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hepatobiliary Surgery and Nutrition 2022年第2期11卷 333-334页

作者： Qing Ye Takanori Ito Linda henry mindie h.nguyen Department of hepatology of The Third Central hospital of Tianjin TianjinChina Department of Gastroenterology and hepatology Nagoya University Graduate School of MedicineNagoyaJapan Division of Gastroenterology and hepatology Stanford University Medical CenterPalo AltoCAUSA

We read the article entitled“The presence of NAFLD in nonobese subjects increased the risk of metabolic abnormalities than obese subjects without NAFLD:A population-based cross-sectional study”by hu et al.(1),which was published in the latest issue of hepatobiliary Surgery Nutrition,with great *** the authors described,due to rapid urbanization and sedentary lifestyles,the prevalence of non-alcoholic fatty liver disease(NAFLD)has *** this population-based,cross-sectional health survey study,in which the data were obtained from community health centers,the investigators reported that the prevalence of NAFLD in Shanghai,China grew from 15%in 2005 to 32.7%in 2017(1).To gain a better understanding of the prevalence of metabolic features in relation to NAFLD status,gender,and age,the authors quantified the risks of having different metabolic conditions between the following 4 groups:(I)the non-obese NAFLD group;(II)the non-obese non-NAFLD group;(III)the obese non-NAFLD group;and(IV)the obese NAFLD group(1).

关键词： NAFLD Surgery obese

Trends of Cirrhosis-related Mortality in the USA during the COVID-19 Pandemic

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Journal of Clinical and Translational hepatology 2023年第3期11卷 751-756页

作者： Yee hui Yeo Xinyuan he Fan Lv Yunyu Zhao Yi Liu Ju Dong Yang Jian Zu Fanpu Ji mindie h.nguyen Division of General Internal Medicine Cedars-Sinai Medical CenterLos AngelesCaliforniaUSA Department of Infectious Diseases the Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxiChina School of Mathematics and Sta-tistics Xi’an Jiaotong UniversityXi’anShaanxiChina Karsh Division of Gastroenterology and hepatology Cedars-Sinai Medical CenterLos AngelesCAUSA National&Local Joint Engineering Research Center of Biodiagnosis and Biotherapy the Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxiChina Division of Gastroenterology and hepa-tology Stanford University Medical CenterPalo AltoCaliforniaUSA Department of Epidemiology and Population health Stanford University Medical CenterPalo AltoCaliforniaUSA

Immunocompromised status and interrupted routine care may render patients with cirrhosis vulnerable to the coronavi-rus disease 2019(COVID-19)pandemic.A nationwide data-set that includes more than 99%of the decedents in the *** April 2012 and September 2021 was *** age-standardized mortality during the pandemic were esti-mated according to prepandemic mortality rates,stratified by *** deaths were determined by estimating the difference between observed and projected mortality rates.A temporal trend analysis of observed mortality rates was also performed in 0.83 million decedents with cirrhosis between April 2012 and September 2021 was *** an increasing trend of cirrhosis-related mortality before the pandemic,with a semiannual percentage change(SAPC)of 0.54%[95%confidence interval(CI):(0.0-1.0%),p=0.036],a precipitous increase with seasonal variation occurred dur-ing the pandemic(SAPC 5.35,95%CI:1.9-8.9,p=0.005).Significantly increased mortality rates were observed in those with alcohol-associated liver disease(ALD),with a SAPC of 8.44(95%CI:4.3-12.8,p=0.001)during the ***-cause mortality of nonalcoholic fatty liver disease rose stead-ily across the entire study period with a SAPC of 6.79(95%CI:6.3-7.3,phe decreasing trend of hCV-related mortality was reversed during the pandemic,while there was no significant change in hBV-related *** there was significant increase in COVID-19-related deaths,more than 55%of the excess deaths were the indirect impact of the *** observed an alarming increase in cirrhosis-related deaths during the pandemic especially for ALD,with evidence in both direct and indirect *** findings have implications on formulating policies for patients with cirrhosis.

