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Evaluation of proximal tubule functions in children with COVId‑19:a prospective analytical study

World Journal of Pediatrics 2022年第9期18卷 607-612页

作者： Fatma devrim Elif Böncüoğlu Elif Kıymet ŞahikaŞahinkaya Ela Cem mine düzgöl Aybüke Akaslan Kara KamileÖtiken Arıkan AslıKantar Ebru Yılmaz Nida dinçel Nuri Bayram İlker devrim department of Pediatric Nephrology University of Health Sciences Dr.Behçet Uz Child Disease and Pediatric Surgery Training and Research HospitalİzmirTurkey department of Pediatric Infectious diseases University of Health Sciences Dr.Behçet Uz Child Disease and Pediatric Surgery Training and Research HospitalİzmirTurkey

Background There are limited numbers of studies focusing on renal efects of coronavirus disease 2019(COVId-19)infection and proximal tubular dysfunction in children with COVId-19 *** purpose of this study was to evaluate the functions of the proximal tubule in hospitalized children with confrmed acute *** The children who were hospitalized for confrmed COVId-19 were included in this prospective descriptive *** presence of at least two of the following four abnormalities was used to diagnose proximal tubule injury:abnormal tubular reabsorption of phosphate,normoglycemic glycosuria,hyperuricosuria,and *** A total of 115 patients were included in the *** a third of the individuals had elevated blood creatinine levels or *** addition,abnormal renal tubular phosphate loss measured by renal tubular phosphate loss was found in 10(8.7%)patients,as was hyperuricosuria in 28.6%.As a result,total proximal tubular dysfunction was found in 24(20.9%)*** One in every fve children with acute COVId-19 infections had proximal tubular dysfunction,according to our ***,the rate of proximal tubular dysfunction was lower than in adults,it should be *** recovery of proximal tubular function in children with COVId-19 should be followed.

关键词： Coronavirus disease 2019(COVId-19) Proteinuria Proximal tubular dysfunction Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Tubular reabsorption of phosphate

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Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic lydia Jiménez-díaz Juan d.Navarro-lópez NeuroPhysiology&Behavior lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

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Effects of different growing media on the cut flower performances of oriental two lilium varieties

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International Journal of Agricultural and Biological Engineering 2020年第5期13卷 85-92页

作者： Özgül Karagüzel Bati Akdeniz Agricultural Research Institute Vegetables and Ornamental Plants DepartmentMinistry of Agriculture and ForestryAntalya 07100Turkey

In this study,six different growing media(peat+pumice:1:1,v/v;peat+perlite:1:1,v/v;rice hull+pumice:1:2,v/v;coarse sand+peat:2:1,v/v;soil;and cocopeat)were evaluated for their effects on the plant growth and flower quality of the oriental‘Siberia’and‘Vespucci’lily *** hundred and twenty bulbs were planted in perforated plastic crates and placed in an unheated *** physical and chemical properties of the growing media were *** number of days to flowering,plant height,the number of flowers,fresh stem weight,the number of leaves and vase life were investigated in the *** results indicated that the use of soilless growing media significantly affected plant growth and flower quality when compared with *** obtained values varied by substrate *** earliest flowering time(154.78 d)and the longest plant height(120.82 cm in the‘Siberia’variety)were determined in peat+pumice,whereas the largest number of flowers(7 flowers in Siberia;5.67 flowers in Vespucci)and the highest stem weight(266.13 g in Vespucci;353.91 g in Siberia)were recorded in *** vase life of the plants grown in soil was longer than that of the plants grown in the soilless *** the number of leaves,rice hull+pumice(57.42 leaves)and sand+peat(54.46 leaves)gave the best results.

关键词： lilium varieties growing media plant growth flower quality

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In vitro antitumor activity of titanocene alanine complex and its interaction with nucleic acids

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Chinese Journal of Chemistry 1997年第3期15卷 225-233页

作者： Zhang, zg Jin, l Yang, P SHANXI UNIV INST MOL SCITAIYUAN 030006SHANXIPEOPLES R CHINA

Titanocene alanine complex, Cp2Ti(O2CCH(CH3)NH3+Cl-)(2), has been found to have in vitro antitumor activity against Ehrlich ascites tumor cells. Study of the interaction between Cp2Ti(O2CCH(CH3)NH3+Cl-)(2) and dNA by UV-VIS spectra, fluorescence spectra, agarose gel electrophoresis reveals that Cp2Ti(O2CCH(CH3)NH3+Cl-)(2) forms a stable compound with dNA in molar ratio 1:1 and reduces the migration rate of ccc-dNA band and oc-dNA band. However, unlike cisplatin, the complex does not induce nicking of dNA even after a long incubation at a high ratio of the complex to dNA. The results suggest that titanocene-based antitumor agents have different mechanism of action from cisplatin-like antitumor agents.

