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Nurses'experiences in voluntary error reporting:An integrative literature review

International Journal of Nursing Sciences 2021年第4期8卷 453-469,I0007页

作者： ming wei jeffrey woo Mark James Avery School of Health&Social Sciences Nanyang PolytechnicSingapore Department of Health Services Management School of MedicineGriffith UniversityBrisbaneAustralia

Objective:This integrative review aimed to examine and understand nurses’experiences of voluntary error reporting(VER)and elucidate factors underlying their decision to engage in ***:This is an integrative review based on Whittemore&Knafl five-stage framework.A systematic search guided by the PRISMA 2020 approach was performed on four electronic databases:CINAHL,Medline(PubMed),Scopus,and ***-reviewed articles published in the English language from January 2010 to December 2020 were retrieved and screened for ***:Totally 31 papers were included in this review following the quality appraisal.A constant comparative approach was used to synthesize findings of eligible studies to report nurses'experiences of VER represented by three major themes:nurses'beliefs,behavior,and sentiments towards VER;nurses'perceived enabling factors of VER and nurses'perceived inhibiting factors of *** of this review revealed that nurses’experiences of VER were less than ***,these negative experiences were accounted for by the interplays of factors that influenced their attitudes,perceptions,emotions,and ***,their negative experiences were underpinned by a spectrum of system,administrative and organizational factors that focuses on attributing the error to human failure characterized by an unsupportive,blaming,and punitive approach to error ***:Findings of this review add to the body of knowledge to inform on the areas of focus to guide nursing management perspectives to strengthen institutional efforts to improve nurses'recognition,reception,and contribution towards *** is recommended that nursing leaders prioritize and invest in strategies to enhance existing institutional error management approaches to establish a just and open patient safety culture that would promote positivity in nurses’overall experiences towards VER.

关键词： Experience Medical errors Nurses Voluntary error reporting Patient safety

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The experience of transition from nursing students to newly graduated registered nurses in Singapore

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International Journal of Nursing Sciences 2020年第1期7卷 81-90页

作者： ming wei jeffrey woo Stuart Andrew Newman School of Health&Social Sciences Nanyang PolytechnicSingapore Susan Wakil School of Nursing and Midwifery The University of SydneyNew South WalesAustralia

Objectives:To investigate the experience of newly graduated registered nurses(NGRNs)in Singapore following their initial 6-12 months of transition from nursing student to registered ***:This mixed-methods study consisted of two *** the first phase,data were collected via the administration of the online survey to 30 *** questionnaire contained 42 items of the fourpoint Likert scale *** the second phase,a focus group interview was conducted with 5 NGRNs to gather complementary information regarding the major findings from the first ***:The survey revealed despite most NGRNs(80%)in this study expressed overall satisfied with their transition,the item score was(2.97±0.61)out of 4,the majority(83.3%)also perceived their transition to professional practice being stressful,the item score was(3.07±0.74)out of *** themes emerged from the interview,'personal transition experience','professional transition experience',and'organizational transition experience',which are entwined to construct overall NGRNs'transition ***:This study reaffirms the theory-practice gap *** signifies the need for closer collaboration between educational,healthcare industry and regulatory stakeholders to examine and address factors that influence their transition experience to better support them for workforce readiness.

关键词： Hospital nursing staff Nursing students Role Singapore

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护士关于主动报告差错体验的整合性综述（英文）

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International Journal of Nursing Sciences 2021年第4期 453-469页

作者： ming wei jeffrey woo Mark James Avery School of Health & Social Sciences Nanyang Polytechnic Department of Health Services Management School of MedicineGriffith University

目的旨在调查和了解护士主动报告差错(voluntary error reporting,VER)的体验,并阐明其决定参与VER的因素。方法按照Whittemore与Knafl的整合性综述方法,对CINAHL,Medline(PubMed),Scopus和Embase 4个数据库进行检索。检索文献发表时... 详细信息

目的旨在调查和了解护士主动报告差错(voluntary error reporting,VER)的体验,并阐明其决定参与VER的因素。方法按照Whittemore与Knafl的整合性综述方法,对CINAHL,Medline(PubMed),Scopus和Embase 4个数据库进行检索。检索文献发表时间限定为2010年1月至2020年12月,仅纳入经过同行评审的英文文献。结果质量评价后最终纳入31篇论文。采用持续比较的方法,综合符合纳入标准的研究结果,总结护理人员的VER体验,包括护士对VER的态度、感知、情绪和实践,护士感知的VER使能因素和护士感知的VER抑制因素3个主题。结果显示,护理人员的VER体验并不理想。这些消极的体验是由影响他们的态度、感知、情绪和实践的因素相互作用而产生;也是由一系列系统、管理和组织因素引起,这些因素侧重于将错误归因于人为失误,并以不支持、指责和惩罚的错误管理方法为特征。结论本综述的结果完善了知识体系,并为重点领域的护理管理观点提供信息,以加强机构的建设,提高护士对VER认可、接受和贡献。建议护理管理者优先考虑并投资于改善现有机构管理方法的策略,以建立更为公正和开放的患者安全文化,这将提高护士对VER的积极性。