关键词： Cirrhosis mortality Alcohol-associated liver disease Epidemiology Nonalcoholic fatty liver disease COVID-19

hepatocellular carcinoma in patients with non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2016年第37期22卷 8294-8303页

作者： Carrie R Wong mindie h nguyen Joseph K Lim Department of Internal Medicine Yale University School of Medicine Division of Gastroenterology and hepatology Stanford University School of Medicine Yale Liver Center Section of Digestive Diseases Yale University School of Medicine

Nonalcoholic fatty liver disease(NAFLD) is the most common chronic liver disease in the United States and represents an increasingly important etiology of hepatocellular carcinoma(hCC) with annual cumulative incidence rates ranging from 2% to 12% in cohorts of NAFLD cirrhosis. While the risk of progression of NAFLD to hCC remains higher among patients with fibrosis or cirrhosis, an increasing amount of literature describes NAFLD-hCC as a disease that can occur in the absence of cirrhosis. Efforts to characterize the pathogenesis of NAFLD-hCC have suggested mechanisms that strongly associate with states of hyperinsulinemia and chronic inflammation, cellular mechanisms including adaptive immune responses and hepatic progenitor cell populations, and genetic polymorphisms including mutations of PNPLA3. Current literature describes NAFLD-hCC mostly as a disease of late presentation with lower rates of receipt of curative therapy and worse prognosis. however, a growing body of evidence has reported comparable and potentially more favorable disease-free and overall survival rates among patients with NAFLD-hCC after receipt of curative treatment. This review summarizes current evidence of epidemiology, pathophysiology, disease presentation, demand and receipt of curative therapy, post-treatment outcomes, and overall survival of NAFLD-associated hCC.

关键词： Fatty liver Nonalcoholic steatohepatitis hepatocellular carcinoma Liver cirrhosis Liver cancer

Characteristics and outcomes of hepatocellular carcinoma patients with macrovascular invasion following surgical resection: a meta-analysis of 40 studies and 8,218 patients

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hepatobiliary Surgery and Nutrition 2022年第6期11卷 848-860,I0001-I0015页

作者： Daniel Q.huang Andrew Tran Eunice XTan Sanjna N.Nerurkar Readon Teh Margaret L.P.Teng Ee Jin Yeo Biyao Zou Connie Wong Carlos O.Esquivel CAndrew Bonham mindie h.nguyen Division of Gastroenterology and hepatology Department of MedicineNational University HospitalSingaporeSingapore Department of Medicine Yong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore Duke University DurhamNCUSA Adelaide Medical School The University of AdelaideAdelaideAustralia Division of Gastroenterology and hepatology Department of MedicineStanford University Medical CenterPalo AltoCAUSA Department of Epidemiology and Population health Stanford University School of MedicineStanfordCAUSA Lane Medical Library Stanford University School of MedicineStanfordCAUSA Division of Abdominal Transplantation Department of SurgeryStanford University School of MedicineStanfordCAUSA

Background:Guidelines recommend that hepatocellular carcinoma(hCC)patients with portal vein tumor thrombosis(PVTT)and/or hepatic vein tumor thrombosis(hVTT)should undergo systemic ***,recent data suggest that surgical resection may be beneficial in selected cases,but outcomes are *** aimed to estimate pooled overall survival(OS),recurrence free survival(RFS)and complication rates in hCC patients with macrovascular invasion(MVI)following surgical ***:In this systematic review and meta-analysis,two investigators independently searched PubMed,Embase,and Cochrane databases from inception to Nov 10,2020,without language restrictions,for studies reporting outcomes of adult hCC patients with MVI who underwent liver resection with curative ***:We screened 8,598 articles and included 40 studies involving 8,218 *** all patients with MVI,the pooled median OS was 14.39 months[95%confidence interval(CI):10.99-18.84],1-year OS was 54.47%(95%CI:46.12-62.58%)and 3-year OS was 23.20%(95%CI:16.61-31.42%).Overall,1-and 3-year RFS were 27.70%(95%CI:21.00-35.57%)and 10.06%(95%CI:6.62-15.01%),*** patients with PVTT,median OS was 20.41 months in those with segmental/2nd order involvement compared to 12.91 months if 1st order branch was involved and 6.41 months if the main trunk was *** pooled rate of major complications was 6.17%(95%CI:3.53-10.56%).Conclusions:Overall median survival was 14.39 months for hCC patients with MVI following *** survival was higher in PVTT with segmental/2nd order involvement at 20.41 versus 6.41 months if the main trunk was involved.

