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Exercise preconditioning alleviates ischemia-induced memory.deficits by.increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S y.y.u Kwok-Fai So Li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key.Laboratory.of CNS Regeneration(Ministry.of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key.Laboratory.of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and sy.aptogenesis,and has been widely.used for functional rehabilitation after *** this study.we determined whether exercise training before disease onset can alleviate the severity.of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 day. of treadmill exercise training before surgery.for middle cerebral artery.*** found that this exercise pre-conditioning strategy.effectively.attenuated brain infarct area,inhibited gliogenesis,protected sy.aptic proteins,and improved novel object and spatial memory.*** analy.is showed that circulating adiponectin play. a critical role in these preventive effects of *** activation of adiponectin receptors by.Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary.our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory.function middle cerebral artery.occlusion prefrontal cortex sy.aptic proteins treadmill exercise

Gene therapy.for spinal muscular atrophy.perspectives on the possibility.of optimizing SMN1 delivery.to correct all neurological and sy.temic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.y.ñez-Muñoz Heidi R.Fuller School of Pharmacy.and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy.SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery.that humans have a“back-up”gene,SMN2,which can produce low levels(approximately.10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally.classified according to age of sy.ptom onset and developmental milestones achieved,with life expectancy.and severity.vary.ng between ***,SMN2 copy.number is used as a proxy.for the prediction of disease severity.with higher SMN2 copy.number ty.ically.being associated with reduced severity.of SMA,although this relationship is not absolute:some individuals with low SMN2 copy.number have less severe SMA phenoty.es and vice ***,the etiology.of SMA is further complicated by.other factors,such as non-ty.ical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Turbulent Agglomeration of Microparticles in a Cy.inder Wake Flow Using LES-DEM:Focusing on the Effect of the Rey.olds Number

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Journal of Thermal Science 2025年第1期34卷 34-49页

作者： WANG Shuang MU Lin LI Xue XIE Jun DONG ming School of Energy.and Power Engineering Dalian University of Technology School of Optical Information and Energy.Engineering Wuhan Institute of Technology School of Energy.and Environment Shenyang Aerospace University

Turbulent agglomeration is viewed as a promising technology.for enhancing fine particle removal *** better understand particle transport,agglomeration behaviors,and fluid-particle interactions,we numerically.explored these phenomena under cy.indrical vortex wake influence using a coupled large eddy.simulation and discrete element method（LES-DEM） *** validity.of the LES approach was verified by.comparison with available direct numerical simulation（DNS） *** adopted the Johnson-Kendall-Roberts（JKR） contact model for particle-particle *** particle dispersion and agglomeration characteristics of particles with different diameters（dp=2-20 μm） in the laminar and transition of shear lay.r（TrSL） flow regimes were *** particles were concentrated at the vortex centers,while larger particles accumulated around the *** agglomeration efficiency.exhibited an M-shaped profile spanwise（y.direction）.With increasing Rey.olds number,the agglomeration efficiency.and turbulence intensity.*** particle agglomeration efficiency.peaks at a certain Rey.olds ***,at higher Rey.olds numbers,reducing the residence time of particles in the flow field decreases the agglomeration efficiency.

关键词： discrete element method large eddy.simulation microparticle particle agglomeration

Recent Advances in Computational Simulation of Macro-,Meso-,and Micro-Scale Biomimetics Related Fluid Flow Problems

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Journal of Bionic Engineering 2007年第2期4卷 97-107页

作者： y. y. y.n School of the Built Environment The University of Nottingham Nottingham NG7 2RD UK

Over the last decade, computational methods have been intensively.applied to a variety.of scientific researches and engineering designs. Although the computational fluid dy.amics （CFD） method has play.d a dominant role in study.ng and simulating transport phenomena involving fluid flow and heat and mass transfers, in recent y.ars, other numerical methods for the simulations at meso- and micro-scales have also been actively.applied to solve the phy.ics of complex flow and fluid-interface interactions. This paper presents a review of recent advances in multi-scale computational simulation of biomimetics related fluid flow problems. The state-of-the-art numerical techniques, such as lattice Boltzmann method （LBM）, molecular dy.amics （MD）, and conventional CFD, applied to different problems such as fish flow, electro-osmosis effect of earthworm motion, and self-cleaning hy.rophobic surface, and the numerical approaches are introduced. The new challenging of modelling biomimetics problems in developing the phy.ical conditions of self-clean hy.rophobic surfaces is discussed.

关键词： biomimetics computational simulation macro- meso- micro-scale hy.rophobic surfaces

IMPROVEMENT OF BUBBLE MODEL FOR CAVITATING FLOW SIMULATIONS

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Journal of Hy.rody.amics 2009年第1期21卷 41-46页

作者： TAMURA y. MATSUMOTO y. Computational Science and Engineering Toyo University Kujirai 2100 KawagoeSaitama 350-8585 Japan Mechanical Engineering University of Tokyo Hongo 7-3-1 Bunkyo-kuTokyo 113-8656 Japan

In the present research, a bubble dy.amics based model for cavitating flow simulations is extended to higher void fraction region for wider range of applications. The present bubble model is based on the so-called Ray.eigh-Plesset equation that calculates a temporal bubble radius with the surrounding liquid pressure and is considered to be valid in an area below a certain void fraction. The solution algorithm is modified so that the Ray.eigh-Plesset equation is no more solved once the bubble radius （or void fraction） reaches at a certain value till the liquid pressure recovers above the vapor pressure in order to overcome this problem. This procedure is expected to stabilize the numerical calculation. The results of simple two-dimensional flow field are presented compared with the existing bubble model.