关键词： titanocene alanine complex dNA antitumor

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Positron Annihilation Study of the Quenched-in Vacancies in CuZnAl Alloys

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Journal of Materials Science & Technology 1995年第6期11卷 409-414页

作者： WEI, zg YANG, dZ dalian Univ of Technology Dalian China

The excess vacancies in ternary CuZnAl and Ti-doped CuZnAl alloys quenched from temperatures between 673 K and 1223 K, and the behaviour of the quenched-in vacancies on postquench aging in martensite phase have been studied by doppler broadening measurements. It has been found that adding Ti to the alloys results in the formation of vacancy-Ti solute atom complexes which lowers the mobility of the vacancies. In the Ti-free alloy, the prominent changes in the lineshape S-parameter during the early stage of martensite aging have evidenced the occurrence of vacancy migration to sinks, clustering or vacancy. related atomic distortion. The role of the vacancies in martensite stabilization has been discussed.

关键词： Intermetallics

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Approximation by Sz´asz Type Operators Involving Apostol-Genocchi Polynomials

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Computer Modeling in Engineering & Sciences 2022年第1期130卷 287-297页

作者： mine Menekse Yılmaz department of Mathematics Faculty of Arts and ScienceUniversity of GaziantepGaziantepTR-27310Turkey

The goal of this paper is to give a form of the operator involving the generating function of Apostol-Genocchi polynomials of orderα.Applying the Korovkin theorem,we arrive at the convergence of the operator with the aid of moments and central *** determine the rate of convergence of the operator using several tools such as K-functional,modulus of continuity,second modulus of *** also give a type of Voronovskaya theorem for estimating ***,we investigate some results about convergence properties of the operator in a weighted ***,we give numerical examples to support our theorems by using the Maple.

关键词： Apostol-Genocchi polynomials rate of convergence Korovkin theorem modulus of continuity Sz´asz type operators generating functions

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Next-generation research on transcriptional regulation of plant immunity

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Molecular Plant 2024年第11期17卷 1651-1653页

作者： Akira mine laboratory of Plant Pathology Graduate School of AgricultureKyoto UniversityKyoto 606-8502Japan

Plant health is fundamental for agricultural production to feed the growing global population as well as for primary production to sustain ecosystem *** innate immune system of plants is integral to their health;it is activated upon recognition of pathogen invasion by immune receptors,leading to pathogen resistance through genome-wide transcriptional *** defense-associated transcriptome reprogramming is mediated by various immune signals,including the phytohormone salicylic acid(SA).SA plays a pivotal role in activating pathogen resistance both locally in infected tissues and systemically in uninfected *** Arabidopsis thaliana,SA is perceived by its receptors NONEXPRESSOR OF PATHOGENESIS-RElATEd GENES 1(NPR1),NPR3,and *** NPR3 and NPR4 function as negative regulators of SA signaling,NPR1 serves as a key positive regulator of SA-mediated transcriptomic changes and pathogen resistance(ding et al.,2018).Consistent with its lack of a dNA-binding domain,NPR1 has been shown to act as a transcription cofactor for multiple transcription factors(TFs)such as TGAs and WRKYs(Wang et al.,2006;Kumar et al.,2022).Besides TFs,other components of the transcriptional machinery are likely to participate in NPR1-regulated transcriptional responses,as NPR1 forms nuclear condensates upon SA induction(Zavaliev et al.,2020).despite decades of research on NPR1’s functions in plant immunity,a comprehensive understanding of how NPR1 cooperates with multiple TFs and other components of the transcriptional machinery to initiate and propagate transcriptional responses to SA is still lacking.