关键词： hepatocellular carcinoma(hCC) resection portal vein macrovascular invasion(MVI) recurrence

Comparison of renal safety of tenofovir and entecavir in patients with chronic hepatitis B: Systematic review with meta-analysis

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World Journal of Gastroenterology 2019年第23期25卷 2961-2972页

作者： hyo-Young Lee hyunwoo Oh Chan-hyuk Park Yee-hui Yeo mindie h nguyen Dae-Won Jun Department of Internal Medicine Hanyang University College of MedicineSeoul 04763South Korea Department of Internal Medicine Hanyang University Guri HospitalHanyang University College of MedicineGuri 11923South Korea Division of Gastroenterology and hepatology Stanford University Medical CenterStanford UniversityStanford 94305CAUnited States

BACKGROUND Recently, the American Association for the Study of Liver Disease suggested no preference between tenofovir(TDF) and entecavir(ETV) regarding potential long-term risks of renal complications. Over the years, renal safety has become a critical concern in nucleos(t)ide analog-treated patients due to the long-term use of these drugs. however, existing studies do not show significant differences in renal dysfunction between these two drugs. Further, there is a paucity of studies comparing the long-term renal effects of TDF and *** To investigate the effects of TDF and ETV on renal function, we performed systematic review and *** Two investigators independently searched the Cochrane Library, MEDLINE, and Embase databases for randomized controlled trials and nonrandomized studies(NRSs) using the keywords 'ChB', 'Tenofovir', and 'Entecavir', and additional references were obtained from the bibliographies of relevant articles published through December 2017. The quality of each study was assessed using the Newcastle-Ottawa scale and the Grading of Recommendations Assessment,Development and Evaluation criteria. The primary outcome was the change in serum creatinine level in the TDF and ETV groups at baseline, 6 mo, 12 mo and24 *** NRSs comprising 2263 participants met the inclusion criteria. Changes in creatinine levels were higher in the TDF group than in the ETV group at 6 mo[mean difference(MD) = 0.03 mg/dL;95%CI: 0.02-0.04;I2 = 0%], 12 mo(MD =0.05 mg/dL;95%CI: 0.02-0.08;I2 = 78%), and 24 mo(MD = 0.07 mg/dL;95%CI:0.01-0.13;I2 = 93%). The change in estimated glomerular filtration rate(eGFR) was significantly higher in the TDF group than in the ETV group at 6 mo[standardized mean difference(SMD),-0.22;95%Cl:-0.36--0.08;I2 = 0%], 12 mo(SMD =-0.24;95%Cl:-0.43--0.05;I2 = 50%), and 24 mo(-0.35;95%Cl:-0.61--0.09;I2= 67%).CONCLUSION TDF statistically significantly increased serum creatinine levels and decreased the eGFR in 6-24 mo compa

关键词： hepatitis B Chronic Tenofovir Entecavir Safety Review Systematic Meta-analysis

Investigation of crack segmentation and fast evaluation of crack propagation, based on deep learning

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Frontiers of Structural and Civil Engineering 2024年第4期18卷 516-535页

作者： Than V.TRAN h.nguyen-XUAN Xiaoying ZhUANG Institute of Photonics Leibniz University HannoverHannover 30167Germany CIRTech Institute HUTECH UniversityHo Chi Minh City 700000Vietnam College of Civil Engineering Tongji UniversityShanghai 200092China

Identifying crack and predicting crack propagation are critical processes for the risk assessment of engineering *** traditional approaches to crack modeling are faced with issues of high computational costs and excessive computing *** address this issue,we explore the potential of deep learning(DL)to increase the efficiency of crack detection and forecasting crack ***,there is no single algorithm that can fit all data sets well or can apply in all cases since specific tasks *** the paper,we present DL models for identifying cracks,especially on concrete surface images,and for predicting crack ***,SegNet and U-Net networks are used to identify concrete *** gradient descent(SGD)and adaptive moment estimation(Adam)algorithms are applied to minimize loss function during ***,time series algorithms including gated recurrent unit(GRU)and long short-term memory(LSTM)are used to predict crack *** experimental findings indicate that the U-Net is more robust and efficient than the SegNet for identifying crack segmentation and achieves the most outstanding *** evaluation of crack propagation,GRU and LSTM are used as DL models and results show good agreement with the experimental data.