关键词：经历医疗差错护士自愿报告差错

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Dimensionality-driven metal to Mott insulator transition in two-dimensional 1T-TaSe2

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National Science Review 2024年第3期11卷 108-118页

作者： Ning Tian Zhe Huang Bo Gyu Jang Shuaifei Guo Ya-Jun Yan Jingjing Gao Yijun Yu Jinwoong Hwang Cenyao Tang Meixiao Wang Xuan Luo Yu Ping Sun Zhongkai Liu Dong-Lai Feng Xianhui Chen Sung-Kwan Mo Minjae Kim Young-woo Son Dawei Shen wei Ruan Yuanbo Zhang State Key Laboratory of Surface Physics New Cornerstone Science Laboratory and Department of PhysicsFudan University Shanghai Qi Zhi Institute Shanghai Research Center for Quantum Sciences Institute for Nanoelectronic Devices and Quantum Computing Fudan University Zhangjiang Fudan International Innovation Center Fudan University State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information Technology(SIMIT)Chinese Academy of Sciences School of Physical Science and Technology ShanghaiTech University Korea Institute for Advanced Study School of Emerging Technology and Department of Physics University of Science and Technology of China Advanced Light Source Lawrence Berkeley National Laboratory ShanghaiTech Laboratory for Topological Physics Key Laboratory of Materials Physics Institute of Solid State Physics Hefei Institutes of Physical ScienceChinese Academy of Sciences High Magnetic Field Laboratory Hefei Institutes of Physical Science Chinese Academy of Sciences Collaborative Innovation Centre of Advanced Microstructures Nanjing University Department of Physics University of Science and Technology of China and Key Laboratory of Strongly Coupled Quantum Matter Physics Chinese Academy of Sciences National Synchrotron Radiation Laboratory University of Science and Technology of China

Two-dimensional materials represent a major frontier for research into exotic many-body quantum phenomena. In the extreme two-dimensional limit, electron-electron interaction often dominates over other electronic energy scales, leading to strongly correlated effects such as quantum spin liquid and unconventional *** dominance is conventionally attributed to the lack of electron screening in the third dimension. Here, we discover an intriguing metal to Mott insulator transition in 1T-TaSe2that defies conventional wisdom. Specifically, we find that dimensionality crossover, instead of reduced screening, drives the transition in atomically thin 1T-TaSe2. A dispersive band crossing the Fermi level is found to be responsible for the bulk metallicity in the material. Reducing the dimensionality,however, effectively quenches the kinetic energy of these initially itinerant electrons, and drives the material into a Mott insulating *** dimensionality-driven metal to Mott insulator transition resolves the long-standing dichotomy between metallic bulk and insulating surface of 1T-TaSe2. Our work further reveals a new pathway for modulating two-dimensional materials that enables exploring strongly correlated systems across uncharted parameter space.

关键词： two-dimensional materials 1T-TaSe2 dimensionality crossover metal to Mott insulator transition

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Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk

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Genes & Diseases 2024年第1期11卷 103-134页

作者： Kevin Qin Michael Yu Jiaming Fan Hongwei Wang Piao Zhao Guozhi Zhaoo wei Zeng Connie Chen Yonghui Wang Annie Wang Zander Schwartz jeffrey Hong Lily Song William Wagstaff Rex C.Haydon Hue H.Luu Sherwin H.Ho Jason Strelzow Russell R.Reid Tong-Chuan He Lewis L.Shi Chicago Medical School Rosalind Franklin University of Medicine and ScienceNorth ChicagoIL 60064USA Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key Laboratory of Diagnostic Medicine and Department of Clinical BiochemistryThe School of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Departments of Orthopaedic Surgery and Urology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Interventional Neurology The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523475China Department of Clinical Laboratory Medicine Shanghai Jiaotong University School of MedicineShanghai 200000China School of Biomedical Engineering Vanderbilt UniversityNashvilleTN 37235USA Laboratory of Craniofacial Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA

Wnt signaling plays a major role in regulating cell proliferation and *** Wnt ligands are a family of 19 secreted glycoproteins that mediate their signaling effects via binding to Frizzled receptors and LRP5/6 coreceptors and transducing the signal either throughβ-catenin in the canonical pathway or through a series of other proteins in the nonca-nonical *** of the individual components of both canonical and noncanonical Wnt signaling have additional functions throughout the body,establishing the complex interplay between Wnt signaling and other signaling *** crosstalk between Wnt signaling and other pathways gives Wnt signaling a vital role in many cellular and organ ***-regulation of this system has been implicated in many diseases affecting a wide array of organ systems,including cancer and embryological defects,and can even cause embryonic *** complexity of this system and its interacting proteins have made Wnt signaling a target for many therapeutic ***,both stimulatory and inhibitory treatments come with potential risks that need to be *** review synthesized much of the current knowl-edge on the Wnt signaling pathway,beginning with the history of Wnt *** thoroughly described the different variants of Wnt signaling,including canonical,noncanonical Wnt/PCP,and the noncanonical Wnt/Ca2+*** description involved each of its components and their involvement in other cellular ***,this review explained the various other pathways and processes that crosstalk with Wnt signaling.

关键词： β-catenin Canonical Wnt Noncanonical Wnt Signal transduction Signaling crosstalk

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Identification of novel small-molecule inhibitors of SARS-CoV-2 by chemical genetics

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4028-4044页

作者： Chris Chun-Yiu Chan Qian Guo Jasper Fuk-woo Chan Kaiming Tang Jian-Piao Cai Kenn Ka-Heng Chik Yixin Huang Mei Dai Bo Qin Chon Phin Ong Allen Wing-Ho Chu Wan-Mui Chan Jonathan Daniel Ip Lei Wen Jessica Oi-Ling Tsang Tong-Yun Wang Yubin Xie Zhenzhi Qin Jianli Cao Zi-wei Ye Hin Chu Kelvin Kai-Wang To Xing-Yi Ge Tao Ni Dong-Yan Jin Sheng Cui Kwok-Yung Yuen Shuofeng Yuan State Key Laboratory of Emerging Infectious Diseases Carol Yu Centre for InfectionDepartment of MicrobiologySchool of Clinical MedicineLi Ka Shing Faculty of Medicinethe University of Hong KongPokfulamHong Kong SAR 999077China Department of Infectious Diseases and Microbiology the University of Hong Kong-Shenzhen HospitalShenzhen 518000China Centre for Virology Vaccinology and TherapeuticsHong Kong Science and Technology ParkHong Kong SAR 999077China Academician Workstation of Hainan Province Hainan Medical University-the University of Hong Kong Joint Laboratory of Tropical Infectious DiseasesHaikou 571100China School of Biomedical Sciences Li Ka Shing Faculty of Medicinethe University of Hong KongPokfulamHong Kong SAR 999077China NHC Key Laboratory of Systems Biology of Pathogens Institute of Pathogen Biology Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China College of Biology Hunan Provincial Key Laboratory of Medical VirologyHunan UniversityChangsha 410082China

There are only eight approved small molecule antiviral drugs for treating *** them,four are nucleotide analogues(remdesivir,JT001,molnupiravir,and azvudine),while the other four are protease inhibitors(nirmatrelvir,ensitrelvir,leritrelvir,and simnotrelvir-ritonavir).Antiviral resistance,unfavourable drug‒drug interaction,and toxicity have been reported in previous *** there is a dearth of new treatment options for *** this work,a three-tier cell-based screening was employed to identify novel compounds with anti-SARS-CoV-2 *** compound,designated 172,demonstrated broad-spectrum antiviral activity against multiple human pathogenic coronaviruses and different SARS-CoV-2 variants of *** studies validated by reverse genetics showed that compound 172 inhibits the 3-chymotrypsin-like protease(3CLpro)by binding to an allosteric site and reduces 3CLpro dimerization.A drug synergistic checkerboard assay demonstrated that compound 172 can achieve drug synergy with nirmatrelvir in *** vivo studies confirmed the antiviral activity of compound 172 in both Golden Syrian Hamsters and K18 humanized ACE2 ***,this study identified an alternative druggable site on the SARS-CoV-23CLpro,proposed a potential combination therapy with nirmatrelvir to reduce the risk of antiviral resistance and shed light on the development of allosteric protease inhibitors for treating a range of coronavirus diseases.

关键词： SARS-CoV-2 High throughput screening Broad-spectrum antiviral treatment 3CLpro inhibitor Allosteric-site inhibitor Animal models Chemical genetics Reverse genetics

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The energy-environment nexus:aerosol science and technology enabling solutions

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Frontiers of Environmental Science & Engineering 2011年第3期5卷 299-312页

作者： Pratim BISWAS wei-Ning WANG woo-Jin AN Aerosol and Air Quality Research Laboratory Department of EnergyEnvironmental and Chemical EngineeringWashington University in St.LouisSt.LouisMO 63130USA

Energy issues are important and consumption is slated to increase across the globe in the *** energy-environment nexus is very important as strategies to meet future energy demand are *** ensure sustainable growth and development,it is essential that energy production is environmentally *** are two temporal issues—one that is immediate,and needs to address the environmental compliance of energy generation from fossil fuel sources;and second that is the need to develop newer alternate and more sustainable approaches in the *** science and technology is an enabling discipline that addresses the energy issue over both these time *** paper is a review of aspects of aerosol science and engineering that helps address carbon neutrality of fossil *** materials to meet these challenges are *** approaches to effective harvesting of sunlight that are enabled by aerosol studies are discussed.