关键词： transcriptional plant immunity

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Influence of recycled polyethylene terephthalate fibres on plastic shrinkage and mechanical properties of concrete

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Frontiers of Structural and Civil Engineering 2022年第6期16卷 792-802页

作者： NecatÖZAŞIK Özgür EREN department of Civil Engineering Eastern Mediterranean UniversityMersin 99628Turkey

Polyethylene terephthalate bottles production has drastically increased year after year due to high versatility of polyethylene terephthalate plastics and considerable consumption of *** tandem with that increase,the major concern of society has been the improper disposal of this non-biodegradable material to the *** deal with this concern,recycled polyethylene terephthalate bottles were incorporated in concrete as fibre reinforcements in this *** objective of this research is to evaluate the mechanical properties of recycled polyethylene terephthalate fibre reinforced concrete(RPFRC)in comparison with control concrete without *** terephthalate fibres with three different diameters(0.45,0.65,and 1.0 mm)and two lengths(20 and 30 mm)were added at various proportions(0.5%,1.0%,1.5%and 2.0%)by volume of concrete in order to determine the effect of fibres initially on compressive,flexural and splitting tensile strengths of *** results revealed that none of the fibres have detrimental effects up to 1%volume fraction,however further addition caused slight reductions on mechanical properties in some *** shrinkage resistance and impact resistance tests were also performed according to related *** terephthalate fibres were observed to have marked improvements on those *** a good performance could be attributed primarily to the bridging effect of fibres.

关键词： recycled PET fibre-reinforced concrete mechanical properties plastic shrinkage impact energy

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Principal Congruence Subgroups of Hecke Groups H(q^(1/2))

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Acta Mathematica Sinica,English Series 2006年第2期22卷 383-392页

作者： Nihal YIlMAZ zgüR department of Mathematics Balikesir University

Using the notion of quadratic reciprocity, we discuss the principal congruence subgroups of the Hecke groups H（√q）,q 〉 5 prime number.

关键词： Hecke group Principal congruence subgroup Congruence subgroup

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Polyethylene glycol has immunoprotective effects on sciatic allografts, but behavioral recovery and graft tolerance require neurorrhaphy and axonal fusion

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Neural Regeneration Research 2025年第4期20卷 1192-1206页

作者： Tyler A.Smith liwen Zhou Cameron l.Ghergherehchi Michelle Mikesh Cathy Z.Yang Haley O.Tucker JuliAnne Allgood Jared S.Bushman George d.Bittner department of Molecular Biosciences University of Texas at AustinAustinTXUSA department of Neuroscience University of Texas at AustinAustinTXUSA division of Pharmaceutical Sciences University of WyomingLaramieWYUSA

Behavioral recovery using(viable)peripheral nerve allografts to repair ablation-type(segmental-loss)peripheral nerve injuries is delayed or poor due to slow and inaccurate axonal ***,such peripheral nerve allografts undergo immunological rejection by the host immune *** contrast,peripheral nerve injuries repaired by polyethylene glycol fusion of peripheral nerve allografts exhibit excellent behavioral recovery within weeks,reduced immune responses,and many axons do not undergo Wallerian *** relative contribution of neurorrhaphy and polyethylene glycol-fusion of axons versus the effects of polyethylene glycol per se was unknown prior to this *** hypothesized that polyethylene glycol might have some immune-protective effects,but polyethylene glycol-fusion was necessary to prevent Wallerian degeneration and functional/behavioral *** examined how polyethylene glycol solutions per se affect functional and behavioral recovery and peripheral nerve allograft morphological and immunological responses in the absence of polyethylene glycol-induced axonal ***-type sciatic nerve injuries in outbred Sprague–dawley rats were repaired according to a modified protocol using the same solutions as polyethylene glycol-fused peripheral nerve allografts,but peripheral nerve allografts were loose-sutured(loose-sutured polyethylene glycol)with an intentional gap of 1–2 mm to prevent fusion by polyethylene glycol of peripheral nerve allograft axons with host *** to negative control peripheral nerve allografts not treated by polyethylene glycol and in contrast to polyethylene glycol-fused peripheral nerve allografts,animals with loose-sutured polyethylene glycol peripheral nerve allografts exhibited Wallerian degeneration for all axons and myelin degeneration by 7 days postoperatively and did not recover sciatic-mediated behavioral functions by 42 days *** morphological signs of rejection,such as col

关键词： allograft rejection axotomy macrophage myelin nerve repair polyethylene glycol(PEG) sciatic nerve T cell transplantation Wallerian degeneration

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