关键词： deep learning crack segmentation crack propagation encoder−decoder recurrent neural network

Advancing Wound Filling Extraction on 3D Faces:An Auto-Segmentation and Wound Face Regeneration Approach

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 2197-2214页

作者： Duong Q.nguyen Thinh D.Le Phuong D.nguyen Nga T.K.Le h.nguyen-Xuan Department of Mathematics and Statistics Quy Nhon UniversityQuy Nhon City55100Viet Nam Applied Research Institute for Science and Technology Quy Nhon UniversityQuy Nhon City55100Viet Nam CIRTECh Institute HUTECH UniversityHo Chi Minh City72308Viet Nam

Facial wound segmentation plays a crucial role in preoperative planning and optimizing patient outcomes in various medical *** this paper,we propose an efficient approach for automating 3D facial wound segmentation using a two-stream graph convolutional *** method leverages the Cir3D-FaIR dataset and addresses the challenge of data imbalance through extensive experimentation with different loss *** achieve accurate segmentation,we conducted thorough experiments and selected a high-performing model from the *** selectedmodel demonstrates exceptional segmentation performance for complex 3D facial ***,based on the segmentation model,we propose an improved approach for extracting 3D facial wound fillers and compare it to the results of the previous *** method achieved a remarkable accuracy of 0.9999993% on the test suite,surpassing the performance of the previous *** this result,we use 3D printing technology to illustrate the shape of the wound *** outcomes of this study have significant implications for physicians involved in preoperative planning and intervention *** automating facial wound segmentation and improving the accuracy ofwound-filling extraction,our approach can assist in carefully assessing and optimizing interventions,leading to enhanced patient ***,it contributes to advancing facial reconstruction techniques by utilizing machine learning and 3D bioprinting for printing skin tissue *** source code is available at https://***/SIMOGroup/WoundFilling3D.

关键词： 3D printing technology face reconstruction 3D segmentation 3D printed model

hepatitis B surface antigen escape mutations: Indications for initiation of antiviral therapy revisited

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World Journal of Clinical Cases 2016年第3期4卷 71-75页

作者： Jennifer Leong Derek Lin mindie h nguyen Division of Liver Diseases Department of Medicine Icahn School of Medicine at Mount Sinai Department of Medicine Stanford University Medical Center Division of Gastroenterology and hepato-logy Stanford University Medical Center

Approximately 240 million people are chronically infected with hepatitis B. The implementation of rigorous vaccination programs has led to an overall decrease in the prevalence of this disease worldwide but this may also have led to emergence of viral mutations that can escape the protection of hepatitis B surface antibody. As this phenomenon is increasingly recognized, concern for transmission to vaccinated individuals has also been raised. herein, we describe two cases where the suspected presence of a hepatitis B surface antigen escape mutation impacted the decision to initiate early antiviral therapy, as well as provide a brief review of these mutations. Our findings described here suggest that a lower threshold for initiating therapy in these individuals should be considered in order to reduce the risk of transmission, as vaccination does not provide protection.

关键词： hepatitis B virus hepatitis B surface antigen Escape mutant hepatitis B immunoglobulin Vaccination

Tungsten-based nanocatalysts with different structures for visible light responsive photocatalytic degradation of bisphenol A

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Journal of Environmental Sciences 2024年第5期139卷 569-588页