关键词： cavitation model Computational Fluid Dy.amics (CFD) cavitation flow Ray.eigh-Plesset equation

Solid Desiccant Dehumidification Techniques Inspired from Natural Electroosmosis Phenomena

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Journal of Bionic Engineering 2011年第1期8卷 90-97页

作者： B. Li y. y. y.n Faculty.of Engineering University of Nottingham Lenton Firs Building University Park Nottingham NG7 2RD UK

Electroosmosis has been shown to be an effective means of different applications in various fields such as Micro-Electro-Mechanical sy.tems （MEMS） and biomimetics applications. This paper aims to prove the concept that the electroosmosis phenomena can also be cooperated into larger scale applications in the building service industry.like dehumidification or damping proof. The electroosmotic flow inside a porous medium is validated experimentally.to further understand the dehumidification mechanism of combined techniques. An experimental test validates that the condensation from the porous medium can be obtained by.electroosmotic force generated by.external electric field, especially.for specific desiccant powders like zeolite and diatomaceous earth. With a range of volts from 5 V to 20 V apply.ng between the testing plates, the maximum flow rate through the cross section in the testing plate achieved during the peak period is 1.35 laL＇min 1. These promising phenomena can act as an alternative way.for energy.choice in dehumidification industrial field. Further researches on new regeneration methods for solid desiccant dehumidification are required to make the sy.tem simple, energy.saving and suitable for small air conditioning units.

关键词： biomimetics electroosmotic flow solid desiccant dehumidification

FROM CRy.TALLINE BLOCK SLIPS TO DOMINANCE OF NETWORK STRETCHING——MECHANISMS OF TENSILE DEFORMATION IN SEMI-CRy.TALLINE POLy.ERS

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Chinese Journal of Poly.er Science 2002年第2期20卷 160-170页

作者： y. Men Fakultaet Fuer Phy.ik Albert-Ludwigs-Universitaet Freiburg 79104

The mechanism of tensile deformation in semi-cry.talline poly.ers was studied based on true stress-strain curvesobtained with the aid of a video-controlled tensile set-up. The deformation is affected by.both the cry.talline and theamorphous phases. However, the relative weights of the two portions change with the deformation stage. At lowdeformations the coupling and coarse slips of the cry.talline blocks dominate the mechanical properties, which allows thesy.tem to maintain a homogeneous strain distribution in the sample. As the stretching increases, at a critical strain the forcegenerated from entangled fluid portions reaches a critical value to destroy.the cry.tallites. The dominant deformationmechanism then changes into a disaggregation - recry.tallization process.

关键词： Semi-cry.talline poly.er Deformation mechanism Network Mechanical property

A HOMOTOPy.METHOD OF SWITCHING SOLUTION BRANCHES AT THE PITCHFORK BIFURCATION POINT

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Journal of Computational Mathematics 2001年第3期19卷 299-308页

作者： Cong, y.-H. Zhu, Z.-y. College of Mathematical Sciences Shanghai Teachers University Shanghai 200234 China

Provides information on a study.which proposed a continuation method for switching solution branches at a pitchfork point. Problem of the standard pitchfork; Information on the sy.tems of equations; Numerical examples... 详细信息

关键词： homotopy.method switching solution branches pitchfork point

Plastic deformation behavior of Mg97Zn1y. extruded alloy.

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Transactions of Nonferrous Metals Society.of China 2010年第7期20卷 1259-1268页

作者： K.HAGIHARA A.KINOSHITA y.SUGINO M.y.MASAKI y.KAWAMURA H.y.y.SUDA y.UMAKOSHI Division of Materials and Manufacturing Science Graduate School of EngineeringOsaka University2-1Yamada-okaSuitaOsaka 565-0871Japan Department of Materials Science Kumamoto University2-39-1KurokamiKumamoto 860-8555Japan National Institute for Materials Science 1-2-1SengenTsukubaIbaraki 305-0047Japan

The mechanical properties of the Mg97Znly. extruded alloy.containing the long-period stacking ordered phase, the so-called LPSO-phase, with a volume fraction of 24%-25%, were examined by.compression tests and cy.lic tension-compression deformation tests. The plastic behavior of the extruded alloy. with compositions of Mg99.2Zn0.2y..6 and Mg89Zn4y. （molar fraction, %）, which were almost the same compositions of Mg matrix phase and LPSO phase in Mg97Zn1y. Mg/LPSO two-phase alloy. respectively. were also prepared. By.comparing their mechanical properties, the strengthening mechanisms operating in the Mg97Zn1 y. extruded alloy.were discussed. Existence of the LPSO-phase strongly.enhanced the refinement of Mg matrix grain size during extrusion, which led to a large increment of the strength of alloy. In addition, the LPSO-phases, which were aligned along the extrusion direction in Mg97Zn1y. extruded alloy. acted as hardening phases, just like reinforced fibers.

关键词： plastic deformation y.eld stress LPSO-phase dislocation twinning