

作者： Song-Lu Tseng Lin Kang Zhu-Jun Li Li-Quan Wang zi-ming Li Tian-Hao Li Jie-Yu Xiang Jiu-Zuo Huang Nan-Ze Yu Xiao Long Department of Plastic and Reconstructive Surgery Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Plastic and Reconstructive Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Biomedical Engineering Facility Institute of Clinical MedicinePeking Union Medical College HospitalChinese Academy of Medical Sciences BeijingBeijing 100021China

Diabetic foot ulcers(DFUs)pose a critical medical challenge,significantly impairing the quality of life of ***-derived stem cells(ADSCs)have been identified as a promising therapeutic approach for improving wound healing in *** extensive exploration of the mechanical aspects of ADSC therapy against DFU,its clinical applications remain *** this review,we aimed to bridge this gap by evaluating the use and advancements of ADSCs in the clinical management of *** review begins with a discussion of the classification and clinical management of diabetic foot *** then discusses the current landscape of clinical trials,focusing on their geographic distribution,reported efficacy,safety profiles,treatment timing,administration techniques,and dosing ***,the review discusses the preclinical strategies to enhance ADSC *** review shows that many trials exhibit biases in study design,unclear inclusion criteria,and intervention *** conclusion,this review underscores the potential of ADSCs in DFU treatment and emphasizes the critical need for further research and refinement of therapeutic approaches,with a focus on improving the quality of future clinical trials to enhance treatment outcomes and advance the field of diabetic wound care.

关键词： Adipose-derived stem cells Diabetic foot ulcers Wound healing Clinical

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

增质提量:城镇化推进与迁移人口人力资本

山西财经大学学报 2024年第2期46卷 1-15页

作者：吕洋高子茗南开大学经济学院天津300071

针对现阶段中国人口流动过程中出现的由迁移规模快速增长向素质结构调整转变这一现象,从城镇化推进角度作出解释。首先构建理论模型,阐述城市扩张通过影响迁移摩擦和就业市场技能溢价从而影响迁移人口人力资本投资的作用机制,之后从城... 详细信息

针对现阶段中国人口流动过程中出现的由迁移规模快速增长向素质结构调整转变这一现象,从城镇化推进角度作出解释。首先构建理论模型,阐述城市扩张通过影响迁移摩擦和就业市场技能溢价从而影响迁移人口人力资本投资的作用机制,之后从城乡接合部土地出让视角刻画区县层面的城镇化水平,并匹配CHIP数据展开实证分析。结果显示,随着各地城乡接合部土地出让总量的提高,迁移人口的人力资本水平呈现“U型”变化,迁移摩擦消减和技能溢价先减后增为其主要驱动。研究结论可为进一步理解中国城市迁移人口的现有演变特征以及研判未来变化趋势提供一定帮助。

关键词：迁移人口城镇化推进人力资本迁移摩擦技能溢价

基于非零漂移过程的非参数跳跃检验方法及有效性研究

在线全文

学校读者我要写书评

暂无评论

数学的实践与认识 2024年第6期54卷 52-68页

作者：王子明范小明西南交通大学数学学院四川成都611756

跳跃的出现会对金融市场造成巨大的影响,传统的BN-S跳跃检验方法假定跳跃-扩散模型中的漂移为零.然而,金融市场短期内的资产泡沫化现象会导致非零漂移的出现.针对非零漂移情形下的跳跃检验问题提出了一种解决方法.首先,使用日内对数收... 详细信息

跳跃的出现会对金融市场造成巨大的影响,传统的BN-S跳跃检验方法假定跳跃-扩散模型中的漂移为零.然而,金融市场短期内的资产泡沫化现象会导致非零漂移的出现.针对非零漂移情形下的跳跃检验问题提出了一种解决方法.首先,使用日内对数收益减去日内均值(或中位数)来消除非零漂移项;随后,重构检验统计量并说明其在极限理论下的渐近一致性;最后,进行模拟以表明方法的可行性及新检验统计量的有效性,并比较使用均值或中位数消除非零漂移的效果差异.将其应用到上证指数进行实证,再与已有考虑带有非零漂移的LM方法进行比较,结果表明该方法能够较好地检验有限样本下带有非零漂移的跳跃,在不考虑隔夜收益时依然有效.

关键词：漂移-扩散过程非零漂移有限样本理论 BN-S方法跳跃