作者： hai Bang Truong Thi Thu Loan Doan nguyen Tien hoang nguyen Van Tam Minh Kim nguyen Le Gia Trung Jin Seog Gwag nguyen Tien Tran Optical Materials Research Group Science and Technology Advanced InstituteVan Lang UniversityHo Chi Minh CityViet Nam Faculty of Applied Technology School of TechnologyVan Lang UniversityHo Chi Minh CityViet Nam The University of Da Nang University of Science and Technology54 Nguyen Luong BangDa NangViet Nam The University of Da Nang University of Science and Education459 Ton Duc Thang St.Lien ChieuDa Nang 550000Viet Nam Institute of Veterinary Science and Technology 31ha zoneTrau QuyGia LamHa Noi 12400Viet Nam Department of Physics Yeungnam UniversityGyeongsanGyeongbuk 38541Republic of Korea Center for Advanced Chemistry Institute of Research and DevelopmentDuy Tan University03 Quang TrungDa Nang 550000Viet Nam Faculty of Natural Sciences Duy Tan University03 Quang TrungDa Nang 550000Viet Nam

Environmental pollution,such as water contamination,is a critical issue that must be absolutely ***,three different morphologies of tungsten-based photocatalysts(WO_(3)nanorods,WO_(3)/WS_(2)nanobricks,WO_(3)/WS_(2)nanorods)are made using a simple hydrothermal method by changing the solvents(h_(2)O,DMF,aqueous hCl solution).The as-prepared nanocatalysts have excellent thermal stability,large porosity,and high *** results show all materials have good photocatalytic activity in aqueous media,with WO_(3)/WS_(2)nanorods(NRs)having the best activity in the photodegradation of bisphenol A(BPA)under visible-light *** may originate from increased migration of charge carriers and effective prevention of electron–hole recombination in WO_(3)/WS_(2)NRs,whereby this photocatalyst is able to generate more reactive·Oh and·O_(2)^(–)species,leading to greater photocatalytic *** 99.6% of BPA is photodegraded within 60 min when using 1.5 g/L WO_(3)/WS_(2)NRs and 5.0 mg/L BPA at ph ***,the optimal conditions(ph,catalyst dosage,initial BPA concentration)for WO_(3)/WS_(2)NRs are also elaborately *** rod-like heterostructures are expressed as potential catalysts with excellent photostability,efficient reusability,and highly active effectivity in different types of *** particular,the removal efficiency of BPA by WO_(3)/WS_(2)NRs reduces by only 1.5% after five recycling runs and even reaches 89.1%in contaminated lake *** study provides promising insights for the nearly complete removal of BPA from wastewater or different water resources,which is advantageous to various applications in environmental remediation.

关键词： Photodegradation Bisphenol A Tungsten-based nanocatalyst Structure Nanorod

GLOBAL BOUND ON ThE GRADIENT OF SOLUTIONS TO p-LAPLACE TYPE EQUATIONS WITh MIXED DATA

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Acta Mathematica Scientia 2024年第4期44卷 1394-1414页

作者： Minh-Phuong TRAN The-Quang TRAN Thanh-Nhan nguyen Applied Analysis Research Group Faculty of Mathematics and StatisticsTon Duc Thang UniversityHo Chi Minh CityVietnam nguyen huu huan high School Thu Duc CityVietnam Group of Analysis and Applied Mathematics Department of MathematicsHo Chi Minh City University of EducationVietnam

In this paper,the study of gradient regularity for solutions of a class of elliptic problems of p-Laplace type is *** particular,we prove a global result concerning Lorentz-Morrey regularity of the non-homogeneous boundary data problem:-div((s^(2)+|▽u|^(2)p-2/2)▽u)=-div(|f|^(p-2)f)+g inΩ,u=h in■Ω,with the(sub-elliptic)degeneracy condition s∈[0,1]and with mixed data f∈L^(p)(Q;R^(n)),g∈Lp/(p-1)(Ω;R^(n))for p∈(1,n).This problem naturally arises in various applications such as dynamics of non-Newtonian fluid theory,electro-rheology,radiation of heat,plastic moulding and many *** on the idea of level-set inequality on fractional maximal distribution functions,it enables us to carry out a global regularity result of the solution via fractional maximal *** to the significance of M_(α)and its relation with Riesz potential,estimates via fractional maximal functions allow us to bound oscillations not only for solution but also its fractional derivatives of orderα.Our approach therefore has its own interest.

关键词： gradient estimates p-Laplace quasilinear elliptic equation fractional maximal operators Lorentz-Morrey spaces