关键词： energy-environment nexus aerosol science and technology fossil fuels carbon dioxide conversion solar energy nanoparticle technology

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Regenerative potential of targeting glycogen synthase kinase-3 signaling in neural tissues

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Neural Regeneration Research 2015年第12期10卷 1912-1913页

作者： Eui-Man Jung jeffrey J.Moffat woo-Yang Kim Department of Developmental Neuroscience Munroe-Meyer InstituteUniversity of Nebraska Medical Center

Multiple roles of glycogen synthase kinase-3（GSK-3）in neural tissues：GSK-3 is a serine/threonine kinase that has two isoforms encoded by two different genes,GSK-3αand GSK-3β,in ***-3 has several sites of serine a... 详细信息

关键词： GSK Regenerative potential of targeting glycogen synthase kinase-3 signaling in neural tissues

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In situ DRIFTS study of photocatalytic CO_(2) reduction under UV irradiation

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Frontiers of Chemical Science and Engineering 2010年第2期4卷 120-126页

作者： jeffrey C.S.WU Chao-wei HUANG Department of Chemical Engineering Taiwan UniversityTaipei 10617China

Photocatalytic reduction of CO_(2) on TiO_(2) and Cu/TiO_(2) photocatalysts was studied by in situ diffuse reflectance infrared Fourier transform spectroscopy(DRIFTS)under UV *** photocatalysts were prepared by sol-gel method via controlled hydrolysis of titanium(IV)*** precursor was loaded onto TiO_(2) during sol-gel procedure.A large amount of adsorbed H_(2)O and surface OH groups was detected at 25℃on the TiO_(2) photocatalyst after being treated at 500℃under air *** and bicarbonate were formed rapidly due to the reaction of CO_(2) with oxygen-vacancy and OH groups,respectively,on TiO_(2) surface upon CO_(2)*** IR spectra indicated that,under UV irradiation,gas-phase CO_(2) further combined with oxygen-vacancy and OH groups to produce more carbonate or *** weak signals of reaction intermediates were found on the IR spectra,which were due to the slow photocatalytic CO_(2) reduction on *** electrons merge with H^(+)ions to form H atoms,which progressively reduce CO_(2) to form formic acid,dioxymethylene,formaldehyde and methoxy as observed in the IR *** well-dispersed Cu,acting as the active site significantly increases the amount of formaldehyde and dioxymethylene,thus promotes the photoactivity of CO_(2) reduction on Cu/TiO_(2).A possible mechanism of the photocatalytic CO_(2) reduction is proposed based on these intermediates and products on the photocatalysts.

关键词： photocatalysis CO_(2) titania in situ infrared spectroscopy Cu/TiO_(2)

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High-efficiency organic solar cells enabled by an alcohol-washable solid additive

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Science China Chemistry 2021年第12期64卷 2161-2168页

作者： Yuanpeng Xie Hwa Sook Ryu Lili Han Yunhao Cai Xiaopeng Duan Donghui wei Han Young woo Yanming Sun School of Chemistry Beihang UniversityBeijing100191China Department of Chemistry College of ScienceKU-KIST Graduate School of Converging Science and TechnologyKorea UniversitySeoul136-713Korea College of Chemistry and Molecular Engineering Zhengzhou UniversityZhengzhou450001China

The solvent additive strategy has been widely utilized to boost the power conversion efficiency(PCE)of organic solar cells(OSCs).However,the residual solvent additive in the active layer tends to induce a gradual morphology degradation and further influences the long-term stability of ***,a solid additive,1,4-diiodobenzene(DIB),was introduced to fabricate efficient *** found that the treatment of DIB can lead to optimized morphology to form a bicontinuous network with intensified intermolecular packing in the donor and acceptor ***,DIB can be easily removed from the active layer via a simple alcohol washing process and no further post-thermal annealing is needed,which is desirable for large-scale manufacturing of *** a result,high efficiencies of 17.47%for PM6:Y6 and 18.13%(certified as 17.7%)for PM6:BTP-eC9 binary OSCs are achieved,which are among the highest efficiencies reported for binary OSCs thus ***,OSCs fabricated with DIB also exhibit superior stability compared with the as-cast and traditional solvent additive processed ***,DIB was successfully applied in different active layers,manifesting its general *** work provides a feasible approach to enhance both the efficiency and stability of OSCs.

关键词： organic solar cells solid additive alcohol washing process efficiency stability

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